iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000118369.12	ENST00000529308.5	ENSP00000431876.1
ENSG00000118369.12	ENST00000530546.5	ENSP00000436253.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
Mentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	14715245

Classification

Family	E-value	Score	Start	End
DUB/USP	1.70e-81	275.7	442	926

Active Site

Position(s)	Description	Evidence
450	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
862	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaq 93
           Gl NlgNtCY+NS+LQ+L++ +++r+++l+     l e+    ++++l+++lq lf  l +s++ a+sp+++l+a +   + fs   qqD++
   Q: 442  GLINLGNTCYVNSILQALFMASDFRHCVLR-----LTEN----NSQPLMTKLQWLFGFLEHSQRPAISPENFLSASW--TPWFSPGTQQDCS 522
           9*****************************.....4433....3579***************************998..677********** PP
   S: 94   EflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke 185
           E+l++lld+l+ee      k+ ++ +++ k+++s + +e+++  +++ ++++F+g++ ++i cl c nvssree f+dlsl++p  e +  +
   Q: 523  EYLKYLLDRLHEEE-----KTGTRICQKLKQSSSPSPPEEPPAPSSTSVEKMFGGKIVTRICCLCCLNVSSREEAFTDLSLAFPPPERCRRR 609
           **************.....67888888888999999999*********************************************99988777 PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 610  rlgsvmrpteditarelppptsaqgpgrvgprrqrkhcitedtpptslyiegldskeaggqssqeeriereeegkeertekeevgeeeestr 701
           99****************************************************************************************** PP
   S: 186  ..........................................................slqdcLesftkeeelegenkyycekckkkqeaek 219
                                                                     s+ d+ + f ++e+l+ en+yyce+c ++q+aek
   Q: 702  gegerekeeeveeeeekveketekeaeqekeedslgagthpdaaipsgertcgsegsrSVLDLVNYFLSPEKLTAENRYYCESCASLQDAEK 793
           ******************************************************************************************** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvkn......... 301
            ++l++ P +Lil L Rfsf+ ++++r+ki + v++pl L l     +        + Y+L++vvvHsG s++sGHY++y+++         
   Q: 794  VVELSQGPCYLILTLLRFSFDLRTMRRRKILDDVSIPLLLRLPLAGGR-------GQAYDLCSVVVHSGvSSESGHYYCYAREgaarpaasl 878
           *************************************99999855555.......89**************************999999999 PP
   S: 302  .......ekgkWllfdDskVtevkeeevleetg....staYvlfYkrr 338
                   +++W+lf+D++V+ ++ e+v + t+    +taYvlfY++r
   Q: 879  gtadrpePENQWYLFNDTRVSFSSFESVSNVTSffpkDTAYVLFYRQR 926
           99999888999*******************999************985 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MDKILEAVVT SSYPVSVKQG LVRRVLEAAR QPLEREQCLA LLALGARLYV GGAEELPRRV 60
GCQLLHVAGR HHPDVFAEFF SARRVLRLLQ GGAGPPGPRA LACVQLGLQL LPEGPAADEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCTGGCCT TAAAGGGGAC GCGGTCAGAG TGGCAGCTCG CGGGGTGGCC CCCGCTCCGG 60
CTCCGCCCCA TTTCACGCAC CTCGCCCCTC CCCATGCTTC ATCCCGCAGC CCCGGGGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:57558

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001744	Ailuropoda melanoleuca	88.44	0.00e+00	972.00
IUUC-Apl-004121	Anas platyrhynchos	67.41	0.00e+00	890.00
IUUC-Bta-012545	Bos taurus	92.08	0.00e+00	1153.00
IUUC-Cja-019731	Callithrix jacchus	97.03	0.00e+00	1196.00
IUUC-Cfa-020095	Canis familiaris	94.49	0.00e+00	1173.00
IUUC-Cpo-021961	Cavia porcellus	93.37	0.00e+00	1157.00
IUUC-Csa-023167	Chlorocebus sabaeus	98.07	0.00e+00	1184.00
IUUC-Dno-029186	Dasypus novemcinctus	83.65	0.00e+00	834.00
IUUC-Dor-030538	Dipodomys ordii	97.74	0.00e+00	978.00
IUUC-Dme-031871	Drosophila melanogaster	31.44	3.00e-45	177.00
IUUC-Ete-032512	Echinops telfairi	88.93	5.00e-104	372.00
IUUC-Eca-033279	Equus caballus	96.73	0.00e+00	908.00
IUUC-Eeu-035120	Erinaceus europaeus	72.24	0.00e+00	831.00
IUUC-Fca-035969	Felis catus	92.84	0.00e+00	894.00
IUUC-Fal-037625	Ficedula albicollis	67.80	0.00e+00	895.00
IUUC-Gga-040767	Gallus gallus	67.01	0.00e+00	887.00
IUUC-Ggo-045323	Gorilla gorilla	98.73	0.00e+00	1391.00
IUUC-Itr-048704	Ictidomys tridecemlineatus	94.03	0.00e+00	1144.00
IUUC-Laf-053999	Loxodonta africana	89.02	0.00e+00	1139.00
IUUC-Mcc-055266	Macaca mulatta	97.18	0.00e+00	1164.00
IUUC-Meu-056906	Macropus eugenii	74.70	0.00e+00	978.00
IUUC-Mga-059595	Meleagris gallopavo	70.79	0.00e+00	872.00
IUUC-Mmr-061720	Microcebus murinus	93.58	0.00e+00	719.00
IUUC-Mdo-062167	Monodelphis domestica	74.70	0.00e+00	973.00
IUUC-Mmu-063298	Mus musculus	91.98	0.00e+00	1147.00
IUUC-Mpu-066195	Mustela putorius furo	93.89	0.00e+00	1156.00
IUUC-Mlu-067583	Myotis lucifugus	88.68	0.00e+00	783.00
IUUC-Opr-070454	Ochotona princeps	90.17	1.00e-158	554.00
IUUC-Ocu-074121	Oryctolagus cuniculus	86.71	0.00e+00	946.00
IUUC-Oga-088593	Otolemur garnettii	94.49	0.00e+00	1145.00
IUUC-Oar-090140	Ovis aries	91.48	0.00e+00	1135.00
IUUC-Pan-092168	Papio anubis	98.37	0.00e+00	1186.00
IUUC-Psi-093707	Pelodiscus sinensis	65.79	0.00e+00	885.00
IUUC-Pab-097614	Pongo abelii	97.94	0.00e+00	1603.00
IUUC-Pca-100683	Procavia capensis	88.23	0.00e+00	1117.00
IUUC-Pva-103146	Pteropus vampyrus	80.68	0.00e+00	1026.00
IUUC-Rno-105061	Rattus norvegicus	92.27	0.00e+00	1154.00
IUUC-Sha-106686	Sarcophilus harrisii	72.65	0.00e+00	956.00
IUUC-Tgu-117024	Taeniopygia guttata	67.86	0.00e+00	897.00
IUUC-Tsy-119505	Tarsius syrichta	80.65	1.00e-166	580.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence