• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045870
Ensembl Protein ID ENSP00000376333.3
UniProt Accession Q6P1M3; Q14521; Q9BR62; L2GL2_HUMAN
Genbank Protein ID CAA60780.1; AAH06503.1; AAH10879.1; AAH64994.1
Protein Name Lethal(2) giant larvae protein homolog 2; HGL
Genbank Nucleotide ID X87342; AC100787; BC010879; BC064994
Gene Name LLGL2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000073350.13 ENST00000167462.9 ENSP00000167462.5
ENSG00000073350.13 ENST00000375227.8 ENSP00000364375.4
ENSG00000073350.13 ENST00000392550.7 ENSP00000376333.3
ENSG00000073350.13 ENST00000577200.5 ENSP00000464397.1
ENSG00000073350.13 ENST00000583658.1 ENSP00000464483.1
ENSG00000073350.13 ENST00000578638.5 ENSP00000463501.1
ENSG00000073350.13 ENST00000578719.1 ENSP00000463150.1
ENSG00000073350.13 ENST00000583514.5 ENSP00000462439.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACmiRWalkTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 9.30e-06 27.5 433 451
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 12   sd.tllvsGsdDgtikvWD 29
           +  +ll++G  Dgt++ WD
   Q: 433  PQrDLLLTGHEDGTVRFWD 451
           55689************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.
 Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.
Protein Sequence
(Fasta)
MRRFLRPGHD PVRERLKRDL FQFNKTVEHG FPHQPSALGY SPSLRILAIG TRSGAIKLYG 60
APGVEFMGLH QENNAVTQIH LLPGQCQLVT LLDDNSLHLW SLKVKGGASE LQEDESFTLR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045870|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTTCCGCTC CCGCCTCTCG TCGCTCCAAC CTCCTCCCTC GCTTGTGCTA AAAATTCCAC 60
CCGCTGTTGC AGACCCTCCG GCCGACACGG AGGAGGTGGG CGCCCCCCCG CACCCCCCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045870|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0268--Exocytosis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR000664--Lethal2_giant
IPR013577--LLGL2
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
Pfam

PF08366--LLGL
PF00400--WD40
PRINTS

PR00962--LETHAL2GIANT
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005886--C:plasma membrane
GO:0005096--F:GTPase activator activity
GO:0030165--F:PDZ domain binding
GO:0017137--F:Rab GTPase binding
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0006887--P:exocytosis
GO:0032878--P:regulation of establishment or maintenance of cell polarity
GO:0017157--P:regulation of exocytosis
GO:0050708--P:regulation of protein secretion
KEGG hsa:3993
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002413 Ailuropoda melanoleuca 90.89 0.00e+00 1795.00
IUUC-Apl-003619 Anas platyrhynchos 77.19 0.00e+00 1570.00
IUUC-Bta-013249 Bos taurus 90.60 0.00e+00 1831.00
IUUC-Cfa-020305 Canis familiaris 92.07 0.00e+00 1844.00
IUUC-Cpo-021354 Cavia porcellus 89.87 0.00e+00 1769.00
IUUC-Csa-024027 Chlorocebus sabaeus 98.14 0.00e+00 1927.00
IUUC-Cin-025693 Ciona intestinalis 44.67 0.00e+00 736.00
IUUC-Dno-028910 Dasypus novemcinctus 88.40 0.00e+00 1678.00
IUUC-Dor-030976 Dipodomys ordii 87.82 0.00e+00 1728.00
IUUC-Ete-032938 Echinops telfairi 77.80 0.00e+00 899.00
IUUC-Eeu-035274 Erinaceus europaeus 89.48 0.00e+00 1653.00
IUUC-Fca-036585 Felis catus 90.51 0.00e+00 1776.00
IUUC-Fal-037603 Ficedula albicollis 78.97 0.00e+00 1588.00
IUUC-Gga-040222 Gallus gallus 75.63 0.00e+00 1562.00
IUUC-Ggo-045203 Gorilla gorilla 98.33 0.00e+00 1928.00
IUUC-Lch-049973 Latimeria chalumnae 70.78 0.00e+00 1407.00
IUUC-Laf-053899 Loxodonta africana 88.73 0.00e+00 1785.00
IUUC-Mcc-055790 Macaca mulatta 97.94 0.00e+00 1921.00
IUUC-Mga-059850 Meleagris gallopavo 74.75 0.00e+00 1517.00
IUUC-Mmr-060930 Microcebus murinus 89.80 0.00e+00 1744.00
IUUC-Mdo-062588 Monodelphis domestica 82.88 0.00e+00 1689.00
IUUC-Mmu-064054 Mus musculus 88.39 0.00e+00 1755.00
IUUC-Mpu-065729 Mustela putorius furo 90.80 0.00e+00 1812.00
IUUC-Mlu-066984 Myotis lucifugus 89.68 0.00e+00 1793.00
IUUC-Nle-069136 Nomascus leucogenys 96.15 0.00e+00 1847.00
IUUC-Oan-073438 Ornithorhynchus anatinus 73.00 0.00e+00 1260.00
IUUC-Ocu-074863 Oryctolagus cuniculus 90.13 0.00e+00 1702.00
IUUC-Ola-086437 Oryzias latipes 65.84 0.00e+00 1225.00
IUUC-Oga-088270 Otolemur garnettii 92.07 0.00e+00 1827.00
IUUC-Ptr-091452 Pan troglodytes 99.49 0.00e+00 1890.00
IUUC-Pan-092654 Papio anubis 98.63 0.00e+00 1942.00
IUUC-Psi-093341 Pelodiscus sinensis 78.97 0.00e+00 1595.00
IUUC-Pva-102373 Pteropus vampyrus 91.88 0.00e+00 1811.00
IUUC-Rno-104988 Rattus norvegicus 90.25 0.00e+00 1790.00
IUUC-Sha-106592 Sarcophilus harrisii 79.10 0.00e+00 1546.00
IUUC-Tgu-117381 Taeniopygia guttata 78.60 0.00e+00 1570.00
IUUC-Tbe-127984 Tupaia belangeri 85.58 0.00e+00 914.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved