iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107533

Ensembl Protein ID

ENSSHAP00000014993.1

UniProt Accession

G3WHT8; G3WHT8_SARHA

Genbank Protein ID

ENSSHAP00000014993

Protein Name

Inhibitor of growth protein

Genbank Nucleotide ID

AEFK01213422

Gene Name

ING2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000012793.1	ENSSHAT00000015118.1	ENSSHAP00000014993.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.30e-09	36.6	216	262

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 216  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT---YKPKGK-WYCPKCR 262
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

LGQQQQQQQQ PLYPAAGLLA GERGRLLSCY VQDYLECVES LPLDMQRNVS VLREIDTKYQ 60
EALKEIDDAC EKYKKENDPH QKKRLQQNLQ RALINSQELG DEKIQIVTQM LELVENRARQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNT TAGGGCAGCA GCAGCAGCAG CAGCAGCAGC 60
CGCTGTACCC GGCGGCCGGG CTCCTGGCCG GGGAGCGGGG CCGGCTCCTC TCCTGCTACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035091--F:phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0072520--P:seminiferous tubule development
GO:0007286--P:spermatid development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	90.81	1.00e-110	392.00
IUUC-Apl-003705	Anas platyrhynchos	89.69	1.00e-90	325.00
IUUC-Aca-004990	Anolis carolinensis	82.24	1.00e-97	349.00
IUUC-Ame-011426	Astyanax mexicanus	71.27	1.00e-85	309.00
IUUC-Bta-012721	Bos taurus	91.18	2.00e-111	394.00
IUUC-Cja-018960	Callithrix jacchus	92.42	9.00e-100	355.00
IUUC-Cfa-020869	Canis familiaris	90.81	2.00e-110	391.00
IUUC-Cpo-021414	Cavia porcellus	89.71	5.00e-109	386.00
IUUC-Csa-023304	Chlorocebus sabaeus	92.28	3.00e-104	370.00
IUUC-Dre-028562	Danio rerio	70.33	5.00e-87	313.00
IUUC-Dno-029945	Dasypus novemcinctus	92.05	1.00e-107	382.00
IUUC-Dor-030141	Dipodomys ordii	91.91	5.00e-111	393.00
IUUC-Ete-032709	Echinops telfairi	90.44	2.00e-118	418.00
IUUC-Eca-033432	Equus caballus	91.91	2.00e-111	395.00
IUUC-Eeu-035285	Erinaceus europaeus	95.10	9.00e-87	312.00
IUUC-Fca-036467	Felis catus	92.05	1.00e-107	382.00
IUUC-Fal-036700	Ficedula albicollis	88.44	3.00e-90	323.00
IUUC-Gmo-038748	Gadus morhua	62.54	2.00e-84	305.00
IUUC-Gga-040175	Gallus gallus	89.24	1.00e-90	325.00
IUUC-Gac-041403	Gasterosteus aculeatus	63.70	1.00e-88	318.00
IUUC-Hsa-045837	Homo sapiens	92.28	3.00e-104	370.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	90.81	2.00e-110	391.00
IUUC-Lch-049965	Latimeria chalumnae	81.68	8.00e-100	356.00
IUUC-Laf-053353	Loxodonta africana	92.44	1.00e-94	338.00
IUUC-Mcc-055155	Macaca mulatta	97.13	6.00e-72	262.00
IUUC-Meu-056470	Macropus eugenii	98.82	2.00e-119	421.00
IUUC-Mga-059570	Meleagris gallopavo	89.24	5.00e-90	323.00
IUUC-Mmr-061385	Microcebus murinus	91.91	1.00e-103	369.00
IUUC-Mdo-062144	Monodelphis domestica	99.22	4.00e-121	427.00
IUUC-Mmu-063215	Mus musculus	90.81	3.00e-111	394.00
IUUC-Mpu-065749	Mustela putorius furo	92.05	7.00e-94	336.00
IUUC-Mlu-067245	Myotis lucifugus	73.53	5.00e-79	286.00
IUUC-Nle-069968	Nomascus leucogenys	96.84	2.00e-80	291.00
IUUC-Ont-071524	Oreochromis niloticus	66.91	5.00e-86	310.00
IUUC-Ocu-074870	Oryctolagus cuniculus	91.54	1.00e-111	395.00
IUUC-Oga-088336	Otolemur garnettii	91.54	3.00e-103	367.00
IUUC-Oar-090136	Ovis aries	91.08	1.00e-109	389.00
IUUC-Ptr-091348	Pan troglodytes	97.37	2.00e-81	294.00
IUUC-Pan-092819	Papio anubis	92.28	3.00e-104	370.00
IUUC-Pfo-096633	Poecilia formosa	66.67	8.00e-80	290.00
IUUC-Pab-098346	Pongo abelii	91.91	9.00e-104	369.00
IUUC-Pca-100278	Procavia capensis	90.55	1.00e-108	385.00
IUUC-Pva-103190	Pteropus vampyrus	92.80	9.00e-109	385.00
IUUC-Rno-104940	Rattus norvegicus	90.91	7.00e-107	379.00
IUUC-Sar-113630	Sorex araneus	94.12	2.00e-86	311.00
IUUC-Ssc-115734	Sus scrofa	92.80	1.00e-108	385.00
IUUC-Tgu-117034	Taeniopygia guttata	88.89	1.00e-90	325.00
IUUC-Tru-118168	Takifugu rubripes	61.57	2.00e-80	292.00
IUUC-Tsy-119494	Tarsius syrichta	96.84	1.00e-80	292.00
IUUC-Tni-120100	Tetraodon nigroviridis	61.83	6.00e-76	276.00
IUUC-Ttr-128442	Tursiops truncatus	95.59	3.00e-87	314.00
IUUC-Vpa-130063	Vicugna pacos	91.54	3.00e-111	394.00
IUUC-Xtr-132348	Xenopus tropicalis	71.69	3.00e-66	245.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence