iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000001629.9	ENST00000265742.7	ENSP00000265742.3
ENSG00000001629.9	ENST00000439883.1	ENSP00000407913.1
ENSG00000001629.9	ENST00000413588.1	ENSP00000406644.1
ENSG00000001629.9	ENST00000422095.1	ENSP00000396406.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	11406394; 15155768

Classification

Family	E-value	Score	Start	End
E3 activity/RBR	3.50e-58	197.4	333	548
UBD/Alpha-Helix/UIM	0.29	13.0	851	868

Active Site

Position(s)	Description	Evidence
532	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++C++++sv e++v + C h+fC+ C++++l+lki+eg++++i+cpa++c++ ++ + i++ +v++e+ kry +++++++ve+++a+kw
   Q: 333  CDICMCSISVFEDPVDMPCGHDFCRGCWESFLNLKIQEGEAHNIFCPAYDCFQLVPVDIIES-VVSKEMDKRYLQFDIKAFVENNPAIKW 421
           **************************************************************.79************************* PP
   S: 91   cpapdCslvvllekea..............eklevecekcgkefCveCkeewHeglsCkelkeklakteeek...........eeaeske 155
           cp+p+C+++v+l+k++              ++  v+c ++g+ fC+eC  e+He+++C+++k++l+k +e+k           e+a+++ 
   Q: 422  CPTPGCDRAVRLTKQGsntsgsdtlsfpllRAPAVDC-GKGHLFCWECLGEAHEPCDCQTWKNWLQKITEMKpeelvgvseayEDAANCL 510
           **************98999999888885544444447.7789*****************************9****************** PP
   S: 156  lleanskkCpkCkvyieknegCnhmtCakCkaefCwlC 193
           +l +nsk+C++Ck++i+knegCnhm+CakCk++fCw+C
   Q: 511  WLLTNSKPCANCKSPIQKNEGCNHMQCAKCKYDFCWIC 548
           ************************************** PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEee 18
           ++d+ + lA++lSlqE +
   Q: 851  EDDPNILLAIQLSLQESG 868
           69999***********86 PP

Organism

Homo sapiens

Functional Description
(View)

Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.

Protein Sequence
(Fasta)

MGNTTTKFRK ALINGDENLA CQIYENNPQL KESLDPNTSY GEPYQHNTPL HYAARHGMNK 60
ILGTFLGRDG NPNKRNVHNE TSMHLLCMGP QIMISEGALH PRLARPTEDD FRRADCLQMI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCAGCGGCC GGAGAGGGAT GGGGGGCGCC CACCCAGTCT GAGCCTCGCC GCGGGCGCCT 60
TCGGCTCACG CAGCGCTTCC CGCGGGCCGC CAGTGCGCAC CCTCGGCCAC ATCAGCCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0449--Lipoprotein
KW-0479--Metal-binding
KW-0519--Myristate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003903--UIM_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50330--UIM
PS50089--ZF_RING_2

Pfam

PF00023--Ank
PF01485--IBR

SMART

SM00248--ANK
SM00647--IBR
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:54467

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002145	Ailuropoda melanoleuca	96.34	0.00e+00	2033.00
IUUC-Apl-003749	Anas platyrhynchos	87.36	0.00e+00	1842.00
IUUC-Aca-004337	Anolis carolinensis	83.08	0.00e+00	1757.00
IUUC-Aly-006224	Arabidopsis lyrata	30.42	2.00e-59	223.00
IUUC-Ame-011136	Astyanax mexicanus	77.61	0.00e+00	1533.00
IUUC-Bta-012896	Bos taurus	95.24	0.00e+00	1953.00
IUUC-Bol-015971	Brassica oleracea	30.35	4.00e-59	222.00
IUUC-Cja-019418	Callithrix jacchus	98.44	0.00e+00	2010.00
IUUC-Cfa-021139	Canis familiaris	96.07	0.00e+00	1996.00
IUUC-Cpo-022432	Cavia porcellus	93.49	0.00e+00	1970.00
IUUC-Cre-022815	Chlamydomonas reinhardtii	28.84	5.00e-56	211.00
IUUC-Csa-023239	Chlorocebus sabaeus	99.27	0.00e+00	2070.00
IUUC-Cho-024329	Choloepus hoffmanni	85.87	0.00e+00	1182.00
IUUC-Dre-028543	Danio rerio	78.86	0.00e+00	1532.00
IUUC-Dno-028949	Dasypus novemcinctus	93.87	0.00e+00	1957.00
IUUC-Dor-031083	Dipodomys ordii	84.46	0.00e+00	972.00
IUUC-Ete-032919	Echinops telfairi	93.06	0.00e+00	758.00
IUUC-Eca-033459	Equus caballus	95.52	0.00e+00	1919.00
IUUC-Eeu-034726	Erinaceus europaeus	74.75	0.00e+00	721.00
IUUC-Fca-036063	Felis catus	96.07	0.00e+00	1986.00
IUUC-Fal-036854	Ficedula albicollis	85.11	0.00e+00	1792.00
IUUC-Gmo-039629	Gadus morhua	64.78	0.00e+00	1189.00
IUUC-Gga-040616	Gallus gallus	87.95	0.00e+00	1860.00
IUUC-Gac-042034	Gasterosteus aculeatus	71.63	0.00e+00	1466.00
IUUC-Ggo-045104	Gorilla gorilla	99.63	0.00e+00	2057.00
IUUC-Hvu-047440	Hordeum vulgare	33.14	2.00e-53	203.00
IUUC-Itr-047991	Ictidomys tridecemlineatus	93.90	0.00e+00	1070.00
IUUC-Lch-050129	Latimeria chalumnae	80.62	0.00e+00	1552.00
IUUC-Loc-052381	Lepisosteus oculatus	77.82	0.00e+00	1576.00
IUUC-Laf-053411	Loxodonta africana	94.97	0.00e+00	1969.00
IUUC-Mcc-055098	Macaca mulatta	99.11	0.00e+00	1890.00
IUUC-Mga-059352	Meleagris gallopavo	87.69	0.00e+00	1855.00
IUUC-Mmr-061763	Microcebus murinus	94.39	0.00e+00	1994.00
IUUC-Mdo-062522	Monodelphis domestica	94.94	0.00e+00	1608.00
IUUC-Mmu-063322	Mus musculus	92.85	0.00e+00	1957.00
IUUC-Mac-065184	Musa acuminata	31.33	1.00e-58	221.00
IUUC-Mpu-065807	Mustela putorius furo	96.25	0.00e+00	1997.00
IUUC-Mlu-067421	Myotis lucifugus	92.05	0.00e+00	1875.00
IUUC-Nle-069468	Nomascus leucogenys	99.82	0.00e+00	2061.00
IUUC-Opr-070381	Ochotona princeps	87.95	0.00e+00	1842.00
IUUC-Ont-072092	Oreochromis niloticus	72.74	0.00e+00	1504.00
IUUC-Oan-072962	Ornithorhynchus anatinus	83.92	0.00e+00	701.00
IUUC-Ocu-074462	Oryctolagus cuniculus	92.85	0.00e+00	1860.00
IUUC-Oba-075918	Oryza barthii	34.09	2.00e-55	210.00
IUUC-Olo-080626	Oryza longistaminata	33.85	7.00e-48	185.00
IUUC-Ome-081812	Oryza meridionalis	34.09	2.00e-55	211.00
IUUC-Ola-086873	Oryzias latipes	76.68	0.00e+00	1465.00
IUUC-Oga-088058	Otolemur garnettii	97.34	0.00e+00	2026.00
IUUC-Oar-089724	Ovis aries	94.98	0.00e+00	1941.00
IUUC-Ptr-090646	Pan troglodytes	99.82	0.00e+00	2062.00
IUUC-Pan-092334	Papio anubis	99.17	0.00e+00	2060.00
IUUC-Psi-093827	Pelodiscus sinensis	88.22	0.00e+00	1827.00
IUUC-Pma-094243	Petromyzon marinus	62.20	0.00e+00	909.00
IUUC-Pfo-097370	Poecilia formosa	69.68	0.00e+00	1462.00
IUUC-Pab-098757	Pongo abelii	99.72	0.00e+00	2091.00
IUUC-Pca-101017	Procavia capensis	89.58	0.00e+00	959.00
IUUC-Ppe-101451	Prunus persica	35.41	6.00e-57	215.00
IUUC-Pva-102797	Pteropus vampyrus	93.43	0.00e+00	1920.00
IUUC-Rno-106046	Rattus norvegicus	93.13	0.00e+00	1964.00
IUUC-Sha-107341	Sarcophilus harrisii	87.99	0.00e+00	1854.00
IUUC-Sar-113328	Sorex araneus	86.98	0.00e+00	1517.00
IUUC-Ssc-115681	Sus scrofa	94.07	0.00e+00	1923.00
IUUC-Tgu-116830	Taeniopygia guttata	87.67	0.00e+00	1846.00
IUUC-Tru-117711	Takifugu rubripes	75.20	0.00e+00	1432.00
IUUC-Tsy-119501	Tarsius syrichta	86.26	0.00e+00	926.00
IUUC-Tni-119911	Tetraodon nigroviridis	65.31	0.00e+00	1223.00
IUUC-Tur-126178	Triticum urartu	30.23	1.00e-43	171.00
IUUC-Tbe-127647	Tupaia belangeri	84.78	0.00e+00	1243.00
IUUC-Ttr-129218	Tursiops truncatus	95.88	0.00e+00	2004.00
IUUC-Vpa-130603	Vicugna pacos	95.33	0.00e+00	1964.00
IUUC-Xtr-132250	Xenopus tropicalis	78.71	0.00e+00	1017.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence