iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074292

Ensembl Protein ID

ENSOCUP00000004174.2

UniProt Accession

G1SML6; G1SML6_RABIT

Genbank Protein ID

ENSOCUP00000004174

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

AAGW02053487

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000004829.3	ENSOCUT00000004827.3	ENSOCUP00000004174.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	90.65	0.00e+00	977.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Oryctolagus cuniculus

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKMPLERPLS EVYVDSSKPA VYNYPEGAAY 60
EFNAAAAAAA AATAPVYSQS GLAYGPGSEA AFGSNGLGGF PQLNSVSPSP LMLLHPPPQL 120

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Nucleotide Sequence
(Fasta)

GTGCTAGTTC TTTATTTTTG AGTTACTGCA TTTCCTAATT TCATGGTCAT AACAGCTTCA 60
GAGCAGAGTC TACCAAAACT GAAAATGCAG GCTCCATGCA CAGAAGCTCT TTCACAGGCT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

KEGG

ocu:100351261

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	92.43	0.00e+00	793.00
IUUC-Apl-003688	Anas platyrhynchos	80.59	0.00e+00	813.00
IUUC-Aca-005222	Anolis carolinensis	77.87	0.00e+00	875.00
IUUC-Ame-010731	Astyanax mexicanus	56.12	1.00e-133	470.00
IUUC-Bta-013112	Bos taurus	84.50	0.00e+00	923.00
IUUC-Cja-019408	Callithrix jacchus	91.99	0.00e+00	995.00
IUUC-Cfa-020694	Canis familiaris	87.67	0.00e+00	940.00
IUUC-Cpo-021426	Cavia porcellus	85.33	0.00e+00	914.00
IUUC-Cre-022648	Chlamydomonas reinhardtii	30.23	2.40e+00	26.60
IUUC-Csa-023736	Chlorocebus sabaeus	92.40	0.00e+00	874.00
IUUC-Dre-027698	Danio rerio	56.32	4.00e-132	464.00
IUUC-Dno-029477	Dasypus novemcinctus	91.06	0.00e+00	767.00
IUUC-Dor-030572	Dipodomys ordii	91.22	0.00e+00	759.00
IUUC-Ete-032849	Echinops telfairi	72.23	0.00e+00	667.00
IUUC-Eca-033605	Equus caballus	85.81	0.00e+00	944.00
IUUC-Eeu-034683	Erinaceus europaeus	92.06	9.00e-111	393.00
IUUC-Fca-035928	Felis catus	93.06	0.00e+00	796.00
IUUC-Fal-036754	Ficedula albicollis	79.47	0.00e+00	909.00
IUUC-Gmo-038872	Gadus morhua	56.44	7.00e-114	404.00
IUUC-Gga-040988	Gallus gallus	79.60	0.00e+00	887.00
IUUC-Gac-042015	Gasterosteus aculeatus	62.40	8.00e-126	444.00
IUUC-Ggo-044749	Gorilla gorilla	91.65	0.00e+00	989.00
IUUC-Hsa-046944	Homo sapiens	90.65	0.00e+00	978.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	90.33	0.00e+00	974.00
IUUC-Loc-052414	Lepisosteus oculatus	58.32	0.00e+00	630.00
IUUC-Mcc-054781	Macaca mulatta	91.49	0.00e+00	989.00
IUUC-Meu-056232	Macropus eugenii	85.79	0.00e+00	929.00
IUUC-Mga-059319	Meleagris gallopavo	79.76	0.00e+00	889.00
IUUC-Mmr-061636	Microcebus murinus	90.59	2.00e-170	591.00
IUUC-Mdo-062661	Monodelphis domestica	86.96	0.00e+00	941.00
IUUC-Mmu-063330	Mus musculus	91.32	0.00e+00	950.00
IUUC-Mpu-065757	Mustela putorius furo	86.86	0.00e+00	956.00
IUUC-Mlu-067712	Myotis lucifugus	90.42	0.00e+00	862.00
IUUC-Nle-069283	Nomascus leucogenys	89.82	0.00e+00	947.00
IUUC-Opr-070391	Ochotona princeps	92.14	0.00e+00	1036.00
IUUC-Ont-071369	Oreochromis niloticus	54.99	5.00e-120	424.00
IUUC-Oan-073734	Ornithorhynchus anatinus	73.76	3.00e-132	464.00
IUUC-Oba-075103	Oryza barthii	28.21	8.00e-03	35.00
IUUC-Ogu-079042	Oryza glumaepatula	28.21	2.00e-03	37.40
IUUC-Olo-080944	Oryza longistaminata	28.21	3.00e-03	34.70
IUUC-Oni-082560	Oryza nivara	28.21	7.00e-03	35.40
IUUC-Ola-087052	Oryzias latipes	51.67	1.00e-128	453.00
IUUC-Oga-088586	Otolemur garnettii	90.37	0.00e+00	970.00
IUUC-Oar-090156	Ovis aries	91.50	0.00e+00	823.00
IUUC-Ptr-091321	Pan troglodytes	91.49	0.00e+00	988.00
IUUC-Pan-092851	Papio anubis	91.32	0.00e+00	987.00
IUUC-Psi-093434	Pelodiscus sinensis	78.43	0.00e+00	921.00
IUUC-Pfo-097379	Poecilia formosa	56.37	2.00e-134	473.00
IUUC-Pab-097735	Pongo abelii	91.32	0.00e+00	987.00
IUUC-Pva-102125	Pteropus vampyrus	88.46	0.00e+00	955.00
IUUC-Rno-106121	Rattus norvegicus	90.83	0.00e+00	944.00
IUUC-Sha-107547	Sarcophilus harrisii	87.12	0.00e+00	939.00
IUUC-Sar-113650	Sorex araneus	79.86	4.00e-179	620.00
IUUC-Tgu-117175	Taeniopygia guttata	78.92	0.00e+00	900.00
IUUC-Tru-117545	Takifugu rubripes	50.71	1.00e-136	480.00
IUUC-Tsy-119586	Tarsius syrichta	76.50	0.00e+00	816.00
IUUC-Tni-120121	Tetraodon nigroviridis	54.07	7.00e-138	484.00
IUUC-Tbe-127548	Tupaia belangeri	82.21	0.00e+00	642.00
IUUC-Ttr-128374	Tursiops truncatus	82.30	0.00e+00	867.00
IUUC-Vpa-130464	Vicugna pacos	83.06	1.00e-156	546.00
IUUC-Xtr-132171	Xenopus tropicalis	69.40	0.00e+00	734.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence