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Tag Content
iUUCD ID IUUC-Dre-028808
Ensembl Protein ID ENSDARP00000094239.3
UniProt Accession Q6NWJ4; Q7SY51; DNJC2_DANRE
Genbank Protein ID AAH55125.1; AAH67568.1
Protein Name DnaJ homolog subfamily C member 2
Genbank Nucleotide ID BC055125; BC067568
Gene Name dnajc2; zgc:85671
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000070477.5 ENSDART00000103463.4 ENSDARP00000094239.3
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Other/Other 75.99 0.00e+00 753.00 IUUC-Hsa-045972
UBD/Other/Other 74.83 0.00e+00 736.00 IUUC-Mmu-063361
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Danio rerio
Functional Description
(View)

Functional Description



     Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (By similarity).
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (By similarity).
Protein Sequence
(Fasta)
MLTEALEGQL TVVYNTVAAS VQVQVEPVGR WFEAFLKRRN RNVSASFQEL EEEEELSEEE 60
EDEELQLEEY PMLKTLDPKD WKNQDHYAVL GLAHVRYKAT QKQIKAAHKA MVLKHHPDKR 120
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Protein Fasta Sequence



>IUUC-Dre-028808|UBD,UBD/Other/Other|Danio rerio
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Nucleotide Sequence
(Fasta)
AGCGCCCAGC GCTTCGGAAT GTTCCGAGTG TGACACCGAG TGCTCCAGCA TACAGCTGTG 60
TGGGCCCATG TGGATCAGGC AGAATTGAGC AGAACAGCAG CTTTAATTCA TCCCAAAATA 120
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Nucleotide Fasta Sequence



>IUUC-Dre-028808|UBD,UBD/Other/Other|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0143--Chaperone
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation

Interpro

IPR001623--DnaJ_domain
IPR009057--Homeobox-like
IPR032003--RAC_head
IPR001005--SANT/Myb
IPR017884--SANT_dom

PROSITE

PS50076--DNAJ_2
PS51293--SANT

Pfam

PF00226--DnaJ
PF00249--Myb_DNA-binding
PF16717--RAC_head

SMART

SM00271--DnaJ
SM00717--SANT

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0043130--F:ubiquitin binding
GO:0016569--P:covalent chromatin modification
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG dre:403080
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000523 Aegilops tauschii 47.32 2.00e-50 193.00
IUUC-Aml-001384 Ailuropoda melanoleuca 83.46 6.00e-115 408.00
IUUC-Atr-002863 Amborella trichopoda 45.81 5.00e-50 192.00
IUUC-Apl-004102 Anas platyrhynchos 73.15 0.00e+00 724.00
IUUC-Aca-004586 Anolis carolinensis 86.05 4.00e-107 382.00
IUUC-Aly-006535 Arabidopsis lyrata 46.83 1.00e-47 184.00
IUUC-Ath-007402 Arabidopsis thaliana 46.80 4.00e-49 189.00
IUUC-Afl-008435 Aspergillus flavus 48.45 4.00e-55 208.00
IUUC-Afu-008810 Aspergillus fumigatus 45.64 2.00e-56 213.00
IUUC-Ani-009141 Aspergillus nidulans 48.05 1.00e-53 204.00
IUUC-Aor-010002 Aspergillus oryzae 48.45 4.00e-55 208.00
IUUC-Ame-011909 Astyanax mexicanus 92.06 2.00e-129 456.00
IUUC-Bta-012870 Bos taurus 82.37 1.00e-117 417.00
IUUC-Bci-013889 Botrytis cinerea 45.05 5.00e-54 205.00
IUUC-Bdi-014225 Brachypodium distachyon 47.52 7.00e-51 195.00
IUUC-Bol-015562 Brassica oleracea 47.78 2.00e-50 193.00
IUUC-Bra-017547 Brassica rapa 47.78 5.00e-51 196.00
IUUC-Cel-018685 Caenorhabditis elegans 40.40 3.00e-81 296.00
IUUC-Cja-019293 Callithrix jacchus 75.90 0.00e+00 751.00
IUUC-Cfa-020528 Canis familiaris 70.83 8.00e-100 358.00
IUUC-Cpo-022171 Cavia porcellus 70.36 7.00e-100 357.00
IUUC-Cre-022887 Chlamydomonas reinhardtii 46.67 1.00e-45 178.00
IUUC-Csa-023129 Chlorocebus sabaeus 75.41 0.00e+00 744.00
IUUC-Cho-025056 Choloepus hoffmanni 77.91 9.00e-138 483.00
IUUC-Cin-025527 Ciona intestinalis 60.29 1.00e-66 248.00
IUUC-Cgl-026448 Colletotrichum gloeosporioides 43.17 8.00e-46 177.00
IUUC-Cme-027325 Cyanidioschyzon merolae 36.36 5.00e-27 116.00
IUUC-Dno-029938 Dasypus novemcinctus 81.72 9.00e-116 410.00
IUUC-Dor-030802 Dipodomys ordii 85.62 8.00e-77 281.00
IUUC-Dme-031862 Drosophila melanogaster 60.10 8.00e-77 281.00
IUUC-Ete-032900 Echinops telfairi 86.49 1.00e-86 314.00
IUUC-Eca-034311 Equus caballus 82.01 5.00e-117 415.00
IUUC-Eeu-034969 Erinaceus europaeus 66.55 4.00e-93 335.00
IUUC-Fca-036146 Felis catus 82.01 4.00e-116 412.00
IUUC-Fal-036866 Ficedula albicollis 83.58 1.00e-115 410.00
IUUC-Fox-038071 Fusarium oxysporum 46.26 9.00e-48 184.00
IUUC-Gmo-039191 Gadus morhua 76.97 0.00e+00 756.00
IUUC-Gga-040158 Gallus gallus 83.09 7.00e-117 414.00
IUUC-Gac-041990 Gasterosteus aculeatus 80.58 0.00e+00 801.00
IUUC-Gma-043759 Glycine max 47.32 3.00e-51 196.00
IUUC-Ggo-045049 Gorilla gorilla 76.16 8.00e-105 374.00
IUUC-Hsa-045972 Homo sapiens 82.01 2.00e-116 413.00
IUUC-Hvu-047309 Hordeum vulgare 46.80 2.00e-49 190.00
IUUC-Itr-048875 Ictidomys tridecemlineatus 70.83 7.00e-102 364.00
IUUC-Kpa-049255 Komagataella pastoris 46.60 7.00e-47 181.00
IUUC-Lch-049756 Latimeria chalumnae 78.63 0.00e+00 777.00
IUUC-Lpe-051235 Leersia perrieri 45.27 2.00e-46 181.00
IUUC-Loc-052580 Lepisosteus oculatus 75.10 3.00e-91 328.00
IUUC-Laf-054095 Loxodonta africana 82.37 2.00e-117 416.00
IUUC-Mcc-054797 Macaca mulatta 73.21 0.00e+00 696.00
IUUC-Meu-056077 Macropus eugenii 85.80 8.00e-78 284.00
IUUC-Mpo-057559 Magnaporthe poae 51.60 1.00e-54 207.00
IUUC-Mtr-058690 Medicago truncatula 49.01 2.00e-50 194.00
IUUC-Mga-059854 Meleagris gallopavo 85.27 2.00e-112 399.00
IUUC-Mmr-061638 Microcebus murinus 82.73 3.00e-118 419.00
IUUC-Mdo-062704 Monodelphis domestica 80.58 1.00e-114 407.00
IUUC-Mmu-063361 Mus musculus 75.24 0.00e+00 760.00
IUUC-Mac-065182 Musa acuminata 46.39 2.00e-47 183.00
IUUC-Mpu-065792 Mustela putorius furo 82.37 1.00e-117 417.00
IUUC-Mlu-067874 Myotis lucifugus 82.73 8.00e-118 417.00
IUUC-Nle-069392 Nomascus leucogenys 81.65 5.00e-116 411.00
IUUC-Opr-070583 Ochotona princeps 85.66 9.00e-113 400.00
IUUC-Ont-071387 Oreochromis niloticus 86.91 3.00e-122 432.00
IUUC-Oan-073081 Ornithorhynchus anatinus 69.55 3.00e-101 362.00
IUUC-Ocu-074901 Oryctolagus cuniculus 82.73 3.00e-118 419.00
IUUC-Oba-075416 Oryza barthii 46.60 2.00e-50 194.00
IUUC-Obr-076383 Oryza brachyantha 48.00 1.00e-50 194.00
IUUC-Ogl-077602 Oryza glaberrima 26.24 2.00e-14 72.80
IUUC-Ogu-078774 Oryza glumaepatula 47.00 2.00e-50 194.00
IUUC-Oin-079255 Oryza indica 41.94 2.00e-20 94.70
IUUC-Olo-080628 Oryza longistaminata 47.00 3.00e-50 193.00
IUUC-Ome-081488 Oryza meridionalis 47.00 2.00e-50 194.00
IUUC-Oni-082149 Oryza nivara 46.55 1.00e-40 161.00
IUUC-Opu-083627 Oryza punctata 46.50 6.00e-50 192.00
IUUC-Oru-084567 Oryza rufipogon 47.00 3.00e-50 193.00
IUUC-Osa-086150 Oryza sativa 26.15 1.00e-13 70.50
IUUC-Ola-086782 Oryzias latipes 82.24 4.00e-73 267.00
IUUC-Olu-087582 Ostreococcus lucimarinus 40.67 2.00e-34 139.00
IUUC-Oga-089051 Otolemur garnettii 82.73 5.00e-118 418.00
IUUC-Oar-090356 Ovis aries 82.08 3.00e-116 412.00
IUUC-Ptr-090858 Pan troglodytes 81.29 2.00e-115 409.00
IUUC-Pan-091826 Papio anubis 75.57 0.00e+00 744.00
IUUC-Psi-094066 Pelodiscus sinensis 84.53 2.00e-112 399.00
IUUC-Ppa-095598 Physcomitrella patens 46.46 3.00e-47 183.00
IUUC-Pfo-097101 Poecilia formosa 83.36 0.00e+00 811.00
IUUC-Pab-098089 Pongo abelii 79.50 2.00e-107 382.00
IUUC-Pop-099771 Populus trichocarpa 47.42 2.00e-53 203.00
IUUC-Pca-100615 Procavia capensis 65.11 4.00e-80 292.00
IUUC-Ppe-101366 Prunus persica 47.29 7.00e-51 195.00
IUUC-Pva-102536 Pteropus vampyrus 82.46 9.00e-112 397.00
IUUC-Pgr-103582 Puccinia graminis 51.60 3.00e-56 212.00
IUUC-Ptt-103970 Puccinia triticina 50.30 7.00e-45 174.00
IUUC-Pte-104323 Pyrenophora teres 45.72 1.00e-53 203.00
IUUC-Rno-105279 Rattus norvegicus 75.24 0.00e+00 759.00
IUUC-Sce-106428 Saccharomyces cerevisiae 32.56 5.60e+00 28.10
IUUC-Sha-107457 Sarcophilus harrisii 82.01 3.00e-116 412.00
IUUC-Sja-107842 Schizosaccharomyces japonicus 46.02 1.00e-47 183.00
IUUC-Spo-108041 Schizosaccharomyces pombe 48.39 1.00e-57 217.00
IUUC-Ssl-108474 Sclerotinia sclerotiorum 44.49 6.00e-43 168.00
IUUC-Smo-109454 Selaginella moellendorffii 51.27 5.00e-53 202.00
IUUC-Sit-110667 Setaria italica 47.80 8.00e-51 195.00
IUUC-Sly-111760 Solanum lycopersicum 44.25 5.00e-42 166.00
IUUC-Stu-112803 Solanum tuberosum 45.32 4.00e-50 192.00
IUUC-Sar-113066 Sorex araneus 70.94 2.00e-79 290.00
IUUC-Sbi-114777 Sorghum bicolor 48.28 2.00e-50 193.00
IUUC-Ssc-115941 Sus scrofa 82.37 1.00e-117 417.00
IUUC-Tgu-116799 Taeniopygia guttata 85.82 1.00e-114 407.00
IUUC-Tru-118137 Takifugu rubripes 83.81 5.00e-112 398.00
IUUC-Tsy-118984 Tarsius syrichta 80.58 2.00e-114 406.00
IUUC-Tni-120898 Tetraodon nigroviridis 86.64 3.00e-125 442.00
IUUC-Tca-120925 Theobroma cacao 48.77 2.00e-53 203.00
IUUC-Tvi-122560 Trichoderma virens 43.33 3.00e-55 209.00
IUUC-Tae-123257 Triticum aestivum 47.32 2.00e-50 193.00
IUUC-Tur-126859 Triticum urartu 47.32 7.00e-50 192.00
IUUC-Tme-127035 Tuber melanosporum 56.28 5.00e-62 231.00
IUUC-Tbe-127978 Tupaia belangeri 73.38 5.00e-98 352.00
IUUC-Ttr-128247 Tursiops truncatus 74.10 1.00e-98 354.00
IUUC-Uma-129601 Ustilago maydis 55.07 7.00e-55 208.00
IUUC-Vda-129704 Verticillium dahliae 46.95 3.00e-50 192.00
IUUC-Vpa-130249 Vicugna pacos 86.05 1.00e-112 400.00
IUUC-Vvi-131626 Vitis vinifera 46.80 2.00e-51 197.00
IUUC-Xtr-132927 Xenopus tropicalis 80.58 2.00e-114 406.00
IUUC-Xma-133433 Xiphophorus maculatus 91.15 2.00e-123 436.00
IUUC-Zma-135295 Zea mays 48.29 6.00e-51 195.00
Created Date 25-Jun-2017

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