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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Mmu-063247
Ensembl Protein ID ENSMUSP00000044276.5
UniProt Accession A2AAY5; B6F0V1; Q1LZL8; Q1LZM5; Q3TB89; Q8BIC6; SPD2B_MOUSE
Genbank Protein ID BAG81976.1; BAC40843.1; BAE42425.1; CAM22517.1; AAI15712.1; AAI15765.1
Protein Name SH3 and PX domain-containing protein 2B; Factor for adipocyte differentiation 49; Tyrosine kinase substrate with four SH3 domains
Genbank Nucleotide ID AB430861; AK089330; AK171384; AL662780; BC115711; BC115764
Gene Name Sh3pxd2b; Fad49; Tks4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000040711.7 ENSMUST00000038753.5 ENSMUSP00000044276.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDHINT
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.90e-24 85.9 223 277
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
    +ek v+y+y+a ++de++l++G vv+v+ +++ egW+k +gk+G P+ + +k
   Q: 223 EEKYTVIYPYTARDQDEMNLERGAVVEVV--QKNLEGWWKI--RYQGKEGWAPASYLKK 277
    67889************************..8899****88..9**********99886 PP
   

Organism Mus musculus
Functional Description
(View)

Functional Description



     Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation.
Protein Sequence
(Fasta)
MPPRRSIVEV KVLDVQKRRV PNKHYVYIIR VTWSSGATEA IYRRYSKFFD LQMQMLDKFP 60
MEGGQKDPKQ RIIPFLPGKI LFRRSHIRDV AVKRLIPIDE YCKALIQLPP YISQCDEVLQ 120
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Protein Fasta Sequence



>IUUC-Mmu-063247|UBD,SH3|Mus musculus
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Nucleotide Sequence
(Fasta)
GGCGGCAAGT GCTCGGCGGC AAGGATCGCT TTGGCCCGGC CCGGCCCGCA CGGCGCTGGG 60
CGCGGAGAAC GGCCATGCCG CCGCGGCGCA GTATCGTGGA GGTGAAGGTG CTGGACGTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Mmu-063247|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0965--Cell junction
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR001683--Phox
IPR011511--SH3_2
IPR001452--SH3_domain
IPR030512--SH3PXD2B

PROSITE

PS50195--PX
PS50002--SH3

Pfam

PF00787--PX
PF00018--SH3_1
PF07653--SH3_2

SMART

SM00312--PX
SM00326--SH3

Gene Ontology

GO:0030054--C:cell junction
GO:0042995--C:cell projection
GO:0005737--C:cytoplasm
GO:0002102--C:podosome
GO:0080025--F:phosphatidylinositol-3,5-bisphosphate binding
GO:0032266--F:phosphatidylinositol-3-phosphate binding
GO:0070273--F:phosphatidylinositol-4-phosphate binding
GO:0010314--F:phosphatidylinositol-5-phosphate binding
GO:0042169--F:SH2 domain binding
GO:0016176--F:superoxide-generating NADPH oxidase activator activity
GO:0060612--P:adipose tissue development
GO:0060348--P:bone development
GO:1904888--P:cranial skeletal system development
GO:0022617--P:extracellular matrix disassembly
GO:0001654--P:eye development
GO:0007507--P:heart development
GO:0002051--P:osteoblast fate commitment
GO:0055114--P:oxidation-reduction process
GO:0071800--P:podosome assembly
GO:1904179--P:positive regulation of adipose tissue development
GO:0045600--P:positive regulation of fat cell differentiation
GO:0010628--P:positive regulation of gene expression
GO:0040018--P:positive regulation of multicellular organism growth
GO:0051496--P:positive regulation of stress fiber assembly
GO:0072657--P:protein localization to membrane
GO:0060378--P:regulation of brood size
GO:0001501--P:skeletal system development
GO:0048705--P:skeletal system morphogenesis
GO:0006801--P:superoxide metabolic process

KEGG mmu:268396
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001572 Ailuropoda melanoleuca 85.78 0.00e+00 1498.00
IUUC-Apl-003349 Anas platyrhynchos 65.87 0.00e+00 1050.00
IUUC-Aca-004769 Anolis carolinensis 66.03 0.00e+00 1079.00
IUUC-Ame-011734 Astyanax mexicanus 47.89 4.00e-136 479.00
IUUC-Bta-012847 Bos taurus 83.24 0.00e+00 1439.00
IUUC-Bci-013600 Botrytis cinerea 32.81 2.00e-14 74.30
IUUC-Cja-019338 Callithrix jacchus 85.43 0.00e+00 1439.00
IUUC-Cfa-020751 Canis familiaris 84.95 0.00e+00 1461.00
IUUC-Cpo-021623 Cavia porcellus 84.23 0.00e+00 1405.00
IUUC-Csa-023399 Chlorocebus sabaeus 86.86 0.00e+00 1463.00
IUUC-Cho-024720 Choloepus hoffmanni 84.45 4.00e-102 365.00
IUUC-Cin-025592 Ciona intestinalis 38.67 9.00e-88 317.00
IUUC-Csv-026038 Ciona savignyi 38.27 3.00e-85 308.00
IUUC-Cgl-026496 Colletotrichum gloeosporioides 31.54 2.00e-14 73.90
IUUC-Cne-026892 Cryptococcus neoformans 27.94 4.00e-09 57.00
IUUC-Dno-029443 Dasypus novemcinctus 80.55 0.00e+00 1192.00
IUUC-Dor-030546 Dipodomys ordii 79.59 0.00e+00 1358.00
IUUC-Ete-032485 Echinops telfairi 71.83 0.00e+00 1127.00
IUUC-Eca-033780 Equus caballus 83.99 0.00e+00 1380.00
IUUC-Fca-036365 Felis catus 83.59 0.00e+00 1415.00
IUUC-Fal-036632 Ficedula albicollis 70.93 0.00e+00 848.00
IUUC-Fox-037760 Fusarium oxysporum 32.69 1.00e-13 71.20
IUUC-Fso-038453 Fusarium solani 33.65 2.00e-13 71.20
IUUC-Gmo-039101 Gadus morhua 69.80 2.00e-145 510.00
IUUC-Ggr-039899 Gaeumannomyces graminis 31.06 4.00e-14 73.20
IUUC-Gga-041167 Gallus gallus 63.89 0.00e+00 1040.00
IUUC-Gac-041676 Gasterosteus aculeatus 56.01 0.00e+00 670.00
IUUC-Ggo-045275 Gorilla gorilla 84.14 0.00e+00 1413.00
IUUC-Hsa-046483 Homo sapiens 85.79 0.00e+00 1453.00
IUUC-Itr-048237 Ictidomys tridecemlineatus 81.96 0.00e+00 1309.00
IUUC-Kpa-049363 Komagataella pastoris 31.09 3.00e-15 76.60
IUUC-Lch-049474 Latimeria chalumnae 58.99 0.00e+00 937.00
IUUC-Loc-052659 Lepisosteus oculatus 59.79 0.00e+00 801.00
IUUC-Laf-054220 Loxodonta africana 84.68 0.00e+00 1419.00
IUUC-Mcc-055001 Macaca mulatta 85.29 0.00e+00 1430.00
IUUC-Meu-056086 Macropus eugenii 69.91 0.00e+00 1127.00
IUUC-Mor-057190 Magnaporthe oryzae 33.65 1.00e-13 71.60
IUUC-Mpo-057398 Magnaporthe poae 33.65 8.00e-14 72.40
IUUC-Mga-059772 Meleagris gallopavo 64.49 0.00e+00 1014.00
IUUC-Mmr-061321 Microcebus murinus 77.50 0.00e+00 1293.00
IUUC-Mdo-061943 Monodelphis domestica 72.52 0.00e+00 1259.00
IUUC-Mpu-065848 Mustela putorius furo 83.76 0.00e+00 1514.00
IUUC-Mlu-067413 Myotis lucifugus 81.76 0.00e+00 1293.00
IUUC-Nle-069834 Nomascus leucogenys 90.33 0.00e+00 1056.00
IUUC-Opr-070355 Ochotona princeps 76.98 0.00e+00 1135.00
IUUC-Ont-071453 Oreochromis niloticus 50.51 2.00e-127 450.00
IUUC-Oan-073473 Ornithorhynchus anatinus 73.52 0.00e+00 835.00
IUUC-Ocu-073822 Oryctolagus cuniculus 79.95 0.00e+00 1316.00
IUUC-Oga-088006 Otolemur garnettii 86.39 0.00e+00 1473.00
IUUC-Oar-090176 Ovis aries 82.00 0.00e+00 1406.00
IUUC-Ptr-090730 Pan troglodytes 83.62 0.00e+00 1409.00
IUUC-Pan-092549 Papio anubis 84.38 0.00e+00 1143.00
IUUC-Pfo-096582 Poecilia formosa 57.12 0.00e+00 679.00
IUUC-Pab-097634 Pongo abelii 86.01 0.00e+00 1459.00
IUUC-Pca-101110 Procavia capensis 75.70 0.00e+00 1098.00
IUUC-Pva-103256 Pteropus vampyrus 79.83 0.00e+00 827.00
IUUC-Rno-106109 Rattus norvegicus 94.41 0.00e+00 1417.00
IUUC-Sce-106380 Saccharomyces cerevisiae 31.86 6.00e-11 62.40
IUUC-Spo-108303 Schizosaccharomyces pombe 28.44 2.00e-10 60.80
IUUC-Ssl-108480 Sclerotinia sclerotiorum 31.90 2.00e-12 67.80
IUUC-Sre-114971 Sporisorium reilianum 34.04 2.00e-10 61.20
IUUC-Ssc-115251 Sus scrofa 81.93 0.00e+00 1316.00
IUUC-Tgu-116480 Taeniopygia guttata 63.32 0.00e+00 944.00
IUUC-Tru-117751 Takifugu rubripes 67.85 3.00e-175 609.00
IUUC-Tni-120253 Tetraodon nigroviridis 53.78 4.00e-175 608.00
IUUC-Tre-121970 Trichoderma reesei 35.24 3.00e-14 73.60
IUUC-Tvi-122571 Trichoderma virens 34.29 8.00e-14 72.00
IUUC-Tme-127033 Tuber melanosporum 33.33 2.00e-13 70.90
IUUC-Tbe-127871 Tupaia belangeri 78.98 0.00e+00 1004.00
IUUC-Ttr-128955 Tursiops truncatus 84.57 0.00e+00 1479.00
IUUC-Uma-129402 Ustilago maydis 34.04 2.00e-10 61.20
IUUC-Vda-129885 Verticillium dahliae 33.65 1.00e-13 71.60
IUUC-Xtr-132258 Xenopus tropicalis 58.87 0.00e+00 897.00
Created Date 25-Jun-2017

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