iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027409

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase

Genbank Nucleotide ID

BX649608

Gene Name

uchl5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000103404.1	ENSDART00000165380.1	ENSDARP00000141540.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/UCH	1.40e-93	314.9	1	316

Active Site

Position(s)	Description	Evidence
88	Nucleophile	{ECO:0000256\|PIRSR:PIRSR038120-1}
164	Proton donor	{ECO:0000256\|PIRSR:PIRSR038120-1}

Domain Profile

DUB/UCH

   S: 1    mnsqvkewleLesdPglftllvedfgvkrdiqveelysLdpenlglyqepvegllllFkinekressrksqvtsndlevvdediiktif 89
           m + + ew+ +esdPg+ft+l++ fg+k+  qvee++s++pen++ + +pv+gl++lFk+++ +e +          ++v+++ +++if
   Q: 1    MAGSAGEWCLMESDPGVFTELIKGFGCKGA-QVEEIWSMEPENFENL-KPVHGLIFLFKWQPGEEPAG---------SIVQDSRLDQIF 78
           667789************************.****************.*******************9.........8899******** PP
   S: 90   fakqvigNsCatyAllsvllncedklldlGttlsrlkestkaespenkalalgnqqvlecihnslariesrseperqdedneqytkeaf 178
           fakqvi+N+Cat+A++svllnc++  + lG+tl ++ke+++++++ +k+lal+n++v++++hn +ar+++++ + +  ++    +++af
   Q: 79   FAKQVINNACATQAIISVLLNCTHPDMLLGETLTEFKEFSNSFDAAMKGLALSNSEVIRQVHNGFARQQMFEFDAKSTAK----EEDAF 163
           **************************9***********************************************988776....89*** PP
   S: 179  hfvsyvningrlyeldglkpfPldlgkkketeelkdklkvvraflerikllesdeirfnllaivadrrviktlrlnvlkid........ 259
           hfvsyv++ngrlyeldgl++ P+dlg  ++++++ ++++ v+   +ri++++++eirfnl+aiv+dr++i+++++  l+ +        
   Q: 164  HFVSYVPVNGRLYELDGLREGPIDLGV-CNQDDWISAVRPVI--EKRIQKYSEGEIRFNLMAIVSDRKMIYEKKIVELQAQlteeepmd 249
           **************************9.78999*********..*****************************9855555566666666 PP
   S: 260  .keLlkLlkdieseeekieaqlddekekrkkfkiddirRtenydeficifikdlaregilrklveet 325
             +  + l+ i+se++k++  +++e++k k++k+++irR++ny  fi++++k+la+ ++l  lve+ 
   Q: 250  tDQSGNHLSSIQSEIAKYQLLIEEENQKLKRYKVENIRRKHNYLPFIMELLKTLAEYQQLIPLVEKA 316
           6333356899******************************************************984 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MAGSAGEWCL MESDPGVFTE LIKGFGCKGA QVEEIWSMEP ENFENLKPVH GLIFLFKWQP 60
GEEPAGSIVQ DSRLDQIFFA KQVINNACAT QAIISVLLNC THPDMLLGET LTEFKEFSNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAATGAGTCT CATTAGCCTT GTTGAACCGC TACACGAGCA CATTTTCTGT TTACTGTAAG 60
ATAAATATAA TTCCAGAAAT GGCGGGAAGC GCTGGGGAAT GGTGTCTTAT GGAAAGTGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001578--Peptidase_C12_UCH
IPR017390--Ubiquitinyl_hydrolase_UCH37
IPR033837--UCH37

Pfam

PF01088--Peptidase_C12

PRINTS

PR00707--UBCTHYDRLASE

Gene Ontology

GO:0031011--C:Ino80 complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dre:406357

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000936	Aegilops tauschii	45.65	8.00e-82	296.00
IUUC-Aml-001866	Ailuropoda melanoleuca	89.78	1.00e-171	595.00
IUUC-Atr-002966	Amborella trichopoda	47.41	2.00e-79	289.00
IUUC-Apl-003306	Anas platyrhynchos	81.84	1.00e-169	589.00
IUUC-Aca-004763	Anolis carolinensis	92.95	8.00e-177	612.00
IUUC-Aly-005581	Arabidopsis lyrata	48.02	8.00e-78	283.00
IUUC-Ath-007283	Arabidopsis thaliana	47.72	7.00e-80	290.00
IUUC-Ago-007999	Ashbya gossypii	37.02	4.00e-31	128.00
IUUC-Acl-008231	Aspergillus clavatus	44.17	4.00e-53	201.00
IUUC-Afl-008557	Aspergillus flavus	39.02	1.00e-54	206.00
IUUC-Afu-008988	Aspergillus fumigatus	45.19	1.00e-53	203.00
IUUC-Ani-009420	Aspergillus nidulans	37.42	4.00e-54	205.00
IUUC-Ang-009859	Aspergillus niger	42.21	6.00e-49	187.00
IUUC-Aor-010145	Aspergillus oryzae	39.02	1.00e-54	206.00
IUUC-Ate-010347	Aspergillus terreus	41.90	1.00e-52	200.00
IUUC-Ame-010791	Astyanax mexicanus	95.44	0.00e+00	655.00
IUUC-Bgr-012298	Blumeria graminis	37.70	6.00e-49	187.00
IUUC-Bta-013251	Bos taurus	89.46	1.00e-169	588.00
IUUC-Bci-013786	Botrytis cinerea	37.24	1.00e-54	207.00
IUUC-Bdi-014132	Brachypodium distachyon	48.46	7.00e-80	290.00
IUUC-Bol-015611	Brassica oleracea	49.39	1.00e-81	296.00
IUUC-Bra-017769	Brassica rapa	49.39	1.00e-81	296.00
IUUC-Cel-018604	Caenorhabditis elegans	46.89	7.00e-81	293.00
IUUC-Cja-019768	Callithrix jacchus	81.23	3.00e-164	571.00
IUUC-Cfa-020207	Canis familiaris	89.78	1.00e-171	595.00
IUUC-Cpo-021925	Cavia porcellus	85.62	3.00e-162	564.00
IUUC-Cre-022919	Chlamydomonas reinhardtii	45.77	7.00e-74	270.00
IUUC-Csa-023958	Chlorocebus sabaeus	88.82	3.00e-168	584.00
IUUC-Cho-024928	Choloepus hoffmanni	89.61	4.00e-38	151.00
IUUC-Cin-025771	Ciona intestinalis	54.63	1.00e-99	356.00
IUUC-Csv-026149	Ciona savignyi	57.37	3.00e-102	365.00
IUUC-Cgl-026424	Colletotrichum gloeosporioides	37.87	6.00e-51	194.00
IUUC-Cne-026955	Cryptococcus neoformans	35.21	9.00e-51	193.00
IUUC-Cme-027104	Cyanidioschyzon merolae	33.24	9.00e-48	184.00
IUUC-Dno-028921	Dasypus novemcinctus	89.78	2.00e-171	594.00
IUUC-Dse-031170	Dothistroma septosporum	36.66	6.00e-55	207.00
IUUC-Dme-031677	Drosophila melanogaster	60.62	4.00e-112	397.00
IUUC-Ete-032707	Echinops telfairi	63.32	7.00e-109	386.00
IUUC-Eca-033776	Equus caballus	89.93	1.00e-156	545.00
IUUC-Eeu-035305	Erinaceus europaeus	72.34	3.00e-76	278.00
IUUC-Fca-035846	Felis catus	82.65	2.00e-166	578.00
IUUC-Fal-037597	Ficedula albicollis	90.62	2.00e-153	534.00
IUUC-Fox-037670	Fusarium oxysporum	48.05	2.00e-52	199.00
IUUC-Fso-038243	Fusarium solani	48.05	8.00e-52	197.00
IUUC-Gmo-038499	Gadus morhua	89.14	3.00e-169	587.00
IUUC-Ggr-039975	Gaeumannomyces graminis	39.84	1.00e-45	176.00
IUUC-Gga-040904	Gallus gallus	90.63	0.00e+00	628.00
IUUC-Gac-042058	Gasterosteus aculeatus	93.29	2.00e-178	617.00
IUUC-Gma-043763	Glycine max	48.66	2.00e-84	305.00
IUUC-Ggo-044699	Gorilla gorilla	83.06	2.00e-153	535.00
IUUC-Hsa-046227	Homo sapiens	89.14	1.00e-170	592.00
IUUC-Hvu-047359	Hordeum vulgare	46.20	6.00e-81	294.00
IUUC-Itr-048989	Ictidomys tridecemlineatus	81.40	9.00e-166	576.00
IUUC-Lch-049829	Latimeria chalumnae	91.37	3.00e-173	600.00
IUUC-Lpe-050899	Leersia perrieri	47.32	2.00e-77	282.00
IUUC-Loc-052264	Lepisosteus oculatus	93.95	2.00e-176	611.00
IUUC-Lma-053110	Leptosphaeria maculans	37.75	2.00e-46	179.00
IUUC-Laf-053639	Loxodonta africana	89.78	1.00e-171	595.00
IUUC-Mcc-055506	Macaca mulatta	88.82	3.00e-168	584.00
IUUC-Mor-057001	Magnaporthe oryzae	43.70	2.00e-52	199.00
IUUC-Mpo-057608	Magnaporthe poae	40.11	1.00e-30	126.00
IUUC-Mtr-057731	Medicago truncatula	49.25	2.00e-84	305.00
IUUC-Mla-059016	Melampsora laricipopulina	41.79	1.00e-41	162.00
IUUC-Mga-060178	Meleagris gallopavo	90.79	1.00e-167	581.00
IUUC-Mvi-060353	Microbotryum violaceum	38.51	3.00e-54	205.00
IUUC-Mmr-060738	Microcebus murinus	89.46	4.00e-171	593.00
IUUC-Mdo-062266	Monodelphis domestica	91.18	1.00e-113	402.00
IUUC-Mmu-063619	Mus musculus	87.54	7.00e-168	582.00
IUUC-Mac-065301	Musa acuminata	50.79	1.00e-87	316.00
IUUC-Mpu-066058	Mustela putorius furo	89.78	1.00e-171	595.00
IUUC-Mlu-067292	Myotis lucifugus	88.82	3.00e-168	584.00
IUUC-Nfi-068275	Neosartorya fischeri	39.42	5.00e-55	207.00
IUUC-Ncr-068713	Neurospora crassa	38.68	2.00e-57	215.00
IUUC-Nle-069013	Nomascus leucogenys	88.50	1.00e-167	582.00
IUUC-Opr-070628	Ochotona princeps	77.94	9.00e-155	539.00
IUUC-Ont-072688	Oreochromis niloticus	93.65	1.00e-178	619.00
IUUC-Oan-073004	Ornithorhynchus anatinus	89.43	1.00e-132	465.00
IUUC-Ocu-074303	Oryctolagus cuniculus	89.78	5.00e-172	597.00
IUUC-Oba-075002	Oryza barthii	47.89	1.00e-80	293.00
IUUC-Obr-076392	Oryza brachyantha	48.26	3.00e-78	285.00
IUUC-Ogl-077271	Oryza glaberrima	47.89	1.00e-80	293.00
IUUC-Ogu-078493	Oryza glumaepatula	47.89	2.00e-81	295.00
IUUC-Oin-080084	Oryza indica	47.89	2.00e-81	295.00
IUUC-Olo-080803	Oryza longistaminata	47.59	6.00e-81	294.00
IUUC-Ome-081146	Oryza meridionalis	46.99	7.00e-80	290.00
IUUC-Oni-082146	Oryza nivara	47.89	2.00e-81	295.00
IUUC-Opu-083633	Oryza punctata	47.95	5.00e-77	281.00
IUUC-Oru-084789	Oryza rufipogon	47.89	2.00e-81	295.00
IUUC-Osa-086196	Oryza sativa	47.89	2.00e-81	295.00
IUUC-Ola-087126	Oryzias latipes	92.33	2.00e-172	598.00
IUUC-Olu-087665	Ostreococcus lucimarinus	39.93	6.00e-66	244.00
IUUC-Oga-089140	Otolemur garnettii	81.76	2.00e-165	575.00
IUUC-Oar-090296	Ovis aries	89.14	6.00e-170	590.00
IUUC-Ptr-090566	Pan troglodytes	89.14	1.00e-170	592.00
IUUC-Pan-092052	Papio anubis	88.82	4.00e-168	584.00
IUUC-Psi-093723	Pelodiscus sinensis	90.97	2.00e-159	554.00
IUUC-Pma-094568	Petromyzon marinus	61.81	7.00e-107	380.00
IUUC-Pno-095120	Phaeosphaeria nodorum	38.44	1.00e-47	183.00
IUUC-Ppa-095761	Physcomitrella patens	46.78	6.00e-84	304.00
IUUC-Pfo-096210	Poecilia formosa	94.25	1.00e-179	622.00
IUUC-Pab-098463	Pongo abelii	89.14	3.00e-170	591.00
IUUC-Pop-099423	Populus trichocarpa	48.96	3.00e-85	308.00
IUUC-Pca-100108	Procavia capensis	88.62	2.00e-131	462.00
IUUC-Ppe-101176	Prunus persica	50.00	3.00e-83	301.00
IUUC-Pva-102629	Pteropus vampyrus	87.79	8.00e-137	479.00
IUUC-Pgr-103419	Puccinia graminis	38.41	8.00e-55	207.00
IUUC-Pte-104207	Pyrenophora teres	42.01	3.00e-30	124.00
IUUC-Pyt-104471	Pyrenophora triticirepentis	38.03	8.00e-54	204.00
IUUC-Rno-105579	Rattus norvegicus	78.02	2.00e-147	514.00
IUUC-Sha-106894	Sarcophilus harrisii	87.68	5.00e-146	509.00
IUUC-Sja-107732	Schizosaccharomyces japonicus	39.66	2.00e-57	215.00
IUUC-Spo-108371	Schizosaccharomyces pombe	39.20	3.00e-59	221.00
IUUC-Ssl-108467	Sclerotinia sclerotiorum	37.68	9.00e-46	177.00
IUUC-Smo-109396	Selaginella moellendorffii	50.77	2.00e-86	312.00
IUUC-Sit-110630	Setaria italica	50.00	2.00e-85	309.00
IUUC-Sly-110972	Solanum lycopersicum	48.24	5.00e-79	287.00
IUUC-Stu-112185	Solanum tuberosum	47.90	3.00e-87	315.00
IUUC-Sar-113294	Sorex araneus	74.22	1.00e-149	522.00
IUUC-Sbi-113951	Sorghum bicolor	50.31	7.00e-86	310.00
IUUC-Ssc-115501	Sus scrofa	88.55	2.00e-159	555.00
IUUC-Tgu-117152	Taeniopygia guttata	90.28	2.00e-153	534.00
IUUC-Tru-118388	Takifugu rubripes	93.61	2.00e-178	617.00
IUUC-Tsy-119109	Tarsius syrichta	89.46	7.00e-171	593.00
IUUC-Tni-120048	Tetraodon nigroviridis	93.61	9.00e-179	619.00
IUUC-Tca-121750	Theobroma cacao	49.11	3.00e-88	318.00
IUUC-Tre-122130	Trichoderma reesei	39.00	2.00e-54	205.00
IUUC-Tvi-122284	Trichoderma virens	39.20	1.00e-50	193.00
IUUC-Tae-124082	Triticum aestivum	45.67	2.00e-80	292.00
IUUC-Tur-126366	Triticum urartu	43.07	2.00e-65	242.00
IUUC-Tme-127187	Tuber melanosporum	38.32	5.00e-57	214.00
IUUC-Tbe-127619	Tupaia belangeri	81.18	1.00e-130	458.00
IUUC-Ttr-128867	Tursiops truncatus	80.00	4.00e-114	404.00
IUUC-Vda-129912	Verticillium dahliae	36.70	2.00e-51	196.00
IUUC-Vpa-130552	Vicugna pacos	91.39	3.00e-117	415.00
IUUC-Vvi-130881	Vitis vinifera	49.26	2.00e-82	299.00
IUUC-Xtr-131934	Xenopus tropicalis	84.19	2.00e-169	588.00
IUUC-Xma-133312	Xiphophorus maculatus	93.93	1.00e-178	618.00
IUUC-Yli-134487	Yarrowia lipolytica	40.00	4.00e-46	178.00
IUUC-Zma-135462	Zea mays	43.08	1.00e-70	260.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence