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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063618
UUCD1 version UUC-MuM-01200
Ensembl Protein ID ENSMUSP00000028842.2
UniProt Accession Q6P8X6; Q9D558; Q9D9E7; UBP50_MOUSE
Genbank Protein ID BAB24831.1; BAB29966.1; AAH61020.1
Protein Name Putative ubiquitin carboxyl-terminal hydrolase 50; Deubiquitinating enzyme 50; Ubiquitin thioesterase 50; Ubiquitin-specific-processing protease 50
Genbank Nucleotide ID AK007018; AK015766; BC061020
Gene Name Usp50
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000027364.12 ENSMUST00000136319.7 ENSMUSP00000121578.1
ENSMUSG00000027364.12 ENSMUST00000028842.8 ENSMUSP00000028842.2
ENSMUSG00000027364.12 ENSMUST00000130356.1 ENSMUSP00000116873.1
ENSMUSG00000027364.12 ENSMUST00000099423.2 ENSMUSP00000127386.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.20e-88 297.8 45 361
Active Site
Position(s) Description Evidence
54 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
321 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           tGl+NlgNtCYmN++LQcL ++++l e++l+ k+  +l+     ++  e++++++ l++ +w +++  vsp+ +l+a++++ + f +  
   Q: 45   TGLRNLGNTCYMNAILQCLCSVSPLVEYFLSgKYITALK-----KDCSEVTTAFAYLMTDMWLGDSDCVSPEIFLSAVGSLYPAFLKKT 128
           7******************************44444443.....5678***************************************** PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvp 177
           qqDaqEfl ++l++l+e+lkk+ + +++e+      ++ ++  +k + +++s+i++lF+gql+ +i+cl+c++ + ++e f+ lslp+p
   Q: 129  QQDAQEFLIYVLNELHEALKKHCRRRVNEK------RTGQSCCRKVPAQETSIITRLFEGQLSYSITCLKCESCTHKNEVFTILSLPIP 211
           *******************55333333333......34456679999****************************************** PP
   S: 178  gkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfc 265
           ++ e+   slqdcL+ f+++++l+ +n++yc+ c+ kqea  +++++k+P+++++h+kRf  + ++ +++k+ + +++pl+ Ldl+p+ 
   Q: 212  SDYEC---SLQDCLQCFFQQDTLTWSNQIYCSFCEIKQEAAVRTTISKVPKIIVFHFKRF--DIQGTVKRKLRTDIHYPLTnLDLTPYI 295
           *****...****************************************************..67789********************** PP
   S: 266  tspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           +   +k   +  Y+L+avv+H G l++GHY+a++kn+  + W+ fdD++V+e++ ++v++   +taY+lfY 
   Q: 296  CPVFRK---HPMYNLCAVVNHFGDLDGGHYTAFCKNSVTQaWYSFDDTRVSEIPDTSVQT---ATAYLLFYS 361
           *95544...89*************************98888*******************...********6 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).
 May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).
Protein Sequence
(Fasta)
MCFIDMASHR PVPADDFGAY YNLAECADYD SLPESKTQPH FQGVTGLRNL GNTCYMNAIL 60
QCLCSVSPLV EYFLSGKYIT ALKKDCSEVT TAFAYLMTDM WLGDSDCVSP EIFLSAVGSL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063618|DUB,USP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGAGGATCC AAGAAGAACT GGGCCTGAGT CAAGTGAAAT CAGACAGCAA CAACACAAAG 60
GGGGGAGGGG GGCATTCAAA CGGTTCAAAA CCAAAAACAA GCCAGGGAGC AGTCCTGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063618|DUB,USP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF00443--UCH
Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:75083
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002089 Ailuropoda melanoleuca 83.11 0.00e+00 643.00
IUUC-Aca-005256 Anolis carolinensis 48.84 5.00e-101 361.00
IUUC-Bta-012753 Bos taurus 79.89 1.00e-177 615.00
IUUC-Cfa-020054 Canis familiaris 79.94 4.00e-160 557.00
IUUC-Cpo-021375 Cavia porcellus 77.18 1.00e-156 545.00
IUUC-Csa-023902 Chlorocebus sabaeus 77.73 8.00e-96 342.00
IUUC-Cho-024755 Choloepus hoffmanni 68.05 1.00e-131 462.00
IUUC-Dor-030311 Dipodomys ordii 81.32 1.00e-88 319.00
IUUC-Ete-032570 Echinops telfairi 64.04 3.00e-101 361.00
IUUC-Eca-034343 Equus caballus 81.38 0.00e+00 639.00
IUUC-Eeu-034510 Erinaceus europaeus 80.25 2.00e-154 537.00
IUUC-Fca-035920 Felis catus 82.84 0.00e+00 635.00
IUUC-Fal-036903 Ficedula albicollis 56.97 2.00e-105 375.00
IUUC-Gac-042261 Gasterosteus aculeatus 43.03 1.00e-73 270.00
IUUC-Ggo-045650 Gorilla gorilla 52.25 4.00e-81 294.00
IUUC-Hsa-046665 Homo sapiens 75.51 2.00e-149 521.00
IUUC-Itr-048167 Ictidomys tridecemlineatus 84.53 0.00e+00 662.00
IUUC-Lch-049925 Latimeria chalumnae 53.17 2.00e-104 372.00
IUUC-Loc-051880 Lepisosteus oculatus 49.54 5.00e-79 289.00
IUUC-Laf-054494 Loxodonta africana 81.57 0.00e+00 635.00
IUUC-Mcc-055507 Macaca mulatta 82.00 3.00e-171 594.00
IUUC-Meu-055906 Macropus eugenii 72.67 2.00e-143 501.00
IUUC-Mmr-061564 Microcebus murinus 60.36 1.00e-101 362.00
IUUC-Mdo-061800 Monodelphis domestica 75.07 3.00e-166 577.00
IUUC-Mpu-066699 Mustela putorius furo 82.57 0.00e+00 640.00
IUUC-Mlu-067672 Myotis lucifugus 80.91 0.00e+00 632.00
IUUC-Opr-070949 Ochotona princeps 77.78 3.00e-143 501.00
IUUC-Oan-073725 Ornithorhynchus anatinus 64.61 2.00e-139 488.00
IUUC-Ocu-074021 Oryctolagus cuniculus 84.32 0.00e+00 654.00
IUUC-Oga-088258 Otolemur garnettii 83.23 3.00e-157 547.00
IUUC-Oar-089881 Ovis aries 80.42 0.00e+00 626.00
IUUC-Ptr-090988 Pan troglodytes 76.12 1.00e-145 509.00
IUUC-Pan-091773 Papio anubis 82.53 0.00e+00 630.00
IUUC-Psi-093243 Pelodiscus sinensis 69.50 1.00e-134 472.00
IUUC-Pab-097713 Pongo abelii 77.62 1.00e-161 562.00
IUUC-Pca-100226 Procavia capensis 65.68 2.00e-124 438.00
IUUC-Pva-103172 Pteropus vampyrus 81.07 1.00e-164 572.00
IUUC-Rno-105950 Rattus norvegicus 92.47 0.00e+00 748.00
IUUC-Sha-107026 Sarcophilus harrisii 69.87 1.00e-163 568.00
IUUC-Ssc-116383 Sus scrofa 83.51 0.00e+00 652.00
IUUC-Tgu-116511 Taeniopygia guttata 55.49 2.00e-98 352.00
IUUC-Tbe-127808 Tupaia belangeri 76.64 5.00e-57 214.00
IUUC-Ttr-129046 Tursiops truncatus 79.29 6.00e-157 546.00
Created Date 25-Jun-2017

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