iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001374

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01128647

Gene Name

HERC6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000003054.1	ENSAMET00000003369.1	ENSAMEP00000003238.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.60e-82	275.7	689	1009

Active Site

Position(s)	Description	Evidence
980	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            dl k l  ef +E   +  Gv +ef++++++e+ ++++g+f y e+++++++p + ++    e+ ++F  +G+l+g++l ++++ +
   Q: 689  TDLCKGLVTEFIKEIYSGGYGVISEFFYCIFEEMTKTEYGMFIYPEEGSYMWFPVSPKF----EKKRYFL-FGILCGLSLNNSNVAN 770
           678889999************************************************99....6789995.5*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           lp++ +++k+ll++k sl+dl+e+ p l k+l+e+++n+ +di e+ ld+ fs++     + k+ +L+p+G ++pV ++Nk+eYv++
   Q: 771  LPFPLALFKKLLDQKPSLQDLKELSPLLGKNLQEVLNNEADDIGEE-LDIYFSIHW----DKKDANLIPNGISVPVDQTNKKEYVSA 852
           **************************************98899887.*****9555....779999********************* PP
   S: 177  vveyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
            v+y++++++k  +e+f++Gf++v+++e l++lF++eel + + G++++d+++++++ +y++gy++++p+i +Fw+++++++ ee++
   Q: 853  CVDYIFNTSVKAVYEEFQRGFYKVCDKEvLFKLFQPEELMTAVVGNTDYDWKQFEENSRYDQGYHKSHPTILMFWKAFHKLTLEEKR 939
           ****************************677******************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
           +fL F+ g++rl ++  +e+   +f +++  s++++P++ TC n L+LP+Ys++e+++e L+++i++++gF
   Q: 940  KFLFFLKGNDRLRVRDKEEMG-IIFRCPETFSETDYPRALTCHNILDLPKYSTMEKVEEALQVTINSNRGF 1009
           *********************.77888889***************************************99 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MYLCWGTSPR GPPRRRQAGX GAELRQAASG ERHSLLLLSN GELHSCGDNS QGQLGRKGVQ 60
RDEHPKRIRT LDNLRVDLVS CGKEHSLAVC YKGRVFAWGA GSEGQLGVGE FKEINLIPTK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTACCTGT GCTGGGGCAC CAGCCCTCGG GGGCCTCCGC GCCGGAGGCA GGCCGGCCNG 60
GGCCGGCGCC GAGCTGCGAC AGGCGGCCTC CGGGGAGCGC CATTCGCTGC TGCTGCTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004663	Anolis carolinensis	45.98	0.00e+00	837.00
IUUC-Bta-013080	Bos taurus	72.16	0.00e+00	1409.00
IUUC-Cja-018891	Callithrix jacchus	70.45	0.00e+00	1404.00
IUUC-Cfa-020763	Canis familiaris	82.29	0.00e+00	1546.00
IUUC-Cpo-022346	Cavia porcellus	68.94	0.00e+00	1394.00
IUUC-Csa-023049	Chlorocebus sabaeus	73.07	0.00e+00	1504.00
IUUC-Dno-029093	Dasypus novemcinctus	71.58	0.00e+00	1428.00
IUUC-Eca-034098	Equus caballus	76.00	0.00e+00	1414.00
IUUC-Eeu-035028	Erinaceus europaeus	56.05	1.00e-154	540.00
IUUC-Fca-036283	Felis catus	83.32	0.00e+00	1576.00
IUUC-Ggo-045553	Gorilla gorilla	70.88	0.00e+00	1413.00
IUUC-Hsa-046396	Homo sapiens	73.46	0.00e+00	1483.00
IUUC-Loc-052700	Lepisosteus oculatus	40.27	0.00e+00	735.00
IUUC-Laf-054433	Loxodonta africana	69.69	0.00e+00	1458.00
IUUC-Mcc-055014	Macaca mulatta	69.87	0.00e+00	1439.00
IUUC-Mdo-061839	Monodelphis domestica	55.19	0.00e+00	1004.00
IUUC-Mmu-064378	Mus musculus	62.08	0.00e+00	1213.00
IUUC-Mpu-066293	Mustela putorius furo	83.78	0.00e+00	1611.00
IUUC-Mlu-067407	Myotis lucifugus	71.98	0.00e+00	1421.00
IUUC-Nle-069978	Nomascus leucogenys	72.38	0.00e+00	1500.00
IUUC-Opr-070190	Ochotona princeps	55.78	0.00e+00	660.00
IUUC-Oga-088780	Otolemur garnettii	66.00	0.00e+00	1314.00
IUUC-Oar-090307	Ovis aries	74.25	0.00e+00	1464.00
IUUC-Ptr-091567	Pan troglodytes	73.75	0.00e+00	1483.00
IUUC-Pan-091802	Papio anubis	68.95	0.00e+00	1412.00
IUUC-Pab-098024	Pongo abelii	59.63	0.00e+00	1132.00
IUUC-Pva-102382	Pteropus vampyrus	70.62	0.00e+00	1342.00
IUUC-Rno-105768	Rattus norvegicus	59.62	0.00e+00	1181.00
IUUC-Sha-106525	Sarcophilus harrisii	52.20	0.00e+00	1025.00
IUUC-Sar-113014	Sorex araneus	58.65	8.00e-151	527.00
IUUC-Vpa-130214	Vicugna pacos	71.14	0.00e+00	1267.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence