iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Psi-093252

Ensembl Protein ID

ENSPSIP00000015268.1

UniProt Accession

K7G4Q7; K7G4Q7_PELSI

Genbank Protein ID

ENSPSIP00000015268

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AGCU01049053

Gene Name

LCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000013438.1	ENSPSIT00000015339.1	ENSPSIP00000015268.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.00e-18	65.6	79	137

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++v +lydye+++d++L l+kG++++++   e++++W+++++ ++g++G +P nFv++++
   Q: 79   QDKLVVALYDYEPTHDGDLGLQKGETLRLL---EESGEWWRAQSLTTGQEGYIPYNFVARVN 137
           6899**************************...99*************************97 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

GHDAPDVPFS QPLAPAGTMG CCCSSDYDDD WIENIDICEH CNYPIDPATK AQTLLRNGSE 60
VRDPLVSYES PTPPCSPMQD KLVVALYDYE PTHDGDLGLQ KGETLRLLEE SGEWWRAQSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCACGACG CGCCGGACGT GCCCTTTTCA CAGCCTCTCG CCCCCGCAGG GACCATGGGC 60
TGCTGCTGCA GTTCTGACTA CGACGACGAC TGGATCGAGA ACATCGACAT CTGCGAGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0045121--C:membrane raft
GO:0000242--C:pericentriolar material
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004722--F:protein serine/threonine phosphatase activity
GO:0006919--P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006882--P:cellular zinc ion homeostasis
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0050870--P:positive regulation of T cell activation
GO:0042493--P:response to drug
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001315	Ailuropoda melanoleuca	70.96	0.00e+00	784.00
IUUC-Apl-004134	Anas platyrhynchos	76.07	0.00e+00	655.00
IUUC-Bta-013264	Bos taurus	74.90	0.00e+00	803.00
IUUC-Cfa-021161	Canis familiaris	70.59	0.00e+00	781.00
IUUC-Cpo-022492	Cavia porcellus	74.90	0.00e+00	798.00
IUUC-Csa-023270	Chlorocebus sabaeus	60.42	9.00e-175	606.00
IUUC-Dno-029365	Dasypus novemcinctus	76.67	0.00e+00	815.00
IUUC-Dor-030892	Dipodomys ordii	71.68	0.00e+00	740.00
IUUC-Eca-033325	Equus caballus	75.24	0.00e+00	796.00
IUUC-Eeu-035004	Erinaceus europaeus	69.06	0.00e+00	630.00
IUUC-Fca-035908	Felis catus	75.10	0.00e+00	802.00
IUUC-Fal-036804	Ficedula albicollis	73.06	0.00e+00	734.00
IUUC-Gga-040997	Gallus gallus	81.71	0.00e+00	859.00
IUUC-Gac-041854	Gasterosteus aculeatus	63.88	0.00e+00	648.00
IUUC-Ggo-045238	Gorilla gorilla	70.96	0.00e+00	783.00
IUUC-Hsa-047039	Homo sapiens	75.10	0.00e+00	798.00
IUUC-Itr-048479	Ictidomys tridecemlineatus	75.29	0.00e+00	805.00
IUUC-Lch-049568	Latimeria chalumnae	73.69	0.00e+00	779.00
IUUC-Loc-052222	Lepisosteus oculatus	60.89	2.00e-169	588.00
IUUC-Laf-054499	Loxodonta africana	70.77	0.00e+00	782.00
IUUC-Mcc-054872	Macaca mulatta	59.79	0.00e+00	646.00
IUUC-Meu-056879	Macropus eugenii	72.78	0.00e+00	775.00
IUUC-Mga-059971	Meleagris gallopavo	79.96	0.00e+00	836.00
IUUC-Mmr-060740	Microcebus murinus	75.68	0.00e+00	805.00
IUUC-Mdo-062192	Monodelphis domestica	74.51	0.00e+00	796.00
IUUC-Mmu-064241	Mus musculus	73.46	0.00e+00	797.00
IUUC-Mpu-066595	Mustela putorius furo	74.71	0.00e+00	796.00
IUUC-Mlu-067069	Myotis lucifugus	73.59	0.00e+00	785.00
IUUC-Opr-070472	Ochotona princeps	71.43	0.00e+00	785.00
IUUC-Ont-071711	Oreochromis niloticus	63.69	0.00e+00	628.00
IUUC-Ocu-074221	Oryctolagus cuniculus	74.90	0.00e+00	796.00
IUUC-Oga-088225	Otolemur garnettii	74.12	0.00e+00	791.00
IUUC-Oar-090244	Ovis aries	68.63	0.00e+00	778.00
IUUC-Ptr-090751	Pan troglodytes	82.91	2.00e-174	604.00
IUUC-Pan-091804	Papio anubis	75.29	0.00e+00	802.00
IUUC-Pab-098168	Pongo abelii	75.61	0.00e+00	761.00
IUUC-Rno-105542	Rattus norvegicus	73.27	0.00e+00	796.00
IUUC-Sha-107524	Sarcophilus harrisii	73.15	0.00e+00	783.00
IUUC-Sar-113235	Sorex araneus	69.05	0.00e+00	659.00
IUUC-Ssc-115624	Sus scrofa	74.90	0.00e+00	799.00
IUUC-Tru-118559	Takifugu rubripes	59.88	3.00e-180	624.00
IUUC-Ttr-129002	Tursiops truncatus	68.57	0.00e+00	742.00
IUUC-Xtr-132224	Xenopus tropicalis	68.68	0.00e+00	723.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence