iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000002963.3	ENSFCAT00000032430.1	ENSFCAP00000024615.1
ENSFCAG00000002963.3	ENSFCAT00000002963.3	ENSFCAP00000002732.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.10e-73	246.5	88	418
ULD/UDP/UBQ/UBQ_Other	9.60e-11	41.4	945	1007

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkea 81
           +Gl+Nlg+tCY+N  LQ+ +   elr++l              +++ee ++ + ++++++lq lf+ l++s++++++p+ ++kal+   
   Q: 88   VGLTNLGATCYVNTFLQVWFLNLELRQALYLcpstcsdyVMGDSIQEE-KDYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALG--- 172
           6*****************************966666554333333333.367788******************************9... PP
   S: 82   eefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
             +++ +qqDaqEf + +++ le++l                       +++k+   ++++++ F g++   ++c++c+++s+  ++f+
   Q: 173  --LDTGQQQDAQEFSKLFMSLLEDTL-----------------------SKQKNPDVRNIVQQQFCGEYAYVTVCNQCGRESKLLSKFY 236
           ..78899*******************.......................457889999******************************* PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleL 259
           +l+l+++g++     +l+dc+++f kee+leg+n+y+ce+c++kq+a++k++l +lP +L l+L+Rf f++++++++k+n+++ f + L
   Q: 237  ELELNIQGHK-----QLTDCISEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNLQLMRFVFDRQTGHKKKLNTYIGFSEIL 320
           **********.....9************************************************************************* PP
   S: 260  dlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvkn.ekgkWllfdDskVtevkeeevleetg................... 327
           d++p+++++      ++ YeL+av++H G s+ sGHY+a+vk+ ++g+W++f+D+ +++++ ++ +   +                   
   Q: 321  DMEPYVEHKGG----SYVYELSAVLIHRGvSAYSGHYIAHVKDpQSGEWYKFNDEDIEKMEGKKLQLGIEedlaepsksqtrkpkcgkg 405
           ******99554....79**************************44555************9999998665999**************** PP
   S: 328  ....staYvlfYk 336
               ++aY+l+Y+
   Q: 406  thcsRNAYMLVYR 418
           ************8 PP

ULD/UDP/UBQ/UBQ_Other

   S: 16   k...vnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdgstihllekks 74
           k   v+   t +eLK +i +++++ p +q+L ++GkiL +d+ tL+ +g+ ++s+i+l  +++
   Q: 945  KallVSANQTLKELKIQIMHAFSVAPFDQNLSIDGKILsDDCATLGTLGVIPESVILLKADEP 1007
           344489999************************************************988775 PP

Organism

Felis catus

Protein Sequence
(Fasta)

APRLQLEKAA WRWAETVRPE EVSQEHIETA YRIWLEPCIR GVCRRNCKGN PNCLVGIGEH 60
IWLGEIDENS FHNIDDPNCE RRKRNSFVGL TNLGATCYVN TFLQVWFLNL ELRQALYLCP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNGCCCCGCG GCTGCAGCTG GAGAAGGCGG CCTGGCGCTG GGCGGAGACG 60
GTGCGGCCCG AGGAGGTGTC GCAGGAGCAC ATCGAGACCG CGTACCGCAT CTGGCTGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR033841--USP48
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS50053--UBIQUITIN_2
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000130	Aegilops tauschii	32.50	2.00e-81	297.00
IUUC-Aml-001357	Ailuropoda melanoleuca	98.46	0.00e+00	2062.00
IUUC-Atr-002976	Amborella trichopoda	31.90	9.00e-78	285.00
IUUC-Apl-003773	Anas platyrhynchos	87.43	0.00e+00	1686.00
IUUC-Aca-004466	Anolis carolinensis	80.87	0.00e+00	867.00
IUUC-Aly-006249	Arabidopsis lyrata	30.24	6.00e-71	262.00
IUUC-Ath-006700	Arabidopsis thaliana	31.02	5.00e-80	292.00
IUUC-Ame-011554	Astyanax mexicanus	68.21	0.00e+00	1437.00
IUUC-Bta-012573	Bos taurus	96.91	0.00e+00	2055.00
IUUC-Bdi-014149	Brachypodium distachyon	32.80	8.00e-83	301.00
IUUC-Bol-016289	Brassica oleracea	29.13	1.00e-77	285.00
IUUC-Bra-017205	Brassica rapa	29.03	1.00e-70	261.00
IUUC-Cel-018662	Caenorhabditis elegans	28.02	2.00e-28	121.00
IUUC-Cja-019991	Callithrix jacchus	96.47	0.00e+00	2059.00
IUUC-Cfa-020294	Canis familiaris	98.74	0.00e+00	2105.00
IUUC-Cpo-021706	Cavia porcellus	94.86	0.00e+00	1940.00
IUUC-Cre-022636	Chlamydomonas reinhardtii	31.56	6.00e-44	174.00
IUUC-Csa-023931	Chlorocebus sabaeus	97.97	0.00e+00	2080.00
IUUC-Cho-024566	Choloepus hoffmanni	97.47	1.00e-160	560.00
IUUC-Cin-025307	Ciona intestinalis	47.16	7.00e-76	276.00
IUUC-Csv-026006	Ciona savignyi	37.29	3.00e-152	532.00
IUUC-Cne-027065	Cryptococcus neoformans	28.27	5.00e-68	253.00
IUUC-Dre-027624	Danio rerio	68.98	0.00e+00	1484.00
IUUC-Dno-029633	Dasypus novemcinctus	98.21	0.00e+00	1326.00
IUUC-Dor-030809	Dipodomys ordii	75.09	0.00e+00	1202.00
IUUC-Ete-032818	Echinops telfairi	91.30	0.00e+00	952.00
IUUC-Eca-033692	Equus caballus	98.07	0.00e+00	2080.00
IUUC-Eeu-035185	Erinaceus europaeus	75.18	0.00e+00	800.00
IUUC-Fal-036913	Ficedula albicollis	86.29	0.00e+00	1824.00
IUUC-Gmo-038532	Gadus morhua	64.97	0.00e+00	1380.00
IUUC-Gga-041041	Gallus gallus	86.68	0.00e+00	1824.00
IUUC-Gac-042570	Gasterosteus aculeatus	65.92	0.00e+00	1415.00
IUUC-Gma-044136	Glycine max	30.10	6.00e-92	332.00
IUUC-Ggo-045367	Gorilla gorilla	92.77	0.00e+00	1940.00
IUUC-Hsa-046019	Homo sapiens	97.78	0.00e+00	2079.00
IUUC-Hvu-047303	Hordeum vulgare	33.77	3.00e-66	246.00
IUUC-Itr-048319	Ictidomys tridecemlineatus	95.54	0.00e+00	2056.00
IUUC-Lch-049989	Latimeria chalumnae	76.20	0.00e+00	1641.00
IUUC-Lpe-051612	Leersia perrieri	32.76	3.00e-80	293.00
IUUC-Loc-052756	Lepisosteus oculatus	70.59	0.00e+00	1533.00
IUUC-Laf-054043	Loxodonta africana	96.49	0.00e+00	2068.00
IUUC-Mcc-054986	Macaca mulatta	96.48	0.00e+00	2061.00
IUUC-Meu-056228	Macropus eugenii	77.44	0.00e+00	867.00
IUUC-Mtr-058762	Medicago truncatula	29.63	3.00e-88	320.00
IUUC-Mga-059896	Meleagris gallopavo	86.11	0.00e+00	1725.00
IUUC-Mvi-060269	Microbotryum violaceum	37.04	3.00e-62	234.00
IUUC-Mmr-060887	Microcebus murinus	97.97	0.00e+00	2076.00
IUUC-Mdo-062506	Monodelphis domestica	93.04	0.00e+00	1986.00
IUUC-Mmu-063642	Mus musculus	92.02	0.00e+00	1992.00
IUUC-Mac-064896	Musa acuminata	32.15	1.00e-77	285.00
IUUC-Mpu-066194	Mustela putorius furo	98.26	0.00e+00	2078.00
IUUC-Mlu-067233	Myotis lucifugus	96.65	0.00e+00	2055.00
IUUC-Nle-069052	Nomascus leucogenys	96.75	0.00e+00	2064.00
IUUC-Opr-070890	Ochotona princeps	94.75	0.00e+00	1247.00
IUUC-Ont-071450	Oreochromis niloticus	64.58	0.00e+00	1365.00
IUUC-Oan-073252	Ornithorhynchus anatinus	89.91	0.00e+00	1063.00
IUUC-Ocu-073796	Oryctolagus cuniculus	96.92	0.00e+00	1770.00
IUUC-Oba-075563	Oryza barthii	32.61	4.00e-82	300.00
IUUC-Obr-076394	Oryza brachyantha	32.44	4.00e-82	299.00
IUUC-Ogl-077339	Oryza glaberrima	38.57	2.00e-41	162.00
IUUC-Ogu-079007	Oryza glumaepatula	33.33	1.00e-74	275.00
IUUC-Oin-079997	Oryza indica	32.61	2.00e-82	300.00
IUUC-Olo-080364	Oryza longistaminata	32.61	3.00e-82	300.00
IUUC-Ome-081165	Oryza meridionalis	33.33	3.00e-75	276.00
IUUC-Oni-083026	Oryza nivara	32.61	2.00e-82	300.00
IUUC-Opu-083284	Oryza punctata	34.39	1.00e-75	278.00
IUUC-Oru-084797	Oryza rufipogon	32.61	3.00e-82	300.00
IUUC-Osa-086221	Oryza sativa	38.57	2.00e-41	162.00
IUUC-Ola-086568	Oryzias latipes	66.11	0.00e+00	1424.00
IUUC-Oga-088687	Otolemur garnettii	95.99	0.00e+00	2049.00
IUUC-Oar-090345	Ovis aries	97.28	0.00e+00	1966.00
IUUC-Ptr-090734	Pan troglodytes	97.78	0.00e+00	2080.00
IUUC-Pan-091704	Papio anubis	94.23	0.00e+00	1982.00
IUUC-Psi-092937	Pelodiscus sinensis	87.01	0.00e+00	1603.00
IUUC-Ppa-095808	Physcomitrella patens	28.00	5.00e-69	256.00
IUUC-Pab-098129	Pongo abelii	97.87	0.00e+00	2081.00
IUUC-Pop-099738	Populus trichocarpa	32.12	4.00e-77	283.00
IUUC-Pca-100647	Procavia capensis	97.87	0.00e+00	684.00
IUUC-Ppe-102091	Prunus persica	31.21	9.00e-84	305.00
IUUC-Pva-102719	Pteropus vampyrus	97.39	0.00e+00	2060.00
IUUC-Rno-105363	Rattus norvegicus	93.62	0.00e+00	2015.00
IUUC-Sha-107620	Sarcophilus harrisii	89.57	0.00e+00	1849.00
IUUC-Smo-109487	Selaginella moellendorffii	28.17	5.00e-84	306.00
IUUC-Sit-110683	Setaria italica	32.81	2.00e-81	297.00
IUUC-Sly-111377	Solanum lycopersicum	29.32	1.00e-80	295.00
IUUC-Stu-111969	Solanum tuberosum	31.61	6.00e-70	258.00
IUUC-Sar-113099	Sorex araneus	96.33	0.00e+00	1738.00
IUUC-Sbi-113833	Sorghum bicolor	42.47	8.00e-57	213.00
IUUC-Ssc-115279	Sus scrofa	90.86	0.00e+00	1371.00
IUUC-Tgu-117519	Taeniopygia guttata	84.21	0.00e+00	1681.00
IUUC-Tru-117651	Takifugu rubripes	65.24	0.00e+00	1408.00
IUUC-Tsy-119201	Tarsius syrichta	94.05	0.00e+00	1818.00
IUUC-Tni-120840	Tetraodon nigroviridis	66.51	0.00e+00	1434.00
IUUC-Tca-121674	Theobroma cacao	29.02	4.00e-84	306.00
IUUC-Tae-125247	Triticum aestivum	26.26	7.00e-84	306.00
IUUC-Tur-126599	Triticum urartu	32.86	1.00e-80	295.00
IUUC-Tbe-127782	Tupaia belangeri	86.48	0.00e+00	1757.00
IUUC-Ttr-128312	Tursiops truncatus	96.62	0.00e+00	2040.00
IUUC-Vpa-130348	Vicugna pacos	97.68	0.00e+00	1976.00
IUUC-Vvi-131353	Vitis vinifera	32.52	4.00e-84	306.00
IUUC-Xtr-132172	Xenopus tropicalis	70.76	0.00e+00	1356.00
IUUC-Xma-133263	Xiphophorus maculatus	67.52	0.00e+00	1396.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence