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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105650
Ensembl Protein ID ENSRNOP00000001979.4
UniProt Accession P49791; NU153_RAT
Protein Name Nuclear pore complex protein Nup153; 153 kDa nucleoporin; Nucleoporin Nup153
Genbank Nucleotide ID L06821
Gene Name Nup153
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000001456.5 ENSRNOT00000001979.5 ENSRNOP00000001979.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
miRNAMapRAID2
Protein-protein Interaction
IIDiRefIndex
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/ZnF/NZF 1.20e-20 73.1 724 749
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/NZF
   S: 4    qWaCsaCTflNePeavkCemCsrpRg 29
            W+C++C  +N+PeavkC++C++p++
   Q: 724  TWDCDTCLVQNKPEAVKCVACETPKP 749
           5************************8 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC (By similarity). The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC) (By similarity).
 Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC (By similarity). The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC) (By similarity).
Protein Sequence
(Fasta)
MASGAGGIGG GGGGGKIRTR RCHQGPVKPY QQGRPQHQGI LSRVTESVKN IVPGWLQRYF 60
NKSENACSCS VNADEVPRWP ENREDEREIY VDENTNTDDG RTTPEPTGSN TEEPSTTSTA 120
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Protein Fasta Sequence


>IUUC-Rno-105650|UBD,NZF|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
TCGCTGAGGA GTGACGGTGT TCTGGCTCGC GACCGCGGCG GCCGCCTCAA CAGCGGTAAT 60
AGGCGCAAGA GCGGCGGCGA CGACGACTGC AGGGACGACG ACGGCGGCGG CGGCGGCGGC 120
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Nucleotide Fasta Sequence


>IUUC-Rno-105650|UBD,NZF|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0238--DNA-binding
KW-0325--Glycoprotein
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0479--Metal-binding
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR026054--Nucleoporin
IPR013913--Nup153_N
IPR018892--Retro-transposon_transp_CS
IPR001876--Znf_RanBP2
PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
Pfam

PF08604--Nup153
PF10599--Nup_retrotrp_bd
PF00641--zf-RanBP
SMART

SM00547--ZnF_RBZ
Gene Ontology

GO:0005642--C:annulate lamellae
GO:0042405--C:nuclear inclusion body
GO:0031965--C:nuclear membrane
GO:0034399--C:nuclear periphery
GO:0005643--C:nuclear pore
GO:0044615--C:nuclear pore nuclear basket
GO:1990875--C:nucleoplasmic side of nuclear pore
GO:0043234--C:protein complex
GO:0003682--F:chromatin binding
GO:0003690--F:double-stranded DNA binding
GO:0008139--F:nuclear localization sequence binding
GO:0005487--F:nucleocytoplasmic transporter activity
GO:0043495--F:protein anchor
GO:0008536--F:Ran GTPase binding
GO:0017056--F:structural constituent of nuclear pore
GO:0008270--F:zinc ion binding
GO:0007067--P:mitotic nuclear division
GO:0051028--P:mRNA transport
GO:0046832--P:negative regulation of RNA export from nucleus
GO:0051292--P:nuclear pore complex assembly
GO:0006606--P:protein import into nucleus
GO:0006405--P:RNA export from nucleus
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002264 Ailuropoda melanoleuca 75.36 0.00e+00 1612.00
IUUC-Aca-005186 Anolis carolinensis 50.00 0.00e+00 919.00
IUUC-Acl-008308 Aspergillus clavatus 44.44 2.70e-02 33.10
IUUC-Ate-010393 Aspergillus terreus 28.57 1.00e-03 37.40
IUUC-Ame-011895 Astyanax mexicanus 53.20 2.00e-90 328.00
IUUC-Bta-013564 Bos taurus 78.26 0.00e+00 1656.00
IUUC-Cja-020012 Callithrix jacchus 80.23 0.00e+00 1839.00
IUUC-Cfa-020210 Canis familiaris 79.06 0.00e+00 1641.00
IUUC-Cpo-022504 Cavia porcellus 74.88 0.00e+00 1619.00
IUUC-Csa-023330 Chlorocebus sabaeus 81.35 0.00e+00 1919.00
IUUC-Cho-024626 Choloepus hoffmanni 55.12 0.00e+00 969.00
IUUC-Cin-025240 Ciona intestinalis 31.05 3.00e-30 127.00
IUUC-Dre-027637 Danio rerio 51.76 3.00e-90 327.00
IUUC-Dno-028993 Dasypus novemcinctus 78.99 0.00e+00 1818.00
IUUC-Dor-030413 Dipodomys ordii 76.10 0.00e+00 898.00
IUUC-Dme-032206 Drosophila melanogaster 38.12 3.00e-39 158.00
IUUC-Ete-032242 Echinops telfairi 58.63 1.00e-145 511.00
IUUC-Eca-033932 Equus caballus 78.05 0.00e+00 1697.00
IUUC-Eeu-034837 Erinaceus europaeus 71.77 3.00e-168 586.00
IUUC-Fca-036100 Felis catus 75.90 0.00e+00 1686.00
IUUC-Fal-037573 Ficedula albicollis 55.32 0.00e+00 948.00
IUUC-Gmo-038683 Gadus morhua 49.89 8.00e-85 309.00
IUUC-Gga-040987 Gallus gallus 59.76 0.00e+00 1019.00
IUUC-Gac-041456 Gasterosteus aculeatus 49.68 5.00e-82 300.00
IUUC-Ggo-045401 Gorilla gorilla 78.96 0.00e+00 1794.00
IUUC-Hsa-046689 Homo sapiens 78.94 0.00e+00 1834.00
IUUC-Itr-048828 Ictidomys tridecemlineatus 76.73 0.00e+00 1724.00
IUUC-Lch-049785 Latimeria chalumnae 44.20 0.00e+00 654.00
IUUC-Loc-052225 Lepisosteus oculatus 50.84 0.00e+00 707.00
IUUC-Laf-053853 Loxodonta africana 78.03 0.00e+00 1664.00
IUUC-Mcc-054790 Macaca mulatta 80.34 0.00e+00 1912.00
IUUC-Meu-056865 Macropus eugenii 75.00 3.00e-145 510.00
IUUC-Mga-059887 Meleagris gallopavo 59.27 0.00e+00 996.00
IUUC-Mmr-061334 Microcebus murinus 79.96 0.00e+00 1852.00
IUUC-Mdo-062359 Monodelphis domestica 66.12 0.00e+00 1447.00
IUUC-Mmu-064267 Mus musculus 92.98 0.00e+00 2258.00
IUUC-Mpu-066696 Mustela putorius furo 76.79 0.00e+00 1522.00
IUUC-Mlu-067812 Myotis lucifugus 74.61 0.00e+00 977.00
IUUC-Nle-069960 Nomascus leucogenys 81.25 0.00e+00 1858.00
IUUC-Opr-070987 Ochotona princeps 73.82 0.00e+00 1219.00
IUUC-Ont-072146 Oreochromis niloticus 49.24 8.00e-83 302.00
IUUC-Oan-072713 Ornithorhynchus anatinus 61.41 0.00e+00 1150.00
IUUC-Ocu-074420 Oryctolagus cuniculus 75.02 0.00e+00 1629.00
IUUC-Ola-086355 Oryzias latipes 43.81 3.00e-144 506.00
IUUC-Oga-089122 Otolemur garnettii 77.37 0.00e+00 1140.00
IUUC-Oar-089695 Ovis aries 78.06 0.00e+00 1655.00
IUUC-Ptr-091104 Pan troglodytes 78.82 0.00e+00 1810.00
IUUC-Pan-092205 Papio anubis 82.30 0.00e+00 1162.00
IUUC-Psi-093592 Pelodiscus sinensis 60.77 0.00e+00 1260.00
IUUC-Pma-094617 Petromyzon marinus 40.16 4.00e-51 196.00
IUUC-Pfo-097481 Poecilia formosa 49.89 8.00e-98 352.00
IUUC-Pab-098350 Pongo abelii 77.08 0.00e+00 1730.00
IUUC-Pca-100728 Procavia capensis 65.87 0.00e+00 663.00
IUUC-Pva-102856 Pteropus vampyrus 76.81 0.00e+00 1590.00
IUUC-Sha-107464 Sarcophilus harrisii 64.87 0.00e+00 944.00
IUUC-Sar-113578 Sorex araneus 71.61 0.00e+00 1491.00
IUUC-Ssc-115536 Sus scrofa 78.62 0.00e+00 1762.00
IUUC-Tgu-116947 Taeniopygia guttata 56.15 0.00e+00 1022.00
IUUC-Tru-117704 Takifugu rubripes 47.74 6.00e-93 336.00
IUUC-Tsy-119514 Tarsius syrichta 77.36 0.00e+00 1492.00
IUUC-Tni-120354 Tetraodon nigroviridis 48.09 3.00e-100 360.00
IUUC-Tbe-128064 Tupaia belangeri 67.87 5.00e-166 579.00
IUUC-Vpa-130533 Vicugna pacos 80.63 0.00e+00 1804.00
IUUC-Xtr-132016 Xenopus tropicalis 45.61 0.00e+00 854.00
Created Date 25-Jun-2017

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