iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052616

Ensembl Protein ID

ENSLOCP00000004401.1

UniProt Accession

W5M7P3; W5M7P3_LEPOC

Genbank Protein ID

ENSLOCP00000004401

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHAT01018251

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000003680.1	ENSLOCT00000004390.1	ENSLOCP00000004382.1
ENSLOCG00000003680.1	ENSLOCT00000004409.1	ENSLOCP00000004401.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.10e-112	374.8	187	720

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++l+     +    ++e+k +l+k++qkl++ +w k++ ++v p++l++ +k++++ f+gy+
   Q: 187  TGLKNIGNTCYMNAALQALSNCPPLTQFFLD-----CGGLVRTEKKPALCKTYQKLVSDIWhKNRPGYVVPTSLFQGIKAINPLFRGYS 270
           7******************************.....999999*******************9999************************ PP
   S: 89   qqDaqEflaflldqleeelkk..................eknkpkeeeeeedkselsde.............................. 129
           qqD+qEfl++l+dql+eelk+                                     e                              
   Q: 271  QQDSQEFLRCLMDQLHEELKEvlvepdepsspaltpgdgP------------------Eddrgqsdndfqscescggsdraegeakpga 341
           *******************887766655543333322220..................1333444456777788888888999****** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 342  eepgevamlipeeevppaasgrgrqkeknrgsrpcragssgdvdkdidtaaepaaavissqgavkvpmqgrasdcypdvpasfgssrsh 430
           ***************************************************************************************** PP
   S: 130  ......................................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
                                                  ++k++kk++s+isd+F+g++ s+++cl+cd+vs++ e+f+d+slp+pgke
   Q: 431  sptpneginaklsssppktgpvwsglapshkkvppfslPKNKTQKKYRSVISDVFDGTIVSSVQCLTCDRVSVTLETFQDISLPIPGKE 519
           **************************************999************************************************ PP
   S: 181  etkke.................................................slqdcLesftkeeelegenkyycekckkkqeaekk 220
           + +k+                                                 +lqdcL++f++++el+g+n+y+cekckk+++ +k 
   Q: 520  DLAKLhssshqtslvkagscgeayapqgwiafvmeyikrwpsrcvfswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKF 608
           99888************************************************************************************ PP
   S: 221  lklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.Wl 307
           +k+++lPevL++hLkRf  ++e ++++ki ++v+fple Ld++pf+++++++q  +++Y+L++v++H+G++ssGHY+ay++n+ ++ W+
   Q: 609  CKVQSLPEVLCIHLKRF--RHELMFSTKIGTHVSFPLEgLDMQPFLAKDSTAQ--TTSYDLLSVICHHGTASSGHYIAYCRNDLNGlWY 693
           *****************..9999*************************88887..9**************************76668** PP
   S: 308  lfdDskVtevkeeevleetgstaYvlfYkr 337
           +fdD++Vtev+e +v++   ++aYvlfYk+
   Q: 694  EFDDQSVTEVSEVTVQN---AEAYVLFYKK 720
           *****************...********98 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

LTSVSQAVSA LPVPCLPQES FIPRTGRHLS GRMSPVGVNG DCPHLECVGE ITKEELIQKS 60
HGKCQDCKVG GPNLWACLEN GCTYVGCGES HADHSTGHSQ DARHNLTVNL TTLRVWCYAC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGAAGTCC TAGCAGAACT AGAAAATGGA GCAGCTACAG ACACTAAAAT TAAGTTAAAA 60
ATATGATGTT TGATTTCACT ATTTATGGGG TTTAGTTGTT TTTATTAGCA TTCAATACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	70.11	0.00e+00	1323.00
IUUC-Apl-003987	Anas platyrhynchos	71.77	0.00e+00	1281.00
IUUC-Aca-004713	Anolis carolinensis	70.18	0.00e+00	1271.00
IUUC-Bta-013132	Bos taurus	72.89	0.00e+00	1328.00
IUUC-Cja-018811	Callithrix jacchus	72.64	0.00e+00	1333.00
IUUC-Cfa-021158	Canis familiaris	70.22	0.00e+00	1328.00
IUUC-Cpo-021910	Cavia porcellus	67.76	0.00e+00	1173.00
IUUC-Csa-023130	Chlorocebus sabaeus	72.56	0.00e+00	1326.00
IUUC-Cho-024383	Choloepus hoffmanni	51.05	1.00e-110	394.00
IUUC-Dre-028639	Danio rerio	77.12	0.00e+00	1378.00
IUUC-Dno-029416	Dasypus novemcinctus	72.01	0.00e+00	1295.00
IUUC-Ete-032994	Echinops telfairi	55.65	2.00e-161	563.00
IUUC-Eca-034248	Equus caballus	72.43	0.00e+00	1337.00
IUUC-Eeu-035357	Erinaceus europaeus	56.59	0.00e+00	920.00
IUUC-Fca-036013	Felis catus	70.01	0.00e+00	1283.00
IUUC-Fal-037509	Ficedula albicollis	71.41	0.00e+00	1300.00
IUUC-Gmo-038944	Gadus morhua	74.57	0.00e+00	1314.00
IUUC-Gga-040647	Gallus gallus	71.21	0.00e+00	1280.00
IUUC-Gac-041752	Gasterosteus aculeatus	77.01	0.00e+00	1383.00
IUUC-Hsa-045694	Homo sapiens	69.96	0.00e+00	1322.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	71.79	0.00e+00	1303.00
IUUC-Lch-050400	Latimeria chalumnae	72.22	0.00e+00	1299.00
IUUC-Laf-053493	Loxodonta africana	72.40	0.00e+00	1324.00
IUUC-Mcc-055542	Macaca mulatta	72.56	0.00e+00	1330.00
IUUC-Meu-056645	Macropus eugenii	62.96	0.00e+00	1080.00
IUUC-Mga-060019	Meleagris gallopavo	72.03	0.00e+00	1096.00
IUUC-Mmr-061241	Microcebus murinus	68.72	0.00e+00	1280.00
IUUC-Mmu-063786	Mus musculus	71.65	0.00e+00	1296.00
IUUC-Mpu-065772	Mustela putorius furo	72.32	0.00e+00	1114.00
IUUC-Mlu-067732	Myotis lucifugus	71.85	0.00e+00	1316.00
IUUC-Nle-069528	Nomascus leucogenys	72.12	0.00e+00	1334.00
IUUC-Opr-070606	Ochotona princeps	68.29	0.00e+00	1179.00
IUUC-Ont-071495	Oreochromis niloticus	77.74	0.00e+00	1395.00
IUUC-Ocu-074457	Oryctolagus cuniculus	70.21	0.00e+00	1300.00
IUUC-Ola-086739	Oryzias latipes	75.43	0.00e+00	1405.00
IUUC-Oga-088720	Otolemur garnettii	71.84	0.00e+00	1337.00
IUUC-Oar-089921	Ovis aries	72.11	0.00e+00	1333.00
IUUC-Ptr-090526	Pan troglodytes	72.45	0.00e+00	1322.00
IUUC-Pan-092396	Papio anubis	72.76	0.00e+00	1324.00
IUUC-Psi-092971	Pelodiscus sinensis	72.76	0.00e+00	1345.00
IUUC-Pfo-097415	Poecilia formosa	74.60	0.00e+00	1354.00
IUUC-Pab-098740	Pongo abelii	72.53	0.00e+00	1347.00
IUUC-Pva-102820	Pteropus vampyrus	67.61	0.00e+00	1090.00
IUUC-Rno-104894	Rattus norvegicus	71.90	0.00e+00	1303.00
IUUC-Sha-107244	Sarcophilus harrisii	68.18	0.00e+00	1198.00
IUUC-Sar-113665	Sorex araneus	71.35	0.00e+00	1323.00
IUUC-Ssc-115793	Sus scrofa	71.71	0.00e+00	1282.00
IUUC-Tgu-117487	Taeniopygia guttata	72.62	0.00e+00	1271.00
IUUC-Tru-117694	Takifugu rubripes	74.15	0.00e+00	1390.00
IUUC-Tsy-119598	Tarsius syrichta	63.76	0.00e+00	1095.00
IUUC-Tni-120189	Tetraodon nigroviridis	70.68	0.00e+00	1298.00
IUUC-Tbe-128125	Tupaia belangeri	79.07	7.00e-83	301.00
IUUC-Ttr-128269	Tursiops truncatus	70.42	0.00e+00	1256.00
IUUC-Vpa-130598	Vicugna pacos	70.01	0.00e+00	1288.00
IUUC-Xtr-132044	Xenopus tropicalis	72.09	0.00e+00	1258.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence