iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oan-073322

Ensembl Protein ID

ENSOANP00000028274.1

UniProt Accession

F6YST6; F6YST6_ORNAN

Protein Name

Non-specific serine/threonine protein kinase

Gene Name

PRKAA1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000004087.3	ENSOANT00000032071.1	ENSOANP00000028274.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	49.55	2.00e-111	400.00	IUUC-Ath-007014
UBD/Alpha-Helix/UBA	38.11	1.00e-94	342.00	IUUC-Spo-108202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MKKLSLWKCV AEEVFQIHEI KIIVFQCLLC AKHCTEVWGR YKVGKHELTG HKVAVKILNR 60
QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI FMVMEYVSGG ELFDYICKNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGAAAG TAAAGATGTC CTTACCCCGC TCTTACCCTG CTATTAAACA GAGAGCCTTG 60
GCCGAACCTT TTCAAGCGAT GGACTTTGGG GCAGAAAATG TTTTATCCAT TCCTTACGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF16579--AdenylateSensor
PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0004679--F:AMP-activated protein kinase activity
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0035174--F:histone serine kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0061762--P:CAMKK-AMPK signaling cascade
GO:0042149--P:cellular response to glucose starvation
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0019395--P:fatty acid oxidation
GO:0042593--P:glucose homeostasis
GO:0006006--P:glucose metabolic process
GO:0035556--P:intracellular signal transduction
GO:0008610--P:lipid biosynthetic process
GO:0043066--P:negative regulation of apoptotic process
GO:0050995--P:negative regulation of lipid catabolic process
GO:0032007--P:negative regulation of TOR signaling
GO:0010508--P:positive regulation of autophagy
GO:0010628--P:positive regulation of gene expression
GO:0048643--P:positive regulation of skeletal muscle tissue development
GO:0006468--P:protein phosphorylation
GO:0042752--P:regulation of circadian rhythm
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1901563--P:response to camptothecin
GO:0010332--P:response to gamma radiation
GO:0042542--P:response to hydrogen peroxide
GO:0009411--P:response to UV

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000134	Aegilops tauschii	43.74	5.00e-109	387.00
IUUC-Aml-001907	Ailuropoda melanoleuca	88.17	0.00e+00	964.00
IUUC-Atr-002770	Amborella trichopoda	45.95	7.00e-115	406.00
IUUC-Apl-003395	Anas platyrhynchos	71.72	0.00e+00	780.00
IUUC-Aca-004480	Anolis carolinensis	68.86	0.00e+00	757.00
IUUC-Aly-006289	Arabidopsis lyrata	49.88	1.00e-113	402.00
IUUC-Ath-007014	Arabidopsis thaliana	50.35	4.00e-115	407.00
IUUC-Ago-007957	Ashbya gossypii	39.70	5.00e-105	374.00
IUUC-Acl-008103	Aspergillus clavatus	57.19	1.00e-92	333.00
IUUC-Afl-008555	Aspergillus flavus	56.47	2.00e-92	333.00
IUUC-Afu-008949	Aspergillus fumigatus	56.83	3.00e-92	332.00
IUUC-Ani-009408	Aspergillus nidulans	58.80	1.00e-92	333.00
IUUC-Ang-009551	Aspergillus niger	57.19	2.00e-93	335.00
IUUC-Aor-010176	Aspergillus oryzae	56.47	2.00e-92	333.00
IUUC-Ate-010287	Aspergillus terreus	56.83	3.00e-92	332.00
IUUC-Ame-011019	Astyanax mexicanus	68.18	0.00e+00	768.00
IUUC-Bgr-012045	Blumeria graminis	40.12	2.00e-91	329.00
IUUC-Bta-012786	Bos taurus	88.17	0.00e+00	966.00
IUUC-Bci-013774	Botrytis cinerea	55.76	1.00e-92	333.00
IUUC-Bdi-014319	Brachypodium distachyon	45.45	3.00e-112	398.00
IUUC-Bol-016242	Brassica oleracea	46.79	1.00e-116	412.00
IUUC-Bra-016750	Brassica rapa	50.70	7.00e-117	413.00
IUUC-Cel-018518	Caenorhabditis elegans	54.95	7.00e-164	570.00
IUUC-Cja-019386	Callithrix jacchus	71.25	0.00e+00	784.00
IUUC-Cfa-020177	Canis familiaris	92.46	0.00e+00	967.00
IUUC-Cpo-021805	Cavia porcellus	68.78	0.00e+00	779.00
IUUC-Cre-022915	Chlamydomonas reinhardtii	52.48	5.00e-88	317.00
IUUC-Csa-024267	Chlorocebus sabaeus	68.73	0.00e+00	778.00
IUUC-Cho-024859	Choloepus hoffmanni	93.80	0.00e+00	974.00
IUUC-Cin-025550	Ciona intestinalis	55.92	7.00e-175	606.00
IUUC-Csv-026139	Ciona savignyi	55.68	2.00e-177	614.00
IUUC-Cne-027044	Cryptococcus neoformans	44.07	4.00e-96	345.00
IUUC-Cme-027289	Cyanidioschyzon merolae	43.41	1.00e-99	356.00
IUUC-Dre-027749	Danio rerio	77.91	0.00e+00	879.00
IUUC-Dno-030006	Dasypus novemcinctus	88.00	0.00e+00	962.00
IUUC-Dor-030578	Dipodomys ordii	68.61	0.00e+00	779.00
IUUC-Dse-031507	Dothistroma septosporum	57.19	8.00e-96	344.00
IUUC-Dme-031704	Drosophila melanogaster	54.75	5.00e-171	593.00
IUUC-Ete-033055	Echinops telfairi	93.02	0.00e+00	1001.00
IUUC-Eca-034239	Equus caballus	93.43	0.00e+00	963.00
IUUC-Fca-035754	Felis catus	88.81	0.00e+00	966.00
IUUC-Fal-037363	Ficedula albicollis	91.90	0.00e+00	942.00
IUUC-Fox-038073	Fusarium oxysporum	55.79	3.00e-93	335.00
IUUC-Fso-038236	Fusarium solani	56.12	4.00e-90	325.00
IUUC-Gmo-039633	Gadus morhua	77.74	0.00e+00	908.00
IUUC-Ggr-039987	Gaeumannomyces graminis	47.93	4.00e-94	338.00
IUUC-Gga-040546	Gallus gallus	69.08	0.00e+00	780.00
IUUC-Gac-041822	Gasterosteus aculeatus	67.49	0.00e+00	746.00
IUUC-Gma-042712	Glycine max	45.29	3.00e-114	404.00
IUUC-Ggo-044797	Gorilla gorilla	88.35	0.00e+00	964.00
IUUC-Hsa-045867	Homo sapiens	88.17	0.00e+00	963.00
IUUC-Hvu-047406	Hordeum vulgare	44.95	3.00e-112	398.00
IUUC-Itr-048134	Ictidomys tridecemlineatus	68.96	0.00e+00	782.00
IUUC-Kpa-049190	Komagataella pastoris	42.05	1.00e-107	382.00
IUUC-Lch-049623	Latimeria chalumnae	85.37	0.00e+00	900.00
IUUC-Lpe-051392	Leersia perrieri	50.23	3.00e-116	411.00
IUUC-Loc-052362	Lepisosteus oculatus	84.23	0.00e+00	871.00
IUUC-Lma-053054	Leptosphaeria maculans	49.05	6.00e-97	348.00
IUUC-Laf-053799	Loxodonta africana	88.17	0.00e+00	995.00
IUUC-Mcc-055862	Macaca mulatta	68.96	0.00e+00	784.00
IUUC-Mor-057170	Magnaporthe oryzae	48.20	2.00e-94	339.00
IUUC-Mpo-057302	Magnaporthe poae	47.93	2.00e-94	339.00
IUUC-Mtr-058309	Medicago truncatula	46.27	6.00e-115	407.00
IUUC-Mla-059058	Melampsora laricipopulina	39.96	1.00e-96	346.00
IUUC-Mga-059206	Meleagris gallopavo	71.61	0.00e+00	772.00
IUUC-Mvi-060337	Microbotryum violaceum	47.35	1.00e-91	330.00
IUUC-Mmr-061761	Microcebus murinus	88.17	0.00e+00	964.00
IUUC-Mdo-062160	Monodelphis domestica	69.01	0.00e+00	775.00
IUUC-Mmu-063406	Mus musculus	69.08	0.00e+00	777.00
IUUC-Mac-064518	Musa acuminata	47.45	2.00e-108	386.00
IUUC-Mpu-066326	Mustela putorius furo	71.67	0.00e+00	776.00
IUUC-Mlu-068227	Myotis lucifugus	93.25	0.00e+00	963.00
IUUC-Nfi-068493	Neosartorya fischeri	56.83	2.00e-92	332.00
IUUC-Ncr-068665	Neurospora crassa	39.80	6.00e-96	344.00
IUUC-Nle-070158	Nomascus leucogenys	68.96	0.00e+00	784.00
IUUC-Opr-070272	Ochotona princeps	87.83	0.00e+00	963.00
IUUC-Ont-072027	Oreochromis niloticus	79.66	0.00e+00	884.00
IUUC-Ocu-074188	Oryctolagus cuniculus	92.88	0.00e+00	956.00
IUUC-Oba-075436	Oryza barthii	45.71	4.00e-117	414.00
IUUC-Obr-076507	Oryza brachyantha	45.82	5.00e-117	414.00
IUUC-Ogl-077718	Oryza glaberrima	50.23	3.00e-113	401.00
IUUC-Ogu-078349	Oryza glumaepatula	45.86	5.00e-117	414.00
IUUC-Oin-079889	Oryza indica	45.92	2.00e-113	402.00
IUUC-Olo-080521	Oryza longistaminata	45.71	4.00e-117	414.00
IUUC-Ome-081630	Oryza meridionalis	45.51	7.00e-117	413.00
IUUC-Oni-082211	Oryza nivara	45.71	1.00e-117	416.00
IUUC-Opu-083617	Oryza punctata	45.36	3.00e-116	411.00
IUUC-Oru-084252	Oryza rufipogon	45.71	4.00e-117	414.00
IUUC-Osa-085548	Oryza sativa	45.71	4.00e-117	414.00
IUUC-Ola-086366	Oryzias latipes	79.76	0.00e+00	898.00
IUUC-Olu-087861	Ostreococcus lucimarinus	47.78	2.00e-108	385.00
IUUC-Oga-088003	Otolemur garnettii	88.35	0.00e+00	965.00
IUUC-Oar-089933	Ovis aries	88.17	0.00e+00	966.00
IUUC-Ptr-090718	Pan troglodytes	88.17	0.00e+00	963.00
IUUC-Pan-092526	Papio anubis	88.35	0.00e+00	964.00
IUUC-Psi-094034	Pelodiscus sinensis	86.83	0.00e+00	939.00
IUUC-Pno-095030	Phaeosphaeria nodorum	57.19	7.00e-96	343.00
IUUC-Ppa-095615	Physcomitrella patens	48.86	2.00e-113	401.00
IUUC-Pfo-097050	Poecilia formosa	78.16	0.00e+00	881.00
IUUC-Pab-098519	Pongo abelii	88.17	0.00e+00	963.00
IUUC-Pop-099781	Populus trichocarpa	50.46	4.00e-116	410.00
IUUC-Pca-101104	Procavia capensis	87.98	0.00e+00	720.00
IUUC-Ppe-101642	Prunus persica	47.29	8.00e-114	403.00
IUUC-Pva-102470	Pteropus vampyrus	68.90	0.00e+00	778.00
IUUC-Pgr-103406	Puccinia graminis	56.98	2.00e-82	299.00
IUUC-Ptt-103713	Puccinia triticina	50.77	4.00e-66	245.00
IUUC-Pte-104259	Pyrenophora teres	53.90	5.00e-96	345.00
IUUC-Pyt-104752	Pyrenophora triticirepentis	54.22	1.00e-96	347.00
IUUC-Rno-104960	Rattus norvegicus	69.08	0.00e+00	780.00
IUUC-Sce-106290	Saccharomyces cerevisiae	39.29	2.00e-104	372.00
IUUC-Sha-107603	Sarcophilus harrisii	89.22	0.00e+00	969.00
IUUC-Sja-107772	Schizosaccharomyces japonicus	49.85	2.00e-99	355.00
IUUC-Spo-108202	Schizosaccharomyces pombe	38.11	6.00e-98	350.00
IUUC-Ssl-108535	Sclerotinia sclerotiorum	55.04	2.00e-91	329.00
IUUC-Smo-109309	Selaginella moellendorffii	44.58	3.00e-113	401.00
IUUC-Sit-109745	Setaria italica	46.36	9.00e-119	419.00
IUUC-Sly-110890	Solanum lycopersicum	50.23	1.00e-114	406.00
IUUC-Stu-112144	Solanum tuberosum	43.83	2.00e-108	385.00
IUUC-Sar-113521	Sorex araneus	95.44	0.00e+00	811.00
IUUC-Sbi-114764	Sorghum bicolor	45.98	8.00e-120	423.00
IUUC-Sre-115141	Sporisorium reilianum	59.23	4.00e-102	365.00
IUUC-Ssc-115732	Sus scrofa	93.43	0.00e+00	964.00
IUUC-Tgu-117190	Taeniopygia guttata	91.53	0.00e+00	937.00
IUUC-Tru-118735	Takifugu rubripes	67.13	0.00e+00	763.00
IUUC-Tsy-119503	Tarsius syrichta	69.02	0.00e+00	731.00
IUUC-Tni-119833	Tetraodon nigroviridis	78.66	0.00e+00	877.00
IUUC-Tca-121386	Theobroma cacao	45.82	2.00e-115	408.00
IUUC-Tre-122070	Trichoderma reesei	49.29	3.00e-95	342.00
IUUC-Tvi-122305	Trichoderma virens	55.40	2.00e-92	333.00
IUUC-Tae-123515	Triticum aestivum	45.62	4.00e-117	414.00
IUUC-Tur-126416	Triticum urartu	44.86	1.00e-111	395.00
IUUC-Tme-127174	Tuber melanosporum	39.45	3.00e-66	245.00
IUUC-Tbe-127791	Tupaia belangeri	72.65	2.00e-99	354.00
IUUC-Ttr-129224	Tursiops truncatus	87.83	0.00e+00	982.00
IUUC-Uma-129372	Ustilago maydis	59.30	4.00e-101	362.00
IUUC-Vda-129819	Verticillium dahliae	50.18	8.00e-79	287.00
IUUC-Vpa-130220	Vicugna pacos	71.24	0.00e+00	768.00
IUUC-Vvi-131649	Vitis vinifera	46.23	6.00e-115	407.00
IUUC-Xtr-132954	Xenopus tropicalis	68.84	0.00e+00	780.00
IUUC-Xma-134082	Xiphophorus maculatus	78.57	0.00e+00	811.00
IUUC-Yli-134422	Yarrowia lipolytica	41.28	2.00e-106	379.00
IUUC-Zma-135621	Zea mays	52.39	3.00e-111	395.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence