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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064041
UUCD1 version UUC-MuM-01044
Ensembl Protein ID ENSMUSP00000121125.1
UniProt Accession Q9WVB2; TLE2_MOUSE
Genbank Protein ID AAD37694.1
Protein Name Transducin-like enhancer protein 2
Genbank Nucleotide ID AF145958
Gene Name Tle2; Grg2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000034771.15 ENSMUST00000135211.7 ENSMUSP00000117453.1
ENSMUSG00000034771.15 ENSMUST00000146916.7 ENSMUSP00000121173.1
ENSMUSG00000034771.15 ENSMUST00000143285.7 ENSMUSP00000122074.1
ENSMUSG00000034771.15 ENSMUST00000146358.7 ENSMUSP00000121125.1
ENSMUSG00000034771.15 ENSMUST00000124854.7 ENSMUSP00000118334.1
ENSMUSG00000034771.15 ENSMUST00000131411.1 ENSMUSP00000114400.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.30e-23 80.6 611 649
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsd..tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++ sd  t+l++G+ D+t+++WDlr+g++l+
   Q: 611  GHTDGASCIDISDygTRLWTGGLDNTVRCWDLREGRQLQ 649
           8**********6668*********************998 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
 Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Protein Sequence
(Fasta)
MYPQGRHPTP LQSGQPFKFS VLEICDRIKE EFQFLQAQYH SLKLECEKLA SEKTEMQRHY 60
VMAAPHQCPQ GGTSYPHWPR LSPLQYYEMS YGLNIEMHKQ AEIVKRLSAI CAQMVPFLTQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064041|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTGAGGGGCT GGGGGCGTGG TCATGGGTGA CTTCTGCCTA GAATCCCTCG GTGAAGGGCT 60
GGGGGTGTGG TCAGAGGTAG AGCTGCTGCC TAGAATCTCC CAGTGAAGGT CTGGGGGCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064041|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway
Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF03920--TLE_N
PF00400--WD40
PRINTS

PR01850--GROUCHOFAMLY
SMART

SM00320--WD40
Gene Ontology

GO:0005615--C:extracellular space
GO:0005925--C:focal adhesion
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0003714--F:transcription corepressor activity
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway
KEGG mmu:21886
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002339 Ailuropoda melanoleuca 90.06 0.00e+00 926.00
IUUC-Bta-013343 Bos taurus 86.44 0.00e+00 1087.00
IUUC-Cja-018857 Callithrix jacchus 86.85 0.00e+00 1036.00
IUUC-Cfa-021227 Canis familiaris 86.43 0.00e+00 1069.00
IUUC-Cpo-021907 Cavia porcellus 87.22 0.00e+00 913.00
IUUC-Csa-023394 Chlorocebus sabaeus 77.68 0.00e+00 1050.00
IUUC-Dno-029791 Dasypus novemcinctus 88.60 0.00e+00 922.00
IUUC-Ete-032720 Echinops telfairi 72.21 0.00e+00 890.00
IUUC-Eca-033329 Equus caballus 86.69 0.00e+00 1110.00
IUUC-Fca-036428 Felis catus 89.33 0.00e+00 907.00
IUUC-Fal-037319 Ficedula albicollis 83.72 0.00e+00 719.00
IUUC-Ggo-045645 Gorilla gorilla 82.08 0.00e+00 845.00
IUUC-Hsa-046801 Homo sapiens 87.92 0.00e+00 1168.00
IUUC-Itr-048745 Ictidomys tridecemlineatus 90.77 0.00e+00 939.00
IUUC-Laf-053750 Loxodonta africana 86.88 0.00e+00 1167.00
IUUC-Mcc-055481 Macaca mulatta 88.31 0.00e+00 1174.00
IUUC-Mmr-061248 Microcebus murinus 87.66 0.00e+00 1191.00
IUUC-Mlu-068206 Myotis lucifugus 77.28 0.00e+00 1048.00
IUUC-Oga-089089 Otolemur garnettii 82.86 0.00e+00 1170.00
IUUC-Oar-089937 Ovis aries 81.04 0.00e+00 1049.00
IUUC-Ptr-090844 Pan troglodytes 82.21 0.00e+00 1023.00
IUUC-Pan-091708 Papio anubis 88.31 0.00e+00 1174.00
IUUC-Psi-094070 Pelodiscus sinensis 64.01 0.00e+00 865.00
IUUC-Pca-100236 Procavia capensis 84.82 0.00e+00 1156.00
IUUC-Rno-105639 Rattus norvegicus 88.27 0.00e+00 1137.00
Created Date 25-Jun-2017

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