iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071348

Ensembl Protein ID

ENSONIP00000014379.1

UniProt Accession

I3JZT4; I3JZT4_ORENI

Genbank Protein ID

ENSONIP00000014379

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

AERX01012648

Gene Name

apaf1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000011426.1	ENSONIT00000014390.1	ENSONIP00000014379.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-58	192.5	660	689
UBD/Beta-Prp	2.90e-102	342.3	962	1230

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H d+v c+af +d +ll+++s D ++kvW+
   Q: 660  HDDEVLCCAFsPDgRLLATCSSDRKVKVWN 689
           9**********999***************9 PP

UBD/Beta-Prp

   S: 6    kghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           +++++s+i+c ++ ++ s ++ g +dgt++v +v +gkll++l+gh+++v  ++fs++g++l+t+seD+ti+vw+ ++gkc  +l+g
   Q: 962  SEEKSSRIRCTCICQQPSAVVLGQEDGTVQVLEVPSGKLLATLQGHTKTVLHCQFSQNGQTLITSSEDATIRVWEWQSGKCK-VLHG 1047
           567789999999999******************************************************************6.6899 PP
   S: 93   hedsvls...lsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtlt 176
           h+++v++   ls sp++++l+s s d t++vwd+e+g++l+++++ h+g++ + +v+pdg+ +++ s+D+t +lW  ++ ++ +tl 
   Q: 1048 HKEQVRCfslLSNSPNDSRLLSWSFDGTVKVWDTESGEKLQDIEA-HHGTILSCHVSPDGCFFATTSTDKTAKLWHCESWQCAYTLI 1133
           *******5555556699************************6665.6667777788999**************************** PP
   S: 177  gghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnght.........dnvksvrfspnderlvsgssDgsiriWdlrsg 254
           g h++ v+s  f+ ++++l++g+++g ++lw+++ g+ ++ +   +          +v++++fsp++ +lvs++  g i+ W +++g
   Q: 1134 G-HKECVRSCRFSWDSQHLATGDDNGEIRLWSVKDGSLLKVCSQESkdgmdslhgGWVTDLHFSPDNSLLVSTG--GYIKWWEVKTG 1217
           9.********************************999988777777778888888*******************..*********** PP
   S: 255  dllktlqlhnssv 267
           + l+t+  + s +
   Q: 1218 KALQTFYTTGSAL 1230
           *****98766544 PP

Organism

Oreochromis niloticus

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MALEEGARSC LLRFRLKLEE DIKPTYLMDH MISDGVMTVD EEERIRTQPT RKDQAGALIE 60
LLLRKDNLTY ISFYNALVKE AYDDLASLLH RDLPHISLNP HKGSSDGSAT DVQSRLSEGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATTACAAG ACCGAGAAAG TACAATAAAT GATGGTCTAT TCTCTACTTA TGTCTTATAG 60
TAACGCATAA TAACTCTTAT GTTACGCAAA TTTACAATGA AAACACCGCC GTTGGAATAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0097190--P:apoptotic signaling pathway
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	54.96	0.00e+00	1409.00
IUUC-Apl-004201	Anas platyrhynchos	55.06	0.00e+00	1417.00
IUUC-Aca-004638	Anolis carolinensis	54.82	0.00e+00	1425.00
IUUC-Ani-009285	Aspergillus nidulans	28.69	2.00e-63	238.00
IUUC-Ame-011062	Astyanax mexicanus	71.13	0.00e+00	1828.00
IUUC-Bta-012865	Bos taurus	55.09	0.00e+00	1431.00
IUUC-Cja-018815	Callithrix jacchus	50.79	0.00e+00	1262.00
IUUC-Cfa-020222	Canis familiaris	51.84	0.00e+00	1309.00
IUUC-Cpo-021524	Cavia porcellus	54.85	0.00e+00	1428.00
IUUC-Csa-023861	Chlorocebus sabaeus	54.77	0.00e+00	1420.00
IUUC-Cho-024484	Choloepus hoffmanni	46.59	0.00e+00	683.00
IUUC-Dre-028006	Danio rerio	66.67	0.00e+00	1645.00
IUUC-Dno-029591	Dasypus novemcinctus	55.48	0.00e+00	1447.00
IUUC-Dor-030237	Dipodomys ordii	44.18	7.00e-169	588.00
IUUC-Ete-032620	Echinops telfairi	50.72	0.00e+00	640.00
IUUC-Eca-033569	Equus caballus	54.93	0.00e+00	1415.00
IUUC-Eeu-035354	Erinaceus europaeus	40.66	2.00e-94	341.00
IUUC-Fca-036337	Felis catus	54.73	0.00e+00	1427.00
IUUC-Fal-037077	Ficedula albicollis	54.82	0.00e+00	1407.00
IUUC-Gmo-039687	Gadus morhua	65.35	0.00e+00	1269.00
IUUC-Gga-040299	Gallus gallus	53.02	0.00e+00	1405.00
IUUC-Gac-041762	Gasterosteus aculeatus	77.48	0.00e+00	1975.00
IUUC-Ggo-045563	Gorilla gorilla	55.09	0.00e+00	1435.00
IUUC-Hsa-046771	Homo sapiens	55.41	0.00e+00	1435.00
IUUC-Lch-050200	Latimeria chalumnae	57.79	0.00e+00	1465.00
IUUC-Loc-052090	Lepisosteus oculatus	66.01	0.00e+00	1698.00
IUUC-Laf-053861	Loxodonta africana	54.81	0.00e+00	1424.00
IUUC-Mcc-055543	Macaca mulatta	54.93	0.00e+00	1428.00
IUUC-Meu-056688	Macropus eugenii	56.16	0.00e+00	1409.00
IUUC-Mga-059243	Meleagris gallopavo	53.42	0.00e+00	1411.00
IUUC-Mmr-061134	Microcebus murinus	52.40	0.00e+00	1207.00
IUUC-Mdo-062913	Monodelphis domestica	55.72	0.00e+00	1409.00
IUUC-Mmu-063811	Mus musculus	55.33	0.00e+00	1437.00
IUUC-Mpu-066780	Mustela putorius furo	54.73	0.00e+00	1402.00
IUUC-Mlu-067276	Myotis lucifugus	55.04	0.00e+00	1426.00
IUUC-Nle-069129	Nomascus leucogenys	54.69	0.00e+00	1425.00
IUUC-Opr-071007	Ochotona princeps	42.18	0.00e+00	652.00
IUUC-Oan-072717	Ornithorhynchus anatinus	55.93	0.00e+00	1470.00
IUUC-Ocu-074286	Oryctolagus cuniculus	55.84	0.00e+00	1207.00
IUUC-Ola-086895	Oryzias latipes	70.37	0.00e+00	1768.00
IUUC-Oga-088678	Otolemur garnettii	55.56	0.00e+00	1439.00
IUUC-Oar-089359	Ovis aries	55.48	0.00e+00	1432.00
IUUC-Ptr-091062	Pan troglodytes	55.09	0.00e+00	1435.00
IUUC-Pan-092528	Papio anubis	58.07	0.00e+00	885.00
IUUC-Psi-093430	Pelodiscus sinensis	56.69	0.00e+00	1443.00
IUUC-Pma-094690	Petromyzon marinus	39.53	5.00e-151	528.00
IUUC-Pfo-097204	Poecilia formosa	80.16	0.00e+00	2087.00
IUUC-Pab-097690	Pongo abelii	55.01	0.00e+00	1432.00
IUUC-Pca-100778	Procavia capensis	43.32	0.00e+00	693.00
IUUC-Pva-102870	Pteropus vampyrus	53.97	0.00e+00	1275.00
IUUC-Rno-104889	Rattus norvegicus	54.45	0.00e+00	1404.00
IUUC-Sha-107465	Sarcophilus harrisii	54.96	0.00e+00	1420.00
IUUC-Sar-113268	Sorex araneus	51.98	2.00e-106	381.00
IUUC-Ssc-115654	Sus scrofa	55.01	0.00e+00	1441.00
IUUC-Tgu-117302	Taeniopygia guttata	54.78	0.00e+00	1417.00
IUUC-Tru-118363	Takifugu rubripes	81.69	0.00e+00	2129.00
IUUC-Tsy-119007	Tarsius syrichta	52.31	0.00e+00	1346.00
IUUC-Tni-120910	Tetraodon nigroviridis	81.27	0.00e+00	2061.00
IUUC-Tbe-127413	Tupaia belangeri	46.00	0.00e+00	823.00
IUUC-Ttr-129213	Tursiops truncatus	51.27	0.00e+00	1286.00
IUUC-Vpa-130146	Vicugna pacos	51.23	0.00e+00	958.00
IUUC-Xtr-132559	Xenopus tropicalis	51.19	0.00e+00	1330.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence