iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021466

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02032358

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000000176.3	ENSCPOT00000000177.2	ENSCPOP00000000153.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-122	408.8	1200	1532

Active Site

Position(s)	Description	Evidence
1500	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1200 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1285
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1286 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1368
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1369 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1455
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1456 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1532
           ************************999***********************************************985 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

LFTISLSPQN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN MDIRGGPHDG 60
ITIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIDID 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGTTCACTA TCTCTTTGTC CCCACAGAAT CTGTACCAGA ACAGGTTTTT AGGCCTGGCC 60
GCCATGGCGT CTCCATCTCG AAATTCCCAG AGCCGGCGCC GATGCAAGGA GCCACTCCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	83.49	0.00e+00	2093.00
IUUC-Apl-003299	Anas platyrhynchos	78.38	0.00e+00	2381.00
IUUC-Aca-005024	Anolis carolinensis	76.72	0.00e+00	2323.00
IUUC-Bta-012604	Bos taurus	84.33	0.00e+00	2525.00
IUUC-Cja-019880	Callithrix jacchus	80.73	0.00e+00	2134.00
IUUC-Cfa-021216	Canis familiaris	87.99	0.00e+00	1791.00
IUUC-Csa-023080	Chlorocebus sabaeus	85.73	0.00e+00	2577.00
IUUC-Cho-024740	Choloepus hoffmanni	92.60	0.00e+00	1137.00
IUUC-Dre-028750	Danio rerio	74.25	0.00e+00	1535.00
IUUC-Dno-030019	Dasypus novemcinctus	84.80	0.00e+00	2555.00
IUUC-Dor-031030	Dipodomys ordii	73.51	0.00e+00	1129.00
IUUC-Ete-032352	Echinops telfairi	94.29	0.00e+00	1261.00
IUUC-Eca-033948	Equus caballus	86.90	0.00e+00	1786.00
IUUC-Eeu-034474	Erinaceus europaeus	70.39	0.00e+00	833.00
IUUC-Fca-036148	Felis catus	83.94	0.00e+00	2490.00
IUUC-Fal-036957	Ficedula albicollis	76.82	0.00e+00	2348.00
IUUC-Gmo-038714	Gadus morhua	68.83	0.00e+00	1012.00
IUUC-Gga-041194	Gallus gallus	77.78	0.00e+00	2350.00
IUUC-Gac-041366	Gasterosteus aculeatus	77.74	0.00e+00	1368.00
IUUC-Ggo-045442	Gorilla gorilla	75.18	0.00e+00	1946.00
IUUC-Hsa-045730	Homo sapiens	85.74	0.00e+00	2579.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	86.72	0.00e+00	2615.00
IUUC-Lch-050185	Latimeria chalumnae	69.12	0.00e+00	1957.00
IUUC-Loc-052744	Lepisosteus oculatus	73.35	0.00e+00	2187.00
IUUC-Laf-054368	Loxodonta africana	98.20	0.00e+00	1502.00
IUUC-Mcc-055487	Macaca mulatta	85.37	0.00e+00	2577.00
IUUC-Meu-056751	Macropus eugenii	91.60	0.00e+00	730.00
IUUC-Mga-059545	Meleagris gallopavo	78.33	0.00e+00	2350.00
IUUC-Mmr-061078	Microcebus murinus	84.24	0.00e+00	2449.00
IUUC-Mdo-062176	Monodelphis domestica	81.20	0.00e+00	1654.00
IUUC-Mmu-063513	Mus musculus	83.30	0.00e+00	2459.00
IUUC-Mpu-065786	Mustela putorius furo	84.98	0.00e+00	2514.00
IUUC-Mlu-067780	Myotis lucifugus	78.97	0.00e+00	2261.00
IUUC-Nle-069213	Nomascus leucogenys	84.93	0.00e+00	2526.00
IUUC-Opr-070208	Ochotona princeps	97.06	0.00e+00	1494.00
IUUC-Ont-072132	Oreochromis niloticus	77.57	0.00e+00	1360.00
IUUC-Oan-072807	Ornithorhynchus anatinus	83.48	0.00e+00	1747.00
IUUC-Ocu-074745	Oryctolagus cuniculus	84.50	0.00e+00	2490.00
IUUC-Ola-086981	Oryzias latipes	79.65	0.00e+00	1423.00
IUUC-Oga-087965	Otolemur garnettii	84.69	0.00e+00	2428.00
IUUC-Oar-089749	Ovis aries	87.77	0.00e+00	1808.00
IUUC-Ptr-091243	Pan troglodytes	85.80	0.00e+00	2580.00
IUUC-Pan-092201	Papio anubis	86.42	0.00e+00	2605.00
IUUC-Psi-093511	Pelodiscus sinensis	77.15	0.00e+00	2306.00
IUUC-Pfo-097001	Poecilia formosa	77.80	0.00e+00	1376.00
IUUC-Pab-098728	Pongo abelii	83.53	0.00e+00	2462.00
IUUC-Pca-100129	Procavia capensis	81.39	0.00e+00	1250.00
IUUC-Pva-102250	Pteropus vampyrus	73.36	0.00e+00	2036.00
IUUC-Rno-105031	Rattus norvegicus	82.75	0.00e+00	2481.00
IUUC-Tgu-117515	Taeniopygia guttata	77.38	0.00e+00	2361.00
IUUC-Tru-117914	Takifugu rubripes	76.39	0.00e+00	1369.00
IUUC-Tsy-119379	Tarsius syrichta	79.17	0.00e+00	790.00
IUUC-Tni-120178	Tetraodon nigroviridis	76.99	0.00e+00	1385.00
IUUC-Tbe-127762	Tupaia belangeri	77.03	0.00e+00	1862.00
IUUC-Ttr-128806	Tursiops truncatus	90.83	0.00e+00	1702.00
IUUC-Xtr-132903	Xenopus tropicalis	72.35	0.00e+00	1826.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence