iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000017608.2	ENSPPYT00000020514.2	ENSPPYP00000019737.2
ENSPPYG00000017608.2	ENSPPYT00000020513.2	ENSPPYP00000019736.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-122	408.7	1276	1608

Active Site

Position(s)	Description	Evidence
1576	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1276 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1361
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1362 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1444
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1445 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1531
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1532 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1608
           ************************999***********************************************985 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN MDLRGGPHDG 60
VTIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIDEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGCTGCA GGGCGGGGCA GCGCTAATGA GAGCAAGCCC GGCTTGTGGT TGGTTCTGGA 60
GTCTGGTACC CACAGAGGAG CAGGCAGGGA GGGAGGGGAT GCAAGCGGGA GGATAAAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	83.93	0.00e+00	2103.00
IUUC-Apl-003299	Anas platyrhynchos	78.14	0.00e+00	2360.00
IUUC-Aca-005024	Anolis carolinensis	77.18	0.00e+00	2325.00
IUUC-Bta-012604	Bos taurus	86.61	0.00e+00	2569.00
IUUC-Cja-019880	Callithrix jacchus	89.17	0.00e+00	2335.00
IUUC-Cfa-021216	Canis familiaris	88.04	0.00e+00	1728.00
IUUC-Cpo-021466	Cavia porcellus	92.77	0.00e+00	1639.00
IUUC-Csa-023080	Chlorocebus sabaeus	96.83	0.00e+00	2865.00
IUUC-Cho-024740	Choloepus hoffmanni	83.57	0.00e+00	1186.00
IUUC-Dno-030019	Dasypus novemcinctus	88.28	0.00e+00	2593.00
IUUC-Dor-031030	Dipodomys ordii	78.03	0.00e+00	792.00
IUUC-Ete-032352	Echinops telfairi	88.89	0.00e+00	1182.00
IUUC-Eca-033948	Equus caballus	87.03	0.00e+00	2492.00
IUUC-Eeu-034474	Erinaceus europaeus	80.83	0.00e+00	818.00
IUUC-Fca-036148	Felis catus	91.99	0.00e+00	1812.00
IUUC-Fal-036957	Ficedula albicollis	79.19	0.00e+00	2357.00
IUUC-Gmo-038714	Gadus morhua	66.92	0.00e+00	936.00
IUUC-Gga-041194	Gallus gallus	78.24	0.00e+00	2337.00
IUUC-Gac-041366	Gasterosteus aculeatus	74.37	0.00e+00	1281.00
IUUC-Ggo-045442	Gorilla gorilla	79.12	0.00e+00	2081.00
IUUC-Hsa-045730	Homo sapiens	96.96	0.00e+00	2873.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	90.71	0.00e+00	2693.00
IUUC-Lch-050185	Latimeria chalumnae	67.67	0.00e+00	1876.00
IUUC-Loc-052744	Lepisosteus oculatus	71.97	0.00e+00	2144.00
IUUC-Laf-054368	Loxodonta africana	93.96	0.00e+00	1427.00
IUUC-Mcc-055487	Macaca mulatta	96.89	0.00e+00	2859.00
IUUC-Mga-059545	Meleagris gallopavo	78.68	0.00e+00	2341.00
IUUC-Mmr-061078	Microcebus murinus	89.39	0.00e+00	2518.00
IUUC-Mdo-062176	Monodelphis domestica	81.22	0.00e+00	1606.00
IUUC-Mmu-063513	Mus musculus	85.47	0.00e+00	2485.00
IUUC-Mpu-065786	Mustela putorius furo	88.90	0.00e+00	2569.00
IUUC-Mlu-067780	Myotis lucifugus	80.80	0.00e+00	2271.00
IUUC-Nle-069213	Nomascus leucogenys	96.65	0.00e+00	2779.00
IUUC-Opr-070208	Ochotona princeps	93.99	0.00e+00	1438.00
IUUC-Ont-072132	Oreochromis niloticus	77.94	0.00e+00	1271.00
IUUC-Oan-072807	Ornithorhynchus anatinus	84.71	0.00e+00	1690.00
IUUC-Ocu-074745	Oryctolagus cuniculus	87.14	0.00e+00	2506.00
IUUC-Ola-086981	Oryzias latipes	71.03	0.00e+00	1387.00
IUUC-Oga-087965	Otolemur garnettii	92.17	0.00e+00	1796.00
IUUC-Oar-089749	Ovis aries	85.67	0.00e+00	2490.00
IUUC-Ptr-091243	Pan troglodytes	96.83	0.00e+00	2868.00
IUUC-Pan-092201	Papio anubis	95.27	0.00e+00	2817.00
IUUC-Psi-093511	Pelodiscus sinensis	77.46	0.00e+00	2294.00
IUUC-Pfo-097001	Poecilia formosa	63.40	0.00e+00	1486.00
IUUC-Pca-100129	Procavia capensis	78.49	0.00e+00	1180.00
IUUC-Pva-102250	Pteropus vampyrus	77.15	0.00e+00	2093.00
IUUC-Rno-105031	Rattus norvegicus	85.43	0.00e+00	2501.00
IUUC-Tgu-117515	Taeniopygia guttata	79.46	0.00e+00	2336.00
IUUC-Tru-117914	Takifugu rubripes	72.98	0.00e+00	1288.00
IUUC-Tsy-119379	Tarsius syrichta	90.37	0.00e+00	803.00
IUUC-Tni-120178	Tetraodon nigroviridis	67.73	0.00e+00	1342.00
IUUC-Tbe-127762	Tupaia belangeri	82.01	0.00e+00	1926.00
IUUC-Ttr-128806	Tursiops truncatus	89.92	0.00e+00	1660.00
IUUC-Vpa-130812	Vicugna pacos	89.33	0.00e+00	651.00
IUUC-Xtr-132903	Xenopus tropicalis	72.43	0.00e+00	1797.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence