iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000025184.1	ENSFCAT00000026331.1	ENSFCAP00000017051.1
ENSFCAG00000025184.1	ENSFCAT00000022344.1	ENSFCAP00000020804.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.20e-135	449.9	589	921

Active Site

Position(s)	Description	Evidence
890	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 589  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 676
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 677  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 762
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 763  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 850
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 851  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 921
           *********************************************************************96 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MATASPRSDT SNNHSGRSQL QVTVSSAKLK RKKNWFGTAV YTEVVVDGEI KKTAKSSSSS 60
NPKWDEQLTV NVTPQTTLEF RVWSHYTLKA DALLGRATID LKQALLIHNR KLERVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACTG CTTCACCACG TTCTGATACT AGTAATAACC ACAGTGGGAG GTCACAGTTA 60
CAGGTAACTG GTAAGTTATT TTCATAATAA CTTAAAATAG CAATTCCCTG CTGAACCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	94.79	0.00e+00	1780.00
IUUC-Apl-003310	Anas platyrhynchos	82.87	0.00e+00	1533.00
IUUC-Aca-005388	Anolis carolinensis	79.19	0.00e+00	1434.00
IUUC-Bta-012857	Bos taurus	92.41	0.00e+00	1701.00
IUUC-Cel-018299	Caenorhabditis elegans	67.36	0.00e+00	842.00
IUUC-Cja-019448	Callithrix jacchus	93.93	0.00e+00	1772.00
IUUC-Cfa-020728	Canis familiaris	95.88	0.00e+00	1800.00
IUUC-Cpo-021635	Cavia porcellus	88.23	0.00e+00	1669.00
IUUC-Csa-023805	Chlorocebus sabaeus	96.78	0.00e+00	1358.00
IUUC-Cho-024943	Choloepus hoffmanni	83.02	0.00e+00	1204.00
IUUC-Cin-025212	Ciona intestinalis	73.88	0.00e+00	909.00
IUUC-Csv-026256	Ciona savignyi	72.84	0.00e+00	904.00
IUUC-Dre-028245	Danio rerio	72.95	0.00e+00	1234.00
IUUC-Dno-029618	Dasypus novemcinctus	94.14	0.00e+00	1751.00
IUUC-Dor-030665	Dipodomys ordii	76.82	0.00e+00	1139.00
IUUC-Dme-032041	Drosophila melanogaster	70.13	0.00e+00	904.00
IUUC-Ete-032779	Echinops telfairi	95.25	0.00e+00	1122.00
IUUC-Eca-033313	Equus caballus	91.97	0.00e+00	1685.00
IUUC-Eeu-035259	Erinaceus europaeus	84.71	0.00e+00	1553.00
IUUC-Fal-037335	Ficedula albicollis	81.79	0.00e+00	1506.00
IUUC-Gmo-039172	Gadus morhua	86.80	0.00e+00	1055.00
IUUC-Gga-040246	Gallus gallus	82.59	0.00e+00	1530.00
IUUC-Gac-042211	Gasterosteus aculeatus	91.30	0.00e+00	1164.00
IUUC-Ggo-045001	Gorilla gorilla	93.46	0.00e+00	1559.00
IUUC-Hsa-046544	Homo sapiens	93.82	0.00e+00	1767.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	91.91	0.00e+00	1693.00
IUUC-Lch-050398	Latimeria chalumnae	77.16	0.00e+00	1398.00
IUUC-Loc-052116	Lepisosteus oculatus	75.54	0.00e+00	1379.00
IUUC-Laf-053551	Loxodonta africana	91.22	0.00e+00	1671.00
IUUC-Meu-056455	Macropus eugenii	68.77	0.00e+00	834.00
IUUC-Mga-059986	Meleagris gallopavo	82.72	0.00e+00	1541.00
IUUC-Mmr-060945	Microcebus murinus	90.68	0.00e+00	1686.00
IUUC-Mdo-063024	Monodelphis domestica	82.00	0.00e+00	1471.00
IUUC-Mmu-063202	Mus musculus	89.80	0.00e+00	1637.00
IUUC-Mpu-065773	Mustela putorius furo	95.13	0.00e+00	1778.00
IUUC-Mlu-067373	Myotis lucifugus	97.11	0.00e+00	652.00
IUUC-Nle-069188	Nomascus leucogenys	94.36	0.00e+00	1776.00
IUUC-Opr-070965	Ochotona princeps	87.31	0.00e+00	1612.00
IUUC-Ont-072226	Oreochromis niloticus	91.53	0.00e+00	1172.00
IUUC-Oan-073497	Ornithorhynchus anatinus	85.59	0.00e+00	1535.00
IUUC-Ocu-073891	Oryctolagus cuniculus	87.97	0.00e+00	1600.00
IUUC-Ola-087438	Oryzias latipes	91.69	0.00e+00	1168.00
IUUC-Oga-087922	Otolemur garnettii	92.21	0.00e+00	1709.00
IUUC-Oar-089317	Ovis aries	90.80	0.00e+00	1656.00
IUUC-Ptr-090484	Pan troglodytes	93.82	0.00e+00	1767.00
IUUC-Pan-092117	Papio anubis	93.82	0.00e+00	1767.00
IUUC-Psi-093338	Pelodiscus sinensis	83.42	0.00e+00	1545.00
IUUC-Pma-094279	Petromyzon marinus	75.09	0.00e+00	849.00
IUUC-Pfo-096171	Poecilia formosa	92.03	0.00e+00	1173.00
IUUC-Pab-098654	Pongo abelii	94.26	0.00e+00	1313.00
IUUC-Pca-100501	Procavia capensis	71.77	0.00e+00	893.00
IUUC-Pva-102811	Pteropus vampyrus	79.07	0.00e+00	1396.00
IUUC-Rno-106125	Rattus norvegicus	89.05	0.00e+00	1624.00
IUUC-Sha-107243	Sarcophilus harrisii	85.13	0.00e+00	1553.00
IUUC-Ssc-115368	Sus scrofa	92.76	0.00e+00	1708.00
IUUC-Tgu-117079	Taeniopygia guttata	81.90	0.00e+00	1496.00
IUUC-Tru-118062	Takifugu rubripes	71.46	0.00e+00	1354.00
IUUC-Tsy-119507	Tarsius syrichta	87.85	0.00e+00	1625.00
IUUC-Tni-120151	Tetraodon nigroviridis	91.19	0.00e+00	1157.00
IUUC-Ttr-129260	Tursiops truncatus	83.95	0.00e+00	1499.00
IUUC-Uma-129332	Ustilago maydis	45.85	1.00e-145	510.00
IUUC-Vpa-130390	Vicugna pacos	81.57	0.00e+00	914.00
IUUC-Xtr-132877	Xenopus tropicalis	69.24	0.00e+00	1190.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence