iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xtr-132158

Ensembl Protein ID

ENSXETP00000038456.4

UniProt Accession

F6XXD7; F6XXD7_XENTR

Genbank Protein ID

ENSXETP00000038456

Protein Name

OTU deubiquitinase 7A

Genbank Nucleotide ID

AAMC01074463

Gene Name

otud7a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000017722.4	ENSXETT00000038456.4	ENSXETP00000038456.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.90e-40	138.0	196	377

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al++++r+ +++++ k+++++++++++k           e+e++++ kl+++e    
   Q: 196  LPLATTGDGNCLLHAASLGMWGFHDRDLvLRKALYTMMRSGAEREALKRRWRWQQTQQNKesglvytedewEREWNELLKLASSEprth 284
           6899*********************************************************************************8877 PP
   S: 75   .ak.g.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYda 134
            +k g                 ee+h+f+La+iL+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++a
   Q: 285  fSKnGgsgggvdnaedpvyeslEEFHVFVLAHILRRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPPNRcHCSPLVLAYDQAHFSA 373
           7444478899******************************************************************************* PP
   S: 135  Lval 138
           Lv++
   Q: 374  LVSM 377
           *986 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

FIPSAPAACK AAPLHDHMTL DMDSVLSDFV RSTGAEPGLA RDLLEGKNWD LTAALSDYEQ 60
LRQVHTANLP QVFNEGKYYK QQEKEITQHV NKIEKPNLQR QDDIAQEKRL SRGISHASSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCATCTGAT GCTGCTGGTG CTGCTGATAG AGCCTGAGAT TGGAGCTGGG TGACCTGAAG 60
CCGTTATCGT GGCCCCAGCG GCTGGATGCA GAAGGGCGCA CGGATTAGAT GGGGCACACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006955--P:immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001551	Ailuropoda melanoleuca	83.62	0.00e+00	937.00
IUUC-Apl-003825	Anas platyrhynchos	80.90	0.00e+00	1357.00
IUUC-Aca-004392	Anolis carolinensis	85.46	0.00e+00	1435.00
IUUC-Ame-011052	Astyanax mexicanus	74.68	0.00e+00	1247.00
IUUC-Bta-013296	Bos taurus	70.93	0.00e+00	1071.00
IUUC-Cel-018468	Caenorhabditis elegans	44.41	3.00e-85	309.00
IUUC-Cja-019141	Callithrix jacchus	80.74	0.00e+00	959.00
IUUC-Cfa-020447	Canis familiaris	83.41	0.00e+00	995.00
IUUC-Cpo-022059	Cavia porcellus	85.38	0.00e+00	880.00
IUUC-Csa-023263	Chlorocebus sabaeus	83.98	0.00e+00	999.00
IUUC-Cho-024611	Choloepus hoffmanni	83.24	5.00e-160	558.00
IUUC-Csv-026177	Ciona savignyi	29.76	7.00e-03	33.50
IUUC-Dre-028617	Danio rerio	72.93	0.00e+00	1254.00
IUUC-Dno-029121	Dasypus novemcinctus	80.73	0.00e+00	975.00
IUUC-Dor-031121	Dipodomys ordii	68.91	2.00e-169	588.00
IUUC-Ete-033068	Echinops telfairi	64.05	0.00e+00	943.00
IUUC-Eca-034413	Equus caballus	83.38	0.00e+00	954.00
IUUC-Fca-036487	Felis catus	78.96	0.00e+00	904.00
IUUC-Fal-037145	Ficedula albicollis	84.90	0.00e+00	1427.00
IUUC-Gmo-038786	Gadus morhua	63.86	0.00e+00	1075.00
IUUC-Gga-040512	Gallus gallus	82.88	0.00e+00	1400.00
IUUC-Gac-041599	Gasterosteus aculeatus	69.03	0.00e+00	1175.00
IUUC-Ggo-044819	Gorilla gorilla	70.61	0.00e+00	1068.00
IUUC-Hsa-046781	Homo sapiens	70.57	0.00e+00	1115.00
IUUC-Lch-050666	Latimeria chalumnae	83.75	0.00e+00	1400.00
IUUC-Loc-052841	Lepisosteus oculatus	87.70	0.00e+00	920.00
IUUC-Laf-053437	Loxodonta africana	83.48	0.00e+00	988.00
IUUC-Mcc-055353	Macaca mulatta	70.12	0.00e+00	1105.00
IUUC-Mga-059741	Meleagris gallopavo	77.89	0.00e+00	1345.00
IUUC-Mmr-061437	Microcebus murinus	81.83	0.00e+00	1041.00
IUUC-Mdo-061907	Monodelphis domestica	87.12	0.00e+00	1486.00
IUUC-Mmu-064074	Mus musculus	70.28	0.00e+00	1116.00
IUUC-Mpu-066004	Mustela putorius furo	81.83	0.00e+00	936.00
IUUC-Nle-069182	Nomascus leucogenys	79.34	0.00e+00	1000.00
IUUC-Opr-070701	Ochotona princeps	72.16	0.00e+00	804.00
IUUC-Ont-072431	Oreochromis niloticus	71.47	0.00e+00	1214.00
IUUC-Oan-073235	Ornithorhynchus anatinus	75.06	0.00e+00	1141.00
IUUC-Ocu-073935	Oryctolagus cuniculus	82.57	0.00e+00	932.00
IUUC-Ola-087026	Oryzias latipes	72.99	0.00e+00	1277.00
IUUC-Oga-088249	Otolemur garnettii	84.19	0.00e+00	1031.00
IUUC-Oar-089476	Ovis aries	71.51	0.00e+00	1141.00
IUUC-Ptr-090548	Pan troglodytes	82.91	0.00e+00	907.00
IUUC-Pan-092616	Papio anubis	71.10	0.00e+00	1093.00
IUUC-Psi-093126	Pelodiscus sinensis	87.15	0.00e+00	1460.00
IUUC-Pfo-096785	Poecilia formosa	85.24	0.00e+00	881.00
IUUC-Pab-098336	Pongo abelii	74.00	0.00e+00	1033.00
IUUC-Pca-100206	Procavia capensis	64.19	0.00e+00	941.00
IUUC-Rno-105483	Rattus norvegicus	65.96	0.00e+00	823.00
IUUC-Sha-106617	Sarcophilus harrisii	82.12	0.00e+00	926.00
IUUC-Ssc-115415	Sus scrofa	79.13	0.00e+00	927.00
IUUC-Tgu-117218	Taeniopygia guttata	84.46	0.00e+00	1073.00
IUUC-Tru-118720	Takifugu rubripes	81.05	0.00e+00	830.00
IUUC-Tni-120795	Tetraodon nigroviridis	83.14	0.00e+00	846.00
IUUC-Vpa-130450	Vicugna pacos	40.81	3.00e-51	196.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence