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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045988
UUCD1 version UUC-HoS-00135
Ensembl Protein ID ENSP00000373272.3
UniProt Accession Q2Q1W2; LIN41_HUMAN
Genbank Protein ID ABB18374.1
Protein Name E3 ubiquitin-protein ligase TRIM71; Protein lin-41 homolog; RING-type E3 ubiquitin transferase TRIM71; Tripartite motif-containing protein 71
Genbank Nucleotide ID DQ232881
Gene Name TRIM71; LIN41
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000206557.5 ENST00000383763.5 ENSP00000373272.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircRNADbCircNetmiRTarBase
microRNATRANSFACTargetScanmiRecords
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
UniProt
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19898466
Classification
Family E-value Score Start End
E3 activity/RING/RING 6.50e-06 28.2 12 95
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..................................kdgplvlpCgHvfhadCl..qkw...pglknssskefrCPlCr 46
           C++C+e++                                  ++ ++vlpC H+f++ Cl  +++    g    +  + rCP+C+
   Q: 12   CLLCKEMCgspaplssnssasssssqtstssggggggpgaaaRR-LHVLPCLHAFCRPCLeaHRLpaaGGGAAGEPLKLRCPVCD 95
           99998888888888888777777777777777777777777444.***************5555599988888999999*****5 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1.
 E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1.
Protein Sequence
(Fasta)
MASFPETDFQ ICLLCKEMCG SPAPLSSNSS ASSSSSQTST SSGGGGGGPG AAARRLHVLP 60
CLHAFCRPCL EAHRLPAAGG GAAGEPLKLR CPVCDQKVVL AEAAGMDALP SSAFLLSNLL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045988|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCTCTCTCCT CCTCCTCCTC CTCTTCCTCT CTGGTCTCCT CCCTCCTCCG GGCTGGGTTG 60
CAAATGGCTT CGTTCCCCGA GACCGATTTC CAGATCTGCT TGCTGTGCAA GGAGATGTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045988|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0943--RNA-mediated gene silencing
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box
SMART

SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING
Gene Ontology

GO:0000932--C:P-body
GO:0035198--F:miRNA binding
GO:0030371--F:translation repressor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0061158--P:3'-UTR-mediated mRNA destabilization
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0035278--P:miRNA mediated inhibition of translation
GO:0010586--P:miRNA metabolic process
GO:0017148--P:negative regulation of translation
GO:0001843--P:neural tube closure
GO:0021915--P:neural tube development
GO:2000637--P:positive regulation of gene silencing by miRNA
GO:0051865--P:protein autoubiquitination
GO:0060964--P:regulation of gene silencing by miRNA
GO:2000177--P:regulation of neural precursor cell proliferation
GO:0072089--P:stem cell proliferation
KEGG hsa:131405
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001234 Ailuropoda melanoleuca 95.68 0.00e+00 1183.00
IUUC-Apl-003905 Anas platyrhynchos 93.66 0.00e+00 1150.00
IUUC-Aca-004326 Anolis carolinensis 85.88 0.00e+00 1213.00
IUUC-Ani-009171 Aspergillus nidulans 27.27 4.60e-02 32.70
IUUC-Ame-011573 Astyanax mexicanus 70.14 0.00e+00 1192.00
IUUC-Bta-013395 Bos taurus 96.48 0.00e+00 1316.00
IUUC-Cel-018188 Caenorhabditis elegans 35.95 2.00e-107 384.00
IUUC-Cja-019863 Callithrix jacchus 99.61 0.00e+00 1360.00
IUUC-Cfa-020285 Canis familiaris 92.98 0.00e+00 1435.00
IUUC-Cpo-021879 Cavia porcellus 93.90 0.00e+00 1487.00
IUUC-Csa-024271 Chlorocebus sabaeus 99.85 0.00e+00 1323.00
IUUC-Cho-024376 Choloepus hoffmanni 98.63 0.00e+00 1184.00
IUUC-Cin-025406 Ciona intestinalis 49.34 0.00e+00 640.00
IUUC-Cne-027010 Cryptococcus neoformans 26.00 2.00e-02 31.60
IUUC-Dno-029022 Dasypus novemcinctus 97.78 0.00e+00 1181.00
IUUC-Dor-031072 Dipodomys ordii 97.12 0.00e+00 1469.00
IUUC-Dme-031997 Drosophila melanogaster 48.18 2.00e-70 260.00
IUUC-Ete-032228 Echinops telfairi 98.25 0.00e+00 822.00
IUUC-Eca-033373 Equus caballus 99.22 0.00e+00 1056.00
IUUC-Eeu-034463 Erinaceus europaeus 96.82 0.00e+00 1138.00
IUUC-Fca-036184 Felis catus 95.83 0.00e+00 1190.00
IUUC-Fal-036918 Ficedula albicollis 83.43 0.00e+00 1170.00
IUUC-Fox-038003 Fusarium oxysporum 32.20 2.00e-03 36.20
IUUC-Gmo-039415 Gadus morhua 71.19 0.00e+00 885.00
IUUC-Gga-040379 Gallus gallus 90.67 0.00e+00 1264.00
IUUC-Gac-042330 Gasterosteus aculeatus 65.59 0.00e+00 1042.00
IUUC-Gma-043819 Glycine max 23.05 4.00e-12 67.40
IUUC-Ggo-045208 Gorilla gorilla 99.85 0.00e+00 1319.00
IUUC-Itr-048371 Ictidomys tridecemlineatus 98.46 0.00e+00 1196.00
IUUC-Kpa-049184 Komagataella pastoris 24.69 7.20e-02 30.80
IUUC-Lch-050324 Latimeria chalumnae 85.97 0.00e+00 1199.00
IUUC-Laf-054272 Loxodonta africana 94.63 0.00e+00 1259.00
IUUC-Mcc-055125 Macaca mulatta 99.08 0.00e+00 1473.00
IUUC-Meu-055934 Macropus eugenii 84.63 0.00e+00 1132.00
IUUC-Mga-059930 Meleagris gallopavo 93.33 0.00e+00 1144.00
IUUC-Mmr-060662 Microcebus murinus 97.33 0.00e+00 1312.00
IUUC-Mdo-062918 Monodelphis domestica 89.44 0.00e+00 1267.00
IUUC-Mmu-064351 Mus musculus 94.55 0.00e+00 1289.00
IUUC-Mpu-066325 Mustela putorius furo 98.25 0.00e+00 1051.00
IUUC-Mlu-067171 Myotis lucifugus 89.58 0.00e+00 1403.00
IUUC-Nle-069692 Nomascus leucogenys 99.85 0.00e+00 1323.00
IUUC-Opr-070354 Ochotona princeps 95.38 0.00e+00 1160.00
IUUC-Ont-072125 Oreochromis niloticus 75.70 0.00e+00 1088.00
IUUC-Oan-073079 Ornithorhynchus anatinus 95.21 0.00e+00 1161.00
IUUC-Ocu-073910 Oryctolagus cuniculus 94.94 0.00e+00 1299.00
IUUC-Ola-087162 Oryzias latipes 76.51 0.00e+00 1090.00
IUUC-Oga-088523 Otolemur garnettii 96.68 0.00e+00 1195.00
IUUC-Oar-090009 Ovis aries 98.26 0.00e+00 692.00
IUUC-Ptr-091173 Pan troglodytes 100.00 0.00e+00 1325.00
IUUC-Pan-091750 Papio anubis 99.70 0.00e+00 1317.00
IUUC-Psi-093053 Pelodiscus sinensis 89.06 0.00e+00 1085.00
IUUC-Pma-094227 Petromyzon marinus 58.99 1.00e-175 610.00
IUUC-Pfo-096980 Poecilia formosa 72.65 0.00e+00 1054.00
IUUC-Pab-098189 Pongo abelii 99.08 0.00e+00 1462.00
IUUC-Pva-103126 Pteropus vampyrus 95.70 0.00e+00 1297.00
IUUC-Rno-105653 Rattus norvegicus 96.02 0.00e+00 1301.00
IUUC-Sce-106389 Saccharomyces cerevisiae 25.64 5.50e-02 32.00
IUUC-Sha-107178 Sarcophilus harrisii 94.34 0.00e+00 1155.00
IUUC-Sar-113613 Sorex araneus 86.04 0.00e+00 983.00
IUUC-Tgu-116963 Taeniopygia guttata 92.99 0.00e+00 1143.00
IUUC-Tsy-119075 Tarsius syrichta 90.07 0.00e+00 1063.00
IUUC-Tni-120704 Tetraodon nigroviridis 81.40 0.00e+00 1011.00
IUUC-Tre-122209 Trichoderma reesei 25.84 1.30e-02 33.50
IUUC-Tbe-128141 Tupaia belangeri 78.23 0.00e+00 815.00
IUUC-Ttr-128908 Tursiops truncatus 93.43 0.00e+00 719.00
IUUC-Xtr-132272 Xenopus tropicalis 84.18 0.00e+00 1164.00
Created Date 25-Jun-2017

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