iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-034239

Ensembl Protein ID

ENSECAP00000020185.1

UniProt Accession

F6V6T6; F6V6T6_HORSE

Protein Name

Non-specific serine/threonine protein kinase

Gene Name

PRKAA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000022617.1	ENSECAT00000024304.1	ENSECAP00000020185.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	39.18	4.00e-96	346.00	IUUC-Spo-108202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Equus caballus

Protein Sequence
(Fasta)

VGKHELTGHK VAVKILNRQK IRSLDVVGKI RREIQNLKLF RHPHIIKLYQ VISTPSDIFM 60
VMEYVSGGEL FDYICKNGRL DEKESRRLFQ QILSGVDYCH RHMVVHRDLK PENVLLDAHM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGGCAAAC ATGAATTGAC TGGGCATAAA GTTGCTGTGA AGATACTCAA TCGCCAGAAG 60
ATTCGAAGCC TCGATGTGGT TGGAAAAATC CGCAGAGAAA TTCAGAACCT CAAGCTTTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF16579--AdenylateSensor
PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0004679--F:AMP-activated protein kinase activity
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0035174--F:histone serine kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0061762--P:CAMKK-AMPK signaling cascade
GO:0042149--P:cellular response to glucose starvation
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0019395--P:fatty acid oxidation
GO:0042593--P:glucose homeostasis
GO:0006006--P:glucose metabolic process
GO:0035556--P:intracellular signal transduction
GO:0008610--P:lipid biosynthetic process
GO:0043066--P:negative regulation of apoptotic process
GO:0050995--P:negative regulation of lipid catabolic process
GO:0032007--P:negative regulation of TOR signaling
GO:0010508--P:positive regulation of autophagy
GO:0010628--P:positive regulation of gene expression
GO:0048643--P:positive regulation of skeletal muscle tissue development
GO:0006468--P:protein phosphorylation
GO:0042752--P:regulation of circadian rhythm
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1901563--P:response to camptothecin
GO:0010332--P:response to gamma radiation
GO:0042542--P:response to hydrogen peroxide
GO:0009411--P:response to UV

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001907	Ailuropoda melanoleuca	99.61	0.00e+00	993.00
IUUC-Atr-002770	Amborella trichopoda	47.68	1.00e-117	416.00
IUUC-Bta-012786	Bos taurus	99.42	0.00e+00	1001.00
IUUC-Cfa-020177	Canis familiaris	99.81	0.00e+00	1002.00
IUUC-Cho-024859	Choloepus hoffmanni	96.80	0.00e+00	988.00
IUUC-Cme-027289	Cyanidioschyzon merolae	45.08	1.00e-101	363.00
IUUC-Dre-027749	Danio rerio	82.81	0.00e+00	888.00
IUUC-Dno-030006	Dasypus novemcinctus	99.42	0.00e+00	992.00
IUUC-Ete-033055	Echinops telfairi	95.65	0.00e+00	1017.00
IUUC-Fca-035754	Felis catus	96.60	0.00e+00	978.00
IUUC-Fal-037363	Ficedula albicollis	94.76	0.00e+00	968.00
IUUC-Gmo-039633	Gadus morhua	82.14	0.00e+00	915.00
IUUC-Gma-042712	Glycine max	47.01	3.00e-117	415.00
IUUC-Ggo-044797	Gorilla gorilla	99.61	0.00e+00	995.00
IUUC-Hsa-045867	Homo sapiens	99.81	0.00e+00	996.00
IUUC-Lch-049623	Latimeria chalumnae	89.75	0.00e+00	914.00
IUUC-Lpe-051392	Leersia perrieri	51.72	1.00e-117	416.00
IUUC-Loc-052362	Lepisosteus oculatus	89.94	0.00e+00	875.00
IUUC-Laf-053799	Loxodonta africana	99.03	0.00e+00	1023.00
IUUC-Mor-057170	Magnaporthe oryzae	50.59	2.00e-95	343.00
IUUC-Mtr-058309	Medicago truncatula	48.05	2.00e-118	419.00
IUUC-Mla-059058	Melampsora laricipopulina	40.50	5.00e-98	351.00
IUUC-Mmr-061761	Microcebus murinus	99.61	0.00e+00	994.00
IUUC-Mlu-068227	Myotis lucifugus	98.65	0.00e+00	997.00
IUUC-Opr-070272	Ochotona princeps	95.27	0.00e+00	970.00
IUUC-Ont-072027	Oreochromis niloticus	83.03	0.00e+00	887.00
IUUC-Oan-073322	Ornithorhynchus anatinus	93.43	0.00e+00	968.00
IUUC-Ocu-074188	Oryctolagus cuniculus	96.21	0.00e+00	977.00
IUUC-Oba-075436	Oryza barthii	47.63	2.00e-118	419.00
IUUC-Obr-076507	Oryza brachyantha	47.53	5.00e-118	417.00
IUUC-Ogu-078349	Oryza glumaepatula	47.63	2.00e-118	419.00
IUUC-Olo-080521	Oryza longistaminata	47.63	2.00e-118	419.00
IUUC-Ome-081630	Oryza meridionalis	47.41	5.00e-118	417.00
IUUC-Opu-083617	Oryza punctata	47.31	1.00e-117	416.00
IUUC-Oru-084252	Oryza rufipogon	47.63	1.00e-118	419.00
IUUC-Osa-085548	Oryza sativa	47.63	1.00e-118	419.00
IUUC-Ola-086366	Oryzias latipes	83.61	0.00e+00	902.00
IUUC-Olu-087861	Ostreococcus lucimarinus	49.63	2.00e-110	392.00
IUUC-Oga-088003	Otolemur garnettii	99.61	0.00e+00	994.00
IUUC-Oar-089933	Ovis aries	99.42	0.00e+00	1001.00
IUUC-Ptr-090718	Pan troglodytes	99.81	0.00e+00	996.00
IUUC-Pan-092526	Papio anubis	99.61	0.00e+00	994.00
IUUC-Psi-094034	Pelodiscus sinensis	93.98	0.00e+00	956.00
IUUC-Ppa-095615	Physcomitrella patens	50.71	3.00e-116	412.00
IUUC-Pfo-097050	Poecilia formosa	82.99	0.00e+00	890.00
IUUC-Pab-098519	Pongo abelii	99.81	0.00e+00	996.00
IUUC-Pop-099781	Populus trichocarpa	53.32	4.00e-119	421.00
IUUC-Pca-101104	Procavia capensis	95.42	0.00e+00	703.00
IUUC-Sha-107603	Sarcophilus harrisii	97.28	0.00e+00	981.00
IUUC-Spo-108202	Schizosaccharomyces pombe	39.59	2.00e-99	356.00
IUUC-Smo-109309	Selaginella moellendorffii	45.61	5.00e-115	407.00
IUUC-Sit-109745	Setaria italica	52.55	3.00e-120	425.00
IUUC-Sar-113521	Sorex araneus	89.53	0.00e+00	866.00
IUUC-Sbi-114764	Sorghum bicolor	47.67	2.00e-121	429.00
IUUC-Ssc-115732	Sus scrofa	99.61	0.00e+00	1000.00
IUUC-Tgu-117190	Taeniopygia guttata	94.17	0.00e+00	961.00
IUUC-Tni-119833	Tetraodon nigroviridis	83.79	0.00e+00	884.00
IUUC-Tre-122070	Trichoderma reesei	49.30	4.00e-97	348.00
IUUC-Tvi-122305	Trichoderma virens	56.27	6.00e-95	341.00
IUUC-Tme-127174	Tuber melanosporum	39.38	3.00e-68	252.00
IUUC-Ttr-129224	Tursiops truncatus	95.27	0.00e+00	989.00
IUUC-Vvi-131649	Vitis vinifera	47.98	8.00e-118	417.00
IUUC-Xma-134082	Xiphophorus maculatus	83.37	0.00e+00	813.00
IUUC-Zma-135621	Zea mays	54.30	1.00e-112	400.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence