iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012956

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase NOSIP; RING-type E3 ubiquitin transferase NOSIP

Genbank Nucleotide ID

BC104600

Gene Name

NOSIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000014450.3	ENSBTAT00000019215.3	ENSBTAP00000019215.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	6.00e-16	58.4	40	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G+ y+r++I +++ +++k
   Q: 40   VKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKK 79
           567789*****************************98887 PP

Organism

Bos taurus

Functional Description
(View)

E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity).

Protein Sequence
(Fasta)

MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGARREEQK ELQRAAAQDH VRGFLEKEAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGAGAGGGA AAACAGCGCT CCTTTCCGGT GTAGGGGTAC TGTTGAAGTA GCCACCGAGG 60
AAAGAGGGTC GTCTGTGAGG TGAGTTCTAG GCGGTAGAAG AATAGTGTTA GTGCGATTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0007275--P:multicellular organism development
GO:0051001--P:negative regulation of nitric-oxide synthase activity
GO:0016567--P:protein ubiquitination

KEGG

bta:511234

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	46.51	1.00e-16	81.30
IUUC-Aml-002069	Ailuropoda melanoleuca	92.68	1.00e-166	578.00
IUUC-Atr-002661	Amborella trichopoda	31.96	9.00e-31	127.00
IUUC-Aca-004630	Anolis carolinensis	75.17	4.00e-136	477.00
IUUC-Aly-006316	Arabidopsis lyrata	30.49	6.00e-30	124.00
IUUC-Ath-007000	Arabidopsis thaliana	30.16	1.00e-29	123.00
IUUC-Acl-008175	Aspergillus clavatus	31.97	9.00e-06	44.70
IUUC-Afl-008440	Aspergillus flavus	33.91	1.00e-05	43.90
IUUC-Afu-009012	Aspergillus fumigatus	33.06	2.00e-06	46.60
IUUC-Ani-009153	Aspergillus nidulans	33.33	4.00e-03	35.80
IUUC-Ang-009556	Aspergillus niger	34.78	6.00e-06	45.10
IUUC-Aor-009892	Aspergillus oryzae	33.91	1.00e-05	44.30
IUUC-Ame-011874	Astyanax mexicanus	64.61	4.00e-110	390.00
IUUC-Bgr-012090	Blumeria graminis	26.28	2.00e-05	43.50
IUUC-Bci-013897	Botrytis cinerea	42.50	8.00e-10	57.80
IUUC-Bdi-014968	Brachypodium distachyon	30.17	4.00e-34	138.00
IUUC-Bol-015578	Brassica oleracea	30.82	2.00e-34	139.00
IUUC-Bra-017234	Brassica rapa	30.82	2.00e-34	139.00
IUUC-Cel-018637	Caenorhabditis elegans	41.23	2.00e-57	215.00
IUUC-Cja-019632	Callithrix jacchus	94.04	8.00e-169	585.00
IUUC-Cfa-020192	Canis familiaris	95.36	9.00e-170	589.00
IUUC-Cpo-021939	Cavia porcellus	90.73	7.00e-155	539.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	34.65	6.00e-43	167.00
IUUC-Csa-023802	Chlorocebus sabaeus	94.37	7.00e-169	586.00
IUUC-Cho-024637	Choloepus hoffmanni	77.98	1.00e-82	298.00
IUUC-Cin-025180	Ciona intestinalis	51.82	3.00e-85	308.00
IUUC-Csv-026206	Ciona savignyi	47.09	5.00e-44	170.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	26.85	6.00e-13	68.20
IUUC-Cne-026827	Cryptococcus neoformans	36.36	1.00e-06	47.40
IUUC-Dre-028092	Danio rerio	65.46	2.00e-117	415.00
IUUC-Dno-029501	Dasypus novemcinctus	89.11	2.00e-143	502.00
IUUC-Dor-030542	Dipodomys ordii	90.79	2.00e-161	560.00
IUUC-Dse-031188	Dothistroma septosporum	25.00	2.00e-15	77.00
IUUC-Dme-031734	Drosophila melanogaster	49.19	1.00e-78	286.00
IUUC-Eca-033577	Equus caballus	97.02	8.00e-174	602.00
IUUC-Fca-035761	Felis catus	96.36	3.00e-172	597.00
IUUC-Fox-037703	Fusarium oxysporum	27.33	6.00e-08	51.60
IUUC-Fso-038208	Fusarium solani	26.11	4.00e-13	68.60
IUUC-Gmo-038523	Gadus morhua	60.62	6.00e-61	226.00
IUUC-Ggr-040087	Gaeumannomyces graminis	41.03	7.00e-10	58.20
IUUC-Gac-042621	Gasterosteus aculeatus	60.38	2.00e-109	388.00
IUUC-Gma-042698	Glycine max	30.93	1.00e-32	133.00
IUUC-Ggo-045357	Gorilla gorilla	94.37	5.00e-169	586.00
IUUC-Hsa-046195	Homo sapiens	94.37	5.00e-169	586.00
IUUC-Hvu-047174	Hordeum vulgare	30.51	4.00e-35	141.00
IUUC-Itr-048487	Ictidomys tridecemlineatus	92.05	8.00e-162	562.00
IUUC-Lch-050569	Latimeria chalumnae	68.27	5.00e-117	413.00
IUUC-Lpe-050992	Leersia perrieri	35.15	3.00e-23	102.00
IUUC-Loc-052522	Lepisosteus oculatus	69.21	5.00e-117	413.00
IUUC-Lma-053254	Leptosphaeria maculans	39.24	1.00e-09	57.40
IUUC-Laf-053397	Loxodonta africana	95.39	4.00e-169	586.00
IUUC-Mcc-054681	Macaca mulatta	94.37	4.00e-169	587.00
IUUC-Meu-056723	Macropus eugenii	83.55	1.00e-150	525.00
IUUC-Mor-056961	Magnaporthe oryzae	37.27	4.00e-10	59.30
IUUC-Mpo-057359	Magnaporthe poae	25.84	2.00e-06	46.20
IUUC-Mtr-058063	Medicago truncatula	31.85	3.00e-34	138.00
IUUC-Mla-059004	Melampsora laricipopulina	30.03	1.00e-25	110.00
IUUC-Mvi-060460	Microbotryum violaceum	29.50	1.00e-24	106.00
IUUC-Mmr-060847	Microcebus murinus	96.69	1.00e-172	598.00
IUUC-Mdo-062480	Monodelphis domestica	84.54	2.00e-152	531.00
IUUC-Mmu-063809	Mus musculus	92.05	1.00e-163	568.00
IUUC-Mac-064870	Musa acuminata	31.27	6.00e-34	137.00
IUUC-Mpu-066322	Mustela putorius furo	97.04	6.00e-173	599.00
IUUC-Mlu-067556	Myotis lucifugus	93.42	5.00e-158	550.00
IUUC-Ncr-068898	Neurospora crassa	38.46	1.00e-07	51.20
IUUC-Nle-070049	Nomascus leucogenys	94.70	2.00e-169	587.00
IUUC-Opr-070972	Ochotona princeps	89.87	6.00e-158	549.00
IUUC-Ont-071682	Oreochromis niloticus	66.67	4.00e-116	410.00
IUUC-Oan-073296	Ornithorhynchus anatinus	98.31	2.00e-32	131.00
IUUC-Ocu-074218	Oryctolagus cuniculus	88.97	1.00e-131	462.00
IUUC-Oba-075284	Oryza barthii	31.62	4.00e-34	138.00
IUUC-Obr-076651	Oryza brachyantha	31.62	7.00e-37	147.00
IUUC-Ogl-077899	Oryza glaberrima	31.62	4.00e-34	138.00
IUUC-Ogu-078477	Oryza glumaepatula	31.96	3.00e-34	138.00
IUUC-Oin-080011	Oryza indica	31.62	4.00e-34	138.00
IUUC-Olo-080545	Oryza longistaminata	31.13	5.00e-27	115.00
IUUC-Ome-081543	Oryza meridionalis	31.62	4.00e-34	138.00
IUUC-Oni-082955	Oryza nivara	31.62	4.00e-34	138.00
IUUC-Opu-083565	Oryza punctata	31.62	3.00e-34	139.00
IUUC-Oru-084474	Oryza rufipogon	31.62	4.00e-34	138.00
IUUC-Osa-085913	Oryza sativa	31.62	4.00e-34	138.00
IUUC-Ola-086851	Oryzias latipes	66.89	4.00e-119	420.00
IUUC-Olu-087724	Ostreococcus lucimarinus	33.01	4.00e-12	65.10
IUUC-Oga-087970	Otolemur garnettii	95.38	5.00e-170	589.00
IUUC-Oar-089756	Ovis aries	96.37	2.00e-168	584.00
IUUC-Ptr-091485	Pan troglodytes	93.38	2.00e-165	574.00
IUUC-Pan-091832	Papio anubis	94.70	2.00e-169	587.00
IUUC-Pma-094551	Petromyzon marinus	63.52	3.00e-109	387.00
IUUC-Pno-094830	Phaeosphaeria nodorum	26.72	1.00e-08	53.90
IUUC-Ppa-095255	Physcomitrella patens	30.56	1.00e-31	130.00
IUUC-Pfo-096373	Poecilia formosa	65.03	4.00e-117	414.00
IUUC-Pab-098247	Pongo abelii	94.37	5.00e-169	586.00
IUUC-Pop-099186	Populus trichocarpa	30.93	5.00e-31	127.00
IUUC-Pca-100677	Procavia capensis	91.30	2.00e-138	484.00
IUUC-Ppe-101403	Prunus persica	30.14	1.00e-31	130.00
IUUC-Pva-103000	Pteropus vampyrus	96.03	4.00e-172	596.00
IUUC-Pgr-103663	Puccinia graminis	30.15	2.00e-29	123.00
IUUC-Ptt-103712	Puccinia triticina	40.00	5.00e-09	54.70
IUUC-Pte-104287	Pyrenophora teres	26.86	2.00e-16	80.10
IUUC-Pyt-104579	Pyrenophora triticirepentis	26.22	2.00e-13	69.70
IUUC-Rno-106069	Rattus norvegicus	92.38	3.00e-164	570.00
IUUC-Sha-106553	Sarcophilus harrisii	83.55	4.00e-151	526.00
IUUC-Smo-108874	Selaginella moellendorffii	32.24	6.00e-38	150.00
IUUC-Sit-110307	Setaria italica	31.62	1.00e-33	136.00
IUUC-Sly-111094	Solanum lycopersicum	32.08	6.00e-33	134.00
IUUC-Stu-112363	Solanum tuberosum	32.88	1.00e-32	133.00
IUUC-Sar-113480	Sorex araneus	94.70	3.00e-158	550.00
IUUC-Sbi-113939	Sorghum bicolor	31.62	3.00e-34	138.00
IUUC-Ssc-115644	Sus scrofa	97.68	9.00e-175	605.00
IUUC-Tru-118781	Takifugu rubripes	66.12	4.00e-121	427.00
IUUC-Tni-119672	Tetraodon nigroviridis	74.71	6.00e-35	138.00
IUUC-Tca-121795	Theobroma cacao	31.62	2.00e-35	142.00
IUUC-Tre-122037	Trichoderma reesei	36.36	2.00e-08	53.10
IUUC-Tvi-122524	Trichoderma virens	26.80	8.00e-17	81.30
IUUC-Tae-122828	Triticum aestivum	30.85	3.00e-35	142.00
IUUC-Tur-126387	Triticum urartu	30.74	2.00e-28	120.00
IUUC-Tme-127111	Tuber melanosporum	40.00	1.00e-09	57.40
IUUC-Ttr-128227	Tursiops truncatus	97.02	1.00e-172	598.00
IUUC-Vda-129924	Verticillium dahliae	27.27	5.00e-15	75.10
IUUC-Vpa-130802	Vicugna pacos	96.63	7.00e-45	173.00
IUUC-Vvi-131105	Vitis vinifera	32.30	7.00e-34	137.00
IUUC-Xtr-132830	Xenopus tropicalis	65.31	4.00e-122	431.00
IUUC-Xma-133618	Xiphophorus maculatus	65.79	8.00e-112	396.00
IUUC-Zma-135389	Zea mays	31.27	2.00e-33	135.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence