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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063413
UUCD1 version UUC-MuM-00050
Ensembl Protein ID ENSMUSP00000049128.7
UniProt Accession Q8VE73; Q3UHY3; Q497I2; Q6A0D6; Q6PB63; Q8R3W4; Q9CVD5; CUL7_MOUSE
Genbank Protein ID BAB25811.1; BAE27723.1; AAH19645.1; AAH26946.2; AAH59865.1; AAI00545.1; BAD32160.1
Protein Name Cullin-7; p185; p193
Genbank Nucleotide ID AK008655; AK147156; CT030702; BC026946; BC059865; BC100544; AK172882
Gene Name Cul7; Kiaa0076
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000038545.13 ENSMUST00000043464.13 ENSMUSP00000049128.7
ENSMUSG00000038545.13 ENSMUST00000145567.7 ENSMUSP00000116133.1
ENSMUSG00000038545.13 ENSMUST00000133393.7 ENSMUSP00000119393.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/Cullin Cullin_N_terminal 17229476
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/Cullin 4.10e-156 522.4 950 1505
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin
   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ freql++++++f      y+++           +++w+++i+ed +++ll+l+++l+ a+R+++++++r+l++++++    
   Q: 950  PTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDIAED-RRSLLHLSSRLNGALRHEQNFAERFLPDMEAA---- 1014
           689***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q++++++++++++  + +d+Yl ++ea++n+++++aa++++++++t+Ll++ve++++a       ++
   Q: 1015 ----QALSKTCWEALVSPLVQNITSPDEDSTSSLgWLLDQYLGCREAAYNPQSRAAAFSSRVRRLTHLLVHVEPREAA-------PP 1090
           ....9*************************************************************************.......** PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
           +va++r+k++++++++++L++r+l+  ++++l+++++s+++eq++++lta++k++d   +V+r++e ++ lqk++se+F+++a+Fl 
   Q: 1091 VVAIPRSKGRNRIHDWSYLITRGLPssIMKNLTRCWRSVVEEQMNKFLTASWKDDD---FVPRYCERYYVLQKSSSELFGPRAAFLL 1174
           ************************999*****************************...**************************** PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           a++++++++v++ ++l+aa+++E++Ar+iDq++++s ++g++++e++aql+++l+ + ++s +++   Fe+yY++++a+RLls  + 
   Q: 1175 AMRNGCADAVLRLPFLRAAHVSEQFARHIDQRIQGSrMGGARGMEMLAQLQRCLESVLIFSPLEIattFEHYYQHYMADRLLS--VG 1259
           ***********************************************************************************..** PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk............................................ 452
           ss++E++v+e++    g++f+s+L ++M+q+l+vSe+l+rqF+                                            
   Q: 1260 SSWLEGAVLEQI----GPCFPSRLpQQMLQSLNVSEELQRQFHvyqlqqldqellkledtekkiqvahedsgredkskkeeaigeaa 1342
           ************....*********************************************************************** PP
   S: 453  ........................eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........l 503
                                   ee+e++++ +++e++vlv+++++Wp+a  +++  ++++LPa+l+ ti+++++fY        l
   Q: 1343 avamaeeedqgkkeegeeegegedEEEERYYKGTMPEVCVLVVTPRFWPVAsvCQMlnPATCLPAYLRGTINHYTNFYsksqsrssL 1429
           ************************9**************************99999999**************************** PP
   S: 504  ekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqv 582
           ek+++R+LqW++ +grae+++    g ++l+Vst+Qm++LL++nn+++vsve+l++++elp+++L+r++++L+ss+   ++
   Q: 1430 EKEPQRRLQWTW-QGRAEVQF----GGQILHVSTVQMWLLLHLNNQKEVSVESLQAISELPPDVLHRAIGPLTSSRgpLDL 1505
           ************.********....*************************************************9944333 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1. Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation. Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development. Does not promote polyubiquitination and proteasomal degradation of p53/TP53. While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions (By similarity). Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation.
 Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1. Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain. Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation. Acts as a regulator in trophoblast cell epithelial-mesenchymal transition and placental development. Does not promote polyubiquitination and proteasomal degradation of p53/TP53. While the Cul7-RING(FBXW8) and the 3M complexes are associated and involved in common processes, CUL7 and the Cul7-RING(FBXW8) complex may be have additional functions (By similarity). Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation.
Protein Sequence
(Fasta)
MVGELRYREF RVPLGPGLHA YPDELIRQRV GHNGHPEYQI RWLILRRGDD GDRDSTVDCK 60
AEHILLWMSD DEIYANCHKM LGENGQVIAP SRESTEAGAL DKSVLGEMET DVKSLIQRAL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063413|E3,Cullin|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGGAGGGCT GCGTCGTCCA GGTGGCACCC GCTACTCCGC CCGCTGATGG CCCCCGGCCC 60
CCAGCTTTCC GCTAAATCAG GCGGAAGCGA GCGGTGGCTG GAGCAGGCGG CGGAGCCTCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063413|E3,Cullin|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0333--Golgi apparatus
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2
PS51284--DOC
Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin
SMART

SM01337--APC10
SM00884--Cullin_Nedd8
Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005794--C:Golgi apparatus
GO:0005622--C:intracellular
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0007030--P:Golgi organization
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0045601--P:regulation of endothelial cell differentiation
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis
KEGG mmu:66515
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002360 Ailuropoda melanoleuca 76.73 0.00e+00 2429.00
IUUC-Bta-013285 Bos taurus 75.37 0.00e+00 2422.00
IUUC-Cja-019033 Callithrix jacchus 74.20 0.00e+00 2295.00
IUUC-Cfa-020695 Canis familiaris 77.91 0.00e+00 1571.00
IUUC-Cpo-021513 Cavia porcellus 72.59 0.00e+00 2277.00
IUUC-Csa-023798 Chlorocebus sabaeus 76.37 0.00e+00 2402.00
IUUC-Dor-030234 Dipodomys ordii 77.19 0.00e+00 2508.00
IUUC-Ete-032612 Echinops telfairi 69.42 0.00e+00 810.00
IUUC-Eca-033408 Equus caballus 77.58 0.00e+00 2392.00
IUUC-Fca-035483 Felis catus 76.49 0.00e+00 2408.00
IUUC-Gmo-038795 Gadus morhua 43.36 0.00e+00 890.00
IUUC-Gac-041628 Gasterosteus aculeatus 45.39 0.00e+00 1080.00
IUUC-Ggo-044721 Gorilla gorilla 77.76 0.00e+00 1933.00
IUUC-Hsa-046406 Homo sapiens 77.84 0.00e+00 1951.00
IUUC-Itr-048525 Ictidomys tridecemlineatus 79.93 0.00e+00 2481.00
IUUC-Lch-049956 Latimeria chalumnae 45.12 0.00e+00 791.00
IUUC-Laf-054068 Loxodonta africana 77.18 0.00e+00 2446.00
IUUC-Mcc-055464 Macaca mulatta 76.61 0.00e+00 2377.00
IUUC-Meu-056198 Macropus eugenii 54.07 0.00e+00 1253.00
IUUC-Mla-058863 Melampsora laricipopulina 37.04 7.00e-03 33.90
IUUC-Mvi-060444 Microbotryum violaceum 35.71 8.50e-02 32.00
IUUC-Mmr-061464 Microcebus murinus 76.40 0.00e+00 2379.00
IUUC-Mdo-062018 Monodelphis domestica 55.34 0.00e+00 1331.00
IUUC-Mpu-066146 Mustela putorius furo 77.38 0.00e+00 2379.00
IUUC-Mlu-067036 Myotis lucifugus 74.67 0.00e+00 2378.00
IUUC-Opr-070670 Ochotona princeps 70.51 0.00e+00 2200.00
IUUC-Oan-073451 Ornithorhynchus anatinus 48.33 0.00e+00 1092.00
IUUC-Ocu-074155 Oryctolagus cuniculus 75.67 0.00e+00 2367.00
IUUC-Olo-080771 Oryza longistaminata 32.86 8.00e-03 35.40
IUUC-Oga-089084 Otolemur garnettii 75.63 0.00e+00 2454.00
IUUC-Oar-090029 Ovis aries 76.79 0.00e+00 2428.00
IUUC-Ptr-091282 Pan troglodytes 76.00 0.00e+00 1930.00
IUUC-Pan-091883 Papio anubis 76.61 0.00e+00 2400.00
IUUC-Pab-098383 Pongo abelii 73.74 0.00e+00 2332.00
IUUC-Pca-100519 Procavia capensis 76.07 0.00e+00 728.00
IUUC-Pva-102417 Pteropus vampyrus 72.25 0.00e+00 1862.00
IUUC-Rno-105962 Rattus norvegicus 86.18 0.00e+00 2743.00
IUUC-Ssc-115899 Sus scrofa 71.43 0.00e+00 2174.00
IUUC-Tsy-118860 Tarsius syrichta 77.72 0.00e+00 1022.00
IUUC-Tbe-127660 Tupaia belangeri 72.96 0.00e+00 1206.00
Created Date 25-Jun-2017

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