iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012479

UUCD1 version

UUC-BoT-01033

Ensembl Protein ID

ENSBTAP00000006290.3

UniProt Accession

Q32LD2; G3X6G9; UBE2T_BOVIN

Genbank Protein ID

AAI09638.1

Protein Name

Ubiquitin-conjugating enzyme E2 T; E2 ubiquitin-conjugating enzyme T; Ubiquitin carrier protein T; Ubiquitin-protein ligase T

Genbank Nucleotide ID

DAAA02043707

Gene Name

UBE2T

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000004790.3	ENSBTAT00000006290.3	ENSBTAP00000006290.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.20e-44	151.5	6	145

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk.. 87
           Rlk+el+ l+++pp+gi++ ++ +  + +++++ilG ++tpYe+gvFkle+++pe+YPf+PP+++flt+i+hPn++++G++Cl++lk  
   Q: 6    RLKRELSLLAAEPPPGITCWQDGD-RMEDLRAQILGGANTPYEKGVFKLEVHIPERYPFEPPQIRFLTPIYHPNIDSAGRICLDVLKlp 93
           99**********************.5************************************************************998 PP
   S: 88   eeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
           ++ +W+p l++++ l+siq+l+aepnp++pl +++++++k n+  + k++r+
   Q: 94   PKGAWRPSLNIATLLTSIQQLMAEPNPDDPLMADISSEFKYNKPVFFKNARQ 145
           99*****************************************999998875 PP

Organism

Bos taurus

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.

Protein Sequence
(Fasta)

MQRTSRLKRE LSLLAAEPPP GITCWQDGDR MEDLRAQILG GANTPYEKGV FKLEVHIPER 60
YPFEPPQIRF LTPIYHPNID SAGRICLDVL KLPPKGAWRP SLNIATLLTS IQQLMAEPNP 120

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Nucleotide Sequence
(Fasta)

AGGCGCGGTG CCGGCTGCTC GGGGCCGTTG CTCTGCGAGG AGAGACCGCG CAGGTGAGAG 60
GCCGCGGGCG GGCGTTCACG GGCGGCGTGG TGGGGTTGGG GGCGCTTTCT TCCTGCCTGA 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070979--P:protein K11-linked ubiquitination
GO:0044314--P:protein K27-linked ubiquitination
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

KEGG

bta:505314

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000366	Aegilops tauschii	55.63	9.00e-47	181.00
IUUC-Aml-001392	Ailuropoda melanoleuca	80.71	3.00e-91	327.00
IUUC-Atr-003069	Amborella trichopoda	46.49	1.00e-49	189.00
IUUC-Apl-003914	Anas platyrhynchos	82.47	3.00e-76	276.00
IUUC-Aca-004381	Anolis carolinensis	66.67	7.00e-77	280.00
IUUC-Aly-006059	Arabidopsis lyrata	51.88	2.00e-45	176.00
IUUC-Ath-007669	Arabidopsis thaliana	57.94	2.00e-43	169.00
IUUC-Ame-011372	Astyanax mexicanus	71.70	2.00e-67	248.00
IUUC-Bdi-014043	Brachypodium distachyon	57.62	8.00e-51	194.00
IUUC-Bol-016011	Brassica oleracea	46.35	4.00e-45	175.00
IUUC-Bra-017419	Brassica rapa	45.31	6.00e-44	171.00
IUUC-Cja-019773	Callithrix jacchus	81.31	7.00e-91	325.00
IUUC-Cfa-020043	Canis familiaris	83.25	2.00e-93	334.00
IUUC-Cpo-021481	Cavia porcellus	80.20	6.00e-91	326.00
IUUC-Cre-022823	Chlamydomonas reinhardtii	44.59	8.00e-29	119.00
IUUC-Csa-024083	Chlorocebus sabaeus	81.73	5.00e-93	333.00
IUUC-Cho-024386	Choloepus hoffmanni	81.97	2.00e-86	311.00
IUUC-Cin-025419	Ciona intestinalis	62.99	2.00e-59	220.00
IUUC-Csv-026224	Ciona savignyi	64.52	5.00e-61	226.00
IUUC-Cme-027179	Cyanidioschyzon merolae	50.32	2.00e-41	160.00
IUUC-Dre-028800	Danio rerio	76.77	9.00e-73	266.00
IUUC-Dno-029833	Dasypus novemcinctus	79.70	3.00e-91	327.00
IUUC-Ete-032625	Echinops telfairi	84.42	6.00e-71	259.00
IUUC-Eca-033821	Equus caballus	90.91	4.00e-82	296.00
IUUC-Eeu-034578	Erinaceus europaeus	80.29	2.00e-61	227.00
IUUC-Fca-036398	Felis catus	83.76	1.00e-94	338.00
IUUC-Fal-037564	Ficedula albicollis	70.26	8.00e-77	279.00
IUUC-Gmo-039142	Gadus morhua	78.06	2.00e-71	260.00
IUUC-Gga-041054	Gallus gallus	67.37	9.00e-74	269.00
IUUC-Gac-041370	Gasterosteus aculeatus	75.48	7.00e-71	259.00
IUUC-Ggo-045370	Gorilla gorilla	81.73	6.00e-92	329.00
IUUC-Hsa-046513	Homo sapiens	82.23	2.00e-92	331.00
IUUC-Hvu-047694	Hordeum vulgare	55.63	1.00e-48	187.00
IUUC-Itr-049076	Ictidomys tridecemlineatus	77.66	4.00e-88	317.00
IUUC-Lch-050484	Latimeria chalumnae	65.38	2.00e-66	244.00
IUUC-Loc-051967	Lepisosteus oculatus	74.84	4.00e-71	260.00
IUUC-Laf-053377	Loxodonta africana	80.20	1.00e-90	325.00
IUUC-Mcc-055453	Macaca mulatta	81.22	1.00e-92	331.00
IUUC-Meu-056745	Macropus eugenii	74.87	1.00e-84	305.00
IUUC-Mga-059729	Meleagris gallopavo	68.42	6.00e-75	273.00
IUUC-Mmr-060581	Microcebus murinus	82.23	5.00e-93	333.00
IUUC-Mdo-062434	Monodelphis domestica	74.11	2.00e-80	293.00
IUUC-Mmu-064379	Mus musculus	76.65	4.00e-85	306.00
IUUC-Mac-064647	Musa acuminata	54.17	5.00e-45	173.00
IUUC-Mpu-066713	Mustela putorius furo	80.71	4.00e-91	326.00
IUUC-Mlu-067525	Myotis lucifugus	88.96	2.00e-80	290.00
IUUC-Nle-069757	Nomascus leucogenys	82.74	5.00e-93	333.00
IUUC-Opr-070756	Ochotona princeps	76.65	1.00e-86	311.00
IUUC-Ont-071956	Oreochromis niloticus	77.42	7.00e-72	262.00
IUUC-Oan-072745	Ornithorhynchus anatinus	83.12	1.00e-76	278.00
IUUC-Ocu-074423	Oryctolagus cuniculus	77.66	3.00e-86	310.00
IUUC-Oba-075569	Oryza barthii	57.24	2.00e-49	190.00
IUUC-Obr-076131	Oryza brachyantha	57.24	2.00e-49	190.00
IUUC-Ogl-077132	Oryza glaberrima	57.24	2.00e-49	190.00
IUUC-Ogu-078880	Oryza glumaepatula	57.89	6.00e-50	191.00
IUUC-Oin-079748	Oryza indica	57.89	5.00e-50	192.00
IUUC-Olo-080501	Oryza longistaminata	58.28	2.00e-50	193.00
IUUC-Ome-081248	Oryza meridionalis	57.62	2.00e-49	190.00
IUUC-Oni-083033	Oryza nivara	57.89	5.00e-50	192.00
IUUC-Opu-083664	Oryza punctata	57.89	4.00e-50	192.00
IUUC-Oru-084580	Oryza rufipogon	57.89	5.00e-50	192.00
IUUC-Osa-085721	Oryza sativa	57.89	5.00e-50	192.00
IUUC-Ola-087559	Oryzias latipes	75.48	2.00e-70	258.00
IUUC-Oga-088420	Otolemur garnettii	80.81	3.00e-90	323.00
IUUC-Oar-090082	Ovis aries	92.39	8.00e-106	375.00
IUUC-Ptr-091134	Pan troglodytes	81.73	6.00e-92	329.00
IUUC-Pan-091735	Papio anubis	81.73	5.00e-93	333.00
IUUC-Psi-094064	Pelodiscus sinensis	71.86	2.00e-80	291.00
IUUC-Pma-094609	Petromyzon marinus	72.19	9.00e-67	245.00
IUUC-Ppa-095553	Physcomitrella patens	55.77	5.00e-49	188.00
IUUC-Pfo-096710	Poecilia formosa	76.47	7.00e-70	256.00
IUUC-Pab-098126	Pongo abelii	82.23	2.00e-92	331.00
IUUC-Pop-099108	Populus trichocarpa	53.29	4.00e-46	179.00
IUUC-Pca-100338	Procavia capensis	80.20	3.00e-90	323.00
IUUC-Ppe-101239	Prunus persica	55.07	5.00e-42	165.00
IUUC-Pva-102756	Pteropus vampyrus	78.77	2.00e-64	236.00
IUUC-Rno-105211	Rattus norvegicus	76.02	4.00e-80	290.00
IUUC-Sha-106969	Sarcophilus harrisii	69.15	4.00e-73	266.00
IUUC-Smo-109052	Selaginella moellendorffii	54.90	7.00e-44	169.00
IUUC-Sit-110464	Setaria italica	57.14	3.00e-47	182.00
IUUC-Sly-110971	Solanum lycopersicum	57.43	6.00e-46	178.00
IUUC-Stu-112126	Solanum tuberosum	58.11	2.00e-46	180.00
IUUC-Sar-113633	Sorex araneus	81.73	2.00e-93	334.00
IUUC-Sbi-114875	Sorghum bicolor	56.95	2.00e-48	186.00
IUUC-Ssc-116375	Sus scrofa	81.73	3.00e-89	320.00
IUUC-Tgu-117292	Taeniopygia guttata	81.70	1.00e-73	268.00
IUUC-Tru-118157	Takifugu rubripes	66.23	4.00e-58	216.00
IUUC-Tsy-119260	Tarsius syrichta	82.56	1.00e-93	335.00
IUUC-Tni-120162	Tetraodon nigroviridis	62.50	2.00e-69	254.00
IUUC-Tca-121255	Theobroma cacao	51.19	4.00e-37	149.00
IUUC-Tae-123184	Triticum aestivum	55.63	1.00e-46	181.00
IUUC-Tbe-127296	Tupaia belangeri	80.20	8.00e-91	325.00
IUUC-Ttr-128443	Tursiops truncatus	86.80	6.00e-96	342.00
IUUC-Vpa-130689	Vicugna pacos	83.16	2.00e-95	341.00
IUUC-Vvi-130925	Vitis vinifera	54.55	4.00e-46	177.00
IUUC-Xma-133779	Xiphophorus maculatus	76.47	4.00e-70	256.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence