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Tag Content
iUUCD ID IUUC-Pgr-103538
Ensembl Protein ID EFP87362
UniProt Accession E3KSX6; E3KSX6_PUCGT
Genbank Protein ID EFP87362.1
Protein Name Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog
Genbank Nucleotide ID DS178306
Gene Name PAC1; LIS1; PGTG_13590
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
PGTG_13590 EFP87362 EFP87362
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 5.10e-53 174.4 118 153
UBD/Beta-Prp 1.50e-71 240.7 119 454
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
    gH +++t+laf ++ l+s+s D+tikvWD+ tg
   Q: 118 GHRSPITALAFhPTfSSLASASEDCTIKVWDYETGE 153
    8***********88889**************99987 PP
   


   UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdk 108
    h s+it+++f+p s la++s+d tikvwd++tg + +l+gh++ v +v+++++g +lv++s+D tik+wd ++ c+ tl h++sv s +f p + +
   Q: 119 HRSPITALAFHPTFSSLASASEDCTIKVWDYETGEFELTLKGHTKVVCDVDYDSKGTFLVSCSSDLTIKLWDCMnNYRCTKTLYDHDHSVSSSRFLPGDTH 219
    677********************************************************************75439*********************99** PP
   S: 109 lvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng................. 192
    +vs+s+d+ti++w++ t c++ tl+gh+++v++v g+llvs+s+D+t r+Wdl tg+ +++g h++ v+ f++
   Q: 220 IVSASRDQTIKIWEVATSFCVK-TLRGHTEWVRGVWPWTHGKLLVSASNDQTARIWDLTTGESKIEFRG-HEHVVEIALFSPPAsnaairemagipsptnq 318
    **********************.************999999***************************9.*****99998887778888888888888999 PP
   S: 193 .........kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn.................... 264
    ++++gs+d+t+++wd+ +g+c++tl gh+++++ + f+pn+ +l+s s+D++ir W lr+g ++k++ h+
   Q: 319 dskikepdpVFVATGSRDKTIRIWDCNSGQCIKTLVGHDNWIRALVFHPNGRHLLSSSDDKTIRAWELRTGRCVKVVDAHEhfvtsmawgrasagggpptt 419
    999999999************************************************************************77777777777777777777 PP
   S: 265 ........ssvisvavlsfgdnvlvlgsedskvniwk 293
    +s++sva+ +v+++gs d++++iw
   Q: 420 npdsnqplNSLSSVAA--RPVSVIATGSVDQSIKIWT 454
    7777777777777777..44677799999*******6 PP
   

Organism Puccinia graminis
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Protein Sequence
(Fasta)
MAPLTSVLSE RQKEELHRAL LDYLSSNGLQ STFEALKAEL PAHQDFQPDP KAKWTGLLEK 60
KWTSVIRLQK KIMDLERENG LLKDELASVG SISSTRKGQQ LEDWLPGRGG GARHTLTGHR 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Pgr-103538|E3,WD_repeat;UBD,Beta-Prp|Puccinia graminis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTGACCATC TCTTTCAATT TTCACTTTCT TTCATTTTTC AATCTGCAAC TTCAACACCA 60
CACACATCAA TACCAGCAAC CAACACTCAA CAGTCAACCA TAGTCTGTAC ATACACACAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Pgr-103538|E3,WD_repeat;UBD,Beta-Prp|Puccinia graminis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005938--C:cell cortex
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0000003--P:reproduction
GO:0047496--P:vesicle transport along microtubule

KEGG pgr:PGTG_13590
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 46.91 1.00e-114 404.00
IUUC-Apl-004024 Anas platyrhynchos 47.43 8.00e-119 418.00
IUUC-Aca-004564 Anolis carolinensis 47.65 8.00e-117 411.00
IUUC-Ago-007862 Ashbya gossypii 27.96 3.00e-37 147.00
IUUC-Acl-008360 Aspergillus clavatus 48.21 8.00e-114 402.00
IUUC-Afl-008502 Aspergillus flavus 46.10 4.00e-108 382.00
IUUC-Afu-008848 Aspergillus fumigatus 50.00 2.00e-122 430.00
IUUC-Ani-009173 Aspergillus nidulans 46.29 1.00e-107 381.00
IUUC-Ang-009873 Aspergillus niger 44.20 2.00e-104 370.00
IUUC-Aor-009973 Aspergillus oryzae 44.44 5.00e-105 372.00
IUUC-Ate-010523 Aspergillus terreus 43.48 1.00e-104 371.00
IUUC-Ame-010969 Astyanax mexicanus 47.43 6.00e-119 419.00
IUUC-Bgr-011972 Blumeria graminis 48.40 9.00e-119 418.00
IUUC-Bta-013106 Bos taurus 47.87 5.00e-119 419.00
IUUC-Bci-013615 Botrytis cinerea 48.09 4.00e-119 419.00
IUUC-Cel-018459 Caenorhabditis elegans 42.73 5.00e-100 355.00
IUUC-Cja-018755 Callithrix jacchus 46.53 2.00e-115 407.00
IUUC-Cfa-020749 Canis familiaris 47.87 5.00e-119 419.00
IUUC-Cpo-022371 Cavia porcellus 47.87 5.00e-119 419.00
IUUC-Csa-023524 Chlorocebus sabaeus 45.93 1.00e-97 347.00
IUUC-Cho-024764 Choloepus hoffmanni 43.14 2.00e-91 327.00
IUUC-Cin-025753 Ciona intestinalis 45.88 5.00e-107 379.00
IUUC-Csv-025817 Ciona savignyi 44.64 2.00e-108 383.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 48.83 2.00e-115 407.00
IUUC-Cne-027087 Cryptococcus neoformans 57.11 9.00e-132 461.00
IUUC-Dre-028314 Danio rerio 47.43 9.00e-119 418.00
IUUC-Dno-029050 Dasypus novemcinctus 47.43 5.00e-119 419.00
IUUC-Dor-030222 Dipodomys ordii 44.07 1.00e-104 371.00
IUUC-Dse-031164 Dothistroma septosporum 47.67 5.00e-115 405.00
IUUC-Dme-031745 Drosophila melanogaster 45.33 2.00e-106 377.00
IUUC-Ete-032508 Echinops telfairi 48.70 1.00e-82 298.00
IUUC-Eca-034288 Equus caballus 46.45 2.00e-113 400.00
IUUC-Eeu-034984 Erinaceus europaeus 43.85 2.00e-103 367.00
IUUC-Fca-036498 Felis catus 47.87 5.00e-119 419.00
IUUC-Fal-036920 Ficedula albicollis 47.43 8.00e-119 418.00
IUUC-Fox-037996 Fusarium oxysporum 48.83 1.00e-119 421.00
IUUC-Fso-038160 Fusarium solani 46.62 1.00e-112 398.00
IUUC-Gmo-038983 Gadus morhua 46.98 6.00e-118 415.00
IUUC-Ggr-040051 Gaeumannomyces graminis 45.20 3.00e-108 383.00
IUUC-Gga-040623 Gallus gallus 47.43 8.00e-119 418.00
IUUC-Gac-041613 Gasterosteus aculeatus 46.76 1.00e-116 411.00
IUUC-Ggo-045410 Gorilla gorilla 44.09 3.00e-101 360.00
IUUC-Hsa-046358 Homo sapiens 47.87 6.00e-119 419.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 47.87 5.00e-119 419.00
IUUC-Kpa-049351 Komagataella pastoris 28.14 2.00e-39 154.00
IUUC-Lch-049936 Latimeria chalumnae 47.20 1.00e-117 414.00
IUUC-Loc-052476 Lepisosteus oculatus 46.68 2.00e-114 403.00
IUUC-Lma-053170 Leptosphaeria maculans 50.43 2.00e-118 417.00
IUUC-Laf-053713 Loxodonta africana 46.62 9.00e-116 408.00
IUUC-Mcc-054628 Macaca mulatta 47.20 8.00e-119 418.00
IUUC-Meu-055927 Macropus eugenii 41.56 5.00e-65 239.00
IUUC-Mor-056962 Magnaporthe oryzae 47.11 3.00e-114 403.00
IUUC-Mpo-057583 Magnaporthe poae 45.42 4.00e-105 373.00
IUUC-Mla-058819 Melampsora laricipopulina 75.82 0.00e+00 708.00
IUUC-Mga-059945 Meleagris gallopavo 47.43 8.00e-119 418.00
IUUC-Mvi-060403 Microbotryum violaceum 59.39 3.00e-154 536.00
IUUC-Mmr-061289 Microcebus murinus 46.91 1.00e-114 404.00
IUUC-Mdo-061912 Monodelphis domestica 47.87 5.00e-119 419.00
IUUC-Mmu-063253 Mus musculus 47.87 5.00e-119 419.00
IUUC-Mpu-066638 Mustela putorius furo 47.87 5.00e-119 419.00
IUUC-Mlu-067267 Myotis lucifugus 46.21 3.00e-115 406.00
IUUC-Nfi-068571 Neosartorya fischeri 46.11 2.00e-109 387.00
IUUC-Ncr-068895 Neurospora crassa 51.18 1.00e-118 418.00
IUUC-Nle-069087 Nomascus leucogenys 50.29 1.00e-96 344.00
IUUC-Opr-070579 Ochotona princeps 47.43 5.00e-119 419.00
IUUC-Ont-071905 Oreochromis niloticus 47.43 8.00e-119 418.00
IUUC-Oan-073072 Ornithorhynchus anatinus 47.87 5.00e-119 419.00
IUUC-Ocu-074180 Oryctolagus cuniculus 47.43 5.00e-119 419.00
IUUC-Ola-086772 Oryzias latipes 47.43 5.00e-119 419.00
IUUC-Oga-088219 Otolemur garnettii 46.44 2.00e-115 407.00
IUUC-Oar-090394 Ovis aries 47.87 5.00e-119 419.00
IUUC-Ptr-091517 Pan troglodytes 47.87 5.00e-119 419.00
IUUC-Pan-092421 Papio anubis 47.20 8.00e-119 418.00
IUUC-Psi-093370 Pelodiscus sinensis 47.43 1.00e-118 417.00
IUUC-Pma-094319 Petromyzon marinus 45.43 8.00e-95 338.00
IUUC-Pno-094815 Phaeosphaeria nodorum 50.43 6.00e-123 432.00
IUUC-Pfo-097089 Poecilia formosa 47.65 9.00e-120 421.00
IUUC-Pab-098421 Pongo abelii 47.87 5.00e-119 419.00
IUUC-Pca-100120 Procavia capensis 41.69 1.00e-69 255.00
IUUC-Pva-102960 Pteropus vampyrus 47.65 8.00e-118 415.00
IUUC-Ptt-103990 Puccinia triticina 74.03 1.00e-97 349.00
IUUC-Pte-104261 Pyrenophora teres 50.43 2.00e-122 430.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 50.85 3.00e-123 433.00
IUUC-Rno-105123 Rattus norvegicus 47.87 5.00e-119 419.00
IUUC-Sce-106208 Saccharomyces cerevisiae 26.12 9.00e-35 139.00
IUUC-Sha-107010 Sarcophilus harrisii 47.87 4.00e-119 419.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 32.97 8.00e-69 252.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 51.32 9.00e-118 415.00
IUUC-Sar-113309 Sorex araneus 46.68 3.00e-112 396.00
IUUC-Sre-115003 Sporisorium reilianum 59.96 3.00e-157 546.00
IUUC-Ssc-116148 Sus scrofa 47.87 5.00e-119 419.00
IUUC-Tgu-117299 Taeniopygia guttata 47.43 7.00e-119 418.00
IUUC-Tru-117721 Takifugu rubripes 47.20 3.00e-118 416.00
IUUC-Tsy-119493 Tarsius syrichta 47.43 3.00e-117 413.00
IUUC-Tni-120355 Tetraodon nigroviridis 46.53 9.00e-116 408.00
IUUC-Tre-121977 Trichoderma reesei 44.10 8.00e-106 375.00
IUUC-Tvi-122661 Trichoderma virens 46.30 3.00e-106 376.00
IUUC-Tme-127031 Tuber melanosporum 49.03 4.00e-116 409.00
IUUC-Tbe-127492 Tupaia belangeri 44.74 3.00e-58 217.00
IUUC-Ttr-128929 Tursiops truncatus 47.43 6.00e-119 419.00
IUUC-Uma-129347 Ustilago maydis 57.56 5.00e-153 532.00
IUUC-Vda-129837 Verticillium dahliae 49.16 2.00e-108 384.00
IUUC-Vpa-130532 Vicugna pacos 43.11 2.00e-90 323.00
IUUC-Xtr-131985 Xenopus tropicalis 47.65 8.00e-119 418.00
IUUC-Xma-133314 Xiphophorus maculatus 47.43 4.00e-119 419.00
IUUC-Yli-134403 Yarrowia lipolytica 36.48 2.00e-80 291.00
Created Date 25-Jun-2017

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