• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Tag Content
iUUCD ID IUUC-Dre-027926
Ensembl Protein ID ENSDARP00000056247.4
UniProt Accession Q6PFM9; B0S5N8; WDR48_DANRE
Genbank Protein ID CAQ15013.1; AAH57489.1
Protein Name WD repeat-containing protein 48; USP1-associated factor 1
Genbank Nucleotide ID BX284666; BC057489
Gene Name wdr48b; wdr48; uaf1; ch211-190k17.1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000038543.4 ENSDART00000056248.4 ENSDARP00000056247.4
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.90e-34 116.5 208 245
UBD/Beta-Prp 1.60e-48 166.4 30 317
ULD/UDP/UFD/RAWUL 9.60e-22 78.2 568 673
ULD/UBL/SUMO 3.10e-54 182.6 559 666
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
    gHtd v +l + d t +sGs Dgti++W+l +++++
   Q: 208 GHTDNVKSLLLnRDgTQCLSGSSDGTIRLWSLGQQRCI 245
    8********88*888*****************999997 PP
   


   UBD/Beta-Prp

   S: 10   ksvitcvkfspdksllatgsrdgtikvwdvttgkl...lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
    + +++++ p + l+t++rd+ i++w+v + k ++s++ h++ v+++ + +gk+l+++s+D t+kvw+ +g c++tl+ h+d
   Q: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQdpyIASMEHHTDWVNDIILCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKD 118
    556677888899999*****************999999*************************************************** PP
   S: 96 svlslsfspsgdklvsGshdrtirvwdletgqclee........tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtlt 176
    +v +l++ ++++ ++s++ dr i +wd++t + l + lsg+++++ +++++++g +++sGs+ +++r+Wd +t l +l+
   Q: 119 YVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTAsnntvttsSLSGNKDSIYSLAMNQTGTVIISGSTEKVLRVWDPRTCAKLMKLK 207
    **********************************99**********************************************99****9 PP
   S: 177 gghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn. 264
    g htd v+sl ++++g++++sgs dgt++lw+l +++c+ t++ h++ v+ +++ + ++++sg+ D+ i++ dlr+ d+ + ++
   Q: 208 G-HTDNVKSLLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEAFTHIYSGGRDRKIYCTDLRNPDMRVLICEEKa 295
    9.**************************************************************************9998888877776 PP
   S: 265 ..............ssvisvav 272
    +s++ +++
   Q: 296 pvlrmeldrsadppQSIWVSTT 317
    7777777777777766666666 PP
   


   ULD/UDP/UFD/RAWUL

   S: 4    sLeplesnkakddsklkkkylrcsarltVkhlkkflaeklkl........sssy.....................evdllcedevLedn 63
    L+p++s++ak+ lkk++l++s++l+V++++++++ek+++ s +++l+c d+vL++n
   Q: 568 YLQPHSSSGAKT---LKKDRLSASDMLQVRKVMEHVYEKIINldtesqatS--SsandkpgeqekeedvsvmaeeKIELMCLDQVLDPN 651
    69**********...*************************99988655541..0567999999999999999999************** PP
   S: 64 etLeeikyifiwkkegpLvLqYr 86
    ++L+++ ++fiwk++g+L+++Yr
   Q: 652 MDLRTV-KHFIWKSGGDLTIHYR 673
    ******.***************9 PP
   


   ULD/UBL/SUMO

   S: 1    eskffkapvslkvagqdGsevlfklklsa....qlkklmeavYvkrinldensvrfv.fngqkireqetpeelevededkiellcq... 81
    ++kf+k+p++l++++++G+++l+k++lsa q++k+me+vY+k+inld +s++++ + + k++eqe++e++ v +e+kiel+c
   Q: 559 MPKFNKIPFYLQPHSSSGAKTLKKDRLSAsdmlQVRKVMEHVYEKIINLDTESQATSsSANDKPGEQEKEEDVSVMAEEKIELMCLdqv 647
    8********************************************************99**************************7556 PP
   S: 82 ...............ksGG 85
    ksGG
   Q: 648 ldpnmdlrtvkhfiwKSGG 666
    6666666666666666665 PP
   

Organism Danio rerio
Functional Description
(View)

Functional Description



     Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes.
Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes.
Protein Sequence
(Fasta)
MATLHRQNAA GRRKVQVSYV IRDEVEKYNR NGVNALQLDP ALNRLFTAGR DSIIRIWSVN 60
QHKQDPYIAS MEHHTDWVND IILCCNGKTL ISASSDTTVK VWNAHKGFCM STLRTHKDYV 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Dre-027926|E3,WD_repeat;UBD,Beta-Prp;ULD,RAWUL;ULD,SUMO|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATTGTCAACA TGCAAGATGG CGACGCTTCA CAGACAGAAC GCCGCTGGAC GGAGAAAGGT 60
CCAGGTGATA ATTTACAGAT AATATTTGTG AAACTTTAAA GCTTATGGCA GTGCATCTAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Dre-027926|E3,WD_repeat;UBD,Beta-Prp;ULD,RAWUL;ULD,SUMO|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0458--Lysosome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR021772--DUF3337
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF11816--DUF3337
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005634--C:nucleus
GO:0016579--P:protein deubiquitination

KEGG dre:334682
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001160 Aegilops tauschii 39.61 6.00e-98 352.00
IUUC-Aml-001533 Ailuropoda melanoleuca 92.47 0.00e+00 1216.00
IUUC-Aca-004875 Anolis carolinensis 93.06 0.00e+00 1254.00
IUUC-Ame-010875 Astyanax mexicanus 94.73 0.00e+00 1098.00
IUUC-Bgr-012288 Blumeria graminis 33.62 2.00e-41 164.00
IUUC-Bta-013379 Bos taurus 92.47 0.00e+00 1217.00
IUUC-Bol-016450 Brassica oleracea 34.03 1.00e-97 351.00
IUUC-Cja-018804 Callithrix jacchus 92.47 0.00e+00 1215.00
IUUC-Cfa-020076 Canis familiaris 92.61 0.00e+00 1219.00
IUUC-Cpo-021721 Cavia porcellus 92.15 0.00e+00 1181.00
IUUC-Csa-023188 Chlorocebus sabaeus 92.61 0.00e+00 1219.00
IUUC-Cho-024932 Choloepus hoffmanni 91.73 0.00e+00 1219.00
IUUC-Cin-025591 Ciona intestinalis 56.28 0.00e+00 721.00
IUUC-Cne-026819 Cryptococcus neoformans 36.40 2.00e-35 145.00
IUUC-Cme-027188 Cyanidioschyzon merolae 31.56 5.00e-71 262.00
IUUC-Dno-029960 Dasypus novemcinctus 92.17 0.00e+00 1211.00
IUUC-Dor-030933 Dipodomys ordii 88.53 0.00e+00 677.00
IUUC-Dse-031532 Dothistroma septosporum 34.49 3.00e-45 177.00
IUUC-Dme-032168 Drosophila melanogaster 55.81 0.00e+00 682.00
IUUC-Ete-033107 Echinops telfairi 91.07 0.00e+00 1157.00
IUUC-Eca-034028 Equus caballus 92.76 0.00e+00 1221.00
IUUC-Fca-035619 Felis catus 92.46 0.00e+00 902.00
IUUC-Fal-036869 Ficedula albicollis 93.05 0.00e+00 1226.00
IUUC-Gmo-038627 Gadus morhua 94.09 0.00e+00 1281.00
IUUC-Gga-040555 Gallus gallus 92.92 0.00e+00 1250.00
IUUC-Gac-042497 Gasterosteus aculeatus 93.94 0.00e+00 1254.00
IUUC-Ggo-045561 Gorilla gorilla 92.61 0.00e+00 1219.00
IUUC-Hsa-045710 Homo sapiens 92.61 0.00e+00 1219.00
IUUC-Itr-049030 Ictidomys tridecemlineatus 90.93 0.00e+00 855.00
IUUC-Kpa-049237 Komagataella pastoris 30.77 1.00e-29 125.00
IUUC-Lch-049507 Latimeria chalumnae 93.35 0.00e+00 1235.00
IUUC-Loc-052373 Lepisosteus oculatus 91.02 0.00e+00 1226.00
IUUC-Laf-053706 Loxodonta africana 92.90 0.00e+00 1194.00
IUUC-Mcc-055046 Macaca mulatta 92.61 0.00e+00 1219.00
IUUC-Meu-056840 Macropus eugenii 75.00 3.00e-142 499.00
IUUC-Mtr-058571 Medicago truncatula 34.43 6.00e-108 385.00
IUUC-Mga-059297 Meleagris gallopavo 92.92 0.00e+00 1250.00
IUUC-Mvi-060419 Microbotryum violaceum 40.64 4.00e-38 154.00
IUUC-Mmr-061196 Microcebus murinus 86.64 0.00e+00 1103.00
IUUC-Mdo-062762 Monodelphis domestica 89.06 0.00e+00 1236.00
IUUC-Mmu-063915 Mus musculus 91.73 0.00e+00 1237.00
IUUC-Mpu-065999 Mustela putorius furo 92.29 0.00e+00 801.00
IUUC-Mlu-068226 Myotis lucifugus 92.16 0.00e+00 1212.00
IUUC-Nle-069416 Nomascus leucogenys 92.61 0.00e+00 1219.00
IUUC-Opr-070515 Ochotona princeps 88.48 0.00e+00 1147.00
IUUC-Ont-072052 Oreochromis niloticus 91.78 0.00e+00 1194.00
IUUC-Oan-073636 Ornithorhynchus anatinus 90.94 0.00e+00 1216.00
IUUC-Ocu-074799 Oryctolagus cuniculus 92.47 0.00e+00 1217.00
IUUC-Oba-075146 Oryza barthii 34.56 9.00e-110 391.00
IUUC-Olo-080531 Oryza longistaminata 31.79 9.00e-99 354.00
IUUC-Ome-081368 Oryza meridionalis 39.53 4.00e-98 352.00
IUUC-Oni-082457 Oryza nivara 34.52 8.00e-110 391.00
IUUC-Opu-084050 Oryza punctata 34.26 9.00e-109 388.00
IUUC-Ola-087546 Oryzias latipes 93.13 0.00e+00 1252.00
IUUC-Oga-087998 Otolemur garnettii 91.68 0.00e+00 1199.00
IUUC-Oar-090303 Ovis aries 92.47 0.00e+00 1217.00
IUUC-Ptr-090588 Pan troglodytes 92.61 0.00e+00 1219.00
IUUC-Pan-092722 Papio anubis 92.61 0.00e+00 1219.00
IUUC-Psi-093911 Pelodiscus sinensis 92.38 0.00e+00 1249.00
IUUC-Pma-094580 Petromyzon marinus 84.79 0.00e+00 1154.00
IUUC-Pfo-096994 Poecilia formosa 93.26 0.00e+00 1248.00
IUUC-Pab-097586 Pongo abelii 92.61 0.00e+00 1219.00
IUUC-Pop-099740 Populus trichocarpa 34.29 2.00e-102 367.00
IUUC-Pca-100458 Procavia capensis 96.15 2.00e-105 376.00
IUUC-Pva-102698 Pteropus vampyrus 88.33 0.00e+00 1202.00
IUUC-Pgr-103649 Puccinia graminis 40.23 4.00e-49 190.00
IUUC-Ptt-103910 Puccinia triticina 43.90 4.00e-53 204.00
IUUC-Rno-104978 Rattus norvegicus 92.13 0.00e+00 1214.00
IUUC-Sha-107079 Sarcophilus harrisii 91.73 0.00e+00 1169.00
IUUC-Sly-111099 Solanum lycopersicum 34.25 8.00e-97 348.00
IUUC-Sar-113408 Sorex araneus 93.35 0.00e+00 734.00
IUUC-Sre-114998 Sporisorium reilianum 39.93 3.00e-51 197.00
IUUC-Ssc-115434 Sus scrofa 92.61 0.00e+00 1219.00
IUUC-Tgu-116517 Taeniopygia guttata 92.91 0.00e+00 1253.00
IUUC-Tru-118174 Takifugu rubripes 93.97 0.00e+00 1259.00
IUUC-Tsy-118935 Tarsius syrichta 92.32 0.00e+00 1243.00
IUUC-Tni-119744 Tetraodon nigroviridis 94.39 0.00e+00 1228.00
IUUC-Tca-121360 Theobroma cacao 34.19 5.00e-112 399.00
IUUC-Tae-125576 Triticum aestivum 34.75 8.00e-112 398.00
IUUC-Tur-126699 Triticum urartu 35.09 6.00e-110 392.00
IUUC-Ttr-129153 Tursiops truncatus 92.02 0.00e+00 1246.00
IUUC-Uma-129604 Ustilago maydis 40.89 2.00e-50 194.00
IUUC-Vpa-130553 Vicugna pacos 91.83 0.00e+00 930.00
IUUC-Xtr-132346 Xenopus tropicalis 91.00 0.00e+00 1206.00
IUUC-Xma-134266 Xiphophorus maculatus 91.58 0.00e+00 664.00
IUUC-Yli-134451 Yarrowia lipolytica 26.96 7.00e-40 159.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved