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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046077
Ensembl Protein ID ENSP00000361944.4
UniProt Accession Q9BTM9; B3KMH3; B4DV08; Q5T4B4; URM1_HUMAN
Genbank Protein ID BAG50985.1; BAG62520.1; CAI13492.1; CAI13493.1; EAW87782.1; AAH03581.1
Protein Name Ubiquitin-related modifier 1
Genbank Nucleotide ID AK001880; AK300877; AL359091; AL359091; CH471090; BC003581
Gene Name URM1; C9orf74
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000167118.10 ENST00000372853.8 ENSP00000361944.4
ENSG00000167118.10 ENST00000470840.5 ENSP00000435186.1
ENSG00000167118.10 ENST00000452446.2 ENSP00000412922.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPTMBioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
ULD/UDP/UBQ/UBQ_Other 42.42 1.00e-14 72.80 IUUC-Sce-106366
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
 Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.
Protein Sequence
(Fasta)
MAAPLSVEVE FGGGAELLFD GIKKHRVTLP GQEEPWDIRN LLIWIKKNLL KERPELFIQG 60
DSVRPGILVL INDADWELLG ELDYQLQDQD SVLFISTLHG G 101
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046077|ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCGGAAATTT GCGGGCGCGC CGGAAGTTGA GGGGAGTTTC CTGCGAGCTC GGCTTCCTCA 60
ACATGGCTGC GCCCTTGTCA GTGGAGGTGG AGTTCGGGTG AGTCACAGAG CTGGGGCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046077|ULD,UBQ_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0819--tRNA processing
KW-0833--Ubl conjugation pathway
Interpro

IPR012675--Beta-grasp_dom
IPR016155--Mopterin_synth/thiamin_S_b
IPR015221--Urm1
Pfam

PF09138--Urm1
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0006400--P:tRNA modification
GO:0034227--P:tRNA thio-modification
GO:0002098--P:tRNA wobble uridine modification
KEGG hsa:81605
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002254 Ailuropoda melanoleuca 97.03 2.00e-53 199.00
IUUC-Atr-003089 Amborella trichopoda 55.56 1.00e-29 120.00
IUUC-Apl-003382 Anas platyrhynchos 86.81 9.00e-43 164.00
IUUC-Aca-004981 Anolis carolinensis 83.17 1.00e-47 180.00
IUUC-Aly-005517 Arabidopsis lyrata 53.26 2.00e-27 113.00
IUUC-Ath-006718 Arabidopsis thaliana 53.57 6.00e-24 102.00
IUUC-Ago-007917 Ashbya gossypii 42.42 1.00e-19 87.40
IUUC-Acl-008054 Aspergillus clavatus 66.00 4.00e-15 72.40
IUUC-Afl-008704 Aspergillus flavus 55.06 3.00e-20 89.40
IUUC-Aor-009890 Aspergillus oryzae 57.43 7.00e-25 105.00
IUUC-Bta-012448 Bos taurus 95.05 1.00e-52 197.00
IUUC-Bci-013865 Botrytis cinerea 46.53 1.00e-21 94.40
IUUC-Bdi-014980 Brachypodium distachyon 60.71 4.00e-24 102.00
IUUC-Bol-016055 Brassica oleracea 55.00 9.00e-24 101.00
IUUC-Bra-016845 Brassica rapa 55.00 9.00e-24 101.00
IUUC-Cel-018485 Caenorhabditis elegans 33.98 8.00e-12 61.60
IUUC-Cja-019587 Callithrix jacchus 97.03 2.00e-53 199.00
IUUC-Cfa-020653 Canis familiaris 94.06 2.00e-52 196.00
IUUC-Cpo-021622 Cavia porcellus 97.03 2.00e-53 199.00
IUUC-Cre-023015 Chlamydomonas reinhardtii 53.06 3.00e-25 105.00
IUUC-Csa-023756 Chlorocebus sabaeus 97.47 2.00e-40 157.00
IUUC-Cgl-026518 Colletotrichum gloeosporioides 45.54 1.00e-20 91.30
IUUC-Cne-026953 Cryptococcus neoformans 56.31 2.00e-27 114.00
IUUC-Cme-027314 Cyanidioschyzon merolae 42.27 1.00e-17 80.90
IUUC-Dre-027884 Danio rerio 77.23 3.00e-44 169.00
IUUC-Dno-029262 Dasypus novemcinctus 93.83 2.00e-39 154.00
IUUC-Dor-030601 Dipodomys ordii 66.34 6.00e-28 115.00
IUUC-Dme-031893 Drosophila melanogaster 64.71 2.00e-32 130.00
IUUC-Ete-032773 Echinops telfairi 89.11 1.00e-47 180.00
IUUC-Eca-034187 Equus caballus 96.04 4.00e-53 199.00
IUUC-Eeu-034808 Erinaceus europaeus 93.07 8.00e-52 194.00
IUUC-Fca-036107 Felis catus 95.05 1.00e-52 197.00
IUUC-Fal-036607 Ficedula albicollis 85.71 2.00e-42 162.00
IUUC-Fox-037698 Fusarium oxysporum 47.12 6.00e-23 99.00
IUUC-Gmo-039492 Gadus morhua 74.26 1.00e-43 167.00
IUUC-Ggr-039965 Gaeumannomyces graminis 47.12 7.00e-20 89.40
IUUC-Gga-041268 Gallus gallus 86.14 2.00e-48 182.00
IUUC-Gac-042111 Gasterosteus aculeatus 78.22 3.00e-46 176.00
IUUC-Gma-043240 Glycine max 53.57 9.00e-23 97.80
IUUC-Ggo-045176 Gorilla gorilla 100.00 9.00e-33 132.00
IUUC-Itr-048111 Ictidomys tridecemlineatus 96.63 6.00e-38 148.00
IUUC-Kpa-049157 Komagataella pastoris 47.47 1.00e-19 87.80
IUUC-Lch-049889 Latimeria chalumnae 79.21 1.00e-45 173.00
IUUC-Lpe-050783 Leersia perrieri 59.04 4.00e-23 99.40
IUUC-Loc-052400 Lepisosteus oculatus 78.22 5.00e-45 172.00
IUUC-Lma-053259 Leptosphaeria maculans 45.54 1.00e-20 91.30
IUUC-Laf-053596 Loxodonta africana 94.17 2.00e-51 193.00
IUUC-Mcc-054845 Macaca mulatta 91.84 4.00e-47 178.00
IUUC-Meu-055968 Macropus eugenii 91.09 8.00e-51 191.00
IUUC-Mor-057126 Magnaporthe oryzae 45.19 7.00e-19 85.90
IUUC-Mpo-057311 Magnaporthe poae 48.51 5.00e-21 93.60
IUUC-Mtr-058266 Medicago truncatula 51.16 2.00e-22 97.10
IUUC-Mla-058847 Melampsora laricipopulina 40.78 5.00e-12 62.80
IUUC-Mga-059468 Meleagris gallopavo 86.81 7.00e-43 164.00
IUUC-Mvi-060235 Microbotryum violaceum 36.42 3.00e-19 87.80
IUUC-Mdo-061948 Monodelphis domestica 90.10 1.00e-50 190.00
IUUC-Mmu-063946 Mus musculus 93.07 9.00e-52 194.00
IUUC-Mac-064812 Musa acuminata 63.89 1.00e-24 104.00
IUUC-Mpu-066763 Mustela putorius furo 94.06 1.00e-51 193.00
IUUC-Mlu-066970 Myotis lucifugus 96.20 3.00e-40 155.00
IUUC-Ncr-068824 Neurospora crassa 44.55 2.00e-19 87.40
IUUC-Nle-069849 Nomascus leucogenys 98.73 5.00e-41 159.00
IUUC-Opr-070227 Ochotona princeps 97.03 2.00e-53 199.00
IUUC-Ont-072530 Oreochromis niloticus 79.21 5.00e-46 175.00
IUUC-Oan-073191 Ornithorhynchus anatinus 79.38 1.00e-41 160.00
IUUC-Ocu-074460 Oryctolagus cuniculus 93.88 1.00e-50 190.00
IUUC-Oba-075499 Oryza barthii 67.19 2.00e-22 98.60
IUUC-Obr-076896 Oryza brachyantha 56.79 8.00e-22 97.10
IUUC-Ogl-077834 Oryza glaberrima 67.19 5.00e-23 98.60
IUUC-Ogu-078622 Oryza glumaepatula 67.19 5.00e-23 98.60
IUUC-Oin-079358 Oryza indica 67.19 2.00e-22 99.00
IUUC-Olo-081035 Oryza longistaminata 51.46 2.00e-23 102.00
IUUC-Oni-082425 Oryza nivara 67.19 5.00e-23 98.60
IUUC-Opu-083461 Oryza punctata 66.67 3.00e-22 97.40
IUUC-Oru-084875 Oryza rufipogon 60.56 6.00e-21 91.70
IUUC-Oga-089128 Otolemur garnettii 95.05 7.00e-53 197.00
IUUC-Oar-089896 Ovis aries 95.05 1.00e-52 197.00
IUUC-Ptr-091618 Pan troglodytes 100.00 8.00e-33 132.00
IUUC-Pan-092238 Papio anubis 97.47 2.00e-40 157.00
IUUC-Psi-093879 Pelodiscus sinensis 86.14 7.00e-48 181.00
IUUC-Pma-094484 Petromyzon marinus 79.21 1.00e-35 140.00
IUUC-Ppa-095801 Physcomitrella patens 58.02 3.00e-22 96.30
IUUC-Pfo-097192 Poecilia formosa 78.22 7.00e-46 174.00
IUUC-Pab-098203 Pongo abelii 99.01 2.00e-45 173.00
IUUC-Pop-099614 Populus trichocarpa 54.76 1.00e-23 100.00
IUUC-Pca-100507 Procavia capensis 94.94 4.00e-40 155.00
IUUC-Ppe-101174 Prunus persica 54.55 2.00e-28 116.00
IUUC-Pva-102735 Pteropus vampyrus 95.05 2.00e-49 186.00
IUUC-Pgr-103510 Puccinia graminis 39.81 4.00e-12 63.50
IUUC-Ptt-103918 Puccinia triticina 35.92 5.00e-10 56.20
IUUC-Pte-104173 Pyrenophora teres 47.57 9.00e-23 98.20
IUUC-Pyt-104806 Pyrenophora triticirepentis 47.57 7.00e-23 98.60
IUUC-Rno-105820 Rattus norvegicus 94.06 3.00e-52 196.00
IUUC-Sce-106366 Saccharomyces cerevisiae 42.42 2.00e-17 80.50
IUUC-Sja-107727 Schizosaccharomyces japonicus 41.67 2.00e-16 77.40
IUUC-Spo-108074 Schizosaccharomyces pombe 39.80 2.00e-09 53.90
IUUC-Smo-108944 Selaginella moellendorffii 59.55 6.00e-26 108.00
IUUC-Sit-110277 Setaria italica 57.14 7.00e-24 101.00
IUUC-Sly-111505 Solanum lycopersicum 53.57 3.00e-24 102.00
IUUC-Stu-112076 Solanum tuberosum 54.76 1.00e-24 104.00
IUUC-Sbi-114274 Sorghum bicolor 58.44 6.00e-24 102.00
IUUC-Sre-114953 Sporisorium reilianum 59.80 1.00e-27 114.00
IUUC-Ssc-115418 Sus scrofa 94.06 1.00e-52 197.00
IUUC-Tgu-117311 Taeniopygia guttata 85.71 3.00e-42 162.00
IUUC-Tru-118598 Takifugu rubripes 79.78 4.00e-40 155.00
IUUC-Tni-120109 Tetraodon nigroviridis 76.47 5.00e-43 165.00
IUUC-Tca-120942 Theobroma cacao 54.22 6.00e-23 98.60
IUUC-Tre-122099 Trichoderma reesei 47.87 1.00e-15 73.90
IUUC-Tvi-122285 Trichoderma virens 51.92 1.00e-20 90.90
IUUC-Tae-125193 Triticum aestivum 59.26 3.00e-23 99.80
IUUC-Tur-126677 Triticum urartu 50.53 1.00e-20 91.70
IUUC-Tme-127120 Tuber melanosporum 48.08 1.00e-23 101.00
IUUC-Tbe-128050 Tupaia belangeri 70.30 2.00e-33 133.00
IUUC-Ttr-129019 Tursiops truncatus 92.08 2.00e-49 186.00
IUUC-Uma-129483 Ustilago maydis 57.84 3.00e-25 106.00
IUUC-Vda-129690 Verticillium dahliae 41.07 2.00e-16 77.40
IUUC-Vvi-131174 Vitis vinifera 55.42 6.00e-24 101.00
IUUC-Xma-133862 Xiphophorus maculatus 78.22 7.00e-46 174.00
IUUC-Yli-134398 Yarrowia lipolytica 46.46 4.00e-19 85.90
IUUC-Zma-134964 Zea mays 58.54 2.00e-22 96.70
Created Date 25-Jun-2017

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