iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-054189

Ensembl Protein ID

ENSLAFP00000018979.1

UniProt Accession

G3TTS1; G3TTS1_LOXAF

Protein Name

Uncharacterized protein

Gene Name

EML4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000023296.2	ENSLAFT00000027411.1	ENSLAFP00000018979.1
ENSLAFG00000023296.2	ENSLAFT00000022169.2	ENSLAFP00000017634.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.80e-20	70.7	725	761
UBD/Beta-Prp	1.20e-40	140.0	509	869

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ +t l++ +d +++ s s+D  i  WD+ +g +
   Q: 725  GHSSYITHLDWsPDnKYIMSNSGDYEILYWDIPSGCK 761
           8***********998****************988865 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.........................................lrslsg 50
           k++k+h+ sv t  ++ +++ ll+ g++d++i++wd +                                               +++g
   Q: 509  KQIKAHDGSVFTLCQM-RNGMLLTGGGKDRKIILWDHDLNPEreievpdqygtiravaegkadqflvgtsrnfilrgtfndgfQIEVQG 596
           689999999***7777.99****************98876557899************************************66677** PP
   S: 51   heaevtavkfspdgkilvtgseDrtikvw.dls........................................tgkcvhtlkghedsvl 98
           h++e + +  +p +++l+t+++Dr ++ w +++                                        t++ v++ +  ++++ 
   Q: 597  HTDELWGLATHPFKDLLLTCAQDRQVCMWnSVEhrlewtrlldepghcadfhpggtvvaigthsgrwfvldaeTRDLVSIHTDGNEQLS 685
           *****************************6444888899************************************************** PP
   S: 99   slsfspsgdklvsGshdrtirvwdletgqclee...tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
            +++s +g  l++Gshd+ i ++ ++++   ++     +gh++ ++++ ++pd+++++s s D  +  Wd+++g+ l + ++ + +++ 
   Q: 686  VMRYSLDGTLLAVGSHDNFIYLYVVSENGRKYSrygKCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPSGCKLIRNRS-DCKDID 773
           ***********************999888887779999*********************************77777777766.666666 PP
   S: 185  sls..........................fdsngkelvsgsldgtvklwdlq...tgecvrtlnghtdnvksvrfs.pnderlvsgssD 243
           +++                           ++n+k ++ +++  +v l+++     +   +++ +h++ v+ v f+ ++++++ +g++D
   Q: 774  WTTytcvlgfhvfgvwpegsdgtdinalvRSHNRKVIAVADDFCKVHLFQYPcskPKAPSHKYSAHSSHVTNVSFTyNDSHLISTGGKD 862
           666666666555555444444433333325555555555555579999998876655669****************55555555666** PP
   S: 244  gsiriWd 250
            si  W 
   Q: 863  MSIIQWK 869
           ***9993 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

LDSFSSSLVD DSISAASTSD VQDRLSALEL RVQQQEDEIT VLKAALADVL RRLAISEDHV 60
ASVKKSVPSK GQPSLREAIS VSCITNGSGG NRKPSHTSSV SIARKETFSS AAKRIVGTPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGGATTCTT TCTCAAGCAG TTTAGTTTAA AAATATTCCT TTTTTTATTT TAATAGATGA 60
TAGTATTTCT GCTGCAAGCA CTTCCGATGT TCAGGACCGC CTGTCAGCTC TCGAGTTACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR005108--HELP
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03451--HELP
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0016020--C:membrane

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001465	Ailuropoda melanoleuca	90.16	0.00e+00	1758.00
IUUC-Apl-003728	Anas platyrhynchos	90.40	0.00e+00	1359.00
IUUC-Aca-004921	Anolis carolinensis	74.28	0.00e+00	1423.00
IUUC-Ame-011846	Astyanax mexicanus	75.43	0.00e+00	1394.00
IUUC-Bta-013457	Bos taurus	90.54	0.00e+00	1727.00
IUUC-Cel-018623	Caenorhabditis elegans	28.76	5.00e-80	292.00
IUUC-Cja-019963	Callithrix jacchus	88.95	0.00e+00	1660.00
IUUC-Cfa-020344	Canis familiaris	91.02	0.00e+00	1754.00
IUUC-Cpo-022426	Cavia porcellus	87.40	0.00e+00	1662.00
IUUC-Csa-023822	Chlorocebus sabaeus	88.95	0.00e+00	1677.00
IUUC-Cho-024398	Choloepus hoffmanni	88.94	0.00e+00	677.00
IUUC-Dno-029822	Dasypus novemcinctus	90.77	0.00e+00	1689.00
IUUC-Dor-030881	Dipodomys ordii	90.87	0.00e+00	889.00
IUUC-Ete-032548	Echinops telfairi	75.58	0.00e+00	1318.00
IUUC-Eca-033255	Equus caballus	89.96	0.00e+00	1779.00
IUUC-Eeu-034609	Erinaceus europaeus	85.16	3.00e-148	519.00
IUUC-Fca-035637	Felis catus	88.97	0.00e+00	1754.00
IUUC-Fal-037030	Ficedula albicollis	83.08	0.00e+00	1550.00
IUUC-Gmo-038662	Gadus morhua	78.86	0.00e+00	1219.00
IUUC-Gga-041202	Gallus gallus	85.78	0.00e+00	1597.00
IUUC-Gac-041394	Gasterosteus aculeatus	71.84	0.00e+00	1289.00
IUUC-Ggo-044734	Gorilla gorilla	88.93	0.00e+00	1647.00
IUUC-Hsa-046616	Homo sapiens	88.05	0.00e+00	1657.00
IUUC-Lch-050585	Latimeria chalumnae	75.64	0.00e+00	1445.00
IUUC-Loc-052753	Lepisosteus oculatus	79.01	0.00e+00	1396.00
IUUC-Mcc-055697	Macaca mulatta	88.15	0.00e+00	1669.00
IUUC-Mmr-060888	Microcebus murinus	88.33	0.00e+00	1623.00
IUUC-Mdo-062025	Monodelphis domestica	82.46	0.00e+00	1478.00
IUUC-Mmu-063591	Mus musculus	84.97	0.00e+00	1661.00
IUUC-Mpu-065718	Mustela putorius furo	89.12	0.00e+00	1740.00
IUUC-Mlu-068068	Myotis lucifugus	89.65	0.00e+00	1721.00
IUUC-Nle-069281	Nomascus leucogenys	88.32	0.00e+00	1603.00
IUUC-Opr-070938	Ochotona princeps	69.51	0.00e+00	1015.00
IUUC-Ont-071488	Oreochromis niloticus	66.60	0.00e+00	1245.00
IUUC-Oan-073561	Ornithorhynchus anatinus	72.89	0.00e+00	986.00
IUUC-Ocu-074399	Oryctolagus cuniculus	88.94	0.00e+00	1688.00
IUUC-Ola-086551	Oryzias latipes	69.50	0.00e+00	1249.00
IUUC-Oga-088783	Otolemur garnettii	89.31	0.00e+00	1733.00
IUUC-Oar-089716	Ovis aries	90.54	0.00e+00	1691.00
IUUC-Ptr-090942	Pan troglodytes	86.56	0.00e+00	1615.00
IUUC-Pan-091831	Papio anubis	87.15	0.00e+00	1670.00
IUUC-Psi-093094	Pelodiscus sinensis	85.50	0.00e+00	1620.00
IUUC-Pfo-097066	Poecilia formosa	68.62	0.00e+00	1228.00
IUUC-Pab-098351	Pongo abelii	88.73	0.00e+00	1649.00
IUUC-Pva-102783	Pteropus vampyrus	79.82	0.00e+00	1491.00
IUUC-Rno-105412	Rattus norvegicus	84.98	0.00e+00	1574.00
IUUC-Sha-106597	Sarcophilus harrisii	83.03	0.00e+00	1593.00
IUUC-Sar-113748	Sorex araneus	72.45	0.00e+00	1299.00
IUUC-Ssc-115740	Sus scrofa	90.06	0.00e+00	1690.00
IUUC-Tgu-116696	Taeniopygia guttata	84.94	0.00e+00	1552.00
IUUC-Tru-118506	Takifugu rubripes	72.94	0.00e+00	1298.00
IUUC-Tsy-119375	Tarsius syrichta	86.21	0.00e+00	1366.00
IUUC-Tni-120392	Tetraodon nigroviridis	68.43	0.00e+00	1169.00
IUUC-Tbe-127468	Tupaia belangeri	83.30	0.00e+00	1565.00
IUUC-Ttr-128746	Tursiops truncatus	86.11	0.00e+00	1732.00
IUUC-Vpa-130697	Vicugna pacos	88.22	0.00e+00	1693.00
IUUC-Xtr-132731	Xenopus tropicalis	77.72	0.00e+00	1527.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence