iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090579

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03116892

Gene Name

CBLC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000011123.4	ENSPTRT00000020670.3	ENSPTRP00000019088.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.70e-06	27.8	233	272

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e+ kd +++ pCgH+ +  Cl +w     + s +++CP Cr
   Q: 233  CKICAESNKD-VKIEPCGHLLCSRCLAAW-----QHSDSQTCPFCR 272
           99********.******************.....6889999****8 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MALAVAPWGR QREEARALGR AVRMLQRREC DPLVSPSLRL LPTQLLREGA HSRRQLAKLA 60
IIFSHMHAEL HALFPGGKYC GHMYQLTKAP AHTFWRESCG APWPTLLKNW QLLAVNHPGY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTCTGG CGGTGGCCCC GTGGGGGCGA CAGCGGGAAG AGGCCCGCGC CCTGGGCCGG 60
GCCAGTCAGG ATGCTGCAGC GCTAGAGAGC ATGCTCGACC CCGCTGTCGT GAGTCCCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006508--P:proteolysis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002286	Ailuropoda melanoleuca	69.91	9.00e-122	430.00
IUUC-Bta-012705	Bos taurus	67.96	4.00e-126	444.00
IUUC-Cja-019179	Callithrix jacchus	77.05	3.00e-151	528.00
IUUC-Csa-023966	Chlorocebus sabaeus	77.68	3.00e-145	508.00
IUUC-Eca-033921	Equus caballus	68.33	5.00e-128	451.00
IUUC-Fca-035747	Felis catus	64.26	2.00e-115	409.00
IUUC-Ggo-044622	Gorilla gorilla	83.75	7.00e-160	556.00
IUUC-Hsa-045735	Homo sapiens	72.57	2.00e-168	585.00
IUUC-Itr-049001	Ictidomys tridecemlineatus	69.78	4.00e-120	424.00
IUUC-Mmr-061310	Microcebus murinus	67.38	2.00e-122	432.00
IUUC-Nle-070065	Nomascus leucogenys	62.57	6.00e-107	380.00
IUUC-Oga-087952	Otolemur garnettii	70.88	2.00e-134	472.00
IUUC-Oar-089382	Ovis aries	66.37	2.00e-122	432.00
IUUC-Pan-092075	Papio anubis	78.96	2.00e-157	548.00
IUUC-Pab-098100	Pongo abelii	69.95	2.00e-127	448.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence