• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046755
Ensembl Protein ID ENSP00000452746.1
UniProt Accession O43586; B5BU74; B5BUK4; O43585; O95657; PPIP1_HUMAN
Genbank Protein ID AAD11958.1; AAD11959.1; AAD00762.1; BAG70124.1; BAG70254.1; EAW99213.1; AAH08602.1
Protein Name Proline-serine-threonine phosphatase-interacting protein 1; CD2-binding protein 1; H-PIP
Genbank Nucleotide ID AF038602; AF038603; U94778; AB451310; AB451440; CH471136; BC008602
Gene Name PSTPIP1; CD2BP1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000140368.12 ENST00000559785.5 ENSP00000452986.1
ENSG00000140368.12 ENST00000558012.5 ENSP00000452746.1
ENSG00000140368.12 ENST00000560223.5 ENSP00000454118.1
ENSG00000140368.12 ENST00000379595.7 ENSP00000368914.3
ENSG00000140368.12 ENST00000559750.5 ENSP00000453531.1
ENSG00000140368.12 ENST00000560796.5 ENSP00000454127.1
ENSG00000140368.12 ENST00000559161.5 ENSP00000453372.1
ENSG00000140368.12 ENST00000559295.5 ENSP00000452743.1
ENSG00000140368.12 ENST00000559859.5 ENSP00000453218.1
ENSG00000140368.12 ENST00000559856.1 ENSP00000453382.1
ENSG00000140368.12 ENST00000558870.1 ENSP00000452779.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELM
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.30e-13 52.3 364 416
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
            ++lydy+aqn deL l +Gd+++vi   e + gW+    e +g+rG++P  + ekl
   Q: 364  YRALYDYTAQNPDELDLSAGDILEVI--LEGEDGWWTV--ERNGQRGFVPGSYLEKL 416
           689***********************..999*****77..9***********99986 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
 Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
Protein Sequence
(Fasta)
MMPQLQFKDA FWCRDFTAHT GYEVLLQRLL DGRKMCKDME ELLRQRAQAE ERYGKELVQI 60
ARKAGGQTEI NSLRASFDSL KQQMENVGSS HIQLALTLRE ELRSLEEFRE RQKEQRKKYE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046755|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CACCAGCATG GCCCTCCATC CGGGGCTGCC CTGGCTGGAC AGGTACAGTT GGGAAAGGAA 60
GGCCTCATGT GTGGGAGCCT TGAGGTTGGC TTTGAGGGTG GGAGGATTTG CCCAGGTAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046755|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0130--Cell adhesion
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0254--Endocytosis
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0399--Innate immunity
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR031160--F_BAR
IPR001060--FCH_dom
IPR030777--PSTPIP1_SH3
IPR001452--SH3_domain
IPR013315--Spectrin_alpha_SH3
PROSITE

PS51741--F_BAR
PS50002--SH3
Pfam

PF00611--FCH
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
PR01887--SPECTRNALPHA
SMART

SM00055--FCH
SM00326--SH3
Gene Ontology

GO:0032154--C:cleavage furrow
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0030027--C:lamellipodium
GO:0016020--C:membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0001931--C:uropod
GO:0007155--P:cell adhesion
GO:0016477--P:cell migration
GO:0006897--P:endocytosis
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0007165--P:signal transduction
KEGG hsa:9051
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001807 Ailuropoda melanoleuca 87.05 0.00e+00 651.00
IUUC-Apl-003258 Anas platyrhynchos 67.80 8.00e-157 546.00
IUUC-Aca-005344 Anolis carolinensis 65.02 2.00e-152 532.00
IUUC-Acl-008110 Aspergillus clavatus 29.61 1.00e-33 138.00
IUUC-Afl-008516 Aspergillus flavus 30.61 6.00e-35 142.00
IUUC-Afu-008763 Aspergillus fumigatus 29.93 1.00e-34 142.00
IUUC-Ani-009231 Aspergillus nidulans 28.95 3.00e-26 114.00
IUUC-Ang-009578 Aspergillus niger 29.82 7.00e-32 132.00
IUUC-Aor-010112 Aspergillus oryzae 30.24 4.00e-35 143.00
IUUC-Ate-010371 Aspergillus terreus 30.27 3.00e-31 130.00
IUUC-Ame-011672 Astyanax mexicanus 45.39 1.00e-28 118.00
IUUC-Bta-013548 Bos taurus 91.11 0.00e+00 697.00
IUUC-Bci-013913 Botrytis cinerea 31.14 3.00e-34 141.00
IUUC-Cja-019037 Callithrix jacchus 93.75 0.00e+00 692.00
IUUC-Cpo-022393 Cavia porcellus 72.77 2.00e-154 538.00
IUUC-Csa-023180 Chlorocebus sabaeus 97.36 0.00e+00 741.00
IUUC-Csv-026227 Ciona savignyi 32.56 6.00e-29 121.00
IUUC-Dre-028698 Danio rerio 57.07 2.00e-133 468.00
IUUC-Dno-028886 Dasypus novemcinctus 89.18 0.00e+00 714.00
IUUC-Eca-033950 Equus caballus 91.83 0.00e+00 739.00
IUUC-Fca-035870 Felis catus 89.66 0.00e+00 682.00
IUUC-Fal-037102 Ficedula albicollis 66.59 7.00e-154 536.00
IUUC-Ggr-039791 Gaeumannomyces graminis 28.57 4.00e-33 137.00
IUUC-Gga-040188 Gallus gallus 68.19 1.00e-160 559.00
IUUC-Gac-041413 Gasterosteus aculeatus 53.48 7.00e-106 377.00
IUUC-Ggo-044750 Gorilla gorilla 95.93 0.00e+00 748.00
IUUC-Itr-048941 Ictidomys tridecemlineatus 90.50 0.00e+00 711.00
IUUC-Lch-049979 Latimeria chalumnae 53.29 4.00e-96 344.00
IUUC-Loc-052618 Lepisosteus oculatus 56.78 9.00e-141 493.00
IUUC-Lma-053224 Leptosphaeria maculans 49.06 2.00e-09 55.80
IUUC-Laf-054116 Loxodonta africana 85.89 2.00e-179 621.00
IUUC-Mcc-055757 Macaca mulatta 97.84 0.00e+00 747.00
IUUC-Mpo-057500 Magnaporthe poae 29.62 5.00e-34 140.00
IUUC-Mga-059524 Meleagris gallopavo 67.08 6.00e-155 540.00
IUUC-Mvi-060493 Microbotryum violaceum 22.22 7.00e-21 96.70
IUUC-Mmr-060735 Microcebus murinus 91.35 0.00e+00 720.00
IUUC-Mdo-062497 Monodelphis domestica 67.61 9.00e-127 446.00
IUUC-Mmu-063381 Mus musculus 87.74 0.00e+00 669.00
IUUC-Mpu-066686 Mustela putorius furo 88.94 0.00e+00 714.00
IUUC-Mlu-067462 Myotis lucifugus 86.54 0.00e+00 683.00
IUUC-Nfi-068483 Neosartorya fischeri 29.61 3.00e-34 140.00
IUUC-Ncr-068751 Neurospora crassa 30.66 9.00e-36 146.00
IUUC-Nle-069072 Nomascus leucogenys 96.39 0.00e+00 739.00
IUUC-Opr-070779 Ochotona princeps 77.11 6.00e-170 590.00
IUUC-Ont-071334 Oreochromis niloticus 53.72 6.00e-130 457.00
IUUC-Ocu-074857 Oryctolagus cuniculus 76.81 3.00e-48 183.00
IUUC-Oba-075752 Oryza barthii 43.08 2.00e-04 43.10
IUUC-Ola-087254 Oryzias latipes 49.05 9.00e-118 417.00
IUUC-Oga-088229 Otolemur garnettii 89.47 0.00e+00 714.00
IUUC-Oar-089195 Ovis aries 84.86 0.00e+00 662.00
IUUC-Pan-091699 Papio anubis 98.08 0.00e+00 747.00
IUUC-Psi-093831 Pelodiscus sinensis 69.21 6.00e-167 580.00
IUUC-Pno-094940 Phaeosphaeria nodorum 28.77 9.00e-31 129.00
IUUC-Pfo-097360 Poecilia formosa 53.49 6.00e-110 390.00
IUUC-Pab-098656 Pongo abelii 91.11 0.00e+00 670.00
IUUC-Pca-100873 Procavia capensis 74.04 2.00e-152 532.00
IUUC-Pva-103137 Pteropus vampyrus 82.17 0.00e+00 640.00
IUUC-Pte-104127 Pyrenophora teres 28.77 8.00e-26 113.00
IUUC-Pyt-104705 Pyrenophora triticirepentis 28.77 1.00e-29 126.00
IUUC-Rno-105299 Rattus norvegicus 86.06 0.00e+00 693.00
IUUC-Sja-107975 Schizosaccharomyces japonicus 24.16 3.00e-24 107.00
IUUC-Spo-108022 Schizosaccharomyces pombe 26.12 1.00e-30 128.00
IUUC-Sre-115063 Sporisorium reilianum 26.26 9.00e-30 125.00
IUUC-Ssc-116422 Sus scrofa 91.35 0.00e+00 730.00
IUUC-Tgu-116919 Taeniopygia guttata 67.31 2.00e-155 542.00
IUUC-Tru-118376 Takifugu rubripes 54.59 3.00e-129 454.00
IUUC-Tni-120177 Tetraodon nigroviridis 54.57 4.00e-124 437.00
IUUC-Tme-126946 Tuber melanosporum 29.29 4.00e-32 133.00
IUUC-Ttr-128642 Tursiops truncatus 90.60 0.00e+00 695.00
IUUC-Uma-129545 Ustilago maydis 26.60 2.00e-30 128.00
IUUC-Vda-129797 Verticillium dahliae 29.62 3.00e-31 130.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved