iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-062698

Ensembl Protein ID

ENSMODP00000020067.3

UniProt Accession

F7G9R7; F7G9R7_MONDO

Protein Name

Protein kinase C

Gene Name

PRKCI

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000016076.3	ENSMODT00000020424.3	ENSMODP00000020067.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/PB1	1.40e-21	76.7	322	404

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelkn.sevalkYeDedGDlvtlksDedldkavslla.skksllrlliqk 83
           +vrvk++ykg+i  + +++e++++fe L+++vr++++++n + +++k+ De+GD +t++s+ +l++a++l++ +k+s l +++++
   Q: 322  QVRVKAYYKGDI--MITHFEPSISFEGLCSEVRDMCSFDNeQLFTMKWIDEEGDPCTVSSQLELEEAFRLYElNKDSELLIHVFP 404
           69**********..88******************************************************************985 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MSSRQLTILA FSEFLRPKKG EVLRGAEPVL GKREGASIEA PVLKSSITHR GSQKKARSAA 60
HTWDTLRTSI PRIPSTKELQ VPVSHSGTPT LAGALIPSDS SGSWPSAPPP PRMSQTEPFD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAGGCACAG AGCGGCTACG TGGGTGGCAA AGGTCATCCA GGCGGCCGGC TCTGGGCTGC 60
CCAGGATCCT TGCTGCTCCC AGCTTGGGTG ACAAAGGCCA CTGCCCTCCT GCCACTGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000961--AGC-kinase_C
IPR034661--aPKC_iota
IPR020454--DAG/PE-bd
IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR002219--PE/DAG-bd
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51285--AGC_KINASE_CTER
PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00564--PB1
PF00069--Pkinase
PF00433--Pkinase_C

PRINTS

PR00008--DAGPEDOMAIN

SMART

SM00109--C1
SM00666--PB1
SM00133--S_TK_X
SM00220--S_TKc

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045171--C:intercellular bridge
GO:0005622--C:intracellular
GO:0015630--C:microtubule cytoskeleton
GO:0005634--C:nucleus
GO:0043220--C:Schmidt-Lanterman incisure
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0005543--F:phospholipid binding
GO:0004697--F:protein kinase C activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0007015--P:actin filament organization
GO:0045216--P:cell-cell junction organization
GO:0032869--P:cellular response to insulin stimulus
GO:0035089--P:establishment of apical/basal cell polarity
GO:0042462--P:eye photoreceptor cell development
GO:0035556--P:intracellular signal transduction
GO:0034351--P:negative regulation of glial cell apoptotic process
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0018105--P:peptidyl-serine phosphorylation
GO:2000353--P:positive regulation of endothelial cell apoptotic process
GO:0090004--P:positive regulation of establishment of protein localization to plasma membrane
GO:0060252--P:positive regulation of glial cell proliferation
GO:0046326--P:positive regulation of glucose import
GO:0010976--P:positive regulation of neuron projection development
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001764	Ailuropoda melanoleuca	95.42	0.00e+00	972.00
IUUC-Apl-003711	Anas platyrhynchos	95.04	0.00e+00	1043.00
IUUC-Aca-005142	Anolis carolinensis	94.25	0.00e+00	1058.00
IUUC-Ame-010977	Astyanax mexicanus	84.60	0.00e+00	948.00
IUUC-Bta-013414	Bos taurus	94.05	0.00e+00	1106.00
IUUC-Bol-015169	Brassica oleracea	35.29	1.00e-50	195.00
IUUC-Cel-018340	Caenorhabditis elegans	55.67	0.00e+00	662.00
IUUC-Cja-019802	Callithrix jacchus	95.91	0.00e+00	1059.00
IUUC-Cfa-021236	Canis familiaris	93.55	0.00e+00	1066.00
IUUC-Cpo-022127	Cavia porcellus	93.83	0.00e+00	1012.00
IUUC-Csa-023332	Chlorocebus sabaeus	97.67	0.00e+00	919.00
IUUC-Cho-025054	Choloepus hoffmanni	63.81	3.00e-119	422.00
IUUC-Cin-025740	Ciona intestinalis	59.18	0.00e+00	676.00
IUUC-Csv-026145	Ciona savignyi	60.21	0.00e+00	675.00
IUUC-Dre-028444	Danio rerio	85.26	0.00e+00	961.00
IUUC-Dno-029228	Dasypus novemcinctus	99.68	0.00e+00	650.00
IUUC-Dme-031630	Drosophila melanogaster	67.47	0.00e+00	756.00
IUUC-Ete-032633	Echinops telfairi	76.01	2.00e-170	592.00
IUUC-Eca-033572	Equus caballus	96.26	0.00e+00	1065.00
IUUC-Eeu-035110	Erinaceus europaeus	95.66	0.00e+00	1088.00
IUUC-Fca-035559	Felis catus	93.87	0.00e+00	1105.00
IUUC-Fal-036953	Ficedula albicollis	95.91	0.00e+00	1054.00
IUUC-Gmo-039334	Gadus morhua	84.38	0.00e+00	977.00
IUUC-Gga-040223	Gallus gallus	93.38	0.00e+00	1079.00
IUUC-Gac-042113	Gasterosteus aculeatus	85.93	0.00e+00	991.00
IUUC-Ggo-044520	Gorilla gorilla	88.75	0.00e+00	983.00
IUUC-Hsa-046991	Homo sapiens	93.54	0.00e+00	1101.00
IUUC-Lch-050263	Latimeria chalumnae	86.42	0.00e+00	1007.00
IUUC-Loc-052221	Lepisosteus oculatus	86.92	0.00e+00	985.00
IUUC-Laf-053591	Loxodonta africana	93.87	0.00e+00	1107.00
IUUC-Mcc-055118	Macaca mulatta	91.72	0.00e+00	1066.00
IUUC-Mga-059886	Meleagris gallopavo	94.86	0.00e+00	1041.00
IUUC-Mmr-060926	Microcebus murinus	93.71	0.00e+00	1104.00
IUUC-Mmu-063689	Mus musculus	93.71	0.00e+00	1096.00
IUUC-Mpu-066630	Mustela putorius furo	95.83	0.00e+00	1090.00
IUUC-Mlu-067416	Myotis lucifugus	90.59	0.00e+00	1017.00
IUUC-Nle-069811	Nomascus leucogenys	93.54	0.00e+00	1101.00
IUUC-Opr-070466	Ochotona princeps	85.65	0.00e+00	733.00
IUUC-Ont-072278	Oreochromis niloticus	85.32	0.00e+00	932.00
IUUC-Oan-073651	Ornithorhynchus anatinus	99.17	0.00e+00	751.00
IUUC-Ocu-074383	Oryctolagus cuniculus	93.87	0.00e+00	1104.00
IUUC-Ola-087283	Oryzias latipes	79.85	0.00e+00	782.00
IUUC-Oga-088337	Otolemur garnettii	86.21	0.00e+00	988.00
IUUC-Oar-089954	Ovis aries	95.91	0.00e+00	1068.00
IUUC-Ptr-091673	Pan troglodytes	93.54	0.00e+00	1101.00
IUUC-Pan-092494	Papio anubis	93.72	0.00e+00	1104.00
IUUC-Psi-094044	Pelodiscus sinensis	95.14	0.00e+00	1073.00
IUUC-Pfo-096661	Poecilia formosa	83.77	0.00e+00	945.00
IUUC-Pab-097659	Pongo abelii	93.55	0.00e+00	1103.00
IUUC-Pca-101107	Procavia capensis	96.74	0.00e+00	776.00
IUUC-Rno-105790	Rattus norvegicus	93.71	0.00e+00	1101.00
IUUC-Sha-106895	Sarcophilus harrisii	96.82	0.00e+00	1048.00
IUUC-Sar-113513	Sorex araneus	93.15	1.00e-167	582.00
IUUC-Ssc-115835	Sus scrofa	95.40	0.00e+00	973.00
IUUC-Tgu-116874	Taeniopygia guttata	93.54	0.00e+00	1084.00
IUUC-Tru-117823	Takifugu rubripes	86.30	0.00e+00	956.00
IUUC-Tsy-119154	Tarsius syrichta	96.09	0.00e+00	1063.00
IUUC-Tni-119968	Tetraodon nigroviridis	83.14	0.00e+00	944.00
IUUC-Tbe-127238	Tupaia belangeri	75.96	0.00e+00	706.00
IUUC-Ttr-129208	Tursiops truncatus	94.04	0.00e+00	1103.00
IUUC-Vpa-130363	Vicugna pacos	84.46	0.00e+00	947.00
IUUC-Xtr-132652	Xenopus tropicalis	83.50	0.00e+00	987.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence