iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132506

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase; von Hippel-Lindau tumor suppressor

Genbank Nucleotide ID

AAMC01055384

Gene Name

vhl

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000001448.2	ENSXETT00000003053.2	ENSXETP00000003053.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	30.43	7.00e-06	47.00	IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	66.20	1.00e-53	206.00	IUUC-Hsa-046547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MPQDVSRPGS VPQLRSFNSR QPVQVVFCNR STRTVQPIWV NFQGDPQSYP TLPAGSGRRM 60
NTYLGHIWLF REAETDVGLM VNKKEVYVPN PNVNGQPALV NISLPVFSLK ERCLQVVRSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGTTGCCAT GGTGAGCGGT GGGGCCTAGT CCTACTGTAA AGCCCCGGGA TGCCGCAGGA 60
CGTTTCCCGT CCAGGTTCCG TTCCTCAACT CCGATCCTTT AACAGCCGCC AGCCGGTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005634--C:nucleus
GO:0030891--C:VCB complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0030218--P:erythrocyte differentiation
GO:0039022--P:pronephric duct development
GO:0016567--P:protein ubiquitination
GO:0045765--P:regulation of angiogenesis
GO:0043576--P:regulation of respiratory gaseous exchange
GO:0030947--P:regulation of vascular endothelial growth factor receptor signaling pathway

KEGG

xtr:549121

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	56.49	5.00e-43	167.00
IUUC-Apl-003580	Anas platyrhynchos	59.04	4.00e-23	98.60
IUUC-Aca-004492	Anolis carolinensis	62.99	3.00e-47	180.00
IUUC-Ang-009806	Aspergillus niger	47.06	1.40e+00	23.90
IUUC-Ame-011818	Astyanax mexicanus	52.60	1.00e-43	169.00
IUUC-Bta-013459	Bos taurus	64.00	4.00e-55	206.00
IUUC-Cel-018173	Caenorhabditis elegans	29.29	3.00e-06	44.30
IUUC-Cja-019826	Callithrix jacchus	61.35	2.00e-55	207.00
IUUC-Cfa-021280	Canis familiaris	62.67	2.00e-52	198.00
IUUC-Cpo-022544	Cavia porcellus	64.79	7.00e-53	199.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	38.24	9.00e-07	47.80
IUUC-Csa-023644	Chlorocebus sabaeus	62.34	1.00e-54	205.00
IUUC-Cho-024479	Choloepus hoffmanni	43.18	2.00e-24	103.00
IUUC-Cin-025505	Ciona intestinalis	25.00	3.00e-05	40.80
IUUC-Cme-027232	Cyanidioschyzon merolae	29.69	1.00e-02	33.50
IUUC-Dre-028350	Danio rerio	50.32	1.00e-30	125.00
IUUC-Dno-029207	Dasypus novemcinctus	63.54	2.00e-31	128.00
IUUC-Dor-030912	Dipodomys ordii	47.14	8.00e-31	126.00
IUUC-Dme-031988	Drosophila melanogaster	30.43	7.00e-07	46.60
IUUC-Eca-034007	Equus caballus	57.50	4.00e-10	55.50
IUUC-Fca-036350	Felis catus	62.50	8.00e-52	196.00
IUUC-Fal-037192	Ficedula albicollis	54.32	2.00e-44	171.00
IUUC-Gmo-038921	Gadus morhua	56.38	2.00e-45	174.00
IUUC-Gga-041016	Gallus gallus	59.57	2.00e-44	171.00
IUUC-Gac-042560	Gasterosteus aculeatus	47.37	3.00e-36	144.00
IUUC-Ggo-045419	Gorilla gorilla	66.20	2.00e-54	204.00
IUUC-Hsa-046547	Homo sapiens	66.20	2.00e-54	204.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	64.00	1.00e-54	204.00
IUUC-Lch-050463	Latimeria chalumnae	61.27	2.00e-49	188.00
IUUC-Loc-052053	Lepisosteus oculatus	53.21	4.00e-47	180.00
IUUC-Laf-053893	Loxodonta africana	63.33	7.00e-54	202.00
IUUC-Mcc-055347	Macaca mulatta	50.35	2.00e-34	138.00
IUUC-Mdo-062169	Monodelphis domestica	57.14	2.00e-30	123.00
IUUC-Mmu-064366	Mus musculus	65.22	4.00e-52	196.00
IUUC-Mpu-066593	Mustela putorius furo	63.33	5.00e-54	203.00
IUUC-Mlu-066926	Myotis lucifugus	63.46	3.00e-55	207.00
IUUC-Nle-069724	Nomascus leucogenys	62.75	1.00e-54	205.00
IUUC-Opr-070679	Ochotona princeps	64.34	4.00e-53	199.00
IUUC-Ont-071332	Oreochromis niloticus	52.20	6.00e-44	169.00
IUUC-Ola-086869	Oryzias latipes	53.95	7.00e-43	166.00
IUUC-Oga-089124	Otolemur garnettii	60.62	1.00e-51	196.00
IUUC-Oar-089799	Ovis aries	63.92	8.00e-33	130.00
IUUC-Ptr-091186	Pan troglodytes	67.05	1.00e-31	127.00
IUUC-Pan-092150	Papio anubis	61.69	7.00e-54	203.00
IUUC-Psi-094039	Pelodiscus sinensis	59.71	5.00e-44	169.00
IUUC-Pma-094129	Petromyzon marinus	42.42	1.00e-25	109.00
IUUC-Pfo-096892	Poecilia formosa	55.56	4.00e-41	160.00
IUUC-Pab-097822	Pongo abelii	62.75	1.00e-54	205.00
IUUC-Pca-101058	Procavia capensis	60.87	8.00e-54	202.00
IUUC-Pva-102932	Pteropus vampyrus	63.40	7.00e-55	206.00
IUUC-Rno-105050	Rattus norvegicus	62.18	7.00e-55	206.00
IUUC-Sha-106738	Sarcophilus harrisii	64.00	4.00e-35	139.00
IUUC-Ssc-115973	Sus scrofa	61.69	2.00e-54	204.00
IUUC-Tgu-116663	Taeniopygia guttata	63.33	3.00e-29	119.00
IUUC-Tru-118654	Takifugu rubripes	53.29	3.00e-44	170.00
IUUC-Ttr-128418	Tursiops truncatus	62.75	3.00e-55	207.00
IUUC-Vpa-130268	Vicugna pacos	59.57	8.00e-30	122.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence