iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107192

Ensembl Protein ID

ENSSHAP00000013659.1

UniProt Accession

G3WE04; G3WE04_SARHA

Genbank Protein ID

ENSSHAP00000013659

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AEFK01027248

Gene Name

BLK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000011673.1	ENSSHAT00000013771.1	ENSSHAP00000013659.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.20e-14	51.9	57	115

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +k++v vl+dyea+nd +L+  +G++++++    + ++W+ +++  +g++G +P+nFv+++e
   Q: 57   EKHYVVVLWDYEAVNDRDLKVVRGEKLQIL---MKTGDWWLAKSLVTGREGYVPSNFVARVE 115
           6899**************************...999************************97 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MGVVSSKKLA KEKRKNWWTF EKEAPITFPN KPPPPVPPLV VFSHLTTPAP VINPDQEKHY 60
VVVLWDYEAV NDRDLKVVRG EKLQILMKTG DWWLAKSLVT GREGYVPSNF VARVETLEIE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGTTTTAG TTCACTAAAT CTCCTCTGAA ACTAAGAAGT ACTTTAGCAA GCCACGTGAC 60
TTCCACTTTT TTGTGCCTGG AAGATTCAGC ATAAAAATTC AACTGGAAGG GTCCCGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0050853--P:B cell receptor signaling pathway
GO:0032024--P:positive regulation of insulin secretion

KEGG

shr:100923306

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	80.09	0.00e+00	803.00
IUUC-Apl-003307	Anas platyrhynchos	76.73	0.00e+00	738.00
IUUC-Aca-004357	Anolis carolinensis	70.11	0.00e+00	677.00
IUUC-Ame-010642	Astyanax mexicanus	70.82	0.00e+00	688.00
IUUC-Bta-012400	Bos taurus	78.77	0.00e+00	805.00
IUUC-Cfa-021056	Canis familiaris	77.93	0.00e+00	810.00
IUUC-Cpo-021779	Cavia porcellus	76.04	0.00e+00	798.00
IUUC-Csa-023557	Chlorocebus sabaeus	80.52	0.00e+00	804.00
IUUC-Dre-027517	Danio rerio	68.55	0.00e+00	693.00
IUUC-Eca-034218	Equus caballus	79.65	0.00e+00	791.00
IUUC-Eeu-035095	Erinaceus europaeus	59.14	4.00e-168	583.00
IUUC-Fca-036015	Felis catus	77.14	0.00e+00	807.00
IUUC-Fal-036946	Ficedula albicollis	76.13	0.00e+00	731.00
IUUC-Gga-040822	Gallus gallus	74.89	0.00e+00	741.00
IUUC-Gac-041860	Gasterosteus aculeatus	66.59	0.00e+00	637.00
IUUC-Ggo-044608	Gorilla gorilla	80.52	0.00e+00	743.00
IUUC-Hsa-046719	Homo sapiens	80.52	0.00e+00	802.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	78.13	0.00e+00	793.00
IUUC-Lch-050114	Latimeria chalumnae	73.76	0.00e+00	704.00
IUUC-Loc-052326	Lepisosteus oculatus	73.39	0.00e+00	713.00
IUUC-Laf-053387	Loxodonta africana	78.13	0.00e+00	810.00
IUUC-Mcc-055026	Macaca mulatta	80.30	0.00e+00	803.00
IUUC-Mga-059427	Meleagris gallopavo	76.58	0.00e+00	730.00
IUUC-Mmr-061660	Microcebus murinus	78.13	0.00e+00	800.00
IUUC-Mdo-062318	Monodelphis domestica	88.25	0.00e+00	908.00
IUUC-Mmu-063325	Mus musculus	77.73	0.00e+00	813.00
IUUC-Mpu-066582	Mustela putorius furo	80.95	0.00e+00	810.00
IUUC-Nle-069624	Nomascus leucogenys	80.52	0.00e+00	793.00
IUUC-Opr-070656	Ochotona princeps	73.76	0.00e+00	737.00
IUUC-Ont-072266	Oreochromis niloticus	71.23	0.00e+00	675.00
IUUC-Ocu-073907	Oryctolagus cuniculus	77.34	0.00e+00	793.00
IUUC-Oga-088057	Otolemur garnettii	76.79	0.00e+00	803.00
IUUC-Oar-089332	Ovis aries	74.90	0.00e+00	771.00
IUUC-Ptr-091551	Pan troglodytes	78.91	0.00e+00	755.00
IUUC-Pan-092173	Papio anubis	80.09	0.00e+00	790.00
IUUC-Psi-093895	Pelodiscus sinensis	72.45	0.00e+00	726.00
IUUC-Pab-097598	Pongo abelii	81.26	0.00e+00	776.00
IUUC-Pva-102135	Pteropus vampyrus	81.60	0.00e+00	805.00
IUUC-Rno-104891	Rattus norvegicus	77.34	0.00e+00	798.00
IUUC-Ssc-115696	Sus scrofa	77.45	0.00e+00	818.00
IUUC-Tgu-117056	Taeniopygia guttata	76.07	0.00e+00	729.00
IUUC-Tbe-127520	Tupaia belangeri	77.89	4.00e-172	597.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence