iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133630

Ensembl Protein ID

ENSXMAP00000011251.1

UniProt Accession

M4A9V7; M4A9V7_XIPMA

Genbank Protein ID

ENSXMAP00000011251

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGAJ01043173

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000011211.1	ENSXMAT00000011265.1	ENSXMAP00000011251.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.50e-134	446.1	520	850

Active Site

Position(s)	Description	Evidence
820	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           + lk+rl+vef+gE+gld+gG++re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl +F+f+Gr+ g+a+++g+lld++
   Q: 520  ELLKARLWVEFEGEKGLDYGGLAREWFFLMSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLTYFKFIGRVAGMAVFHGKLLDAF 608
           66899************************************************************************************ PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           + ++fyk++l+k+++l+d+e+vd+e+++slk+i++n   d e+  ldl+f+++ee++get++++Lkp+G++i Vtn+Nk+eY++lv+++
   Q: 609  FIRPFYKMMLQKPITLQDMESVDSEYFNSLKWILDN---DPED--LDLRFTIDEELFGETRQHDLKPDGSEIVVTNQNKREYIDLVMQW 692
           **********************************99...6666..79999999************************************ PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+ ++i++q++af+eGf e+ip++l+++F+ +elell+cG  ++dv+d++++tkyk+gy  d+ +iqwFw+++  +++e+r ++LqFvT
   Q: 693  RFVNRIQKQMTAFKEGFFELIPKDLIRIFDGNELELLMCGLGDVDVNDWRQNTKYKNGYCGDHMVIQWFWKTVLLMDAEKRIRLLQFVT 781
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           g+sr+P++Gfael     p+lf+i+++++ d+lP+++TCfn+L+LP+Y+s e+l+ekL +Aie+++gF+
   Q: 782  GTSRVPMNGFAELYgsngPQLFTIEQWGTSDKLPRAHTCFNRLDLPPYESFEELREKLNIAIENAQGFD 850
           ********************************************************************8 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MCPLVSPFQT RDDFLGQVDV PLNQIPTENP NAQRPYTFKD FLLHPRSHKS RVKGHLRLKM 60
TYLPKNLGSE EETADQTEDS DPGWELLDQD MSGPRQSQLL PPLPPGWEER QDNLGRNYFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAGTCTTGT TGATGTTTGT TTTGGAGATG ATTCTCATGT GTCCACTTGT CTCTCCTTTT 60
CAGACACGTG ATGACTTTCT TGGACAGGTG GACGTTCCTT TAAATCAGAT ACCGGTGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	66.55	0.00e+00	1115.00
IUUC-Ame-011138	Astyanax mexicanus	71.45	0.00e+00	1132.00
IUUC-Bta-012453	Bos taurus	64.43	0.00e+00	1063.00
IUUC-Cfa-020258	Canis familiaris	66.51	0.00e+00	1073.00
IUUC-Cin-025157	Ciona intestinalis	53.45	0.00e+00	848.00
IUUC-Dno-029159	Dasypus novemcinctus	61.56	0.00e+00	929.00
IUUC-Ete-032409	Echinops telfairi	73.79	0.00e+00	764.00
IUUC-Fca-036384	Felis catus	66.47	0.00e+00	1094.00
IUUC-Gac-042607	Gasterosteus aculeatus	73.94	0.00e+00	1229.00
IUUC-Lch-050445	Latimeria chalumnae	68.39	0.00e+00	1147.00
IUUC-Laf-053638	Loxodonta africana	64.12	0.00e+00	1041.00
IUUC-Meu-056897	Macropus eugenii	85.37	3.00e-154	539.00
IUUC-Mmr-061061	Microcebus murinus	66.67	0.00e+00	1113.00
IUUC-Mlu-068148	Myotis lucifugus	66.04	0.00e+00	1089.00
IUUC-Ont-071664	Oreochromis niloticus	76.25	0.00e+00	1233.00
IUUC-Oga-088241	Otolemur garnettii	59.88	0.00e+00	944.00
IUUC-Oar-089797	Ovis aries	65.58	0.00e+00	1088.00
IUUC-Psi-093618	Pelodiscus sinensis	66.90	0.00e+00	1094.00
IUUC-Pfo-097145	Poecilia formosa	94.14	0.00e+00	951.00
IUUC-Pca-100568	Procavia capensis	59.31	0.00e+00	884.00
IUUC-Tru-117675	Takifugu rubripes	69.43	0.00e+00	1171.00
IUUC-Tni-119993	Tetraodon nigroviridis	70.33	0.00e+00	1156.00
IUUC-Tbe-127408	Tupaia belangeri	61.04	0.00e+00	825.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence