iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035824

Ensembl Protein ID

ENSFCAP00000006423.3

UniProt Accession

M3W6R3; M3W6R3_FELCA

Genbank Protein ID

ENSFCAP00000006423

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02031567

Gene Name

HUWE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000006914.3	ENSFCAT00000006920.3	ENSFCAP00000006423.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.40e-122	407.4	4039	4373
UBD/Alpha-Helix/UBA	5.50e-08	32.7	1318	1355

Active Site

Position(s)	Description	Evidence
4341	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++++k+rl++ f+gEeg+d+gG+ re++  +s+e++np++ lf++s++d+ t+++np+s + np+hl++F+f+Gr+++ka++d+rll
   Q: 4039 PEEMKNRLYIVFEGEEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYTINPSSHC-NPNHLSYFKFVGRIVAKAVYDNRLL 4124
           6799*******************************************************86.99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++ +++sfyk++lgk++ + d+e+ d ++y+ l +++en   d+++lg dltfs++ +++g +++++Lkp+G+ni Vt+eNk+eYv+
   Q: 4125 ECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLEN---DVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEYVH 4208
           *************************************99...********************************************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           lv+++r++  i++q++af eGf+e+ip++l+s+Fte+elelli+G ++id++dlk++t+y++ y+++s +iqwFw++l++f++ +r+
   Q: 4209 LVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPTIDIDDLKSNTEYHK-YQSNSIQIQWFWRALRSFDQADRA 4294
           ************************************************************66.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           +fLqFvTg+s++Pl+Gfa+l+     ++f+i++ d+s+drlPs++TCfn+L+LP Y+s e+l+++Ll+Ai+e+ +gF+l
   Q: 4295 KFLQFVTGTSKVPLQGFAALEgmngIQKFQIHRdDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECsEGFGL 4373
           *********************99998999999988899***************************************97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
           ++++l+ql++MGF+re+a +aL++   + e A+eyLl++
   Q: 1318 NQQQLQQLMDMGFTREHAMEALLN-TSTMEQATEYLLTH 1355
           89**********************.7***********98 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 60
FDGILADAGQ TVENMSWMLV CDRPEREQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGGTGAAGG GGCCCGGCGG CCTGCCCCAG CCCTCCCTCA ACCCCGCCTT CTCTCCCCTC 60
CCCCAGGCCT TGGCAAGAGC CAGCCCTAAG CTAGCCGCAT CTTCTGGGGC AGCGGGGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR004170--WWE-dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50918--WWE

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA
PF02825--WWE

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006284--P:base-excision repair
GO:0016574--P:histone ubiquitination
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	41.03	3.00e-106	382.00
IUUC-Aml-001684	Ailuropoda melanoleuca	99.63	0.00e+00	4441.00
IUUC-Atr-003044	Amborella trichopoda	52.69	7.00e-126	446.00
IUUC-Apl-003729	Anas platyrhynchos	93.54	0.00e+00	694.00
IUUC-Aca-005263	Anolis carolinensis	92.39	0.00e+00	3108.00
IUUC-Aly-006083	Arabidopsis lyrata	51.77	2.00e-126	448.00
IUUC-Ath-007472	Arabidopsis thaliana	51.77	2.00e-126	449.00
IUUC-Ago-008005	Ashbya gossypii	46.36	4.00e-131	464.00
IUUC-Acl-008254	Aspergillus clavatus	46.46	7.00e-134	473.00
IUUC-Afl-008712	Aspergillus flavus	45.57	8.00e-136	478.00
IUUC-Afu-009022	Aspergillus fumigatus	46.27	2.00e-133	471.00
IUUC-Ani-009412	Aspergillus nidulans	46.83	3.00e-135	478.00
IUUC-Ang-009771	Aspergillus niger	46.83	3.00e-134	474.00
IUUC-Aor-010186	Aspergillus oryzae	44.74	1.00e-126	447.00
IUUC-Ate-010253	Aspergillus terreus	46.99	3.00e-134	474.00
IUUC-Ame-011067	Astyanax mexicanus	81.08	0.00e+00	3653.00
IUUC-Bgr-012043	Blumeria graminis	46.62	6.00e-139	490.00
IUUC-Bta-012813	Bos taurus	99.13	0.00e+00	4447.00
IUUC-Bci-013995	Botrytis cinerea	45.97	2.00e-137	486.00
IUUC-Bdi-014884	Brachypodium distachyon	51.99	6.00e-127	450.00
IUUC-Bol-016533	Brassica oleracea	58.33	4.00e-89	320.00
IUUC-Bra-016637	Brassica rapa	44.36	4.00e-123	437.00
IUUC-Cel-018179	Caenorhabditis elegans	61.52	0.00e+00	646.00
IUUC-Cja-018741	Callithrix jacchus	99.38	0.00e+00	4435.00
IUUC-Cfa-020083	Canis familiaris	97.76	0.00e+00	4425.00
IUUC-Cpo-021923	Cavia porcellus	98.05	0.00e+00	4385.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	48.83	1.00e-119	422.00
IUUC-Csa-023853	Chlorocebus sabaeus	99.29	0.00e+00	4442.00
IUUC-Cho-024718	Choloepus hoffmanni	100.00	0.00e+00	814.00
IUUC-Cin-025627	Ciona intestinalis	42.59	0.00e+00	1930.00
IUUC-Csv-025824	Ciona savignyi	48.10	0.00e+00	1447.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	52.44	2.00e-136	481.00
IUUC-Cne-027095	Cryptococcus neoformans	41.21	3.00e-105	378.00
IUUC-Cme-027267	Cyanidioschyzon merolae	50.00	2.00e-115	411.00
IUUC-Dre-028525	Danio rerio	82.04	0.00e+00	3633.00
IUUC-Dno-029680	Dasypus novemcinctus	98.26	0.00e+00	4367.00
IUUC-Dor-030902	Dipodomys ordii	96.05	0.00e+00	1212.00
IUUC-Dse-031197	Dothistroma septosporum	47.12	6.00e-138	487.00
IUUC-Dme-032122	Drosophila melanogaster	65.88	0.00e+00	791.00
IUUC-Ete-032690	Echinops telfairi	90.45	0.00e+00	1248.00
IUUC-Eca-033915	Equus caballus	98.91	0.00e+00	4405.00
IUUC-Eeu-034963	Erinaceus europaeus	93.94	0.00e+00	2964.00
IUUC-Fox-037756	Fusarium oxysporum	53.53	7.00e-137	483.00
IUUC-Fso-038464	Fusarium solani	54.48	1.00e-136	483.00
IUUC-Gmo-039073	Gadus morhua	83.21	0.00e+00	3655.00
IUUC-Ggr-039946	Gaeumannomyces graminis	52.98	2.00e-134	475.00
IUUC-Gga-040309	Gallus gallus	98.38	0.00e+00	654.00
IUUC-Gac-042430	Gasterosteus aculeatus	83.44	0.00e+00	3729.00
IUUC-Gma-044247	Glycine max	51.99	2.00e-125	445.00
IUUC-Ggo-044785	Gorilla gorilla	99.25	0.00e+00	4400.00
IUUC-Hsa-046879	Homo sapiens	99.29	0.00e+00	4400.00
IUUC-Hvu-047697	Hordeum vulgare	44.99	8.00e-128	453.00
IUUC-Itr-048430	Ictidomys tridecemlineatus	98.77	0.00e+00	1480.00
IUUC-Kpa-049228	Komagataella pastoris	48.78	9.00e-141	496.00
IUUC-Lch-050252	Latimeria chalumnae	88.85	0.00e+00	3362.00
IUUC-Lpe-051550	Leersia perrieri	51.99	5.00e-127	450.00
IUUC-Loc-052472	Lepisosteus oculatus	83.88	0.00e+00	3754.00
IUUC-Lma-053159	Leptosphaeria maculans	45.69	4.00e-136	481.00
IUUC-Laf-054154	Loxodonta africana	98.34	0.00e+00	4394.00
IUUC-Mcc-055085	Macaca mulatta	97.66	0.00e+00	4390.00
IUUC-Meu-056727	Macropus eugenii	94.72	0.00e+00	1912.00
IUUC-Mor-057201	Magnaporthe oryzae	46.49	7.00e-135	476.00
IUUC-Mpo-057597	Magnaporthe poae	46.11	6.00e-133	470.00
IUUC-Mtr-058088	Medicago truncatula	52.69	2.00e-126	448.00
IUUC-Mla-058888	Melampsora laricipopulina	49.12	3.00e-116	411.00
IUUC-Mvi-060320	Microbotryum violaceum	40.75	1.00e-123	439.00
IUUC-Mmr-060820	Microcebus murinus	96.95	0.00e+00	4357.00
IUUC-Mdo-062930	Monodelphis domestica	92.21	0.00e+00	4135.00
IUUC-Mmu-063601	Mus musculus	98.26	0.00e+00	4263.00
IUUC-Mac-065557	Musa acuminata	52.09	8.00e-119	423.00
IUUC-Mpu-066653	Mustela putorius furo	97.63	0.00e+00	4313.00
IUUC-Mlu-067418	Myotis lucifugus	98.63	0.00e+00	4472.00
IUUC-Nfi-068278	Neosartorya fischeri	46.46	6.00e-134	473.00
IUUC-Ncr-068813	Neurospora crassa	46.68	3.00e-136	481.00
IUUC-Nle-069418	Nomascus leucogenys	98.88	0.00e+00	4365.00
IUUC-Opr-070187	Ochotona princeps	84.17	0.00e+00	882.00
IUUC-Ont-071300	Oreochromis niloticus	83.80	0.00e+00	3704.00
IUUC-Oan-073046	Ornithorhynchus anatinus	88.47	0.00e+00	5274.00
IUUC-Ocu-074178	Oryctolagus cuniculus	98.50	0.00e+00	4437.00
IUUC-Oba-075757	Oryza barthii	51.76	7.00e-127	450.00
IUUC-Obr-076553	Oryza brachyantha	45.17	8.00e-126	446.00
IUUC-Ogl-077520	Oryza glaberrima	51.76	7.00e-127	450.00
IUUC-Ogu-078278	Oryza glumaepatula	51.76	8.00e-127	450.00
IUUC-Oin-079767	Oryza indica	51.76	9.00e-127	449.00
IUUC-Olo-080380	Oryza longistaminata	51.28	4.00e-125	444.00
IUUC-Ome-081925	Oryza meridionalis	51.28	4.00e-125	444.00
IUUC-Oni-082619	Oryza nivara	51.76	7.00e-127	450.00
IUUC-Opu-083684	Oryza punctata	51.28	3.00e-125	444.00
IUUC-Oru-084501	Oryza rufipogon	51.76	8.00e-127	450.00
IUUC-Osa-086251	Oryza sativa	51.76	2.00e-125	443.00
IUUC-Ola-087437	Oryzias latipes	85.32	0.00e+00	2133.00
IUUC-Olu-087813	Ostreococcus lucimarinus	50.50	7.00e-114	403.00
IUUC-Oga-088903	Otolemur garnettii	98.75	0.00e+00	4385.00
IUUC-Oar-090210	Ovis aries	97.51	0.00e+00	4410.00
IUUC-Ptr-090502	Pan troglodytes	99.16	0.00e+00	3392.00
IUUC-Pan-092368	Papio anubis	99.16	0.00e+00	3429.00
IUUC-Pma-094246	Petromyzon marinus	74.30	0.00e+00	1290.00
IUUC-Pno-094871	Phaeosphaeria nodorum	52.76	1.00e-134	476.00
IUUC-Ppa-095657	Physcomitrella patens	51.36	4.00e-125	444.00
IUUC-Pfo-096232	Poecilia formosa	81.29	0.00e+00	3670.00
IUUC-Pab-098583	Pongo abelii	99.34	0.00e+00	4403.00
IUUC-Pop-099613	Populus trichocarpa	53.16	3.00e-128	454.00
IUUC-Pca-100310	Procavia capensis	83.93	0.00e+00	1657.00
IUUC-Ppe-102109	Prunus persica	52.46	1.00e-126	449.00
IUUC-Pva-102116	Pteropus vampyrus	98.96	0.00e+00	4448.00
IUUC-Pgr-103465	Puccinia graminis	43.29	1.00e-127	452.00
IUUC-Ptt-103813	Puccinia triticina	41.21	5.00e-115	410.00
IUUC-Pte-104018	Pyrenophora teres	52.39	3.00e-133	471.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	52.41	6.00e-133	470.00
IUUC-Rno-105889	Rattus norvegicus	90.51	0.00e+00	3872.00
IUUC-Sce-106449	Saccharomyces cerevisiae	45.11	1.00e-126	449.00
IUUC-Sha-106961	Sarcophilus harrisii	90.61	0.00e+00	4075.00
IUUC-Sja-107814	Schizosaccharomyces japonicus	45.54	4.00e-128	454.00
IUUC-Spo-108024	Schizosaccharomyces pombe	46.21	2.00e-130	461.00
IUUC-Smo-109428	Selaginella moellendorffii	51.10	1.00e-130	462.00
IUUC-Sit-110598	Setaria italica	52.46	2.00e-127	452.00
IUUC-Sly-111285	Solanum lycopersicum	51.67	8.00e-128	453.00
IUUC-Stu-112582	Solanum tuberosum	32.35	5.00e-57	216.00
IUUC-Sar-113291	Sorex araneus	93.28	0.00e+00	2734.00
IUUC-Sbi-114042	Sorghum bicolor	52.46	6.00e-128	453.00
IUUC-Sre-114958	Sporisorium reilianum	56.50	6.00e-139	487.00
IUUC-Ssc-115754	Sus scrofa	99.54	0.00e+00	4435.00
IUUC-Tru-118570	Takifugu rubripes	83.15	0.00e+00	3751.00
IUUC-Tsy-119159	Tarsius syrichta	92.80	0.00e+00	2090.00
IUUC-Tni-120836	Tetraodon nigroviridis	77.84	0.00e+00	1997.00
IUUC-Tca-121479	Theobroma cacao	51.29	2.00e-124	442.00
IUUC-Tre-121909	Trichoderma reesei	53.41	7.00e-133	470.00
IUUC-Tvi-122370	Trichoderma virens	53.18	8.00e-133	470.00
IUUC-Tae-125214	Triticum aestivum	51.04	3.00e-125	444.00
IUUC-Tme-127172	Tuber melanosporum	46.99	6.00e-139	490.00
IUUC-Tbe-127506	Tupaia belangeri	95.80	0.00e+00	1496.00
IUUC-Ttr-129253	Tursiops truncatus	91.41	0.00e+00	2200.00
IUUC-Uma-129355	Ustilago maydis	49.06	5.00e-141	494.00
IUUC-Vda-129886	Verticillium dahliae	47.44	2.00e-138	488.00
IUUC-Vpa-130708	Vicugna pacos	97.79	0.00e+00	3883.00
IUUC-Vvi-131170	Vitis vinifera	51.00	7.00e-127	449.00
IUUC-Xtr-132123	Xenopus tropicalis	85.65	0.00e+00	5093.00
IUUC-Xma-133869	Xiphophorus maculatus	81.29	0.00e+00	3679.00
IUUC-Yli-134657	Yarrowia lipolytica	45.44	4.00e-130	461.00
IUUC-Zma-135570	Zea mays	44.58	4.00e-128	454.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence