iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Drug and target
GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	4.10e-08	33.5	278	316

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 278  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 316
           89********************************99986 PP

Organism

Rattus norvegicus

Functional Description
(View)

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins (By similarity).

Protein Sequence
(Fasta)

MLTFMASDSE EEVCDERTSL MSAESPTSRS CQDSRPGPED GENTAQWRSQ ENEDDCEEDP 60
DHYACSGVPG RPSGLEEELT LKYGAKHVIM LFVPVTLCMI VVVATIKSVR FYTEKNGQLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGACTGACA GCTGCGTCAA GCTCCTCCCA CCGTGAGGCG CCTGTCTGAT GAGCTGAGAG 60
CCAGAATAAA CTCTGGAACG GTGTTGTCGC TGAGGTAATA GCCTACCCAG TGCGGTGTTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0043025--C:neuronal cell body
GO:0005637--C:nuclear inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing
GO:0001666--P:response to hypoxia

KEGG

rno:81751

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	86.83	3.00e-178	617.00
IUUC-Apl-003959	Anas platyrhynchos	75.53	1.00e-158	552.00
IUUC-Aca-005160	Anolis carolinensis	73.04	1.00e-156	545.00
IUUC-Ame-010686	Astyanax mexicanus	80.58	6.00e-146	510.00
IUUC-Bta-013097	Bos taurus	93.54	0.00e+00	710.00
IUUC-Cja-018824	Callithrix jacchus	93.53	0.00e+00	725.00
IUUC-Cfa-020253	Canis familiaris	93.53	0.00e+00	733.00
IUUC-Cpo-021401	Cavia porcellus	93.30	0.00e+00	733.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	33.89	3.00e-29	123.00
IUUC-Csa-023369	Chlorocebus sabaeus	95.31	0.00e+00	747.00
IUUC-Dre-028526	Danio rerio	71.33	2.00e-143	501.00
IUUC-Dor-031127	Dipodomys ordii	90.18	0.00e+00	683.00
IUUC-Ete-033081	Echinops telfairi	81.91	6.00e-92	331.00
IUUC-Eca-034387	Equus caballus	93.97	0.00e+00	696.00
IUUC-Eeu-034846	Erinaceus europaeus	79.71	6.00e-148	517.00
IUUC-Fca-035396	Felis catus	92.84	0.00e+00	719.00
IUUC-Fal-037457	Ficedula albicollis	75.65	1.00e-157	549.00
IUUC-Gmo-038550	Gadus morhua	83.19	2.00e-106	379.00
IUUC-Gga-040706	Gallus gallus	76.15	4.00e-152	531.00
IUUC-Gac-042511	Gasterosteus aculeatus	66.24	1.00e-128	452.00
IUUC-Gma-043822	Glycine max	36.21	3.00e-23	102.00
IUUC-Ggo-045338	Gorilla gorilla	95.31	0.00e+00	746.00
IUUC-Hsa-046455	Homo sapiens	95.31	0.00e+00	747.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	94.64	0.00e+00	744.00
IUUC-Lch-049638	Latimeria chalumnae	68.52	2.00e-141	495.00
IUUC-Lpe-051132	Leersia perrieri	36.23	9.00e-17	81.30
IUUC-Loc-052427	Lepisosteus oculatus	74.50	2.00e-154	538.00
IUUC-Laf-053758	Loxodonta africana	89.36	0.00e+00	726.00
IUUC-Mcc-054755	Macaca mulatta	95.09	0.00e+00	746.00
IUUC-Mmr-060890	Microcebus murinus	93.08	0.00e+00	723.00
IUUC-Mdo-062197	Monodelphis domestica	78.88	6.00e-174	603.00
IUUC-Mmu-063823	Mus musculus	97.10	0.00e+00	765.00
IUUC-Mac-064858	Musa acuminata	42.61	1.00e-20	93.60
IUUC-Mpu-066181	Mustela putorius furo	92.86	0.00e+00	726.00
IUUC-Nle-069596	Nomascus leucogenys	94.68	0.00e+00	697.00
IUUC-Opr-070344	Ochotona princeps	92.41	0.00e+00	711.00
IUUC-Ont-071867	Oreochromis niloticus	70.56	6.00e-133	467.00
IUUC-Oan-073378	Ornithorhynchus anatinus	74.33	1.00e-152	532.00
IUUC-Ocu-074652	Oryctolagus cuniculus	92.63	0.00e+00	696.00
IUUC-Obr-076302	Oryza brachyantha	36.23	1.00e-16	81.30
IUUC-Ogl-077097	Oryza glaberrima	36.23	3.00e-16	80.10
IUUC-Ogu-078570	Oryza glumaepatula	36.23	2.00e-16	80.10
IUUC-Oin-079244	Oryza indica	36.96	2.00e-16	80.50
IUUC-Ome-081814	Oryza meridionalis	35.75	6.00e-17	82.00
IUUC-Oni-082057	Oryza nivara	36.96	2.00e-16	80.50
IUUC-Opu-084176	Oryza punctata	36.96	3.00e-16	79.70
IUUC-Oru-084618	Oryza rufipogon	36.96	2.00e-16	80.50
IUUC-Osa-085602	Oryza sativa	36.31	6.00e-17	81.60
IUUC-Ola-086707	Oryzias latipes	68.89	7.00e-107	380.00
IUUC-Olu-087811	Ostreococcus lucimarinus	38.73	5.00e-47	181.00
IUUC-Oga-088560	Otolemur garnettii	93.57	0.00e+00	699.00
IUUC-Oar-089200	Ovis aries	93.32	0.00e+00	689.00
IUUC-Ptr-090569	Pan troglodytes	95.09	0.00e+00	745.00
IUUC-Pan-091742	Papio anubis	95.09	0.00e+00	745.00
IUUC-Pma-094612	Petromyzon marinus	75.46	2.00e-126	445.00
IUUC-Ppa-095431	Physcomitrella patens	31.78	7.00e-28	118.00
IUUC-Pab-098531	Pongo abelii	95.31	0.00e+00	747.00
IUUC-Pca-101120	Procavia capensis	90.85	0.00e+00	709.00
IUUC-Pva-102934	Pteropus vampyrus	84.15	0.00e+00	672.00
IUUC-Sha-106876	Sarcophilus harrisii	78.25	4.00e-171	594.00
IUUC-Sly-110865	Solanum lycopersicum	59.26	2.00e-08	50.80
IUUC-Ssc-115380	Sus scrofa	94.42	0.00e+00	758.00
IUUC-Tgu-117280	Taeniopygia guttata	75.81	2.00e-158	551.00
IUUC-Tbe-127632	Tupaia belangeri	94.41	2.00e-179	621.00
IUUC-Ttr-129008	Tursiops truncatus	92.19	0.00e+00	714.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence