iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108248

UUCD1 version

UUC-ScP-00029

Ensembl Protein ID

SPBC1734.06.1:pep

UniProt Accession

O74747; RAD18_SCHPO

Genbank Protein ID

BAB84669.1; CAA21300.1

Protein Name

Postreplication repair E3 ubiquitin-protein ligase rad18; RAD18 homolog; RING-type E3 ubiquitin transferase rad18

Genbank Nucleotide ID

AB079544; CU329671

Gene Name

rhp18; SPBC1734.06

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPBC1734.06	SPBC1734.06.1	SPBC1734.06.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	HINT	Mentha
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17762864

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.20e-06	27.1	29	67

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+e f+  pl+++C H+f+  C+  +       + + +CP Cr
   Q: 29   CLICHEYFRA-PLITSCSHTFCSFCIRDY------LREHPMCPACR 67
           ********88.******************......**********8 PP

Organism

Schizosaccharomyces pombe

Functional Description
(View)

E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme ubc2/rad6 to form the ubc2-rad18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA (By similarity).

Protein Sequence
(Fasta)

MNELDATDPS DWNQTKIPSL KGLDSSLRCL ICHEYFRAPL ITSCSHTFCS FCIRDYLREH 60
PMCPACRAPE QESRLRKNTI LEEILESFKV IRPTLFEFLK VENVPKPVLQ APETVIAQDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTACTCTGT TTAAACTTCC TTCAACTCGA TCTAAAAACT TTGCAACGTC TGCCATTTCT 60
GACCGAGCCC CAAAATTGAA ATTACAAGAG TGCAAATTTC AAAAATCCTT TATAGATAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004580--Rad18
IPR003034--SAP_dom
IPR006642--Znf_Rad18_put
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50800--SAP
PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING
SM00513--SAP
SM00734--ZnF_Rad18

Gene Ontology

GO:0005634--C:nucleus
GO:0097505--C:Rad6-Rad18 complex
GO:0003684--F:damaged DNA binding
GO:0043142--F:single-stranded DNA-dependent ATPase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0044773--P:mitotic DNA damage checkpoint
GO:0006301--P:postreplication repair
GO:1990920--P:proteasome localization to nuclear periphery
GO:0006513--P:protein monoubiquitination
GO:1901044--P:protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
GO:0009411--P:response to UV

KEGG

spo:SPBC1734.06

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002086	Ailuropoda melanoleuca	27.57	1.00e-22	99.40
IUUC-Apl-003657	Anas platyrhynchos	36.14	3.00e-11	61.20
IUUC-Aca-004790	Anolis carolinensis	40.91	5.00e-11	60.50
IUUC-Ago-007876	Ashbya gossypii	27.74	1.00e-29	122.00
IUUC-Acl-008246	Aspergillus clavatus	30.73	9.00e-41	159.00
IUUC-Afl-008666	Aspergillus flavus	44.33	6.00e-23	99.80
IUUC-Afu-009052	Aspergillus fumigatus	29.90	1.00e-41	161.00
IUUC-Ani-009488	Aspergillus nidulans	28.57	1.00e-45	174.00
IUUC-Ang-009681	Aspergillus niger	30.52	4.00e-45	173.00
IUUC-Aor-010037	Aspergillus oryzae	31.17	2.00e-45	174.00
IUUC-Ate-010516	Aspergillus terreus	43.88	2.00e-23	100.00
IUUC-Ame-010630	Astyanax mexicanus	23.08	2.00e-23	101.00
IUUC-Bgr-012178	Blumeria graminis	32.06	7.00e-48	182.00
IUUC-Bta-012976	Bos taurus	40.00	6.00e-14	70.10
IUUC-Bci-013680	Botrytis cinerea	25.81	3.00e-40	157.00
IUUC-Bdi-015017	Brachypodium distachyon	40.00	2.00e-08	51.60
IUUC-Cel-018356	Caenorhabditis elegans	40.00	2.00e-08	49.70
IUUC-Cja-019453	Callithrix jacchus	27.94	6.00e-23	100.00
IUUC-Cfa-020856	Canis familiaris	41.25	3.00e-14	70.90
IUUC-Cpo-021950	Cavia porcellus	26.26	1.00e-20	92.40
IUUC-Cre-022788	Chlamydomonas reinhardtii	31.88	5.00e-09	53.10
IUUC-Csa-023997	Chlorocebus sabaeus	25.89	3.00e-20	90.90
IUUC-Cho-024771	Choloepus hoffmanni	28.16	7.00e-16	76.30
IUUC-Cin-025364	Ciona intestinalis	30.00	7.00e-11	59.30
IUUC-Csv-026203	Ciona savignyi	31.37	3.00e-09	53.10
IUUC-Cgl-026668	Colletotrichum gloeosporioides	28.53	5.00e-40	156.00
IUUC-Cme-027202	Cyanidioschyzon merolae	37.08	6.00e-15	73.60
IUUC-Dre-028479	Danio rerio	25.06	1.00e-23	101.00
IUUC-Dno-028943	Dasypus novemcinctus	26.05	3.00e-21	94.70
IUUC-Dor-031046	Dipodomys ordii	35.21	4.00e-05	40.80
IUUC-Dse-031235	Dothistroma septosporum	23.36	5.00e-16	77.00
IUUC-Ete-032301	Echinops telfairi	44.44	1.00e-09	55.80
IUUC-Eca-033725	Equus caballus	42.50	1.00e-14	72.80
IUUC-Eeu-034573	Erinaceus europaeus	41.89	2.00e-12	64.70
IUUC-Fca-036495	Felis catus	26.98	4.00e-22	97.10
IUUC-Fal-036791	Ficedula albicollis	28.13	5.00e-19	87.00
IUUC-Fox-037868	Fusarium oxysporum	42.45	3.00e-24	103.00
IUUC-Fso-038144	Fusarium solani	27.60	8.00e-40	155.00
IUUC-Gmo-039152	Gadus morhua	25.28	2.00e-20	90.90
IUUC-Ggr-039737	Gaeumannomyces graminis	41.49	4.00e-20	90.50
IUUC-Gga-040788	Gallus gallus	26.67	3.00e-19	87.80
IUUC-Gac-041993	Gasterosteus aculeatus	22.99	2.00e-22	98.20
IUUC-Gma-044371	Glycine max	26.09	8.00e-08	50.10
IUUC-Ggo-044889	Gorilla gorilla	26.98	2.00e-20	91.70
IUUC-Hsa-045957	Homo sapiens	26.42	4.00e-21	94.00
IUUC-Itr-048998	Ictidomys tridecemlineatus	40.96	2.00e-14	71.60
IUUC-Kpa-049300	Komagataella pastoris	30.09	8.00e-35	138.00
IUUC-Lch-050172	Latimeria chalumnae	40.00	2.00e-11	60.80
IUUC-Loc-052609	Lepisosteus oculatus	25.58	3.00e-20	90.90
IUUC-Lma-053037	Leptosphaeria maculans	28.74	8.00e-37	146.00
IUUC-Laf-053889	Loxodonta africana	26.79	2.00e-21	95.10
IUUC-Mcc-055853	Macaca mulatta	25.60	3.00e-19	87.80
IUUC-Meu-056866	Macropus eugenii	27.12	3.00e-14	70.90
IUUC-Mor-057071	Magnaporthe oryzae	27.30	3.00e-42	164.00
IUUC-Mpo-057628	Magnaporthe poae	42.22	1.00e-19	89.40
IUUC-Mla-058953	Melampsora laricipopulina	28.83	3.00e-10	58.50
IUUC-Mga-059687	Meleagris gallopavo	25.67	5.00e-19	86.70
IUUC-Mvi-060412	Microbotryum violaceum	26.33	7.00e-22	96.70
IUUC-Mmr-061563	Microcebus murinus	42.50	4.00e-14	70.90
IUUC-Mdo-062655	Monodelphis domestica	25.70	1.00e-20	92.80
IUUC-Mmu-063647	Mus musculus	42.50	1.00e-14	72.40
IUUC-Mpu-065778	Mustela putorius furo	42.50	2.00e-14	72.00
IUUC-Mlu-068205	Myotis lucifugus	24.85	5.00e-17	80.10
IUUC-Nfi-068501	Neosartorya fischeri	29.41	3.00e-42	163.00
IUUC-Ncr-068917	Neurospora crassa	27.48	4.00e-41	160.00
IUUC-Nle-068990	Nomascus leucogenys	26.49	1.00e-20	92.40
IUUC-Opr-071146	Ochotona princeps	25.37	3.00e-20	90.90
IUUC-Ont-071835	Oreochromis niloticus	37.04	2.00e-10	58.50
IUUC-Oan-072827	Ornithorhynchus anatinus	24.77	3.00e-15	73.20
IUUC-Ocu-073986	Oryctolagus cuniculus	26.49	1.00e-19	89.00
IUUC-Ola-086997	Oryzias latipes	43.90	2.00e-16	77.40
IUUC-Olu-087771	Ostreococcus lucimarinus	30.50	8.00e-25	105.00
IUUC-Oga-088092	Otolemur garnettii	42.50	1.00e-14	72.80
IUUC-Oar-089651	Ovis aries	41.25	2.00e-14	72.00
IUUC-Ptr-091103	Pan troglodytes	26.49	1.00e-20	92.40
IUUC-Pan-092478	Papio anubis	41.25	8.00e-14	69.70
IUUC-Psi-093356	Pelodiscus sinensis	25.06	2.00e-22	98.60
IUUC-Pma-094579	Petromyzon marinus	43.48	3.00e-09	54.30
IUUC-Pfo-096663	Poecilia formosa	37.04	2.00e-10	58.90
IUUC-Pab-098515	Pongo abelii	26.65	2.00e-20	92.00
IUUC-Pca-100939	Procavia capensis	42.22	3.00e-10	57.80
IUUC-Pva-102377	Pteropus vampyrus	40.26	7.00e-13	66.60
IUUC-Pgr-103556	Puccinia graminis	23.34	3.00e-21	94.70
IUUC-Pte-104362	Pyrenophora teres	28.64	9.00e-41	159.00
IUUC-Pyt-104823	Pyrenophora triticirepentis	28.39	1.00e-36	145.00
IUUC-Rno-105866	Rattus norvegicus	42.50	8.00e-15	73.20
IUUC-Sce-106454	Saccharomyces cerevisiae	26.38	1.00e-34	138.00
IUUC-Sha-107515	Sarcophilus harrisii	24.67	5.00e-22	96.70
IUUC-Sja-107689	Schizosaccharomyces japonicus	38.25	1.00e-74	271.00
IUUC-Ssl-108430	Sclerotinia sclerotiorum	26.23	2.00e-35	141.00
IUUC-Sar-113356	Sorex araneus	42.22	2.00e-10	57.80
IUUC-Sbi-114470	Sorghum bicolor	26.03	6.00e-08	51.20
IUUC-Sre-115123	Sporisorium reilianum	29.77	9.00e-14	69.30
IUUC-Ssc-115992	Sus scrofa	23.36	6.00e-12	63.20
IUUC-Tgu-117286	Taeniopygia guttata	28.44	5.00e-20	90.10
IUUC-Tru-117959	Takifugu rubripes	25.00	1.00e-16	78.60
IUUC-Tsy-119329	Tarsius syrichta	42.22	7.00e-10	56.60
IUUC-Tni-120570	Tetraodon nigroviridis	25.66	2.00e-19	87.80
IUUC-Tre-121893	Trichoderma reesei	44.32	9.00e-21	92.40
IUUC-Tvi-122405	Trichoderma virens	27.99	6.00e-38	149.00
IUUC-Tbe-127758	Tupaia belangeri	41.56	2.00e-13	68.60
IUUC-Ttr-128841	Tursiops truncatus	41.25	3.00e-14	71.20
IUUC-Uma-129563	Ustilago maydis	34.68	5.00e-12	63.90
IUUC-Vda-130021	Verticillium dahliae	31.72	6.00e-18	82.40
IUUC-Vpa-130169	Vicugna pacos	40.74	2.00e-13	68.60
IUUC-Xtr-132308	Xenopus tropicalis	28.72	5.00e-15	73.20
IUUC-Xma-133868	Xiphophorus maculatus	44.00	2.00e-10	58.20
IUUC-Yli-134474	Yarrowia lipolytica	29.88	2.00e-35	140.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence