iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000005339.14	ENST00000262367.9	ENSP00000262367.5
ENSG00000005339.14	ENST00000382070.7	ENSP00000371502.3
ENSG00000005339.14	ENST00000637492.1	ENSP00000490244.1
ENSG00000005339.14	ENST00000570939.2	ENSP00000461002.2
ENSG00000005339.14	ENST00000573517.6	ENSP00000460474.2
ENSG00000005339.14	ENST00000571826.5	ENSP00000459490.1
ENSG00000005339.14	ENST00000572134.1	ENSP00000458254.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Drug and target
TTD	DrugBank	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	19805293

Organism

Homo sapiens

Functional Description
(View)

Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902).

Protein Sequence
(Fasta)

MAENLLDGPP NPKRAKLSSP GFSANDSTDF GSLFDLENDL PDELIPNGGE LGLLNSGNLV 60
PDAASKHKQL SELLRGGSGS SINPGIGNVS ASSPVQQGLG GQAQGQPNSA NMASLSAMGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCTTTTTTT TTTAATTGAG GAATCAACAG CCGCCATCTT GTCGCGGACC CGACCGGGGC 60
TTCGAGCGCG ATCTACTCGG CCCCGCCGGT CCCGGGCCCC ACAACCGCCC GCGCACCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0012--Acyltransferase
KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0103--Bromodomain
KW-0160--Chromosomal rearrangement
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0945--Host-virus interaction
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR031162--CBP_P300_HAT
IPR013178--Histone_AcTrfase_Rtt109/CBP
IPR003101--KIX_dom
IPR009110--Nuc_rcpt_coact
IPR014744--Nuc_rcpt_coact_CREBbp
IPR010303--RING_CBP-p300
IPR000197--Znf_TAZ
IPR000433--Znf_ZZ

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS51727--CBP_P300_HAT
PS50952--KIX
PS50134--ZF_TAZ
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF00439--Bromodomain
PF09030--Creb_binding
PF06001--DUF902
PF08214--HAT_KAT11
PF02172--KIX
PF02135--zf-TAZ
PF00569--ZZ

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM01250--KAT11
SM00551--ZnF_TAZ
SM00291--ZnF_ZZ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000123--C:histone acetyltransferase complex
GO:0016604--C:nuclear body
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016407--F:acetyltransferase activity
GO:0003682--F:chromatin binding
GO:0000987--F:core promoter proximal region sequence-specific DNA binding
GO:0003684--F:damaged DNA binding
GO:0004402--F:histone acetyltransferase activity
GO:0043426--F:MRF binding
GO:0002039--F:p53 binding
GO:0034212--F:peptide N-acetyltransferase activity
GO:0001102--F:RNA polymerase II activating transcription factor binding
GO:0001105--F:RNA polymerase II transcription coactivator activity
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0004871--F:signal transducer activity
GO:0003713--F:transcription coactivator activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008134--F:transcription factor binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001191--F:transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0008270--F:zinc ion binding
GO:1904837--P:beta-catenin-TCF complex assembly
GO:0044255--P:cellular lipid metabolic process
GO:0034644--P:cellular response to UV
GO:0042733--P:embryonic digit morphogenesis
GO:0016573--P:histone acetylation
GO:0042592--P:homeostatic process
GO:0018076--P:N-terminal peptidyl-lysine acetylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007219--P:Notch signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0032481--P:positive regulation of type I interferon production
GO:0006473--P:protein acetylation
GO:0006461--P:protein complex assembly
GO:0042981--P:regulation of apoptotic process
GO:1900034--P:regulation of cellular response to heat
GO:0008589--P:regulation of smoothened signaling pathway
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0006355--P:regulation of transcription, DNA-templated
GO:0001666--P:response to hypoxia
GO:0048511--P:rhythmic process
GO:0007165--P:signal transduction
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0006367--P:transcription initiation from RNA polymerase II promoter
GO:0016032--P:viral process

KEGG

hsa:1387

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001156	Aegilops tauschii	31.90	1.00e-92	335.00
IUUC-Aml-001390	Ailuropoda melanoleuca	97.76	0.00e+00	1753.00
IUUC-Apl-003917	Anas platyrhynchos	88.66	0.00e+00	1879.00
IUUC-Aca-005023	Anolis carolinensis	72.86	0.00e+00	1647.00
IUUC-Ath-007233	Arabidopsis thaliana	40.81	8.00e-76	279.00
IUUC-Bta-012732	Bos taurus	95.22	0.00e+00	1991.00
IUUC-Bdi-014481	Brachypodium distachyon	32.52	1.00e-91	332.00
IUUC-Bol-016000	Brassica oleracea	41.51	4.00e-76	280.00
IUUC-Bra-018090	Brassica rapa	41.51	3.00e-76	281.00
IUUC-Cja-019859	Callithrix jacchus	94.79	0.00e+00	1956.00
IUUC-Cfa-020117	Canis familiaris	95.88	0.00e+00	1990.00
IUUC-Cpo-021490	Cavia porcellus	88.42	0.00e+00	2249.00
IUUC-Csa-024144	Chlorocebus sabaeus	96.70	0.00e+00	1997.00
IUUC-Cin-025624	Ciona intestinalis	63.00	0.00e+00	1072.00
IUUC-Dre-027824	Danio rerio	86.02	0.00e+00	1585.00
IUUC-Dno-029638	Dasypus novemcinctus	93.06	0.00e+00	2200.00
IUUC-Dor-030279	Dipodomys ordii	89.22	0.00e+00	1874.00
IUUC-Dme-031716	Drosophila melanogaster	75.69	0.00e+00	793.00
IUUC-Ete-032742	Echinops telfairi	85.03	0.00e+00	1537.00
IUUC-Eca-034081	Equus caballus	96.46	0.00e+00	2029.00
IUUC-Eeu-035154	Erinaceus europaeus	93.07	0.00e+00	1539.00
IUUC-Fca-035657	Felis catus	96.55	0.00e+00	1881.00
IUUC-Gmo-039229	Gadus morhua	80.43	0.00e+00	1505.00
IUUC-Gga-041000	Gallus gallus	87.96	0.00e+00	1862.00
IUUC-Gac-042302	Gasterosteus aculeatus	63.46	0.00e+00	2036.00
IUUC-Ggo-044545	Gorilla gorilla	99.33	0.00e+00	2192.00
IUUC-Hvu-047619	Hordeum vulgare	31.72	8.00e-91	329.00
IUUC-Itr-048347	Ictidomys tridecemlineatus	97.61	0.00e+00	1607.00
IUUC-Loc-052536	Lepisosteus oculatus	88.99	0.00e+00	1600.00
IUUC-Laf-054354	Loxodonta africana	92.89	0.00e+00	2191.00
IUUC-Mtr-058740	Medicago truncatula	37.76	8.00e-68	253.00
IUUC-Mga-060006	Meleagris gallopavo	87.58	0.00e+00	1858.00
IUUC-Mmr-060671	Microcebus murinus	98.30	0.00e+00	2018.00
IUUC-Mdo-062089	Monodelphis domestica	91.91	0.00e+00	1935.00
IUUC-Mmu-063137	Mus musculus	95.31	0.00e+00	3545.00
IUUC-Mac-065060	Musa acuminata	33.88	2.00e-101	364.00
IUUC-Mpu-066456	Mustela putorius furo	95.98	0.00e+00	1999.00
IUUC-Mlu-067119	Myotis lucifugus	95.87	0.00e+00	1990.00
IUUC-Nle-069683	Nomascus leucogenys	99.46	0.00e+00	2179.00
IUUC-Opr-070886	Ochotona princeps	88.40	0.00e+00	1731.00
IUUC-Ont-071852	Oreochromis niloticus	86.10	0.00e+00	1551.00
IUUC-Oan-073606	Ornithorhynchus anatinus	87.37	0.00e+00	1823.00
IUUC-Oin-079283	Oryza indica	40.00	7.00e-74	273.00
IUUC-Olo-080969	Oryza longistaminata	40.00	9.00e-74	273.00
IUUC-Ola-086899	Oryzias latipes	83.67	0.00e+00	1527.00
IUUC-Oga-088968	Otolemur garnettii	96.95	0.00e+00	2006.00
IUUC-Oar-090446	Ovis aries	97.49	0.00e+00	1742.00
IUUC-Ptr-090698	Pan troglodytes	100.00	0.00e+00	2184.00
IUUC-Pma-094328	Petromyzon marinus	83.47	0.00e+00	1000.00
IUUC-Pfo-096203	Poecilia formosa	82.75	0.00e+00	1503.00
IUUC-Pab-098523	Pongo abelii	99.52	0.00e+00	2009.00
IUUC-Pca-100486	Procavia capensis	89.43	0.00e+00	1558.00
IUUC-Ppe-101498	Prunus persica	38.38	2.00e-68	254.00
IUUC-Pva-102672	Pteropus vampyrus	96.26	0.00e+00	1815.00
IUUC-Sit-110128	Setaria italica	40.11	3.00e-73	271.00
IUUC-Stu-112845	Solanum tuberosum	37.34	5.00e-65	242.00
IUUC-Sar-113479	Sorex araneus	79.41	0.00e+00	807.00
IUUC-Sbi-114827	Sorghum bicolor	40.54	2.00e-74	275.00
IUUC-Tgu-117133	Taeniopygia guttata	84.28	0.00e+00	1790.00
IUUC-Tru-118390	Takifugu rubripes	82.87	0.00e+00	1526.00
IUUC-Tsy-119388	Tarsius syrichta	83.87	0.00e+00	1656.00
IUUC-Tae-125906	Triticum aestivum	32.04	1.00e-92	335.00
IUUC-Ttr-128447	Tursiops truncatus	95.63	0.00e+00	1996.00
IUUC-Vpa-130585	Vicugna pacos	90.85	0.00e+00	1156.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence