iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000221926.11	ENST00000416464.6	ENSP00000399918.2
ENSG00000221926.11	ENST00000578237.5	ENSP00000463188.1
ENSG00000221926.11	ENST00000579219.5	ENSP00000463639.1
ENSG00000221926.11	ENST00000580110.5	ENSP00000464072.1
ENSG00000221926.11	ENST00000578744.5	ENSP00000465907.1
ENSG00000221926.11	ENST00000494759.1	ENSP00000465169.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	PHOSIDA	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	77.17	0.00e+00	853.00	IUUC-Mmu-064112

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Homo sapiens

Functional Description
(View)

Belongs to the TRIM/RBCC family.

Protein Sequence
(Fasta)

MAELDLMAPG PLPRATAQPP APLSPDSGSP SPDSGSASPV EEEDVGSSEK LGRETEEQDS 60
DSAEQGDPAG EGKEVLCDFC LDDTRRVKAV KSCLTCMVNY CEEHLQPHQV NIKLQSHLLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTCCGGCC CCTTTCTCTG GAGGATCTCC GCGCGTGGCG AGTCTGTGTC CTCCCTGTCC 60
CCCAGAGCAG ACACCCTCTC TGTGTCTGGA CCGGGGAGGA GCAGACGCTG GACAGGGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0016605--C:PML body
GO:0003677--F:DNA binding
GO:0019966--F:interleukin-1 binding
GO:0032089--F:NACHT domain binding
GO:0008270--F:zinc ion binding
GO:0043966--P:histone H3 acetylation
GO:0043967--P:histone H4 acetylation
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0045618--P:positive regulation of keratinocyte differentiation
GO:0048386--P:positive regulation of retinoic acid receptor signaling pathway
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0060416--P:response to growth hormone
GO:0046683--P:response to organophosphorus
GO:0032526--P:response to retinoic acid

KEGG

hsa:10626

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004831	Anolis carolinensis	58.19	6.00e-165	574.00
IUUC-Ame-011828	Astyanax mexicanus	41.68	6.00e-113	401.00
IUUC-Cel-018330	Caenorhabditis elegans	35.14	9.80e-01	28.50
IUUC-Cfa-021057	Canis familiaris	26.81	3.00e-35	143.00
IUUC-Csa-023023	Chlorocebus sabaeus	93.97	0.00e+00	1062.00
IUUC-Dre-028527	Danio rerio	47.56	6.00e-122	431.00
IUUC-Dno-029983	Dasypus novemcinctus	76.72	0.00e+00	815.00
IUUC-Dor-030707	Dipodomys ordii	72.06	0.00e+00	769.00
IUUC-Eeu-035116	Erinaceus europaeus	83.29	7.00e-178	616.00
IUUC-Fca-036509	Felis catus	79.12	0.00e+00	814.00
IUUC-Gmo-038676	Gadus morhua	49.69	3.00e-136	478.00
IUUC-Gac-042349	Gasterosteus aculeatus	50.10	3.00e-134	472.00
IUUC-Itr-048514	Ictidomys tridecemlineatus	76.99	0.00e+00	817.00
IUUC-Lch-050316	Latimeria chalumnae	50.11	2.00e-128	452.00
IUUC-Loc-052345	Lepisosteus oculatus	50.61	3.00e-141	495.00
IUUC-Laf-054026	Loxodonta africana	73.60	0.00e+00	775.00
IUUC-Meu-055918	Macropus eugenii	69.19	2.00e-65	241.00
IUUC-Mtr-057668	Medicago truncatula	33.33	7.00e-03	33.90
IUUC-Mla-058986	Melampsora laricipopulina	35.56	1.20e-01	31.20
IUUC-Mmr-061463	Microcebus murinus	80.47	0.00e+00	832.00
IUUC-Mdo-062213	Monodelphis domestica	63.67	0.00e+00	630.00
IUUC-Mmu-064112	Mus musculus	76.46	0.00e+00	840.00
IUUC-Mpu-066313	Mustela putorius furo	79.96	0.00e+00	855.00
IUUC-Nle-069328	Nomascus leucogenys	94.72	1.00e-165	575.00
IUUC-Ont-071376	Oreochromis niloticus	49.00	2.00e-130	459.00
IUUC-Oan-072819	Ornithorhynchus anatinus	72.22	5.00e-121	427.00
IUUC-Ola-086649	Oryzias latipes	60.47	1.00e-64	238.00
IUUC-Oar-089659	Ovis aries	73.06	0.00e+00	789.00
IUUC-Ptr-091335	Pan troglodytes	93.79	0.00e+00	981.00
IUUC-Pan-092676	Papio anubis	94.33	0.00e+00	1066.00
IUUC-Psi-093388	Pelodiscus sinensis	55.42	2.00e-170	592.00
IUUC-Pma-094734	Petromyzon marinus	26.00	1.00e-26	114.00
IUUC-Pno-095021	Phaeosphaeria nodorum	32.61	3.20e-01	30.80
IUUC-Pfo-096093	Poecilia formosa	47.93	1.00e-127	450.00
IUUC-Pab-098339	Pongo abelii	98.05	0.00e+00	1068.00
IUUC-Rno-105051	Rattus norvegicus	75.27	0.00e+00	820.00
IUUC-Sar-113179	Sorex araneus	82.61	1.00e-176	612.00
IUUC-Ssc-115658	Sus scrofa	26.71	8.00e-35	142.00
IUUC-Tru-118333	Takifugu rubripes	50.61	9.00e-140	490.00
IUUC-Tsy-119001	Tarsius syrichta	88.26	5.00e-156	544.00
IUUC-Tni-119728	Tetraodon nigroviridis	50.10	1.00e-135	476.00
IUUC-Ttr-128416	Tursiops truncatus	79.22	0.00e+00	682.00
IUUC-Vpa-130818	Vicugna pacos	71.73	0.00e+00	755.00
IUUC-Xtr-132369	Xenopus tropicalis	50.91	1.00e-132	466.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence