iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106248

UUCD1 version

UUC-SaC-00057

Ensembl Protein ID

YPR164W

UniProt Accession

Q06211; D6W4G5; MMS1_YEAST

Genbank Protein ID

AAB68151.1; AAG02022.1; DAA11581.1

Protein Name

E3 ubiquitin-protein ligase linker protein MMS1; Methyl methanesulfonate-sensitivity protein 1; Regulator of Ty1 transposition protein 108; Synthetically lethal with MCM10 protein 6

Genbank Nucleotide ID

U25840; U14001; BK006949

Gene Name

MMS1; KIM3; RTT108; SLM6; YPR164W

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YPR164W	YPR164W	YPR164W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DDB1	DDB1	18704118

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes (CRLs), which mediate the ubiquitination of target proteins. The CRL associates with CDC34 as the E2 ubiquitin-conjugating enzyme. The functional specificity of the CRL depends on the type of the associated substrate receptor protein. RTT101(MMS1-MMS22) promotes fork progression through damaged DNA or natural pause sites by stabilizing replication proteins like the replication fork-pausing complex (FPC) and leading-strand polymerase at stalled replication forks. RTT101(MMS1-MMS22) ubiquitinates the acetylated histones H3K56ac-H4 at lysine residues H3K121, H3K122 and H3K125. Ubiquitination is required for efficient histone deposition during replication-coupled nucleosome assembly, probably by facilitating the transfer of H3-H4 from ASF1 to other chaperones involved in histone deposition. RTT101(MMS1-CRT10) may regulate nucleotide synthesis through transcriptional regulation of ribonucleotide reductase. RTT101(MMS1) is also involved in the non-functional rRNA decay (NRD) of 25S rRNA through the selective, ubiquitination-dependent degradation of nonfunctional ribosomal particles. Involved in the regulation of TY1 transposition.

Protein Sequence
(Fasta)

MLGLRTHGLD RYEHYIRRPS DFGKLELQDW LNHKSFRVSP NLLIDSSTTR EWNEPELFYQ 60
NTEDETWVRP CVGPKLEPSM MMLRYHDSNI GQMPQFCYPI SSPINFKPVL KYILQERSEL 120

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Nucleotide Sequence
(Fasta)

ATGCTAGGTT TGCGAACTCA TGGTTTAGAC AGGTATGAAC ATTATATTCG TCGCCCGTCG 60
GATTTTGGCA AACTTGAGCT GCAAGATTGG TTGAATCATA AGTCATTCCG AGTTTCCCCC 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Gene Ontology

GO:0035361--C:Cul8-RING ubiquitin ligase complex
GO:0005634--C:nucleus
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0010526--P:negative regulation of transposition, RNA-mediated
GO:0070651--P:nonfunctional rRNA decay
GO:0000725--P:recombinational repair
GO:0031297--P:replication fork processing

KEGG

sce:YPR164W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001295	Ailuropoda melanoleuca	26.37	8.00e-03	33.10
IUUC-Apl-003730	Anas platyrhynchos	25.27	7.00e-03	33.10
IUUC-Aly-006250	Arabidopsis lyrata	28.71	2.00e-04	38.50
IUUC-Ath-007358	Arabidopsis thaliana	26.00	2.00e-03	35.40
IUUC-Ago-007856	Ashbya gossypii	24.95	6.00e-61	227.00
IUUC-Afu-008991	Aspergillus fumigatus	34.18	3.30e-02	30.80
IUUC-Ani-009322	Aspergillus nidulans	32.73	2.00e-02	31.20
IUUC-Bta-012715	Bos taurus	26.37	6.00e-03	33.50
IUUC-Bci-013883	Botrytis cinerea	27.42	7.00e-03	33.50
IUUC-Bol-015479	Brassica oleracea	29.17	5.00e-03	33.10
IUUC-Cel-018622	Caenorhabditis elegans	27.18	2.50e-01	28.50
IUUC-Cja-019792	Callithrix jacchus	23.26	3.60e-02	32.00
IUUC-Cfa-020291	Canis familiaris	26.37	6.00e-03	33.50
IUUC-Cpo-021597	Cavia porcellus	25.27	2.90e-02	31.20
IUUC-Csa-023507	Chlorocebus sabaeus	25.27	2.50e-02	31.60
IUUC-Cho-024921	Choloepus hoffmanni	40.54	9.00e-03	30.40
IUUC-Cin-025733	Ciona intestinalis	29.76	3.00e-03	32.30
IUUC-Cgl-026738	Colletotrichum gloeosporioides	25.44	5.00e-03	33.90
IUUC-Dno-029500	Dasypus novemcinctus	26.88	8.00e-03	33.10
IUUC-Dor-030953	Dipodomys ordii	35.71	4.00e-03	32.70
IUUC-Dme-031998	Drosophila melanogaster	38.30	3.50e-02	31.60
IUUC-Eca-033486	Equus caballus	26.37	6.00e-03	33.50
IUUC-Eeu-034839	Erinaceus europaeus	25.27	2.70e-02	31.20
IUUC-Fal-037436	Ficedula albicollis	25.27	7.00e-03	33.10
IUUC-Fox-037782	Fusarium oxysporum	42.11	4.70e-02	29.30
IUUC-Gmo-038822	Gadus morhua	25.69	2.00e-03	36.60
IUUC-Gga-040301	Gallus gallus	25.27	7.00e-03	33.10
IUUC-Gma-044277	Glycine max	28.85	1.00e+00	27.30
IUUC-Lma-052976	Leptosphaeria maculans	30.36	7.00e-03	33.10
IUUC-Mla-058825	Melampsora laricipopulina	24.73	1.20e-02	32.00
IUUC-Mga-059333	Meleagris gallopavo	25.27	7.00e-03	33.10
IUUC-Mpu-066360	Mustela putorius furo	31.25	1.00e-02	35.40
IUUC-Mlu-067954	Myotis lucifugus	26.37	6.00e-03	33.50
IUUC-Nfi-068372	Neosartorya fischeri	32.73	2.60e-02	30.80
IUUC-Ont-071254	Oreochromis niloticus	23.85	9.00e-03	34.30
IUUC-Oba-075778	Oryza barthii	29.79	8.00e-03	33.50
IUUC-Obr-076901	Oryza brachyantha	36.11	6.00e-03	33.50
IUUC-Ola-087089	Oryzias latipes	25.00	1.80e-02	32.30
IUUC-Oga-088263	Otolemur garnettii	25.27	2.90e-02	31.20
IUUC-Oar-090302	Ovis aries	26.37	7.00e-03	33.10
IUUC-Ptr-090472	Pan troglodytes	25.27	2.50e-02	31.60
IUUC-Pan-091878	Papio anubis	25.27	2.50e-02	31.60
IUUC-Pma-094521	Petromyzon marinus	39.34	3.20e-02	30.00
IUUC-Pno-094965	Phaeosphaeria nodorum	35.56	2.30e-02	32.00
IUUC-Pfo-096324	Poecilia formosa	24.77	8.00e-03	34.30
IUUC-Pab-097577	Pongo abelii	25.27	2.50e-02	31.60
IUUC-Pca-100132	Procavia capensis	26.88	1.40e-02	32.00
IUUC-Ppe-101482	Prunus persica	34.69	2.30e-02	32.30
IUUC-Pva-102919	Pteropus vampyrus	29.41	2.30e-02	31.60
IUUC-Pyt-104495	Pyrenophora triticirepentis	31.71	1.30e-02	30.40
IUUC-Rno-105702	Rattus norvegicus	25.27	1.70e-02	32.00
IUUC-Sha-107261	Sarcophilus harrisii	27.91	1.50e-02	33.10
IUUC-Ssl-108669	Sclerotinia sclerotiorum	28.38	1.20e-01	28.50
IUUC-Smo-109091	Selaginella moellendorffii	33.33	1.00e-02	32.00
IUUC-Ssc-115379	Sus scrofa	26.37	7.00e-03	33.10
IUUC-Tgu-116895	Taeniopygia guttata	25.27	8.00e-03	33.10
IUUC-Tru-118373	Takifugu rubripes	24.77	1.00e-02	34.30
IUUC-Tsy-119321	Tarsius syrichta	37.50	6.90e-02	31.60
IUUC-Tni-119750	Tetraodon nigroviridis	24.77	1.50e-02	33.50
IUUC-Tvi-122279	Trichoderma virens	29.03	3.60e-02	31.20
IUUC-Tae-124206	Triticum aestivum	32.56	4.00e-03	33.90
IUUC-Ttr-128445	Tursiops truncatus	29.41	2.70e-02	31.20
IUUC-Vpa-130459	Vicugna pacos	29.41	2.40e-02	31.60

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence