iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-089084

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03061153

Gene Name

CUL7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000012700.2	ENSOGAT00000012711.2	ENSOGAP00000011388.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	1.30e-147	493.1	999	1545

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ freql++++++f      y+++           +++w+++++ed +++ll+l+++l+ a+R+++++++ +l++++++    
   Q: 999  PTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDMAED-RRSLLHLSSRLNGALRQEQNFADCFLPDDEAA---- 1063
           589***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q++++++++ ++   + +d+Yl+++ea+ n+++++aa++++++++t+Ll++ve+++++       ++
   Q: 1064 ----RALGKTCWEALVSPLVQNITSPDEDGISPLgWLLDQYLECREAAHNPQSRAAAFSSRVRRLTHLLVHVEPCEVS-------PP 1139
           ....9*************************************************************************.......** PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
           +v ++r k++++ +++++L++r+l+  ++++l+++++s+++eq++++lt++++++d   +V+r++e +n lqk++se+F+++a+Fl 
   Q: 1140 VVTTPRPKGRNRSHDWSSLATRGLPssIMRNLTRCWRSVVEEQVNNFLTSSWRDDD---FVPRYCERFNSLQKSSSELFGPRAAFLL 1223
           ************************999*****************************...**************************** PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           al+++++ +++k ++l+aa+++E++Ar+iDq++++s ++g++++e++aql+++l+++ ++ ++++   Fe+yY++++a+RLl   + 
   Q: 1224 ALQNGCAGALLKLPFLRAAHVSEQFARHIDQRIQGSrIGGARGMEMLAQLQRCLEAVLIFCGLEIattFEHYYQHYMADRLLG--VG 1308
           ***********************************************************************************..** PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk............................................ 452
           ss++E++v+e++    g++f+++L ++M+++l++Se+l+rqF+                                            
   Q: 1309 SSWLEGAVLEQI----GPCFPNRLpQQMLRSLSTSEELQRQFHvyqlqrldqellkledtekkiqvgqetggeehesekdeeagaaa 1391
           ************....*********************************************************************** PP
   S: 453  ............eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRkLqWqh 515
                       e+++ ++e +++e+svlvLs+++Wp a  ++t  ++++LP++l+ t++++++fY        le++s+R+LqW++
   Q: 1392 amglvegeeeeeENEDLYYEGTMPEVSVLVLSPRCWPIAsiCHTlnPRTCLPPYLRGTLNRYSNFYsksqrhptLEQGSQRRLQWTW 1478
           **********98889999*********************9999899***************************************** PP
   S: 516  tlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkep 587
            lgrael++    g ++l+Vst+Qm++LL++n+ + vsve+l + ++l++++L++++ +L+s +  +  +ep
   Q: 1479 -LGRAELQF----GDQTLHVSTVQMWLLLYLNDLKVVSVESLLELSGLSPDMLNQAIAPLTSARGPLDLHEP 1545
           .********....*************************************************9854444555 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MVGELRYREF RVPLGPGLHA YPDELIRQRV GHNGHPEYQI RWLILRRGDD GEGGSSQVDC 60
KAEHILLWMS NDEIYANCHK MLGEDGQVIG PSQESTGEAG ALDKSVLGEM ETDVKSLIQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGGGGG AACTCCGCTA CAGGGAATTC AGGGTGCCCC TGGGACCTGG TTTGCATGCC 60
TATCCTGATG AGCTGATCCG CCAACGGGTG GGCCACAATG GGCATCCAGA ATACCAGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	85.48	0.00e+00	2799.00
IUUC-Bta-013285	Bos taurus	86.35	0.00e+00	2792.00
IUUC-Cja-019033	Callithrix jacchus	83.43	0.00e+00	2688.00
IUUC-Cfa-020695	Canis familiaris	87.98	0.00e+00	1774.00
IUUC-Cpo-021513	Cavia porcellus	78.00	0.00e+00	2486.00
IUUC-Csa-023798	Chlorocebus sabaeus	87.64	0.00e+00	2797.00
IUUC-Dno-029587	Dasypus novemcinctus	83.26	0.00e+00	1528.00
IUUC-Dor-030234	Dipodomys ordii	82.26	0.00e+00	2769.00
IUUC-Ete-032612	Echinops telfairi	78.38	0.00e+00	922.00
IUUC-Eca-033408	Equus caballus	87.75	0.00e+00	2770.00
IUUC-Fca-035483	Felis catus	87.39	0.00e+00	2820.00
IUUC-Gmo-038795	Gadus morhua	44.26	0.00e+00	932.00
IUUC-Gac-041628	Gasterosteus aculeatus	45.18	0.00e+00	1313.00
IUUC-Ggo-044721	Gorilla gorilla	88.22	0.00e+00	2775.00
IUUC-Hsa-046406	Homo sapiens	88.22	0.00e+00	2815.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	86.37	0.00e+00	2746.00
IUUC-Lch-049956	Latimeria chalumnae	44.18	0.00e+00	1088.00
IUUC-Laf-054068	Loxodonta africana	84.29	0.00e+00	2788.00
IUUC-Mcc-055464	Macaca mulatta	87.82	0.00e+00	2795.00
IUUC-Meu-056198	Macropus eugenii	55.14	0.00e+00	1303.00
IUUC-Mmr-061464	Microcebus murinus	92.02	0.00e+00	2921.00
IUUC-Mdo-062018	Monodelphis domestica	57.42	0.00e+00	1394.00
IUUC-Mmu-063413	Mus musculus	75.85	0.00e+00	2376.00
IUUC-Mpu-066146	Mustela putorius furo	86.09	0.00e+00	2679.00
IUUC-Mlu-067036	Myotis lucifugus	85.95	0.00e+00	2785.00
IUUC-Opr-070670	Ochotona princeps	76.80	0.00e+00	2492.00
IUUC-Oan-073451	Ornithorhynchus anatinus	51.50	0.00e+00	1191.00
IUUC-Ocu-074155	Oryctolagus cuniculus	83.37	0.00e+00	2674.00
IUUC-Oar-090029	Ovis aries	85.25	0.00e+00	2773.00
IUUC-Ptr-091282	Pan troglodytes	90.07	0.00e+00	2888.00
IUUC-Pan-091883	Papio anubis	87.81	0.00e+00	2821.00
IUUC-Pab-098383	Pongo abelii	88.16	0.00e+00	2809.00
IUUC-Pca-100519	Procavia capensis	75.78	0.00e+00	828.00
IUUC-Pva-102417	Pteropus vampyrus	84.75	0.00e+00	2237.00
IUUC-Rno-105962	Rattus norvegicus	77.42	0.00e+00	2508.00
IUUC-Sar-113750	Sorex araneus	75.62	9.00e-166	578.00
IUUC-Ssc-115899	Sus scrofa	81.75	0.00e+00	2445.00
IUUC-Tsy-118860	Tarsius syrichta	86.11	0.00e+00	1156.00
IUUC-Tbe-127660	Tupaia belangeri	85.20	0.00e+00	1434.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence