iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046201

UUCD1 version

UUC-HoS-00250

Ensembl Protein ID

ENSP00000427223.1

UniProt Accession

Q8TCQ1; D3DP29; Q9NWR0; MARH1_HUMAN

Genbank Protein ID

BAA91319.1; CAD28529.1; EAX04835.1

Protein Name

E3 ubiquitin-protein ligase MARCH1; Membrane-associated RING finger protein 1; Membrane-associated RING-CH protein I; RING finger protein 171; RING-type E3 ubiquitin transferase MARCH1

Genbank Nucleotide ID

AK000675; AL713759; CH471056

Gene Name

MARCH1; RNF171

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000145416.13	ENST00000503008.5	ENSP00000427223.1
ENSG00000145416.13	ENST00000514618.5	ENSP00000421322.1
ENSG00000145416.13	ENST00000339875.9	ENSP00000345676.5
ENSG00000145416.13	ENST00000510786.1	ENSP00000424089.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
Mentha
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19666567

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	4	9.7	80	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf.kdgplvlpCgHv....f.hadClqkwpglknssskefrCPlCr 46
           C iC+++  ++ pl++pC  +    f h++Cl++w     +ss +  C lC+
   Q: 80   CRICHCEGdEESPLITPCRCTgtlrFvHQSCLHQW----IKSSDTRCCELCK 127
           ****88774444******876778855********....8899999*****6 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.

Protein Sequence
(Fasta)

MLGWCEAIAR NPHRIPNNTR TPEISGDLAD ASQTSTLNEK SPGRSASRSS NISKASSPTT 60
GTAPRSQSRL SVCPSTQDIC RICHCEGDEE SPLITPCRCT GTLRFVHQSC LHQWIKSSDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGGAGGGG AGAGGACTGG GGAGCCGAGC CAGAGCCGGG CTGCCTGCCA CCCGGCTGCT 60
CGTCCGCTAG CTGGGGAGGA GCGCTCCACC CGCAACTGAC AAAGGATGGG AGAATGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0391--Immunity
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0031901--C:early endosome membrane
GO:0005789--C:endoplasmic reticulum membrane
GO:0005768--C:endosome
GO:0016021--C:integral component of membrane
GO:0031902--C:late endosome membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0005886--C:plasma membrane
GO:0032588--C:trans-Golgi network membrane
GO:0042287--F:MHC protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002495--P:antigen processing and presentation of peptide antigen via MHC class II
GO:0006955--P:immune response
GO:0000209--P:protein polyubiquitination

KEGG

hsa:55016

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001621	Ailuropoda melanoleuca	96.89	5.00e-156	543.00
IUUC-Aca-004316	Anolis carolinensis	88.26	5.00e-149	520.00
IUUC-Cja-019593	Callithrix jacchus	98.62	1.00e-157	548.00
IUUC-Cfa-020376	Canis familiaris	97.79	9.00e-146	509.00
IUUC-Cpo-021447	Cavia porcellus	96.19	4.00e-154	537.00
IUUC-Cho-024995	Choloepus hoffmanni	99.24	4.00e-74	270.00
IUUC-Cin-025566	Ciona intestinalis	44.35	8.00e-17	80.50
IUUC-Dor-030770	Dipodomys ordii	77.16	1.00e-114	405.00
IUUC-Eeu-034876	Erinaceus europaeus	94.12	3.00e-164	570.00
IUUC-Fca-035915	Felis catus	97.92	2.00e-157	547.00
IUUC-Gga-041073	Gallus gallus	88.97	3.00e-152	530.00
IUUC-Ggo-045247	Gorilla gorilla	99.65	6.00e-160	556.00
IUUC-Lch-049814	Latimeria chalumnae	88.48	3.00e-115	407.00
IUUC-Mcc-055170	Macaca mulatta	98.96	9.00e-159	552.00
IUUC-Meu-056594	Macropus eugenii	75.79	2.00e-64	238.00
IUUC-Mga-059662	Meleagris gallopavo	88.54	1.00e-130	458.00
IUUC-Mmr-060572	Microcebus murinus	98.96	9.00e-159	552.00
IUUC-Mdo-062427	Monodelphis domestica	92.77	7.00e-131	459.00
IUUC-Mmu-063388	Mus musculus	95.50	1.00e-154	538.00
IUUC-Nle-069120	Nomascus leucogenys	99.65	6.00e-160	556.00
IUUC-Oan-072984	Ornithorhynchus anatinus	93.08	1.00e-161	561.00
IUUC-Ocu-074267	Oryctolagus cuniculus	95.50	2.00e-154	537.00
IUUC-Obr-076417	Oryza brachyantha	29.22	6.00e-10	58.20
IUUC-Ptr-090476	Pan troglodytes	99.31	2.00e-158	551.00
IUUC-Pan-092390	Papio anubis	99.13	1.00e-136	479.00
IUUC-Psi-093584	Pelodiscus sinensis	89.27	2.00e-152	531.00
IUUC-Pca-100362	Procavia capensis	71.97	2.00e-105	375.00
IUUC-Rno-106041	Rattus norvegicus	95.24	3.00e-132	464.00
IUUC-Sha-107488	Sarcophilus harrisii	92.73	2.00e-148	518.00
IUUC-Sar-113258	Sorex araneus	95.20	4.00e-142	497.00
IUUC-Sbi-113840	Sorghum bicolor	29.68	6.00e-10	57.80
IUUC-Tgu-116539	Taeniopygia guttata	87.24	6.00e-150	523.00
IUUC-Tsy-119324	Tarsius syrichta	97.93	7.00e-156	542.00
IUUC-Tbe-127567	Tupaia belangeri	93.51	4.00e-130	456.00
IUUC-Ttr-129098	Tursiops truncatus	92.07	3.00e-134	470.00
IUUC-Vpa-130287	Vicugna pacos	75.43	3.00e-108	384.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence