iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027421

Ensembl Protein ID

ENSDARP00000048276.6

UniProt Accession

F1QDQ1; F1QDQ1_DANRE

Genbank Protein ID

ENSDARP00000048276

Protein Name

Coatomer subunit alpha

Genbank Nucleotide ID

BX649372

Gene Name

copa

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000004173.11	ENSDART00000048277.7	ENSDARP00000048276.6

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.10e-35	118.3	50	80
UBD/Beta-Prp	1.00e-74	252.3	3	324

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDl 30
           H ++v++++f  + +l+vsG+dD +ikvW++
   Q: 50   HDGPVRGIDFhkQQPLFVSGGDDYKIKVWNY 80
           99********97449**************96 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           t +++++++++ + f+p++++++++  +g i++wd+++ +l+ ++ +h+++v+ ++f+++++++v+g++D+ ikvw+++ + c+ tl g
   Q: 3    TKFETKSARVKGLSFHPKRPWILASLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLG 91
           67889999********************************************************************************* PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl............... 166
           h d+++++ f+ +  +++s+s+d+tir+w++++++c+  +l+gh++ v+c+++hp+++l+vs+slD+tvr+Wd+               
   Q: 92   HLDYIRTTFFHHEYPWILSASDDQTIRIWNWQSRTCVC-VLTGHNHYVMCAQFHPSEDLVVSASLDQTVRVWDIsglrkknlspgavdt 179
           **************************************.************************************************** PP
   S: 167  ............ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec..vrtlnghtdnvksvrfspnderlvsgs 241
                       +++ ++++  +gh++ v++ +f+++++ +vsg++d++vk+w + +++   ++t++gh +nv++  f+p++e+++s s
   Q: 180  evrgisgvdlfgASDAVVKHVLEGHDRGVNWAAFHPSMPLIVSGADDRQVKIWRMNESKAweLDTCRGHYNNVSCAVFHPRQELILSNS 268
           ************888888877777********************************8888789************************** PP
   S: 242  sDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +D+sir+Wd+ +++ ++t+ + +++++   + +++ n +++g  ds   ++kl++++p
   Q: 269  EDKSIRVWDMSKRTGVQTFRRDHDRFWVLGA-HPNLNLFAAG-HDSGMLVFKLERERP 324
           ***************************9999.4444444333.589999999988765 PP

Organism

Danio rerio

Functional Description
(View)

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.

Protein Sequence
(Fasta)

MLTKFETKSA RVKGLSFHPK RPWILASLHN GVIQLWDYRM CTLIDKFDEH DGPVRGIDFH 60
KQQPLFVSGG DDYKIKVWNY KLRRCLFTLL GHLDYIRTTF FHHEYPWILS ASDDQTIRIW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGATTGAGT AGACGTGTCA GCTACGGAAG TGGAGCTGCA GAATCAAACA CGCAAAGTCC 60
CTTCCTACCG GGGGATGATT TTAGGCTTCT AATTCGCATA AACGGATCAA TATCTTCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0931--ER-Golgi transport
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0653--Protein transport
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR016391--Coatomer_asu
IPR010714--Coatomer_asu_C
IPR006692--Coatomer_WD-assoc_reg
IPR020472--G-protein_beta_WD-40_rep
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF04053--Coatomer_WDAD
PF06957--COPI_C
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030126--C:COPI vesicle coat
GO:0000139--C:Golgi membrane
GO:0005198--F:structural molecule activity
GO:0006886--P:intracellular protein transport
GO:0030903--P:notochord development
GO:0061053--P:somite development
GO:0016192--P:vesicle-mediated transport

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000064	Aegilops tauschii	61.58	0.00e+00	1083.00
IUUC-Aml-001758	Ailuropoda melanoleuca	85.66	0.00e+00	2225.00
IUUC-Atr-002493	Amborella trichopoda	53.86	0.00e+00	1301.00
IUUC-Apl-003385	Anas platyrhynchos	82.86	0.00e+00	1847.00
IUUC-Aca-005154	Anolis carolinensis	93.24	4.00e-118	416.00
IUUC-Aly-006020	Arabidopsis lyrata	61.03	0.00e+00	1070.00
IUUC-Ath-007058	Arabidopsis thaliana	61.30	0.00e+00	1065.00
IUUC-Ago-007992	Ashbya gossypii	44.17	0.00e+00	1029.00
IUUC-Acl-008027	Aspergillus clavatus	56.56	0.00e+00	1000.00
IUUC-Afl-008644	Aspergillus flavus	56.83	0.00e+00	994.00
IUUC-Afu-008964	Aspergillus fumigatus	49.39	0.00e+00	1197.00
IUUC-Ani-009379	Aspergillus nidulans	56.60	0.00e+00	1012.00
IUUC-Ang-009756	Aspergillus niger	49.63	0.00e+00	1201.00
IUUC-Aor-010174	Aspergillus oryzae	56.83	0.00e+00	993.00
IUUC-Ate-010302	Aspergillus terreus	48.38	0.00e+00	1208.00
IUUC-Ame-011229	Astyanax mexicanus	95.67	0.00e+00	2341.00
IUUC-Bgr-012300	Blumeria graminis	48.31	0.00e+00	1151.00
IUUC-Bta-012524	Bos taurus	86.37	0.00e+00	2217.00
IUUC-Bci-013781	Botrytis cinerea	49.35	0.00e+00	1197.00
IUUC-Bdi-014214	Brachypodium distachyon	52.82	0.00e+00	1306.00
IUUC-Bol-015925	Brassica oleracea	60.70	0.00e+00	1058.00
IUUC-Bra-016978	Brassica rapa	60.12	0.00e+00	1054.00
IUUC-Cel-018115	Caenorhabditis elegans	63.25	0.00e+00	1108.00
IUUC-Cja-019107	Callithrix jacchus	83.95	0.00e+00	2165.00
IUUC-Cfa-020675	Canis familiaris	85.50	0.00e+00	2193.00
IUUC-Cpo-021813	Cavia porcellus	86.29	0.00e+00	2235.00
IUUC-Cre-022969	Chlamydomonas reinhardtii	63.29	0.00e+00	1092.00
IUUC-Csa-023523	Chlorocebus sabaeus	86.61	0.00e+00	2241.00
IUUC-Cho-024704	Choloepus hoffmanni	72.52	0.00e+00	1682.00
IUUC-Cin-025572	Ciona intestinalis	71.31	0.00e+00	1825.00
IUUC-Csv-025864	Ciona savignyi	74.64	0.00e+00	1287.00
IUUC-Cgl-026510	Colletotrichum gloeosporioides	57.74	0.00e+00	1021.00
IUUC-Cne-027053	Cryptococcus neoformans	51.70	0.00e+00	1233.00
IUUC-Cme-027222	Cyanidioschyzon merolae	39.88	4.00e-140	493.00
IUUC-Dno-029303	Dasypus novemcinctus	85.84	0.00e+00	2226.00
IUUC-Dor-030290	Dipodomys ordii	80.39	0.00e+00	928.00
IUUC-Dse-031543	Dothistroma septosporum	46.89	0.00e+00	1120.00
IUUC-Dme-031945	Drosophila melanogaster	75.72	0.00e+00	1280.00
IUUC-Ete-032873	Echinops telfairi	81.22	0.00e+00	1930.00
IUUC-Eca-033773	Equus caballus	84.09	0.00e+00	2162.00
IUUC-Eeu-034874	Erinaceus europaeus	73.00	0.00e+00	1301.00
IUUC-Fca-035739	Felis catus	85.46	0.00e+00	2174.00
IUUC-Fal-037263	Ficedula albicollis	79.33	0.00e+00	1966.00
IUUC-Fox-037738	Fusarium oxysporum	48.67	0.00e+00	1202.00
IUUC-Fso-038153	Fusarium solani	49.55	0.00e+00	1203.00
IUUC-Gmo-039602	Gadus morhua	88.75	0.00e+00	2161.00
IUUC-Ggr-039931	Gaeumannomyces graminis	56.85	0.00e+00	1012.00
IUUC-Gga-040590	Gallus gallus	85.21	0.00e+00	2204.00
IUUC-Gac-041318	Gasterosteus aculeatus	91.04	0.00e+00	2314.00
IUUC-Gma-043894	Glycine max	54.14	0.00e+00	1325.00
IUUC-Ggo-045029	Gorilla gorilla	86.06	0.00e+00	2234.00
IUUC-Hsa-046078	Homo sapiens	85.98	0.00e+00	2233.00
IUUC-Hvu-047556	Hordeum vulgare	53.81	0.00e+00	1330.00
IUUC-Itr-048881	Ictidomys tridecemlineatus	81.82	0.00e+00	1501.00
IUUC-Kpa-049256	Komagataella pastoris	44.93	0.00e+00	1074.00
IUUC-Lch-049706	Latimeria chalumnae	86.20	0.00e+00	2184.00
IUUC-Lpe-051316	Leersia perrieri	61.70	0.00e+00	1082.00
IUUC-Loc-051867	Lepisosteus oculatus	69.49	0.00e+00	1215.00
IUUC-Lma-053138	Leptosphaeria maculans	47.94	0.00e+00	1158.00
IUUC-Laf-053510	Loxodonta africana	86.68	0.00e+00	2235.00
IUUC-Mcc-055836	Macaca mulatta	85.41	0.00e+00	2222.00
IUUC-Meu-056238	Macropus eugenii	80.69	0.00e+00	1113.00
IUUC-Mor-057172	Magnaporthe oryzae	49.16	0.00e+00	1191.00
IUUC-Mpo-057300	Magnaporthe poae	48.85	0.00e+00	1172.00
IUUC-Mtr-058248	Medicago truncatula	54.29	0.00e+00	1331.00
IUUC-Mla-059019	Melampsora laricipopulina	51.53	0.00e+00	1265.00
IUUC-Mga-059499	Meleagris gallopavo	85.07	0.00e+00	2198.00
IUUC-Mvi-060336	Microbotryum violaceum	59.00	0.00e+00	1065.00
IUUC-Mmr-061102	Microcebus murinus	86.14	0.00e+00	2201.00
IUUC-Mdo-062594	Monodelphis domestica	87.10	0.00e+00	2276.00
IUUC-Mmu-063736	Mus musculus	86.14	0.00e+00	2224.00
IUUC-Mac-065398	Musa acuminata	51.06	0.00e+00	1209.00
IUUC-Mpu-066701	Mustela putorius furo	85.42	0.00e+00	2200.00
IUUC-Mlu-067392	Myotis lucifugus	85.48	0.00e+00	2214.00
IUUC-Nfi-068270	Neosartorya fischeri	57.06	0.00e+00	1004.00
IUUC-Ncr-068892	Neurospora crassa	49.07	0.00e+00	1180.00
IUUC-Nle-069634	Nomascus leucogenys	91.97	0.00e+00	1305.00
IUUC-Opr-070952	Ochotona princeps	72.94	0.00e+00	1566.00
IUUC-Ont-072488	Oreochromis niloticus	92.48	0.00e+00	2295.00
IUUC-Oan-073184	Ornithorhynchus anatinus	44.22	3.00e-68	251.00
IUUC-Ocu-074211	Oryctolagus cuniculus	86.20	0.00e+00	2233.00
IUUC-Oba-075761	Oryza barthii	61.46	0.00e+00	1081.00
IUUC-Obr-076429	Oryza brachyantha	61.82	0.00e+00	1085.00
IUUC-Ogl-077364	Oryza glaberrima	61.46	0.00e+00	1081.00
IUUC-Ogu-078257	Oryza glumaepatula	61.46	0.00e+00	1080.00
IUUC-Oin-079274	Oryza indica	61.34	0.00e+00	1079.00
IUUC-Olo-080466	Oryza longistaminata	61.85	0.00e+00	1071.00
IUUC-Ome-081668	Oryza meridionalis	60.88	0.00e+00	906.00
IUUC-Oni-082874	Oryza nivara	61.46	0.00e+00	1079.00
IUUC-Opu-083885	Oryza punctata	61.58	0.00e+00	1080.00
IUUC-Oru-084274	Oryza rufipogon	61.46	0.00e+00	1080.00
IUUC-Osa-085565	Oryza sativa	61.46	0.00e+00	1080.00
IUUC-Ola-086921	Oryzias latipes	91.82	0.00e+00	2265.00
IUUC-Olu-087639	Ostreococcus lucimarinus	54.42	0.00e+00	1325.00
IUUC-Oga-087991	Otolemur garnettii	81.69	0.00e+00	2093.00
IUUC-Oar-089590	Ovis aries	86.78	0.00e+00	2236.00
IUUC-Ptr-090808	Pan troglodytes	86.06	0.00e+00	2235.00
IUUC-Pan-092475	Papio anubis	86.22	0.00e+00	2229.00
IUUC-Psi-093044	Pelodiscus sinensis	75.81	0.00e+00	1314.00
IUUC-Pno-094839	Phaeosphaeria nodorum	47.92	0.00e+00	1109.00
IUUC-Ppa-095390	Physcomitrella patens	56.94	0.00e+00	1371.00
IUUC-Pfo-097493	Poecilia formosa	92.40	0.00e+00	2261.00
IUUC-Pab-098497	Pongo abelii	86.69	0.00e+00	2242.00
IUUC-Pop-099992	Populus trichocarpa	55.36	0.00e+00	1320.00
IUUC-Pca-100413	Procavia capensis	82.21	0.00e+00	950.00
IUUC-Ppe-101899	Prunus persica	53.93	0.00e+00	1307.00
IUUC-Pva-102126	Pteropus vampyrus	82.41	0.00e+00	2126.00
IUUC-Pgr-103376	Puccinia graminis	50.43	0.00e+00	1271.00
IUUC-Ptt-103978	Puccinia triticina	45.15	0.00e+00	1056.00
IUUC-Pte-104126	Pyrenophora teres	47.55	0.00e+00	1117.00
IUUC-Pyt-104778	Pyrenophora triticirepentis	45.64	3.00e-177	616.00
IUUC-Rno-105428	Rattus norvegicus	86.94	0.00e+00	2235.00
IUUC-Sce-106464	Saccharomyces cerevisiae	43.01	0.00e+00	996.00
IUUC-Sha-107301	Sarcophilus harrisii	86.30	0.00e+00	2215.00
IUUC-Sja-107961	Schizosaccharomyces japonicus	45.20	0.00e+00	1082.00
IUUC-Spo-108217	Schizosaccharomyces pombe	47.15	0.00e+00	1132.00
IUUC-Ssl-108643	Sclerotinia sclerotiorum	49.27	0.00e+00	1199.00
IUUC-Smo-109582	Selaginella moellendorffii	63.63	0.00e+00	1135.00
IUUC-Sit-109697	Setaria italica	61.58	0.00e+00	1080.00
IUUC-Sly-111447	Solanum lycopersicum	54.48	0.00e+00	1344.00
IUUC-Stu-112564	Solanum tuberosum	54.66	0.00e+00	1343.00
IUUC-Sar-113313	Sorex araneus	75.26	0.00e+00	1309.00
IUUC-Sbi-114388	Sorghum bicolor	61.94	0.00e+00	1083.00
IUUC-Sre-115209	Sporisorium reilianum	57.18	0.00e+00	1035.00
IUUC-Ssc-115933	Sus scrofa	86.45	0.00e+00	2236.00
IUUC-Tgu-117109	Taeniopygia guttata	70.67	0.00e+00	668.00
IUUC-Tru-117772	Takifugu rubripes	90.15	0.00e+00	2240.00
IUUC-Tsy-119105	Tarsius syrichta	73.91	0.00e+00	1873.00
IUUC-Tni-120556	Tetraodon nigroviridis	74.11	0.00e+00	1593.00
IUUC-Tca-121046	Theobroma cacao	53.90	0.00e+00	1343.00
IUUC-Tre-121951	Trichoderma reesei	56.16	0.00e+00	1014.00
IUUC-Tvi-122359	Trichoderma virens	49.27	0.00e+00	1185.00
IUUC-Tae-125732	Triticum aestivum	54.05	0.00e+00	1327.00
IUUC-Tur-126754	Triticum urartu	61.58	0.00e+00	1085.00
IUUC-Tme-127170	Tuber melanosporum	50.24	0.00e+00	1222.00
IUUC-Tbe-127882	Tupaia belangeri	67.26	0.00e+00	758.00
IUUC-Ttr-128217	Tursiops truncatus	83.71	0.00e+00	2158.00
IUUC-Uma-129337	Ustilago maydis	57.41	0.00e+00	1034.00
IUUC-Vda-129828	Verticillium dahliae	48.23	0.00e+00	1174.00
IUUC-Vpa-130537	Vicugna pacos	85.17	0.00e+00	2208.00
IUUC-Vvi-130958	Vitis vinifera	63.03	0.00e+00	1098.00
IUUC-Xtr-132857	Xenopus tropicalis	82.77	0.00e+00	2108.00
IUUC-Xma-133138	Xiphophorus maculatus	92.08	0.00e+00	2256.00
IUUC-Yli-134399	Yarrowia lipolytica	50.52	0.00e+00	865.00
IUUC-Zma-135612	Zea mays	53.06	0.00e+00	1307.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence