iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046977

UUCD1 version

UUC-HoS-00038

Ensembl Protein ID

ENSP00000444596.1

UniProt Accession

O75592; A6NJC6; Q5JSX8; Q5VZN6; Q6PIB6; Q9UQ11; Q9Y6E4; MYCB2_HUMAN

Genbank Protein ID

AAC39928.1; CAH73736.1; CAH73736.1; CAH73736.1; CAH73736.1; CAI16842.1; CAI16842.1; CAI16842.1; CAI16842.1; CAI39759.1; CAI39759.1; CAI39759.1; CAI39759.1; CAI39758.1; CAI39758.1; EAW80565.1; BAA74939.1; AAH37971.1; AAD39842.1

Protein Name

E3 ubiquitin-protein ligase MYCBP2; Myc-binding protein 2; Pam/highwire/rpm-1 protein; Protein associated with Myc; RING-type E3 ubiquitin transferase MYCBP2

Genbank Nucleotide ID

AF075587; AL159154; AL159158; AL359257; AC001226; AL159158; AL159154; AL359257; AC001226; AL359257; AL159158; AL159154; AC001226; AL359257; AC001226; CH471093; AB020723; BC037971; AF083244

Gene Name

MYCBP2; KIAA0916; PAM

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000005810.17	ENST00000544440.6	ENSP00000444596.1
ENSG00000005810.17	ENST00000429715.1	ENSP00000413907.1
ENSG00000005810.17	ENST00000466564.2	ENSP00000481482.1
ENSG00000005810.17	ENST00000612956.4	ENSP00000483488.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM	SZDB
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18753128

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 activity/RING/RING	32.31	0.00e+00	642.00	IUUC-Cel-018686
E3 activity/RING/RING	62.57	0.00e+00	728.00	IUUC-Dme-031777

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis.

Protein Sequence
(Fasta)

MPVPDGSVAA AGLGLGLPAA DSRGHYQLLL SGRALADRYR RIYTAALNDR DQGGGSAGHP 60
ASRNKKILNK KKLKRKQKSK SKVKTRSKSE NLENTVIIPD IKLHSNPSAF NIYCNVRHCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGGTGGCG GCGGCAGTGG CGGCACCGCC TCCTCCTCAC ATTCCCGGGG TGGCGGGGTT 60
AGATGAGCGG CCCCAGTAGC GGCGAGGGCG GCGCGGGGGG GAGGAGGAGA AGAAGGAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR017868--Filamin/ABP280_repeat-like
IPR008979--Galactose-bd-like
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR012983--PHR
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003646--SH3-like_bac-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51284--DOC
PS50194--FILAMIN_REPEAT
PS00626--RCC1_2
PS50012--RCC1_3
PS50089--ZF_RING_2

Pfam

PF03256--ANAPC10
PF00630--Filamin
PF08005--PHR
PF00415--RCC1
PF08239--SH3_3
PF13639--zf-RING_2

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM00184--RING

Gene Ontology

GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016567--P:protein ubiquitination
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:23077

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001951	Ailuropoda melanoleuca	97.13	0.00e+00	8641.00
IUUC-Apl-003625	Anas platyrhynchos	91.54	0.00e+00	8121.00
IUUC-Aca-005207	Anolis carolinensis	91.12	0.00e+00	8062.00
IUUC-Ame-010649	Astyanax mexicanus	83.80	0.00e+00	7588.00
IUUC-Bta-012670	Bos taurus	98.51	0.00e+00	8730.00
IUUC-Cel-018686	Caenorhabditis elegans	32.56	0.00e+00	663.00
IUUC-Cja-019910	Callithrix jacchus	99.35	0.00e+00	8863.00
IUUC-Cfa-020184	Canis familiaris	97.57	0.00e+00	8721.00
IUUC-Cpo-021334	Cavia porcellus	94.30	0.00e+00	8433.00
IUUC-Csa-023291	Chlorocebus sabaeus	97.86	0.00e+00	8839.00
IUUC-Cho-024927	Choloepus hoffmanni	88.41	0.00e+00	1583.00
IUUC-Cin-025345	Ciona intestinalis	54.43	0.00e+00	949.00
IUUC-Csv-026264	Ciona savignyi	50.51	0.00e+00	1094.00
IUUC-Dre-028645	Danio rerio	83.77	0.00e+00	7584.00
IUUC-Dno-029670	Dasypus novemcinctus	94.96	0.00e+00	8450.00
IUUC-Dor-030993	Dipodomys ordii	92.06	0.00e+00	2432.00
IUUC-Dme-031777	Drosophila melanogaster	62.38	0.00e+00	725.00
IUUC-Ete-032613	Echinops telfairi	93.36	0.00e+00	8232.00
IUUC-Eca-034364	Equus caballus	96.88	0.00e+00	8741.00
IUUC-Eeu-035200	Erinaceus europaeus	80.53	0.00e+00	2565.00
IUUC-Fca-036054	Felis catus	97.33	0.00e+00	8687.00
IUUC-Fal-036991	Ficedula albicollis	92.64	0.00e+00	8268.00
IUUC-Gmo-038487	Gadus morhua	85.72	0.00e+00	4170.00
IUUC-Gga-041035	Gallus gallus	92.01	0.00e+00	8279.00
IUUC-Gac-041637	Gasterosteus aculeatus	85.27	0.00e+00	4111.00
IUUC-Ggo-045091	Gorilla gorilla	99.28	0.00e+00	7652.00
IUUC-Itr-048995	Ictidomys tridecemlineatus	97.70	0.00e+00	2395.00
IUUC-Lch-050171	Latimeria chalumnae	71.85	0.00e+00	1259.00
IUUC-Loc-052822	Lepisosteus oculatus	85.39	0.00e+00	7718.00
IUUC-Laf-054065	Loxodonta africana	96.78	0.00e+00	8721.00
IUUC-Mcc-054947	Macaca mulatta	97.88	0.00e+00	8842.00
IUUC-Meu-056600	Macropus eugenii	90.63	0.00e+00	1541.00
IUUC-Mga-059559	Meleagris gallopavo	93.77	0.00e+00	7650.00
IUUC-Mmr-060973	Microcebus murinus	97.64	0.00e+00	7233.00
IUUC-Mdo-061938	Monodelphis domestica	96.10	0.00e+00	4966.00
IUUC-Mmu-063569	Mus musculus	95.42	0.00e+00	8623.00
IUUC-Mpu-066457	Mustela putorius furo	96.92	0.00e+00	8618.00
IUUC-Mlu-067165	Myotis lucifugus	98.36	0.00e+00	8317.00
IUUC-Nle-069042	Nomascus leucogenys	99.44	0.00e+00	8882.00
IUUC-Opr-070201	Ochotona princeps	87.64	0.00e+00	2958.00
IUUC-Ont-072263	Oreochromis niloticus	85.48	0.00e+00	7549.00
IUUC-Oan-073108	Ornithorhynchus anatinus	92.35	0.00e+00	4491.00
IUUC-Ocu-074359	Oryctolagus cuniculus	95.19	0.00e+00	6989.00
IUUC-Ola-087074	Oryzias latipes	84.00	0.00e+00	4375.00
IUUC-Oga-088322	Otolemur garnettii	98.66	0.00e+00	8775.00
IUUC-Oar-089244	Ovis aries	97.20	0.00e+00	8685.00
IUUC-Ptr-091449	Pan troglodytes	99.40	0.00e+00	8907.00
IUUC-Pan-091756	Papio anubis	96.51	0.00e+00	5127.00
IUUC-Psi-093387	Pelodiscus sinensis	92.98	0.00e+00	6274.00
IUUC-Pma-094327	Petromyzon marinus	70.76	2.00e-123	435.00
IUUC-Ppa-095276	Physcomitrella patens	40.31	6.00e-56	212.00
IUUC-Pfo-097372	Poecilia formosa	84.24	0.00e+00	4351.00
IUUC-Pab-097572	Pongo abelii	94.64	0.00e+00	7087.00
IUUC-Pca-101007	Procavia capensis	93.25	0.00e+00	4064.00
IUUC-Pva-102217	Pteropus vampyrus	94.59	0.00e+00	4422.00
IUUC-Rno-105422	Rattus norvegicus	94.45	0.00e+00	8316.00
IUUC-Sha-107119	Sarcophilus harrisii	92.97	0.00e+00	3283.00
IUUC-Smo-108712	Selaginella moellendorffii	39.60	2.00e-56	213.00
IUUC-Sar-113595	Sorex araneus	95.68	0.00e+00	2338.00
IUUC-Ssc-115690	Sus scrofa	98.43	0.00e+00	8430.00
IUUC-Tgu-116555	Taeniopygia guttata	94.12	0.00e+00	7877.00
IUUC-Tru-117796	Takifugu rubripes	83.08	0.00e+00	4330.00
IUUC-Tsy-118924	Tarsius syrichta	96.30	0.00e+00	5799.00
IUUC-Tni-120759	Tetraodon nigroviridis	82.08	0.00e+00	7427.00
IUUC-Ttr-128814	Tursiops truncatus	97.41	0.00e+00	3739.00
IUUC-Vpa-130430	Vicugna pacos	95.22	0.00e+00	8323.00
IUUC-Xtr-131898	Xenopus tropicalis	87.33	0.00e+00	1592.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence