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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046099
Ensembl Protein ID ENSP00000432540.1
UniProt Accession Q9UKW4; B1AMM0; B1APV5; B4E232; B7ZLR1; E9PQ97; O60498; O95230; Q9Y5X8; VAV3_HUMAN
Genbank Protein ID AAD03799.1; AAC79695.1; AAD20349.1; AAD20348.1; BAG64994.1; BAH14666.1; CAH72458.1; CAH72458.1; CAH72458.1; CAH72458.1; CAH72458.1; CAH73195.1; CAH73195.1; CAH73195.1; CAH73195.1; CAH73195.1; CAH73196.1; CAH73196.1; CAH73196.1; CAI14457.1; CAI14457.1; CAI14457.1; CAI14457.1; CAI14457.1; CAI14458.1; CAI14458.1; CAI14458.1; CAI21786.1; CAI21786.1; CAI21786.1; CAI21786.1; CAI21786.1; EAW51252.1; AAI43970.1
Protein Name Guanine nucleotide exchange factor VAV3
Genbank Nucleotide ID AF035442; AF067817; AF118887; AF118886; AK304088; AK316295; AL391235; AC114491; AL353892; AL513206; AL591042; AL513206; AC114491; AL353892; AL391235; AL591042; AL513206; AC114491; AL591042; AL591042; AC114491; AL353892; AL391235; AL513206; AL591042; AC114491; AL513206; AL353892; AC114491; AL391235; AL513206; AL591042; CH471156; BC143969
Gene Name VAV3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000134215.15 ENST00000370056.8 ENSP00000359073.4
ENSG00000134215.15 ENST00000527011.5 ENSP00000432540.1
ENSG00000134215.15 ENST00000529413.5 ENSP00000432865.1
ENSG00000134215.15 ENST00000415432.6 ENSP00000394897.2
ENSG00000134215.15 ENST00000529809.5 ENSP00000431544.1
ENSG00000134215.15 ENST00000490388.2 ENSP00000433559.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkmiRecordsRepTarSomamiR
miRcodeRAID2LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 7.00e-15 56.4 822 873
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 822  IARYDFCARDMRELSLLKGDVVKIY-TKMSANGWWRG--EVNGRVGWFPSTYVEE 873
           688*********************9.999999*****..9*************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).
 Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a crucial event for osteoclast proper cytoskeleton organization and function. This signaling pathway involves RAC1, but not RHO, activation. Necessary for proper wound healing. In the course of wound healing, required for the phagocytotic cup formation preceding macrophage phagocytosis of apoptotic neutrophils. Responsible for integrin beta-2 (ITGB2)-mediated macrophage adhesion and, to a lesser extent, contributes to beta-3 (ITGB3)-mediated adhesion. Does not affect integrin beta-1 (ITGB1)-mediated adhesion (By similarity).
Protein Sequence
(Fasta)
MEPWKQCAQW LIHCKVLPTN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL RAHSINLKEI 60
NLRPQMSQFL CLKNIRTFLT ACCETFGMRK SELFEAFDLF DVRDFGKVIE TLSRLSRTPI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046099|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGCAGCCG CCGCCGAGCC GGCCGGGGCG CACGGAGAGC GCGCGGGACT CGCTGCAGCG 60
GCGGCCGGGT CGCGGCGCAC CCGGGCCGGG ACCGGAGCCG AGCCTAGCGC GGCGCCCGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046099|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0877--Alternative promoter usage
KW-0025--Alternative splicing
KW-0037--Angiogenesis
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR003096--SM22_calponin
PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN
SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0005070--F:SH3/SH2 adaptor activity
GO:0001525--P:angiogenesis
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0048013--P:ephrin receptor signaling pathway
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0038096--P:Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030168--P:platelet activation
GO:0043065--P:positive regulation of apoptotic process
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0043087--P:regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
GO:0006906--P:vesicle fusion
KEGG hsa:10451
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001362 Ailuropoda melanoleuca 93.71 0.00e+00 1597.00
IUUC-Apl-003734 Anas platyrhynchos 83.77 0.00e+00 1342.00
IUUC-Aca-004477 Anolis carolinensis 85.94 0.00e+00 1484.00
IUUC-Ame-011279 Astyanax mexicanus 64.31 0.00e+00 1103.00
IUUC-Bta-012722 Bos taurus 93.03 0.00e+00 1586.00
IUUC-Cja-018941 Callithrix jacchus 95.96 0.00e+00 1616.00
IUUC-Cfa-020266 Canis familiaris 93.53 0.00e+00 1422.00
IUUC-Cpo-021966 Cavia porcellus 92.15 0.00e+00 1377.00
IUUC-Csa-023892 Chlorocebus sabaeus 95.31 0.00e+00 1493.00
IUUC-Dre-028199 Danio rerio 67.77 0.00e+00 1152.00
IUUC-Dno-029474 Dasypus novemcinctus 93.71 0.00e+00 1598.00
IUUC-Eca-033961 Equus caballus 93.53 0.00e+00 1449.00
IUUC-Eeu-034719 Erinaceus europaeus 76.79 0.00e+00 660.00
IUUC-Fca-036572 Felis catus 93.40 0.00e+00 1561.00
IUUC-Fal-036802 Ficedula albicollis 88.23 0.00e+00 1565.00
IUUC-Gmo-039409 Gadus morhua 67.46 0.00e+00 1153.00
IUUC-Gga-040884 Gallus gallus 83.31 0.00e+00 1459.00
IUUC-Gac-041395 Gasterosteus aculeatus 69.17 0.00e+00 1230.00
IUUC-Ggo-044460 Gorilla gorilla 93.92 0.00e+00 1421.00
IUUC-Itr-048144 Ictidomys tridecemlineatus 96.89 0.00e+00 1490.00
IUUC-Lch-049650 Latimeria chalumnae 73.03 9.00e-106 375.00
IUUC-Loc-052487 Lepisosteus oculatus 71.06 0.00e+00 1224.00
IUUC-Laf-054564 Loxodonta africana 93.03 0.00e+00 1590.00
IUUC-Mcc-054622 Macaca mulatta 98.86 0.00e+00 1706.00
IUUC-Meu-056680 Macropus eugenii 83.20 0.00e+00 1417.00
IUUC-Mga-060013 Meleagris gallopavo 80.32 0.00e+00 1389.00
IUUC-Mmr-061251 Microcebus murinus 95.97 0.00e+00 1709.00
IUUC-Mdo-061875 Monodelphis domestica 90.51 0.00e+00 1564.00
IUUC-Mmu-063735 Mus musculus 92.23 0.00e+00 1598.00
IUUC-Mpu-065856 Mustela putorius furo 94.06 0.00e+00 1602.00
IUUC-Mlu-068108 Myotis lucifugus 94.17 0.00e+00 1549.00
IUUC-Nle-069863 Nomascus leucogenys 98.27 0.00e+00 1679.00
IUUC-Opr-070372 Ochotona princeps 84.64 0.00e+00 1050.00
IUUC-Ont-072286 Oreochromis niloticus 69.57 0.00e+00 1213.00
IUUC-Ocu-074194 Oryctolagus cuniculus 94.29 0.00e+00 1607.00
IUUC-Ola-086336 Oryzias latipes 68.34 0.00e+00 1204.00
IUUC-Oar-089272 Ovis aries 92.91 0.00e+00 1625.00
IUUC-Ptr-090652 Pan troglodytes 93.84 0.00e+00 1617.00
IUUC-Pan-092550 Papio anubis 98.86 0.00e+00 1522.00
IUUC-Psi-093784 Pelodiscus sinensis 84.65 0.00e+00 1350.00
IUUC-Ppa-095161 Physcomitrella patens 43.64 4.00e-09 55.80
IUUC-Pfo-097308 Poecilia formosa 71.64 0.00e+00 1281.00
IUUC-Pab-098698 Pongo abelii 93.83 0.00e+00 1619.00
IUUC-Pva-102262 Pteropus vampyrus 93.16 0.00e+00 1533.00
IUUC-Rno-105421 Rattus norvegicus 91.66 0.00e+00 1602.00
IUUC-Sha-107325 Sarcophilus harrisii 90.40 0.00e+00 1578.00
IUUC-Sar-113456 Sorex araneus 88.00 0.00e+00 1515.00
IUUC-Tgu-116595 Taeniopygia guttata 80.73 0.00e+00 1380.00
IUUC-Tru-117884 Takifugu rubripes 64.75 0.00e+00 1186.00
IUUC-Tsy-119429 Tarsius syrichta 85.87 0.00e+00 1328.00
IUUC-Tni-119951 Tetraodon nigroviridis 67.27 0.00e+00 1137.00
IUUC-Tbe-127995 Tupaia belangeri 85.50 4.00e-179 622.00
IUUC-Ttr-128281 Tursiops truncatus 93.37 0.00e+00 1589.00
IUUC-Xtr-132427 Xenopus tropicalis 70.53 0.00e+00 1268.00
Created Date 25-Jun-2017

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