iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000185345.18	ENST00000366898.5	ENSP00000355865.1
ENSG00000185345.18	ENST00000366897.5	ENSP00000355863.1
ENSG00000185345.18	ENST00000366896.5	ENSP00000355862.1
ENSG00000185345.18	ENST00000479615.5	ENSP00000434414.1
ENSG00000185345.18	ENST00000366892.5	ENSP00000355858.1
ENSG00000185345.18	ENST00000615065.1	ENSP00000484112.1
ENSG00000185345.18	ENST00000612485.1	ENSP00000480716.1
ENSG00000185345.18	ENST00000610470.4	ENSP00000483773.1
ENSG00000185345.18	ENST00000612540.1	ENSP00000478353.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RBR	RBR	18344614; 20194754; 17553932; 19663908; 19642705; 19875440; 19363481; 19229105; 17360614; 15492001; 20164189; 19880420; 21292769; 21173115; 17512523; 11739749; 21378096; 19146857; 15963499; 17059562; 20889974; 23503661; 25545884; 25621951
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	10818204; 12621021; 12634850; 12826399; 15606901

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	4.10e-24	86.0	1	74

Active Site

Position(s)	Description	Evidence
431	N/A	{ECO:0000250\|UniProtKB:Q9JK66}

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkks 74
           m ++v++++++ f++ev++d+++ +lKe +ak++gvp++q+++I+aGk+L++d+t+++++++++s+vh+v+++ 
   Q: 1    MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPW 74
           89*****99999**********************************************************9975 PP

Organism

Homo sapiens

Functional Description
(View)

Functional Description

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins, such as BCL2, SYT11, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPT5, TOMM20, USP30, ZNF746 and AIMP2 (PubMed:10973942, PubMed:10888878, PubMed:11431533, PubMed:12150907, PubMed:12628165, PubMed:16135753, PubMed:21376232, PubMed:23754282, PubMed:23620051, PubMed:24660806, PubMed:24751536). Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context (PubMed:19229105, PubMed:20889974, PubMed:25621951). Participates in the removal and/or detoxification of abnormally folded or damaged protein by mediating 'Lys-63'-linked polyubiquitination of misfolded proteins such as PARK7: 'Lys-63'-linked polyubiquitinated misfolded proteins are then recognized by HDAC6, leading to their recruitment to aggresomes, followed by degradation (PubMed:17846173, PubMed:19229105). Mediates 'Lys-63'-linked polyubiquitination of a 22 kDa O-linked glycosylated isoform of SNCAIP, possibly playing a role in Lewy-body formation (PubMed:11590439, PubMed:11431533, PubMed:19229105, PubMed:11590439, PubMed:15728840). Mediates monoubiquitination of BCL2, thereby acting as a positive regulator of autophagy (PubMed:20889974). Promotes the autophagic degradation of dysfunctional depolarized mitochondria (mitophagy) by promoting the ubiquitination of mitochondrial proteins such as TOMM20, RHOT1/MIRO1 and USP30 (PubMed:19029340, PubMed:19966284, PubMed:23620051, PubMed:24896179, PubMed:25527291). Preferentially assembles 'Lys-6'-, 'Lys-11'- and 'Lys-63'-linked polyubiquitin chains following mitochondrial damage, leading to mitophagy (PubMed:25621951). Mediates 'Lys-48'-linked polyubiquitination of ZNF746, followed by degradation of ZNF746 by the proteasome; possibly playing a role in the regulation of neuron death (PubMed:21376232). Limits the production of reactive oxygen species (ROS). Regulates cyclin-E during neuronal apoptosis. In collaboration with CHPF isoform 2, may enhance cell viability and protect cells from oxidative stress (PubMed:22082830). Independently of its ubiquitin ligase activity, protects from apoptosis by the transcriptional repression of p53/TP53 (PubMed:19801972). May protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity (PubMed:11439185). May play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. May represent a tumor suppressor gene.

Protein Sequence
(Fasta)

MIVFVRFNSS HGFPVEVDSD TSIFQLKEVV AKRQGVPADQ LRVIFAGKEL RNDWTVQNCD 60
LDQQSIVHIV QRPWRKGQEM NATGGDDPRN AAGGCEREPQ SLTRVDLSSS VLPGDSVGLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGGAGGAT TTAACCCAGG AGAGCCGCTG GTGGGAGGCG CGGCTGGCGC CGCTGCGCGC 60
ATGGGCCTGT TCCTGGCCCG CAGCCGCCAC CTACCCAGTG ACCATGATAG GTACGTGGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0256--Endoplasmic reticulum
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-0523--Neurodegeneration
KW-0539--Nucleus
KW-0907--Parkinson disease
KW-0908--Parkinsonism
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0702--S-nitrosylation
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0016235--C:aggresome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0097413--C:Lewy body
GO:0005739--C:mitochondrion
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0098793--C:presynapse
GO:0043234--C:protein complex
GO:0000151--C:ubiquitin ligase complex
GO:0003779--F:actin binding
GO:0008013--F:beta-catenin binding
GO:0051087--F:chaperone binding
GO:0097602--F:cullin family protein binding
GO:0019899--F:enzyme binding
GO:1990444--F:F-box domain binding
GO:0001664--F:G-protein coupled receptor binding
GO:0031072--F:heat shock protein binding
GO:0042826--F:histone deacetylase binding
GO:0030544--F:Hsp70 protein binding
GO:0042802--F:identical protein binding
GO:0019900--F:kinase binding
GO:0030165--F:PDZ domain binding
GO:0043274--F:phospholipase binding
GO:0019901--F:protein kinase binding
GO:0017124--F:SH3 domain binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0015631--F:tubulin binding
GO:0043130--F:ubiquitin binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:1990381--F:ubiquitin-specific protease binding
GO:0008270--F:zinc ion binding
GO:0008344--P:adult locomotory behavior
GO:0070842--P:aggresome assembly
GO:0044257--P:cellular protein catabolic process
GO:0044267--P:cellular protein metabolic process
GO:1903351--P:cellular response to dopamine
GO:0071287--P:cellular response to manganese ion
GO:0097237--P:cellular response to toxic substance
GO:0034620--P:cellular response to unfolded protein
GO:0007417--P:central nervous system development
GO:0042417--P:dopamine metabolic process
GO:0051583--P:dopamine uptake involved in synaptic transmission
GO:0036503--P:ERAD pathway
GO:0010994--P:free ubiquitin chain polymerization
GO:0007612--P:learning
GO:0016236--P:macroautophagy
GO:0000423--P:macromitophagy
GO:0000266--P:mitochondrial fission
GO:0007005--P:mitochondrion organization
GO:0099074--P:mitochondrion to lysosome transport
GO:0000422--P:mitophagy
GO:0044828--P:negative regulation by host of viral genome replication
GO:0032232--P:negative regulation of actin filament bundle assembly
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0060548--P:negative regulation of cell death
GO:1902236--P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903382--P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903542--P:negative regulation of exosomal secretion
GO:0010629--P:negative regulation of gene expression
GO:0033132--P:negative regulation of glucokinase activity
GO:0046676--P:negative regulation of insulin secretion
GO:1905366--P:negative regulation of intralumenal vesicle formation
GO:1902254--P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:0046329--P:negative regulation of JNK cascade
GO:0010637--P:negative regulation of mitochondrial fusion
GO:0043524--P:negative regulation of neuron apoptotic process
GO:1901215--P:negative regulation of neuron death
GO:1903202--P:negative regulation of oxidative stress-induced cell death
GO:1903377--P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1902283--P:negative regulation of primary amine oxidase activity
GO:0001933--P:negative regulation of protein phosphorylation
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:1904049--P:negative regulation of spontaneous neurotransmitter secretion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0070050--P:neuron cellular homeostasis
GO:0042415--P:norepinephrine metabolic process
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:0043388--P:positive regulation of DNA binding
GO:0010628--P:positive regulation of gene expression
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0098779--P:positive regulation of macromitophagy in response to mitochondrial depolarization
GO:0090141--P:positive regulation of mitochondrial fission
GO:0010636--P:positive regulation of mitochondrial fusion
GO:1903599--P:positive regulation of mitophagy
GO:0051582--P:positive regulation of neurotransmitter uptake
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032092--P:positive regulation of protein binding
GO:0045732--P:positive regulation of protein catabolic process
GO:1902530--P:positive regulation of protein linear polyubiquitination
GO:1905477--P:positive regulation of protein localization to membrane
GO:1905281--P:positive regulation of retrograde transport, endosome to Golgi
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0010498--P:proteasomal protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0016579--P:protein deubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0044314--P:protein K27-linked ubiquitination
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0070585--P:protein localization to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0010506--P:regulation of autophagy
GO:0060828--P:regulation of canonical Wnt signaling pathway
GO:1900407--P:regulation of cellular response to oxidative stress
GO:0042053--P:regulation of dopamine metabolic process
GO:0014059--P:regulation of dopamine secretion
GO:0010906--P:regulation of glucose metabolic process
GO:0032368--P:regulation of lipid transport
GO:0051881--P:regulation of mitochondrial membrane potential
GO:0010821--P:regulation of mitochondrion organization
GO:0031647--P:regulation of protein stability
GO:1903214--P:regulation of protein targeting to mitochondrion
GO:0031396--P:regulation of protein ubiquitination
GO:2000377--P:regulation of reactive oxygen species metabolic process
GO:1902803--P:regulation of synaptic vesicle transport
GO:0034976--P:response to endoplasmic reticulum stress
GO:0006979--P:response to oxidative stress
GO:0001964--P:startle response
GO:0035249--P:synaptic transmission, glutamatergic
GO:0006351--P:transcription, DNA-templated
GO:0055069--P:zinc ion homeostasis

KEGG

hsa:5071

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	85.07	6.00e-145	506.00
IUUC-Apl-003304	Anas platyrhynchos	78.96	4.00e-161	560.00
IUUC-Aca-004908	Anolis carolinensis	79.63	2.00e-50	189.00
IUUC-Ame-011856	Astyanax mexicanus	63.58	3.00e-173	601.00
IUUC-Bta-013014	Bos taurus	84.38	0.00e+00	694.00
IUUC-Cel-018687	Caenorhabditis elegans	28.73	2.00e-44	173.00
IUUC-Cja-019274	Callithrix jacchus	96.18	1.00e-165	575.00
IUUC-Cfa-020461	Canis familiaris	82.70	7.00e-142	496.00
IUUC-Cpo-022251	Cavia porcellus	84.08	6.00e-145	506.00
IUUC-Csa-023112	Chlorocebus sabaeus	96.18	2.00e-157	548.00
IUUC-Cho-024504	Choloepus hoffmanni	61.47	7.00e-152	530.00
IUUC-Dre-028202	Danio rerio	62.02	4.00e-160	558.00
IUUC-Dno-028946	Dasypus novemcinctus	70.48	5.00e-41	158.00
IUUC-Dor-030508	Dipodomys ordii	74.09	2.00e-143	501.00
IUUC-Dme-031980	Drosophila melanogaster	42.19	1.00e-107	383.00
IUUC-Ete-032281	Echinops telfairi	65.29	3.00e-85	308.00
IUUC-Eca-033228	Equus caballus	84.78	1.00e-145	509.00
IUUC-Fca-036045	Felis catus	68.75	2.00e-24	103.00
IUUC-Fal-037507	Ficedula albicollis	72.69	0.00e+00	707.00
IUUC-Gmo-038744	Gadus morhua	59.65	3.00e-94	338.00
IUUC-Gga-040353	Gallus gallus	73.35	0.00e+00	700.00
IUUC-Gac-042519	Gasterosteus aculeatus	50.64	5.00e-132	464.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	83.80	0.00e+00	768.00
IUUC-Loc-052389	Lepisosteus oculatus	65.25	2.00e-171	595.00
IUUC-Laf-053412	Loxodonta africana	67.78	4.00e-29	119.00
IUUC-Mcc-054933	Macaca mulatta	97.42	0.00e+00	917.00
IUUC-Meu-055963	Macropus eugenii	62.50	2.00e-137	482.00
IUUC-Mga-059626	Meleagris gallopavo	80.00	3.00e-32	129.00
IUUC-Mmr-061566	Microcebus murinus	91.36	3.00e-102	363.00
IUUC-Mdo-062933	Monodelphis domestica	86.11	4.00e-33	132.00
IUUC-Mmu-063561	Mus musculus	83.66	0.00e+00	814.00
IUUC-Mpu-065799	Mustela putorius furo	82.70	3.00e-138	484.00
IUUC-Mlu-068134	Myotis lucifugus	80.39	4.00e-160	557.00
IUUC-Nle-070078	Nomascus leucogenys	96.66	3.00e-172	597.00
IUUC-Opr-070541	Ochotona princeps	84.85	0.00e+00	764.00
IUUC-Ont-071743	Oreochromis niloticus	51.06	1.00e-129	456.00
IUUC-Oan-073700	Ornithorhynchus anatinus	88.89	4.00e-25	105.00
IUUC-Ola-086426	Oryzias latipes	61.49	1.00e-59	222.00
IUUC-Oga-088867	Otolemur garnettii	89.20	0.00e+00	829.00
IUUC-Oar-089365	Ovis aries	82.27	8.00e-174	602.00
IUUC-Ptr-091371	Pan troglodytes	99.35	0.00e+00	932.00
IUUC-Pan-092443	Papio anubis	96.88	6.00e-166	576.00
IUUC-Psi-093851	Pelodiscus sinensis	67.51	9.00e-94	336.00
IUUC-Pfo-097194	Poecilia formosa	49.25	3.00e-128	451.00
IUUC-Pab-097999	Pongo abelii	81.48	5.00e-159	553.00
IUUC-Pca-100410	Procavia capensis	78.35	0.00e+00	661.00
IUUC-Pva-102300	Pteropus vampyrus	76.41	0.00e+00	688.00
IUUC-Rno-105556	Rattus norvegicus	81.31	3.00e-138	484.00
IUUC-Sha-106992	Sarcophilus harrisii	94.44	2.00e-26	110.00
IUUC-Sar-113121	Sorex araneus	91.38	7.00e-61	227.00
IUUC-Ssc-116435	Sus scrofa	82.59	1.00e-138	485.00
IUUC-Tgu-117489	Taeniopygia guttata	72.94	0.00e+00	713.00
IUUC-Tru-117927	Takifugu rubripes	52.46	5.00e-141	494.00
IUUC-Tsy-119372	Tarsius syrichta	92.35	2.00e-177	615.00
IUUC-Tni-120043	Tetraodon nigroviridis	49.79	2.00e-127	449.00
IUUC-Tbe-127539	Tupaia belangeri	78.14	0.00e+00	711.00
IUUC-Ttr-129149	Tursiops truncatus	82.37	0.00e+00	793.00
IUUC-Vpa-130439	Vicugna pacos	63.23	5.00e-162	564.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence