iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053710

Ensembl Protein ID

ENSLAFP00000004253.3

UniProt Accession

G3SVI4; G3SVI4_LOXAF

Protein Name

Uncharacterized protein

Gene Name

LATS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000005083.3	ENSLAFT00000005083.3	ENSLAFP00000004253.3
ENSLAFG00000005083.3	ENSLAFT00000026465.1	ENSLAFP00000021021.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	1.50e-06	28.5	103	140

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLl 39
           + ++ + l++ GFd++ ++qaL+ + n ++eaA+e++ 
   Q: 103  NPQMFQDLQAAGFDEDMVIQALQKTnNRSIEAAIEFIS 140
           67899*******************99*********975 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MKRSEKPEGY RQMRPKTFPA SNYTGSSRQM LQEIRESLRN LSKPSDTAKA EHNMSKMSAE 60
DPRQVRNPPK FGTYHKALQE IRNSLLPFAN ETSSSSRSTS EVNPQMFQDL QAAGFDEDMV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGAGGA GTGAAAAGCC AGAAGGATAT AGACAAATGA GGCCTAAGAC CTTTCCTGCC 60
AGTAACTATA CTGGCAGCAG CCGGCAAATG TTGCAAGAAA TTCGGGAATC TCTTAGGAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR000961--AGC-kinase_C
IPR011009--Kinase-like_dom
IPR028741--LATS1/Warts
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS51285--AGC_KINASE_CTER
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF00069--Pkinase
PF00627--UBA

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000922--C:spindle pole
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0051220--P:cytoplasmic sequestering of protein
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0035329--P:hippo signaling
GO:0009755--P:hormone-mediated signaling pathway
GO:0001827--P:inner cell mass cell fate commitment
GO:0001828--P:inner cell mass cellular morphogenesis
GO:0030216--P:keratinocyte differentiation
GO:0060644--P:mammary gland epithelial cell differentiation
GO:0007067--P:mitotic nuclear division
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0030833--P:regulation of actin filament polymerization
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000819--P:sister chromatid segregation

KEGG

lav:100670670

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001895	Ailuropoda melanoleuca	93.91	0.00e+00	1950.00
IUUC-Apl-003278	Anas platyrhynchos	82.89	0.00e+00	1765.00
IUUC-Aca-005319	Anolis carolinensis	80.30	0.00e+00	1679.00
IUUC-Ame-011324	Astyanax mexicanus	63.62	0.00e+00	1259.00
IUUC-Bta-013438	Bos taurus	93.37	0.00e+00	1906.00
IUUC-Cel-018517	Caenorhabditis elegans	49.89	1.00e-127	451.00
IUUC-Cja-019072	Callithrix jacchus	93.90	0.00e+00	1969.00
IUUC-Cfa-021267	Canis familiaris	94.35	0.00e+00	1974.00
IUUC-Cpo-021496	Cavia porcellus	90.57	0.00e+00	1655.00
IUUC-Csa-023255	Chlorocebus sabaeus	93.90	0.00e+00	1948.00
IUUC-Cho-024461	Choloepus hoffmanni	98.40	0.00e+00	788.00
IUUC-Cin-025264	Ciona intestinalis	63.68	6.00e-141	493.00
IUUC-Dre-028034	Danio rerio	82.31	0.00e+00	922.00
IUUC-Dno-029888	Dasypus novemcinctus	91.52	0.00e+00	1954.00
IUUC-Dor-030144	Dipodomys ordii	84.36	0.00e+00	1661.00
IUUC-Dme-031656	Drosophila melanogaster	73.43	0.00e+00	655.00
IUUC-Ete-032813	Echinops telfairi	94.08	0.00e+00	1231.00
IUUC-Eca-033781	Equus caballus	94.35	0.00e+00	1935.00
IUUC-Eeu-035007	Erinaceus europaeus	91.08	0.00e+00	1914.00
IUUC-Fca-036142	Felis catus	89.49	0.00e+00	1842.00
IUUC-Fal-036626	Ficedula albicollis	82.28	0.00e+00	1767.00
IUUC-Gmo-038688	Gadus morhua	86.46	0.00e+00	784.00
IUUC-Gga-040553	Gallus gallus	83.23	0.00e+00	1772.00
IUUC-Gac-042031	Gasterosteus aculeatus	63.64	0.00e+00	1232.00
IUUC-Ggo-045242	Gorilla gorilla	94.00	0.00e+00	1952.00
IUUC-Hsa-046081	Homo sapiens	93.90	0.00e+00	1950.00
IUUC-Itr-048668	Ictidomys tridecemlineatus	94.12	0.00e+00	1676.00
IUUC-Lch-049425	Latimeria chalumnae	76.87	0.00e+00	1630.00
IUUC-Loc-052418	Lepisosteus oculatus	66.70	0.00e+00	1325.00
IUUC-Mcc-055079	Macaca mulatta	93.90	0.00e+00	1946.00
IUUC-Mga-059713	Meleagris gallopavo	82.65	0.00e+00	1770.00
IUUC-Mmr-061728	Microcebus murinus	94.96	0.00e+00	1981.00
IUUC-Mdo-061942	Monodelphis domestica	87.01	0.00e+00	1790.00
IUUC-Mmu-063504	Mus musculus	90.81	0.00e+00	1867.00
IUUC-Mpu-066034	Mustela putorius furo	93.55	0.00e+00	1938.00
IUUC-Mlu-067986	Myotis lucifugus	93.55	0.00e+00	1941.00
IUUC-Nle-069202	Nomascus leucogenys	93.90	0.00e+00	1950.00
IUUC-Opr-070801	Ochotona princeps	93.49	0.00e+00	1264.00
IUUC-Ont-072487	Oreochromis niloticus	60.31	0.00e+00	1213.00
IUUC-Oan-073128	Ornithorhynchus anatinus	86.07	0.00e+00	1583.00
IUUC-Ocu-073998	Oryctolagus cuniculus	95.15	0.00e+00	1428.00
IUUC-Ola-086858	Oryzias latipes	60.92	0.00e+00	1161.00
IUUC-Oga-088874	Otolemur garnettii	92.42	0.00e+00	1903.00
IUUC-Oar-089236	Ovis aries	93.47	0.00e+00	1910.00
IUUC-Ptr-091425	Pan troglodytes	94.26	0.00e+00	1961.00
IUUC-Pan-091851	Papio anubis	94.00	0.00e+00	1947.00
IUUC-Psi-093825	Pelodiscus sinensis	84.36	0.00e+00	1462.00
IUUC-Pfo-096326	Poecilia formosa	61.03	0.00e+00	1159.00
IUUC-Pab-097815	Pongo abelii	93.99	0.00e+00	1954.00
IUUC-Pva-102836	Pteropus vampyrus	92.23	0.00e+00	1847.00
IUUC-Ptt-103762	Puccinia triticina	37.78	5.00e-92	332.00
IUUC-Rno-106053	Rattus norvegicus	91.25	0.00e+00	1898.00
IUUC-Sha-106843	Sarcophilus harrisii	87.50	0.00e+00	1840.00
IUUC-Sar-113649	Sorex araneus	91.89	0.00e+00	1513.00
IUUC-Ssc-115486	Sus scrofa	97.38	0.00e+00	860.00
IUUC-Tgu-116903	Taeniopygia guttata	82.28	0.00e+00	1752.00
IUUC-Tru-118760	Takifugu rubripes	63.88	0.00e+00	1261.00
IUUC-Tsy-119361	Tarsius syrichta	93.70	0.00e+00	1679.00
IUUC-Tni-120058	Tetraodon nigroviridis	82.20	0.00e+00	870.00
IUUC-Tbe-127681	Tupaia belangeri	94.35	0.00e+00	1546.00
IUUC-Ttr-128652	Tursiops truncatus	94.91	0.00e+00	1645.00
IUUC-Vpa-130538	Vicugna pacos	93.11	0.00e+00	1913.00
IUUC-Xtr-132895	Xenopus tropicalis	71.96	0.00e+00	1249.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence