iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020269

Ensembl Protein ID

ENSCAFP00000002634.3

UniProt Accession

E2RMV6; E2RMV6_CANLF

Genbank Protein ID

ENSCAFP00000002634

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03007933

Gene Name

DDX58

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000001807.3	ENSCAFT00000002841.3	ENSCAFP00000002634.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	4.00e-48	162.2	101	172

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLktL..vqkegWfrefl 73
           eeyrlll++lq++++++  + d+l   +se+l+ +e+e+i++++++kg m++ae+++++L  ++ke+W+++++
   Q: 101  EEYRLLLKRLQPEFKTTVNPNDILP-KISECLISQECEEIIQICSNKGLMAGAEKMVECLlrSDKENWPKTLK 172
           8************************.********************************************985 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MTAEERRNLH AFRDYVIKTL DPAYILSYMA PWFKDDEVQY IQAEKNNKGT MEAASLFLKC 60
LLELQEEGWF RGFLDALGHA GYSGLYEAIE SWNFQKIESL EEYRLLLKRL QPEFKTTVNP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACGGCCG AGGAGCGGCG AAACCTGCAC GCCTTCCGGG ACTATGTCAT CAAGACTCTG 60
GACCCTGCCT ACATCCTGAG CTACATGGCC CCCTGGTTTA AGGATGGTGA GTGGTCCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0862--Zinc

Interpro

IPR031964--CARD_dom
IPR011545--DEAD/DEAH_box_helicase_dom
IPR011029--DEATH-like_dom
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR021673--RLR_CTR

PROSITE

PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS51789--RLR_CTR

Pfam

PF16739--CARD_2
PF00270--DEAD
PF00271--Helicase_C
PF11648--RIG-I_C-RD

SMART

SM00487--DEXDc
SM00490--HELICc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0005923--C:bicellular tight junction
GO:0005829--C:cytosol
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0003690--F:double-stranded DNA binding
GO:0003725--F:double-stranded RNA binding
GO:0016817--F:hydrolase activity, acting on acid anhydrides
GO:0003727--F:single-stranded RNA binding
GO:0008270--F:zinc ion binding
GO:0009597--P:detection of virus
GO:0045087--P:innate immune response
GO:0002230--P:positive regulation of defense response to virus by host
GO:0032725--P:positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032727--P:positive regulation of interferon-alpha production
GO:0032728--P:positive regulation of interferon-beta production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0042993--P:positive regulation of transcription factor import into nucleus
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0030334--P:regulation of cell migration
GO:0043330--P:response to exogenous dsRNA
GO:0039529--P:RIG-I signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001898	Ailuropoda melanoleuca	88.70	0.00e+00	1655.00
IUUC-Apl-003966	Anas platyrhynchos	51.93	0.00e+00	889.00
IUUC-Aca-004499	Anolis carolinensis	47.34	0.00e+00	812.00
IUUC-Ame-011950	Astyanax mexicanus	43.51	0.00e+00	712.00
IUUC-Bta-012489	Bos taurus	82.42	0.00e+00	1514.00
IUUC-Cel-018230	Caenorhabditis elegans	30.45	9.00e-74	271.00
IUUC-Cja-018716	Callithrix jacchus	80.95	0.00e+00	1506.00
IUUC-Cpo-022507	Cavia porcellus	73.37	0.00e+00	1380.00
IUUC-Csa-024209	Chlorocebus sabaeus	81.05	0.00e+00	1516.00
IUUC-Cho-025104	Choloepus hoffmanni	74.11	0.00e+00	1192.00
IUUC-Cin-025792	Ciona intestinalis	33.00	4.00e-82	299.00
IUUC-Dno-028954	Dasypus novemcinctus	78.39	0.00e+00	1418.00
IUUC-Eca-034039	Equus caballus	83.32	0.00e+00	1549.00
IUUC-Eeu-035009	Erinaceus europaeus	70.02	0.00e+00	924.00
IUUC-Fca-036169	Felis catus	88.81	0.00e+00	1680.00
IUUC-Fal-037579	Ficedula albicollis	54.26	0.00e+00	910.00
IUUC-Fso-038398	Fusarium solani	26.04	1.00e-21	99.40
IUUC-Ggo-045318	Gorilla gorilla	79.62	0.00e+00	1380.00
IUUC-Hsa-046671	Homo sapiens	81.70	0.00e+00	1498.00
IUUC-Itr-047996	Ictidomys tridecemlineatus	75.00	0.00e+00	1386.00
IUUC-Lch-050461	Latimeria chalumnae	50.44	0.00e+00	881.00
IUUC-Loc-052582	Lepisosteus oculatus	47.97	0.00e+00	837.00
IUUC-Laf-054324	Loxodonta africana	80.26	0.00e+00	1455.00
IUUC-Mcc-055390	Macaca mulatta	80.52	0.00e+00	1501.00
IUUC-Meu-056365	Macropus eugenii	64.16	3.00e-130	459.00
IUUC-Mpo-057328	Magnaporthe poae	31.71	7.10e-01	30.00
IUUC-Mvi-060497	Microbotryum violaceum	26.05	9.00e-25	109.00
IUUC-Mmr-061407	Microcebus murinus	80.62	0.00e+00	1538.00
IUUC-Mmu-063939	Mus musculus	74.38	0.00e+00	1372.00
IUUC-Mpu-066226	Mustela putorius furo	88.21	0.00e+00	1560.00
IUUC-Mlu-068092	Myotis lucifugus	84.05	0.00e+00	1528.00
IUUC-Nfi-068405	Neosartorya fischeri	28.19	4.00e-15	77.80
IUUC-Opr-070246	Ochotona princeps	65.68	0.00e+00	672.00
IUUC-Oan-072742	Ornithorhynchus anatinus	61.04	0.00e+00	964.00
IUUC-Ocu-073959	Oryctolagus cuniculus	73.90	0.00e+00	1396.00
IUUC-Oga-089173	Otolemur garnettii	80.73	0.00e+00	1489.00
IUUC-Oar-089369	Ovis aries	81.55	0.00e+00	1481.00
IUUC-Ptr-091032	Pan troglodytes	81.70	0.00e+00	1498.00
IUUC-Pan-092383	Papio anubis	80.95	0.00e+00	1511.00
IUUC-Psi-093432	Pelodiscus sinensis	55.84	0.00e+00	1056.00
IUUC-Pma-094367	Petromyzon marinus	40.65	8.00e-114	404.00
IUUC-Pab-098416	Pongo abelii	81.91	0.00e+00	1407.00
IUUC-Pca-101006	Procavia capensis	80.51	0.00e+00	671.00
IUUC-Pva-102966	Pteropus vampyrus	84.70	0.00e+00	1581.00
IUUC-Pgr-103529	Puccinia graminis	26.01	1.00e-26	115.00
IUUC-Rno-105059	Rattus norvegicus	75.04	0.00e+00	905.00
IUUC-Ssl-108450	Sclerotinia sclerotiorum	31.63	5.00e-05	45.10
IUUC-Sar-113202	Sorex araneus	67.44	0.00e+00	1036.00
IUUC-Ssc-116120	Sus scrofa	81.34	0.00e+00	1480.00
IUUC-Tgu-117314	Taeniopygia guttata	52.55	0.00e+00	931.00
IUUC-Tsy-119453	Tarsius syrichta	79.20	0.00e+00	841.00
IUUC-Tre-122194	Trichoderma reesei	24.62	1.00e-19	92.40
IUUC-Ttr-128421	Tursiops truncatus	79.26	0.00e+00	1234.00
IUUC-Vpa-130602	Vicugna pacos	79.12	0.00e+00	1397.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence